dbPTM

MED18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MED18_HUMAN
UniProt AC	Q9BUE0
Protein Name	Mediator of RNA polymerase II transcription subunit 18
Gene Name	MED18
Organism	Homo sapiens (Human).
Sequence Length	208
Subcellular Localization	Nucleus .
Protein Description	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors..
Protein Sequence	MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQDMVSDDMKNFAEQLKPLVHLEKIDPKRLM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	LLKGQQASPFVLRAR HHHCCCCCHHHHHHH	17.96	30266825
78	Methylation	RARRSMDRAGAPWHL HHHCCHHCCCCCCEE	26.69	115483127
93	Sulfoxidation	RYLGQPEMGDKNRHA EECCCCCCCCCCHHH	12.23	21406390
96	Ubiquitination	GQPEMGDKNRHALVR CCCCCCCCCHHHHHH	50.59	33845483
103	Ubiquitination	KNRHALVRNCVDIAT CCHHHHHHHHHHHHC	31.51	21906983
125	Sulfoxidation	LMEMGFRMDHEFVAK HHHCCCCCCHHHHHC	6.03	30846556
194	Ubiquitination	KNFAEQLKPLVHLEK HHHHHHHHHHHHHHH	35.68	29967540
201	Ubiquitination	KPLVHLEKIDPKRLM HHHHHHHHCCHHHCC	59.79	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MED18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MED18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
66	Phosphorylation	74 (8)	R ⇒ C	rs139242087	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653
78	Methylation	74 (4)	R ⇒ C	rs139242087	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED20_HUMAN	MED20	physical	12584197
MED13_HUMAN	MED13	physical	15989967
MED12_HUMAN	MED12	physical	15989967
MED1_HUMAN	MED1	physical	15989967
MED17_HUMAN	MED17	physical	15989967
MED20_HUMAN	MED20	physical	15989967
MED21_HUMAN	MED21	physical	15989967
MED12_HUMAN	MED12	physical	20133760
MED13_HUMAN	MED13	physical	20133760
CCNC_HUMAN	CCNC	physical	20133760
MED16_HUMAN	MED16	physical	20133760
MED17_HUMAN	MED17	physical	20133760
MED1_HUMAN	MED1	physical	20133760
MED28_HUMAN	MED28	physical	20133760
MED24_HUMAN	MED24	physical	20133760
MED22_HUMAN	MED22	physical	20133760
MED23_HUMAN	MED23	physical	20133760
MED4_HUMAN	MED4	physical	20133760
MED29_HUMAN	MED29	physical	20133760
MED8_HUMAN	MED8	physical	20133760
MED31_HUMAN	MED31	physical	20133760
MED15_HUMAN	MED15	physical	20133760
MED6_HUMAN	MED6	physical	20133760
MED14_HUMAN	MED14	physical	20133760
MED30_HUMAN	MED30	physical	20133760
MED26_HUMAN	MED26	physical	20133760
MED10_HUMAN	MED10	physical	20133760
MED27_HUMAN	MED27	physical	20133760
MED20_HUMAN	MED20	physical	20133760
MED21_HUMAN	MED21	physical	20133760
MED4_HUMAN	MED4	physical	22939629
MED1_HUMAN	MED1	physical	22939629
MED24_HUMAN	MED24	physical	22939629
MED8_HUMAN	MED8	physical	22939629
MED21_HUMAN	MED21	physical	22939629
PI42B_HUMAN	PIP4K2B	physical	22939629
TRI39_HUMAN	TRIM39	physical	25416956
HOMEZ_HUMAN	HOMEZ	physical	25416956
MED1_HUMAN	MED1	physical	26344197
MED11_HUMAN	MED11	physical	26344197
MED12_HUMAN	MED12	physical	26344197
MED14_HUMAN	MED14	physical	26344197
MED15_HUMAN	MED15	physical	26344197
MED16_HUMAN	MED16	physical	26344197
MED17_HUMAN	MED17	physical	26344197
MED19_HUMAN	MED19	physical	26344197
MED23_HUMAN	MED23	physical	26344197
MED24_HUMAN	MED24	physical	26344197
MED27_HUMAN	MED27	physical	26344197
MED4_HUMAN	MED4	physical	26344197
MED8_HUMAN	MED8	physical	26344197
TRI39_HUMAN	TRIM39	physical	21516116
MED19_HUMAN	MED19	physical	28514442
MED1_HUMAN	MED1	physical	28514442
MED7_HUMAN	MED7	physical	28514442
CCNC_HUMAN	CCNC	physical	28514442
MED8_HUMAN	MED8	physical	28514442
MED26_HUMAN	MED26	physical	28514442
MED27_HUMAN	MED27	physical	28514442
MED28_HUMAN	MED28	physical	28514442
MED20_HUMAN	MED20	physical	28514442
MED13_HUMAN	MED13	physical	28514442
MED17_HUMAN	MED17	physical	28514442
MD13L_HUMAN	MED13L	physical	28514442
MED6_HUMAN	MED6	physical	28514442
MED22_HUMAN	MED22	physical	28514442
MD12L_HUMAN	MED12L	physical	28514442
MED9_HUMAN	MED9	physical	28514442
MED24_HUMAN	MED24	physical	28514442
MED14_HUMAN	MED14	physical	28514442
MED10_HUMAN	MED10	physical	28514442
MED31_HUMAN	MED31	physical	28514442
MED4_HUMAN	MED4	physical	28514442
MED11_HUMAN	MED11	physical	28514442
MED30_HUMAN	MED30	physical	28514442
MED16_HUMAN	MED16	physical	28514442
MED23_HUMAN	MED23	physical	28514442
MED25_HUMAN	MED25	physical	28514442
MED12_HUMAN	MED12	physical	28514442
MED29_HUMAN	MED29	physical	28514442
MED15_HUMAN	MED15	physical	28514442
CDK19_HUMAN	CDK19	physical	28514442
CDK8_HUMAN	CDK8	physical	28514442
MTMR3_HUMAN	MTMR3	physical	28514442
G6PD_HUMAN	G6PD	physical	28514442
MTMR4_HUMAN	MTMR4	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
GPN3_HUMAN	GPN3	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MED18_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.	16964243 [Abstract]