| UniProt ID | SLF2_HUMAN | |
|---|---|---|
| UniProt AC | Q8IX21 | |
| Protein Name | SMC5-SMC6 complex localization factor protein 2 {ECO:0000312|HGNC:HGNC:17814} | |
| Gene Name | SLF2 {ECO:0000303|PubMed:25931565, ECO:0000312|HGNC:HGNC:17814} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1173 | |
| Subcellular Localization | Nucleus . Mainly localizes in the nucleus (PubMed:24561620). Colocalizes with PCNA on replication sites (PubMed:24561620). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA inters | |
| Protein Description | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. [PubMed: 25931565 The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks] | |
| Protein Sequence | MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAHAAAGKRTESPGDRKQSIIDFFKPASKQDRHMLDSPQKSNIKYGGSRLSITGTEQFERKLSSPKESKPKRVPPEKSPIIEAFMKGVKEHHEDHGIHESRRPCLSLASKYLAKGTNIYVPSSYHLPKEMKSLKKKHRSPERRKSLFIHENNEKNDRDRGKTNADSKKQTTVAEADIFNNSSRSLSSRSSLSRHHPEESPLGAKFQLSLASYCRERELKRLRKEQMEQRINSENSFSEASSLSLKSSIERKYKPRQEQRKQNDIIPGKNNLSNVENGHLSRKRSSSDSWEPTSAGSKQNKFPEKRKRNSVDSDLKSTRESMIPKARESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKEPSDETDGSSAGLAPSNSGNSGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEKSAIKKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLVPLNAKNCALPVSKKDKERSSSKECSGHSTESTKHKEHKAKTNKADSNVSSGKISGGPLRSEYGTPTKSPPAALEVVPCIPSPAAPSDKAPSEGESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSLEEIMALNFNQTPAATGKPPALSKGLRSQSSDYTGHVHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIPDHHPGEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGKESEDSSYKPIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNIRDWNTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHEDVPNASNLQVSVLHRYLVQMKPSDLLKKMVLKKKAEQPDGIIDDSLHLELEKQAYYLTYILLHLVGEVSCSHSFSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTRRCMPAR ------CCCCCCCCC | 24144214 | ||
| 14 | Phosphorylation | PARPGFPSSPAPGSS CCCCCCCCCCCCCCC | 29978859 | ||
| 15 | Phosphorylation | ARPGFPSSPAPGSSP CCCCCCCCCCCCCCC | 29255136 | ||
| 20 | Phosphorylation | PSSPAPGSSPPRCHL CCCCCCCCCCCCCCC | 29255136 | ||
| 21 | Phosphorylation | SSPAPGSSPPRCHLR CCCCCCCCCCCCCCC | 29255136 | ||
| 50 | Phosphorylation | SPGDRKQSIIDFFKP CCCCCCCHHHHHHCC | 28857561 | ||
| 68 | Phosphorylation | QDRHMLDSPQKSNIK CCHHCCCCCCCCCCC | 25159151 | ||
| 72 | Phosphorylation | MLDSPQKSNIKYGGS CCCCCCCCCCCCCCC | 25404012 | ||
| 76 | Phosphorylation | PQKSNIKYGGSRLSI CCCCCCCCCCCCCEE | - | ||
| 82 | Phosphorylation | KYGGSRLSITGTEQF CCCCCCCEEECHHHH | 28348404 | ||
| 109 | Phosphorylation | KRVPPEKSPIIEAFM CCCCCCCCHHHHHHH | 22199227 | ||
| 137 | Phosphorylation | ESRRPCLSLASKYLA CCCHHHHHHHHHHHH | 20860994 | ||
| 170 | Phosphorylation | SLKKKHRSPERRKSL HHHHHHCCHHHHHHH | - | ||
| 176 | Phosphorylation | RSPERRKSLFIHENN CCHHHHHHHEEECCC | 25849741 | ||
| 193 | Phosphorylation | NDRDRGKTNADSKKQ CCCCCCCCCCCHHHC | 27251275 | ||
| 197 | Phosphorylation | RGKTNADSKKQTTVA CCCCCCCHHHCCCHH | 27251275 | ||
| 220 | Phosphorylation | SRSLSSRSSLSRHHP CCCCCCCCHHHHCCC | 18691976 | ||
| 221 | Phosphorylation | RSLSSRSSLSRHHPE CCCCCCCHHHHCCCC | 20068231 | ||
| 223 | Phosphorylation | LSSRSSLSRHHPEES CCCCCHHHHCCCCCC | 21406692 | ||
| 230 | Phosphorylation | SRHHPEESPLGAKFQ HHCCCCCCCCCHHHH | 20873877 | ||
| 263 | Phosphorylation | QMEQRINSENSFSEA HHHHHHHCCCCHHHH | 30266825 | ||
| 266 | Phosphorylation | QRINSENSFSEASSL HHHHCCCCHHHHHHC | 30266825 | ||
| 268 | Phosphorylation | INSENSFSEASSLSL HHCCCCHHHHHHCHH | 30266825 | ||
| 271 | Phosphorylation | ENSFSEASSLSLKSS CCCHHHHHHCHHHHH | 30266825 | ||
| 272 | Phosphorylation | NSFSEASSLSLKSSI CCHHHHHHCHHHHHH | 24719451 | ||
| 274 | Phosphorylation | FSEASSLSLKSSIER HHHHHHCHHHHHHHH | 24719451 | ||
| 315 | Phosphorylation | GHLSRKRSSSDSWEP CCCCCCCCCCCCCCC | 30576142 | ||
| 316 | Phosphorylation | HLSRKRSSSDSWEPT CCCCCCCCCCCCCCC | 25159151 | ||
| 317 | Phosphorylation | LSRKRSSSDSWEPTS CCCCCCCCCCCCCCC | 25159151 | ||
| 319 | Phosphorylation | RKRSSSDSWEPTSAG CCCCCCCCCCCCCCC | 30576142 | ||
| 323 | Phosphorylation | SSDSWEPTSAGSKQN CCCCCCCCCCCCCCC | 23312004 | ||
| 324 | Phosphorylation | SDSWEPTSAGSKQNK CCCCCCCCCCCCCCC | 23312004 | ||
| 327 | Phosphorylation | WEPTSAGSKQNKFPE CCCCCCCCCCCCCCH | 23532336 | ||
| 340 | Phosphorylation | PEKRKRNSVDSDLKS CHHHHHCCCCHHHHH | 25849741 | ||
| 343 | Phosphorylation | RKRNSVDSDLKSTRE HHHCCCCHHHHHHHH | 28102081 | ||
| 394 | Ubiquitination | LRLEDISKEPSDETD EEHHHCCCCCCCCCC | 29967540 | ||
| 400 | Phosphorylation | SKEPSDETDGSSAGL CCCCCCCCCCCCCCC | - | ||
| 403 | Phosphorylation | PSDETDGSSAGLAPS CCCCCCCCCCCCCCC | 28387310 | ||
| 404 | Phosphorylation | SDETDGSSAGLAPSN CCCCCCCCCCCCCCC | - | ||
| 415 | Phosphorylation | APSNSGNSGHHSTRN CCCCCCCCCCCCCCC | 30576142 | ||
| 420 | Phosphorylation | GNSGHHSTRNSDQIQ CCCCCCCCCCCCCEE | 28387310 | ||
| 431 | Phosphorylation | DQIQVAGTKETKMQK CCEEECCCCCCCCCC | 30576142 | ||
| 444 | Phosphorylation | QKPHLPLSQEKSAIK CCCCCCHHHHHHHHH | 17525332 | ||
| 454 | Phosphorylation | KSAIKKASNLQKNKT HHHHHHHHHHHCCCC | - | ||
| 464 | Phosphorylation | QKNKTASSTTKEKET HCCCCCCCCCCCHHC | 23322592 | ||
| 465 | Phosphorylation | KNKTASSTTKEKETK CCCCCCCCCCCHHCC | 23322592 | ||
| 471 | Phosphorylation | STTKEKETKLPLLSR CCCCCHHCCCCHHHC | 23322592 | ||
| 477 | Phosphorylation | ETKLPLLSRVPSAGS HCCCCHHHCCCCCCC | 29514088 | ||
| 481 | Phosphorylation | PLLSRVPSAGSSLVP CHHHCCCCCCCCCCC | 30266825 | ||
| 484 | Phosphorylation | SRVPSAGSSLVPLNA HCCCCCCCCCCCCCC | 30266825 | ||
| 485 | Phosphorylation | RVPSAGSSLVPLNAK CCCCCCCCCCCCCCC | 30266825 | ||
| 508 | Phosphorylation | KDKERSSSKECSGHS HHHCCCCCCCCCCCC | - | ||
| 512 | Phosphorylation | RSSSKECSGHSTEST CCCCCCCCCCCCHHH | - | ||
| 515 | Phosphorylation | SKECSGHSTESTKHK CCCCCCCCCHHHHHH | - | ||
| 518 | Phosphorylation | CSGHSTESTKHKEHK CCCCCCHHHHHHHHH | - | ||
| 549 | Phosphorylation | GGPLRSEYGTPTKSP CCCCCCCCCCCCCCC | 26074081 | ||
| 551 | Phosphorylation | PLRSEYGTPTKSPPA CCCCCCCCCCCCCCC | 28985074 | ||
| 553 | Phosphorylation | RSEYGTPTKSPPAAL CCCCCCCCCCCCCEE | 26074081 | ||
| 555 | Phosphorylation | EYGTPTKSPPAALEV CCCCCCCCCCCEEEE | 29255136 | ||
| 568 | Phosphorylation | EVVPCIPSPAAPSDK EEECCCCCCCCCCCC | 29255136 | ||
| 573 | Phosphorylation | IPSPAAPSDKAPSEG CCCCCCCCCCCCCCC | 29255136 | ||
| 578 | Phosphorylation | APSDKAPSEGESSGN CCCCCCCCCCCCCCC | 25159151 | ||
| 582 | Phosphorylation | KAPSEGESSGNSNAG CCCCCCCCCCCCCCC | 28102081 | ||
| 583 | Phosphorylation | APSEGESSGNSNAGS CCCCCCCCCCCCCCC | 28102081 | ||
| 586 | Phosphorylation | EGESSGNSNAGSSAL CCCCCCCCCCCCHHH | 28102081 | ||
| 590 | Phosphorylation | SGNSNAGSSALKRKL CCCCCCCCHHHHHHH | 28102081 | ||
| 603 | Phosphorylation | KLRGDFDSDEESLGY HHCCCCCCCHHHHCC | 22617229 | ||
| 607 | Phosphorylation | DFDSDEESLGYNLDS CCCCCHHHHCCCCCC | 20363803 | ||
| 610 | Phosphorylation | SDEESLGYNLDSDEE CCHHHHCCCCCCHHH | 28450419 | ||
| 614 | Phosphorylation | SLGYNLDSDEEEETL HHCCCCCCHHHHHHH | 22617229 | ||
| 620 | Phosphorylation | DSDEEEETLKSLEEI CCHHHHHHHHHHHHH | 28450419 | ||
| 647 | Ubiquitination | GKPPALSKGLRSQSS CCCCHHHCCCCCCCC | - | ||
| 651 | Phosphorylation | ALSKGLRSQSSDYTG HHHCCCCCCCCCCCC | 28450419 | ||
| 653 | Phosphorylation | SKGLRSQSSDYTGHV HCCCCCCCCCCCCCC | 28348404 | ||
| 654 | Phosphorylation | KGLRSQSSDYTGHVH CCCCCCCCCCCCCCC | 28450419 | ||
| 656 | Phosphorylation | LRSQSSDYTGHVHPG CCCCCCCCCCCCCCC | 28450419 | ||
| 657 | Phosphorylation | RSQSSDYTGHVHPGT CCCCCCCCCCCCCCC | 28450419 | ||
| 665 | Phosphorylation | GHVHPGTYTNTLERL CCCCCCCCHHHHHHH | 28450419 | ||
| 668 | Phosphorylation | HPGTYTNTLERLVKE CCCCCHHHHHHHHHH | 28555341 | ||
| 679 | Phosphorylation | LVKEMEDTQRLDELQ HHHHHHHHHHHHHHH | - | ||
| 687 | Ubiquitination | QRLDELQKQLQEDIR HHHHHHHHHHHHHHH | 29967540 | ||
| 701 | Phosphorylation | RQGRGIKSPIRIGEE HCCCCCCCCEECCCC | 23401153 | ||
| 710 | Phosphorylation | IRIGEEDSTDDEDGL EECCCCCCCCCCCCH | 25159151 | ||
| 711 | Phosphorylation | RIGEEDSTDDEDGLL ECCCCCCCCCCCCHH | 25159151 | ||
| 757 | Phosphorylation | SGKIFNQYTLDLRDS HCCCCEEEEEECCCC | 30266825 | ||
| 758 | Phosphorylation | GKIFNQYTLDLRDSG CCCCEEEEEECCCCC | 30266825 | ||
| 774 | Ubiquitination | IGQSAVEKLILKSGK CCHHHHHHHHHHCCC | 29967540 | ||
| 903 | Ubiquitination | ESEDSSYKPIFSTLP CCCCCCCCCCCCCCC | 29967540 | ||
| 948 | O-linked_Glycosylation | ILMLFKMSLEKQLKQ HHHHHHHCHHHHHHC | 30379171 | ||
| 1018 | Phosphorylation | RQLRQCLSLVIISKL HHHHHHHHHHHHHHH | 19664994 | ||
| 1024 | Ubiquitination | LSLVIISKLLDEKHE HHHHHHHHHHHCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLF2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLF2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLF2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ITA1_HUMAN | ITGA1 | physical | 26496610 | |
| GCFC2_HUMAN | GCFC2 | physical | 26496610 | |
| RAD18_HUMAN | RAD18 | physical | 26496610 | |
| SLF1_HUMAN | ANKRD32 | physical | 26496610 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
