| UniProt ID | SLF1_HUMAN | |
|---|---|---|
| UniProt AC | Q9BQI6 | |
| Protein Name | SMC5-SMC6 complex localization factor protein 1 {ECO:0000312|HGNC:HGNC:25408} | |
| Gene Name | SLF1 {ECO:0000303|PubMed:25931565, ECO:0000312|HGNC:HGNC:25408} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1058 | |
| Subcellular Localization | Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Relocalizes with RAD18 to nuclear foci in response to DNA damage. Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chr | |
| Protein Description | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. [PubMed: 25931565 The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks] | |
| Protein Sequence | MEDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKDNFKAPFYPIQYLGDFLLEKEIQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRETMYRTQKEMQNHEDVNVGSILIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKKDEDIQRSYTLRRKRKKGKESNCKKGVEHEKIKSTLRRHIYNRDQKEMKNSIFAEYAKESKAMAIKTDVDVVEIKNTLRKHIYRAQAVRYNCIRIDKQPVYNVEVKNAEFPRGVLNLIESLIEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDNIDTFSGRYFHILSALLHLHPPWKSPAMSRYYLELFQCPTCMKGAWSLVEVLIRSCLFNESFCHQISENIGSKVLHLTLLKFFFNLIESEVQHLSQKLYDWSDSQNLKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKFKSNDVFKHELAYLLAGILGAAIDYWIFLGLKMGRNVMRHMSDDLGSYVSLSCDDFSSQELEIFICSFSSSWLQMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGVLGSGKIQVSKKIGQRPCFDSQRTLLMLNGTKQKQVEGLPELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLSRMLLNFCSIFDLSSEFILASKGLTHLNELLMACKSHKETTSVHTDWLLDLYAGNIKTLQKLPHILKELPENLKVCPGVHTEALMITLEMMCRSVMEFS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Ubiquitination | -MEDGTPKHIIQMTG -CCCCCCCHHEEECC | - | ||
| 7 | Ubiquitination | -MEDGTPKHIIQMTG -CCCCCCCHHEEECC | - | ||
| 16 | Acetylation | IIQMTGFKMEEKEAL HEEECCCCHHHHHHH | 7369645 | ||
| 25 | Ubiquitination | EEKEALVKLLLKLDC HHHHHHHHHHHHCCC | - | ||
| 25 | Acetylation | EEKEALVKLLLKLDC HHHHHHHHHHHHCCC | 7369655 | ||
| 36 | Ubiquitination | KLDCTFIKSEKYKNC HCCCCEECCHHHCCC | - | ||
| 36 | Ubiquitination | KLDCTFIKSEKYKNC HCCCCEECCHHHCCC | - | ||
| 41 | Ubiquitination | FIKSEKYKNCTHLIA EECCHHHCCCHHHHH | - | ||
| 44 | Phosphorylation | SEKYKNCTHLIAERL CHHHCCCHHHHHHHH | 17192257 | ||
| 56 | Ubiquitination | ERLCKSEKFLAACAA HHHHCCHHHHHHHHC | - | ||
| 78 | Sumoylation | DYIIHSAKSGRWLDE CEEEEECCCCCCCCC | - | ||
| 78 | Ubiquitination | DYIIHSAKSGRWLDE CEEEEECCCCCCCCC | - | ||
| 78 | Sumoylation | DYIIHSAKSGRWLDE CEEEEECCCCCCCCC | - | ||
| 78 | Ubiquitination | DYIIHSAKSGRWLDE CEEEEECCCCCCCCC | - | ||
| 101 | Phosphorylation | IEKDSRYSPQMQSAP CCCCCCCCCCCCCCC | 28985074 | ||
| 106 | Phosphorylation | RYSPQMQSAPKRWRE CCCCCCCCCCHHHHH | 28985074 | ||
| 109 | Ubiquitination | PQMQSAPKRWREELK CCCCCCCHHHHHHHH | - | ||
| 109 | Ubiquitination | PQMQSAPKRWREELK CCCCCCCHHHHHHHH | - | ||
| 141 | Phosphorylation | RTDKRSDSLIRVLEA EECCCCHHHHHHHHC | 24719451 | ||
| 150 | Ubiquitination | IRVLEAGKANVILPK HHHHHCCCCCEEECC | - | ||
| 157 | Ubiquitination | KANVILPKSSPSGIT CCCEEECCCCCCCCC | - | ||
| 158 | Phosphorylation | ANVILPKSSPSGITH CCEEECCCCCCCCCH | 25159151 | ||
| 159 | Phosphorylation | NVILPKSSPSGITHV CEEECCCCCCCCCHH | 25159151 | ||
| 161 | Phosphorylation | ILPKSSPSGITHVIA EECCCCCCCCCHHHH | 23911959 | ||
| 164 | Phosphorylation | KSSPSGITHVIASNA CCCCCCCCHHHHCCC | 23663014 | ||
| 183 | Sumoylation | EKEKDNFKAPFYPIQ HHHHCCCCCCCCCHH | - | ||
| 183 | Sumoylation | EKEKDNFKAPFYPIQ HHHHCCCCCCCCCHH | - | ||
| 223 | Ubiquitination | HSNEETNKDFRKDAG CCCCCCCHHHHHHHH | - | ||
| 227 | Ubiquitination | ETNKDFRKDAGFLEM CCCHHHHHHHHHHHH | - | ||
| 235 | Sumoylation | DAGFLEMKGALRETM HHHHHHHHHHHHHHH | - | ||
| 235 | Ubiquitination | DAGFLEMKGALRETM HHHHHHHHHHHHHHH | - | ||
| 235 | Sumoylation | DAGFLEMKGALRETM HHHHHHHHHHHHHHH | - | ||
| 235 | Methylation | DAGFLEMKGALRETM HHHHHHHHHHHHHHH | - | ||
| 241 | Phosphorylation | MKGALRETMYRTQKE HHHHHHHHHHHHHHH | 25954137 | ||
| 247 | Ubiquitination | ETMYRTQKEMQNHED HHHHHHHHHHCCCCC | - | ||
| 275 | Ubiquitination | EKFSGSSKDLKFVKM CCCCCCCCCCEEEEE | - | ||
| 278 | Sumoylation | SGSSKDLKFVKMRNT CCCCCCCEEEEECCC | - | ||
| 278 | Sumoylation | SGSSKDLKFVKMRNT CCCCCCCEEEEECCC | - | ||
| 285 | Phosphorylation | KFVKMRNTFGSHTYE EEEEECCCCCCCCCC | 29083192 | ||
| 288 | Phosphorylation | KMRNTFGSHTYENQK EECCCCCCCCCCCHH | 29083192 | ||
| 290 | Phosphorylation | RNTFGSHTYENQKEI CCCCCCCCCCCHHHH | 29083192 | ||
| 291 | Phosphorylation | NTFGSHTYENQKEIK CCCCCCCCCCHHHHH | 29083192 | ||
| 295 | Ubiquitination | SHTYENQKEIKKKDE CCCCCCHHHHHHCCH | - | ||
| 309 | Phosphorylation | EDIQRSYTLRRKRKK HHHHHHHHHHHHHHC | 24719451 | ||
| 348 | Sumoylation | NRDQKEMKNSIFAEY CCCHHHHHHHHHHHH | - | ||
| 348 | Sumoylation | NRDQKEMKNSIFAEY CCCHHHHHHHHHHHH | - | ||
| 348 | Ubiquitination | NRDQKEMKNSIFAEY CCCHHHHHHHHHHHH | - | ||
| 357 | Ubiquitination | SIFAEYAKESKAMAI HHHHHHHHHHHCCEE | - | ||
| 365 | Sumoylation | ESKAMAIKTDVDVVE HHHCCEECCCCCHHH | - | ||
| 365 | Sumoylation | ESKAMAIKTDVDVVE HHHCCEECCCCCHHH | - | ||
| 374 | Ubiquitination | DVDVVEIKNTLRKHI CCCHHHHHHHHHHHH | - | ||
| 379 | Ubiquitination | EIKNTLRKHIYRAQA HHHHHHHHHHHHHHH | - | ||
| 396 | Ubiquitination | YNCIRIDKQPVYNVE ECEEEECCCCEEEEE | - | ||
| 405 | Ubiquitination | PVYNVEVKNAEFPRG CEEEEEECCCCCCHH | - | ||
| 482 | Phosphorylation | HLHPPWKSPAMSRYY HHCCCCCCHHHHHHH | 26437602 | ||
| 489 | Phosphorylation | SPAMSRYYLELFQCP CHHHHHHHHHHCCCC | 30576142 | ||
| 565 | Ubiquitination | WSDSQNLKITGKAML CCCCCCCEECCEEEE | - | ||
| 646 | Phosphorylation | RNVMRHMSDDLGSYV HHHHHHCCCCHHHCE | 22468782 | ||
| 654 | Phosphorylation | DDLGSYVSLSCDDFS CCHHHCEEEECCCCC | 46164229 | ||
| 661 | Phosphorylation | SLSCDDFSSQELEIF EEECCCCCCCCEEEE | 22468782 | ||
| 703 | Phosphorylation | SVSSEPLSLQKMVYS CCCCCCCCHHHHHHH | 24719451 | ||
| 717 | Ubiquitination | SYLPALGKTGVLGSG HHHHHCCCCCCCCCC | - | ||
| 725 | Ubiquitination | TGVLGSGKIQVSKKI CCCCCCCCEEEEEEC | - | ||
| 731 | Ubiquitination | GKIQVSKKIGQRPCF CCEEEEEECCCCCCC | - | ||
| 750 | O-linked_Glycosylation | TLLMLNGTKQKQVEG EEEECCCCCHHHCCC | 30379171 | ||
| 753 | Ubiquitination | MLNGTKQKQVEGLPE ECCCCCHHHCCCCHH | - | ||
| 768 | Ubiquitination | LLDLNLAKCSSSLKK HHHHHHHHCHHHHHH | - | ||
| 780 | Phosphorylation | LKKLKKKSEGELSCS HHHHHHCCCCCCCCC | 28270605 | ||
| 785 | Phosphorylation | KKSEGELSCSKENCP HCCCCCCCCCCCCCH | 28270605 | ||
| 787 | Phosphorylation | SEGELSCSKENCPSV CCCCCCCCCCCCHHH | 28270605 | ||
| 788 | Acetylation | EGELSCSKENCPSVV CCCCCCCCCCCHHHH | 20167786 | ||
| 788 | Ubiquitination | EGELSCSKENCPSVV CCCCCCCCCCCHHHH | - | ||
| 797 | Ubiquitination | NCPSVVKKMNFHKTN CCHHHHHHCCCCCCC | 21906983 | ||
| 802 | Ubiquitination | VKKMNFHKTNLKGET HHHCCCCCCCCCCCH | 2190698 | ||
| 806 | Sumoylation | NFHKTNLKGETALHR CCCCCCCCCCHHHHH | - | ||
| 806 | Ubiquitination | NFHKTNLKGETALHR CCCCCCCCCCHHHHH | - | ||
| 806 | Sumoylation | NFHKTNLKGETALHR CCCCCCCCCCHHHHH | - | ||
| 909 | Ubiquitination | LLQQRNAKGELPLDY EEEECCCCCCCCCCE | - | ||
| 916 | Phosphorylation | KGELPLDYVVSPQIK CCCCCCCEEECHHHH | 22817900 | ||
| 919 | Phosphorylation | LPLDYVVSPQIKEEL CCCCEEECHHHHHHH | 25159151 | ||
| 923 | Ubiquitination | YVVSPQIKEELFAIT EEECHHHHHHHHHHE | - | ||
| 931 | Sumoylation | EELFAITKIEDTVEN HHHHHHEEEHHHHHH | 28112733 | ||
| 931 | Ubiquitination | EELFAITKIEDTVEN HHHHHHEEEHHHHHH | - | ||
| 1017 | Phosphorylation | LYAGNIKTLQKLPHI HHCCCHHHHHHHHHH | - | ||
| 1020 | Ubiquitination | GNIKTLQKLPHILKE CCHHHHHHHHHHHHH | - | ||
| 1026 | Ubiquitination | QKLPHILKELPENLK HHHHHHHHHCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLF1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RAD18_HUMAN | RAD18 | physical | 22036607 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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