MTMR4_HUMAN - dbPTM
MTMR4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTMR4_HUMAN
UniProt AC Q9NYA4
Protein Name Myotubularin-related protein 4
Gene Name MTMR4
Organism Homo sapiens (Human).
Sequence Length 1195
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein . Localized to perinuclear region.
Protein Description Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3)..
Protein Sequence MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVGLEPWHSNPEGSETSFVDSGVGGPQQTVGEVGLPPPLPSSQKDYLSNKPFKSHKSCSPSYKLLNTAVPREMKSNTSDPEIKVLEETKGPAPDPSAQDELGRTLDGIGEPPEHCPETEAVSALSKVISNKCDGVCNFPESSQNSPTGTPQQAQPDSMLGVPSKCVLDHSLSTVCNPPSAACQTPLDPSTDFLNQDPSGSVASISHQEQLSSVPDLTHGEEDIGKRGNNRNGQLLENPRFGKMPLELVRKPISQSQISEFSFLGSNWDSFQGMVTSFPSGEATPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREGVKSPVCSSHSNGHCTGPGGKNQMWLSSHPKQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPIATASS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMGEEGPPSLEYIQAK
CCCCCCCCHHHHCHH		36.6525159151
11PhosphorylationEGPPSLEYIQAKDLF
CCCCCHHHHCHHHCC		12.0230108239
92MethylationFQLHISCKDSKVVRC
EEEEEECCCCCEEEE		59.24-
92"N6,N6-dimethyllysine"FQLHISCKDSKVVRC
EEEEEECCCCCEEEE		59.24-
95"N6,N6-dimethyllysine"HISCKDSKVVRCHFS
EEECCCCCEEEEECH		55.68-
95MethylationHISCKDSKVVRCHFS
EEECCCCCEEEEECH		55.68-
184UbiquitinationSHINSNYKLCPSYPQ
EEECCCCCCCCCCCC		48.11-
192UbiquitinationLCPSYPQKLLVPVWI
CCCCCCCCEEEEEEE		39.0129967540
200O-linked_GlycosylationLLVPVWITDKELENV
EEEEEEECCHHHCHH		25.8829351928
202UbiquitinationVPVWITDKELENVAS
EEEEECCHHHCHHHH		56.39-
209PhosphorylationKELENVASFRSWKRI
HHHCHHHHCCCCCCC		19.5324719451
257UbiquitinationYLVTSIAKACALDPG
HHHHHHHHHHCCCCC		42.18-
314PhosphorylationLILDARSYTAAVANR
EEEECCCHHHHHHHH		8.5422817900
589PhosphorylationENMDLYLSPVAQSQE
CCCCEEECCCCCCCC		12.0826074081
594PhosphorylationYLSPVAQSQEFSGRS
EECCCCCCCCCCCCC		23.1826074081
598PhosphorylationVAQSQEFSGRSLDRL
CCCCCCCCCCCCCCC		32.3226074081
601PhosphorylationSQEFSGRSLDRLPKT
CCCCCCCCCCCCCCC		37.8430266825
608PhosphorylationSLDRLPKTRSMDDLL
CCCCCCCCCCHHHHH		26.4923401153
610PhosphorylationDRLPKTRSMDDLLSA
CCCCCCCCHHHHHHH		31.6223401153
616PhosphorylationRSMDDLLSACDTSSP
CCHHHHHHHCCCCCC		33.8630266825
620PhosphorylationDLLSACDTSSPLTRT
HHHHHCCCCCCCCCC		30.8723927012
621PhosphorylationLLSACDTSSPLTRTS
HHHHCCCCCCCCCCC		19.3923927012
622PhosphorylationLSACDTSSPLTRTSS
HHHCCCCCCCCCCCC		26.4823927012
625PhosphorylationCDTSSPLTRTSSDPN
CCCCCCCCCCCCCCC		34.9723927012
627PhosphorylationTSSPLTRTSSDPNLN
CCCCCCCCCCCCCCC		27.6123401153
628PhosphorylationSSPLTRTSSDPNLNN
CCCCCCCCCCCCCCC		29.4730266825
629PhosphorylationSPLTRTSSDPNLNNH
CCCCCCCCCCCCCCC		57.3823401153
715PhosphorylationAVPREMKSNTSDPEI
CCCHHHHCCCCCCCH		43.9928102081
717PhosphorylationPREMKSNTSDPEIKV
CHHHHCCCCCCCHHH		41.4123312004
718PhosphorylationREMKSNTSDPEIKVL
HHHHCCCCCCCHHHH		56.2530576142
729UbiquitinationIKVLEETKGPAPDPS
HHHHHHCCCCCCCCC		67.2029967540
882UbiquitinationLENPRFGKMPLELVR
CCCCCCCCCCHHHHC		34.33-
945PhosphorylationNSKQMRATGPCFGGQ
CCCCCHHCCCCCCHH		31.1528555341
961PhosphorylationAQREGVKSPVCSSHS
HHHCCCCCCCCCCCC		21.8425849741
965PhosphorylationGVKSPVCSSHSNGHC
CCCCCCCCCCCCCCC		31.1823927012
966PhosphorylationVKSPVCSSHSNGHCT
CCCCCCCCCCCCCCC		26.3023927012
991PhosphorylationSSHPKQVSSTKPVPL
CCCCCCCCCCCCCCC		29.7828122231
992PhosphorylationSHPKQVSSTKPVPLN
CCCCCCCCCCCCCCC		41.4128122231
993PhosphorylationHPKQVSSTKPVPLNC
CCCCCCCCCCCCCCC		31.6828464451
1002PhosphorylationPVPLNCPSPVPPLYL
CCCCCCCCCCCCEEE		40.5026657352
1008PhosphorylationPSPVPPLYLDDDGLP
CCCCCCEEECCCCCC		17.5428122231
1018PhosphorylationDDGLPFPTDVIQHRL
CCCCCCCHHHHHHHH		43.1928122231
1081PhosphorylationKESDGSDTEDFGSDH
ECCCCCCCCCCCCCC		38.87-
1086PhosphorylationSDTEDFGSDHSEDCL
CCCCCCCCCCCHHHH		31.95-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseNEDD4P46934
PMID:19125695
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTMR4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTMR4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NEDD4_HUMANNEDD4physical
19125695
CEP55_HUMANCEP55physical
27880917
MTMR3_HUMANMTMR3physical
27880917
RBCC1_HUMANRB1CC1physical
27880917
TM160_HUMANTMEM160physical
27880917
KPCI_HUMANPRKCIphysical
27880917
SMG7_HUMANSMG7physical
27880917
GOGA5_HUMANGOLGA5physical
27880917
MTMR4_HUMANMTMR4physical
27432908
CEP55_HUMANCEP55physical
27432908
MTMR3_HUMANMTMR3physical
27432908
PDIP2_HUMANPOLDIP2physical
27432908
1433F_HUMANYWHAHphysical
27432908
ATR_HUMANATRphysical
27432908
DJC10_HUMANDNAJC10physical
27432908
AP2M1_HUMANAP2M1physical
27432908
SCO2_HUMANSCO2physical
27432908
AP2A2_HUMANAP2A2physical
27432908
DUS7_HUMANDUSP7physical
27432908
1433B_HUMANYWHABphysical
27432908
ACD11_HUMANACAD11physical
27432908
1433Z_HUMANYWHAZphysical
27432908
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTMR4_HUMAN

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Related Literatures of Post-Translational Modification

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