MED16_HUMAN - dbPTM
MED16_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MED16_HUMAN
UniProt AC Q9Y2X0
Protein Name Mediator of RNA polymerase II transcription subunit 16
Gene Name MED16
Organism Homo sapiens (Human).
Sequence Length 877
Subcellular Localization Nucleus .
Protein Description Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors..
Protein Sequence MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26UbiquitinationCEWEKWSKSTHCPSV
HHHHHHCCCCCCCCC		59.25-
26 (in isoform 2)Ubiquitination-59.25-
48PhosphorylationCRNLIAFTMDLRSDD
HHHHHHHHCCCCCCC		10.76-
53O-linked_GlycosylationAFTMDLRSDDQDLTR
HHHCCCCCCCCCHHH		53.4930379171
138UbiquitinationIVALSWLHNGVKLAL
EEEEEEHHCCEEEEE		23.8022817900
149UbiquitinationKLALHVEKSGASSFG
EEEEEEECCCCCCCC		53.7721906983
149 (in isoform 1)Ubiquitination-53.7721890473
149 (in isoform 2)Ubiquitination-53.7721890473
149 (in isoform 3)Ubiquitination-53.7721890473
149 (in isoform 4)Ubiquitination-53.7721890473
149 (in isoform 5)Ubiquitination-53.7721890473
157UbiquitinationSGASSFGEKFSRVKF
CCCCCCCHHCCCCEE		49.2522817900
158UbiquitinationGASSFGEKFSRVKFS
CCCCCCHHCCCCEEC		49.3627667366
158 (in isoform 1)Ubiquitination-49.3621890473
158 (in isoform 2)Ubiquitination-49.3621890473
158 (in isoform 3)Ubiquitination-49.3621890473
158 (in isoform 4)Ubiquitination-49.3621890473
158 (in isoform 5)Ubiquitination-49.3621890473
163UbiquitinationGEKFSRVKFSPSLTL
CHHCCCCEECCCEEE		38.7322817900
191PhosphorylationVSGLVTVSLLKPSGQ
ECCEEEEEEECCCCC		20.7224719451
252UbiquitinationCVSVVSEKCRIDTEI
HHHHHCHHCCCCCHH		22.7029967540
252 (in isoform 2)Ubiquitination-22.70-
257PhosphorylationSEKCRIDTEILPSLF
CHHCCCCCHHHHHHH		23.6620068231
262PhosphorylationIDTEILPSLFMRCTT
CCCHHHHHHHHHHCC		30.6920068231
274 (in isoform 2)Ubiquitination-65.28-
276UbiquitinationTDLNRKDKFPAITHL
CCCCCCCCCCHHHHH		57.17-
276 (in isoform 2)Ubiquitination-57.17-
284UbiquitinationFPAITHLKFLARDMS
CCHHHHHHHHHCCCC		30.63-
284 (in isoform 2)Ubiquitination-30.63-
310PhosphorylationSSIVECWSLRKEGLP
CCHHHHHHHCCCCCC		29.9224719451
313UbiquitinationVECWSLRKEGLPVNN
HHHHHHCCCCCCCCC		62.5221906983
313 (in isoform 1)Ubiquitination-62.5221890473
313 (in isoform 2)Ubiquitination-62.5221890473
313 (in isoform 3)Ubiquitination-62.5221890473
313 (in isoform 4)Ubiquitination-62.5221890473
313 (in isoform 5)Ubiquitination-62.5221890473
326PhosphorylationNNIFQQISPVVGDKQ
CCHHHHHCCCCCCCC		13.8028102081
332UbiquitinationISPVVGDKQPTILKW
HCCCCCCCCCCEEEE		52.8521906983
332 (in isoform 1)Ubiquitination-52.8521890473
332 (in isoform 2)Ubiquitination-52.8521890473
332 (in isoform 3)Ubiquitination-52.8521890473
332 (in isoform 4)Ubiquitination-52.8521890473
332 (in isoform 5)Ubiquitination-52.8521890473
338UbiquitinationDKQPTILKWRILSAT
CCCCCEEEEEEHHCC		30.4927667366
338 (in isoform 2)Ubiquitination-30.49-
355UbiquitinationLDRVSAVALPKLPIS
HHHEEEEECCCCCEE		20.1923000965
358UbiquitinationVSAVALPKLPISLTN
EEEEECCCCCEECCC		68.6829967540
358 (in isoform 2)Ubiquitination-68.68-
360UbiquitinationAVALPKLPISLTNTD
EEECCCCCEECCCCC		21.9023000965
364PhosphorylationPKLPISLTNTDLKVA
CCCCEECCCCCCEEC		29.31-
399UbiquitinationHIVHRLSLQTMAVFY
EEEEEEEHHHHHHHH		6.1021890473
424PhosphorylationPAMKRPRTAGPAVHL
CCCCCCCCCCCCHHH		38.3528348404
440PhosphorylationAMQLSWTSLALVGID
HHCCCCCCEEEEEEC		12.8427732954
448PhosphorylationLALVGIDSHGKLSVL
EEEEEECCCCCEEEE		32.0227732954
453PhosphorylationIDSHGKLSVLRLSPS
ECCCCCEEEEEECCC		23.6924719451
461UbiquitinationVLRLSPSMGHPLEVG
EEEECCCCCCCHHHH		6.9323000965
466UbiquitinationPSMGHPLEVGLALRH
CCCCCCHHHHHHHHH		38.7023000965
505UbiquitinationSMVQSLVEKLHEEYT
HHHHHHHHHHHHHHH		56.0121890473
520UbiquitinationRQTAALQQVLSTRIL
HHHHHHHHHHHHHHH		38.6821890473
530AcetylationSTRILAMKASLCKLS
HHHHHHHHHHHHCCC		29.2625953088
530UbiquitinationSTRILAMKASLCKLS
HHHHHHHHHHHHCCC		29.2623000965
530 (in isoform 2)Ubiquitination-29.26-
530 (in isoform 3)Ubiquitination-29.26-
535UbiquitinationAMKASLCKLSPCTVT
HHHHHHHCCCCCCHH		58.2423000965
535 (in isoform 2)Ubiquitination-58.24-
547PhosphorylationTVTRVCDYHTKLFLI
CHHEECCCCCHHHHH		13.28-
549PhosphorylationTRVCDYHTKLFLIAI
HEECCCCCHHHHHHH		24.18-
562PhosphorylationAISSTLKSLLRPHFL
HHHHHHHHHHCHHHC		35.4324719451
570UbiquitinationLLRPHFLNTPDKSPG
HHCHHHCCCCCCCCC		48.9321890473
571PhosphorylationLRPHFLNTPDKSPGD
HCHHHCCCCCCCCCC		34.7030576142
574UbiquitinationHFLNTPDKSPGDRLT
HHCCCCCCCCCCHHH		60.8122817900
574 (in isoform 1)Ubiquitination-60.8121890473
574 (in isoform 2)Ubiquitination-60.8121890473
574 (in isoform 3)Ubiquitination-60.8121890473
574 (in isoform 4)Ubiquitination-60.8121890473
574 (in isoform 5)Ubiquitination-60.8121890473
586UbiquitinationRLTEICTKITDVDID
HHHHHHHHCCCCCCC		38.9229901268
588PhosphorylationTEICTKITDVDIDKV
HHHHHHCCCCCCCCE		31.37-
594UbiquitinationITDVDIDKVMINLKT
CCCCCCCCEEEECCC		33.7529967540
621UbiquitinationLQQLLQWVGDFVLYL
HHHHHHHHHHHHHHH		3.2121963094
626UbiquitinationQWVGDFVLYLLASLP
HHHHHHHHHHHHCCC		2.2321890473
633UbiquitinationLYLLASLPNQGSLLR
HHHHHCCCCCCCCCC		28.7122505724
642UbiquitinationQGSLLRPGHSFLRDG
CCCCCCCCCCCCCCC		23.7221890473
676UbiquitinationKPSCLPVYTATSDTQ
CHHHEEEEECCCCCH		6.6821890473
682PhosphorylationVYTATSDTQDSMSLL
EEECCCCCHHHHHHH		33.76-
685PhosphorylationATSDTQDSMSLLFRL
CCCCCHHHHHHHHHH		10.64-
687PhosphorylationSDTQDSMSLLFRLLT
CCCHHHHHHHHHHHH		26.35-
694PhosphorylationSLLFRLLTKLWICCR
HHHHHHHHHHHHHCC		28.78-
695UbiquitinationLLFRLLTKLWICCRD
HHHHHHHHHHHHCCC		41.6221890473
695 (in isoform 1)Ubiquitination-41.6221890473
695 (in isoform 2)Ubiquitination-41.6221890473
727UbiquitinationLPSQLLIPSLDWLPA
CHHHHCCCCCCCEEC		28.8921963094
739UbiquitinationLPASDGLVSRLQPKQ
EECCCCHHHHCCCCC		3.7022505724
745UbiquitinationLVSRLQPKQPLRLQF
HHHHCCCCCCEEEEE		52.1427667366
745 (in isoform 1)Ubiquitination-52.1421890473
745 (in isoform 2)Ubiquitination-52.1421890473
748UbiquitinationRLQPKQPLRLQFGRA
HCCCCCCEEEEECCC		8.7121890473
757PhosphorylationLQFGRAPTLPGSAAT
EEECCCCCCCCCCEE		44.60-
764 (in isoform 3)Ubiquitination-18.1121890473
778UbiquitinationARAPGQPKIDHLRRL
CCCCCCCCCCHHHHC		53.5329967540
778 (in isoform 2)Ubiquitination-53.53-
796UbiquitinationACPTEECKACTRCGC
CCCHHHCHHCCCCCC		50.1821963094
796 (in isoform 2)Ubiquitination-50.18-
805PhosphorylationCTRCGCVTMLKSPNR
CCCCCCEEEECCCCC		22.3629083192
808MethylationCGCVTMLKSPNRTTA
CCCEEEECCCCCCHH		53.71115972943
808UbiquitinationCGCVTMLKSPNRTTA
CCCEEEECCCCCCHH		53.7122505724
808 (in isoform 2)Ubiquitination-53.71-
809PhosphorylationGCVTMLKSPNRTTAV
CCEEEECCCCCCHHH		24.3624275569
813PhosphorylationMLKSPNRTTAVKQWE
EECCCCCCHHHHHHH		26.2529083192
814PhosphorylationLKSPNRTTAVKQWEQ
ECCCCCCHHHHHHHH		26.6429083192
817UbiquitinationPNRTTAVKQWEQRWI
CCCCHHHHHHHHHHH		47.4327667366
817 (in isoform 1)Ubiquitination-47.4321890473
817 (in isoform 2)Ubiquitination-47.4321890473
827 (in isoform 3)Ubiquitination-1.88-
836 (in isoform 3)Ubiquitination-56.2621890473
867PhosphorylationHSPRTPRSLDHLHPE
CCCCCCCCHHCCCCC		39.0820068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MED16_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MED16_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MED16_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MED9_HUMANMED9physical
22939629
MED29_HUMANMED29physical
22939629
MED1_HUMANMED1physical
22939629
MED8_HUMANMED8physical
22939629
MED4_HUMANMED4physical
22939629
MED24_HUMANMED24physical
22939629
MED18_HUMANMED18physical
22939629
MED21_HUMANMED21physical
22939629
RALY_HUMANRALYphysical
22939629
MED1_HUMANMED1physical
26344197
MED12_HUMANMED12physical
26344197
MED14_HUMANMED14physical
26344197
MED24_HUMANMED24physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MED16_HUMAN

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Related Literatures of Post-Translational Modification

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