dbPTM

MTMR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTMR3_HUMAN
UniProt AC	Q13615
Protein Name	Myotubularin-related protein 3
Gene Name	MTMR3
Organism	Homo sapiens (Human).
Sequence Length	1198
Subcellular Localization	Cytoplasm . Membrane Peripheral membrane protein .
Protein Description	Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. [PubMed: 10733931]
Protein Sequence	MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDEETRHSLECI ---CCHHHHHHHHHH	31.47	22617229
8	Phosphorylation	MDEETRHSLECIQAN CCHHHHHHHHHHHHC	23.67	25159151
56	Phosphorylation	EDAIIALSNYRLHIK HHHHHEEECEEEEEE	23.85	-
184	Ubiquitination	RISNINEKYKLCGSY ECCCCCHHHCCCCCC	43.10	-
210	O-linked_Glycosylation	DKELESVSSFRSWKR HHHHCHHHHCCCCCC	32.79	29237092
211	O-linked_Glycosylation	KELESVSSFRSWKRI HHHCHHHHCCCCCCC	23.64	29237092
259	Ubiquitination	HLVQSVAKACASDSR HHHHHHHHHHHCCCC	41.67	-
263	Phosphorylation	SVAKACASDSRSSGS HHHHHHHCCCCCCCC	35.68	29978859
265	Phosphorylation	AKACASDSRSSGSKL HHHHHCCCCCCCCCC	31.41	29978859
267	Phosphorylation	ACASDSRSSGSKLST HHHCCCCCCCCCCCC	42.90	29978859
268	Phosphorylation	CASDSRSSGSKLSTR HHCCCCCCCCCCCCC	46.07	24719451
270	Phosphorylation	SDSRSSGSKLSTRNT CCCCCCCCCCCCCCC	32.16	29978859
288	Phosphorylation	FPNGGDLSDVEFDSS CCCCCCCHHCCCCCH	44.33	29802988
294	Phosphorylation	LSDVEFDSSLSNASG CHHCCCCCHHCCCCC	38.20	28102081
295	Phosphorylation	SDVEFDSSLSNASGA HHCCCCCHHCCCCCC	37.35	28102081
297	Phosphorylation	VEFDSSLSNASGAES CCCCCHHCCCCCCCH	32.09	28102081
300	Phosphorylation	DSSLSNASGAESLAI CCHHCCCCCCCHHCC	42.67	28102081
304	Phosphorylation	SNASGAESLAIQPQK CCCCCCCHHCCCCCE	23.67	28102081
354	Phosphorylation	MGMANIHSIRRSFQS EECCCHHHHHHHHHH	17.62	24719451
361	Phosphorylation	SIRRSFQSLRLLCTQ HHHHHHHHHHHHHHC	17.28	24719451
533	Phosphorylation	EKHTQERTCSVWSLL CCCCCHHHHHHHHHH	14.37	25690035
538	Phosphorylation	ERTCSVWSLLRAGNK HHHHHHHHHHHHCCH	18.51	25690035
581	Phosphorylation	AVYLPCPSPTTPVDD EEEECCCCCCCCCCC	41.41	28348404
583	Phosphorylation	YLPCPSPTTPVDDSC EECCCCCCCCCCCCC	48.33	28348404
584	Phosphorylation	LPCPSPTTPVDDSCA ECCCCCCCCCCCCCC	25.38	28348404
589	Phosphorylation	PTTPVDDSCAPYPAP CCCCCCCCCCCCCCC	14.02	26074081
593	Phosphorylation	VDDSCAPYPAPGTSP CCCCCCCCCCCCCCC	8.10	26074081
598	Phosphorylation	APYPAPGTSPDDPPL CCCCCCCCCCCCCCH	35.71	26074081
599	Phosphorylation	PYPAPGTSPDDPPLS CCCCCCCCCCCCCHH	32.04	26074081
606	Phosphorylation	SPDDPPLSRLPKTRS CCCCCCHHHCCCCCC	37.23	26074081
611	Phosphorylation	PLSRLPKTRSYDNLT CHHHCCCCCCCCCCC	23.94	23401153
613	Phosphorylation	SRLPKTRSYDNLTTA HHCCCCCCCCCCCHH	41.91	29255136
614	Phosphorylation	RLPKTRSYDNLTTAC HCCCCCCCCCCCHHC	12.93	29255136
618	Phosphorylation	TRSYDNLTTACDNTV CCCCCCCCHHCCCCC	20.71	29255136
619	Phosphorylation	RSYDNLTTACDNTVP CCCCCCCHHCCCCCC	28.58	29255136
624	Phosphorylation	LTTACDNTVPLASRR CCHHCCCCCCCCCCC	15.39	23927012
629	Phosphorylation	DNTVPLASRRCSDPS CCCCCCCCCCCCCCC	28.13	23927012
633	Phosphorylation	PLASRRCSDPSLNEK CCCCCCCCCCCHHHH	51.23	23401153
636	Phosphorylation	SRRCSDPSLNEKWQE CCCCCCCCHHHHHHH	49.14	23927012
647	Phosphorylation	KWQEHRRSLELSSLA HHHHHHHHHHHHHCC	26.59	29255136
651	Phosphorylation	HRRSLELSSLAGPGE HHHHHHHHHCCCCCC	17.58	30266825
652	Phosphorylation	RRSLELSSLAGPGED HHHHHHHHCCCCCCC	34.56	30266825
662	Phosphorylation	GPGEDPLSADSLGKP CCCCCCCCHHHCCCC	35.10	23403867
665	Phosphorylation	EDPLSADSLGKPTRV CCCCCHHHCCCCCCC	38.44	23403867
670	Phosphorylation	ADSLGKPTRVPGGAE HHHCCCCCCCCCCCE	48.02	23403867
701	Phosphorylation	QEATKEESGVEEPAH HHHHHHHCCCCCCHH	49.59	25159151
731	Phosphorylation	EKESRRKTPEASAIG CHHHHCCCCCCHHHC	25.26	30266825
735	Phosphorylation	RRKTPEASAIGLHQD HCCCCCCHHHCCCCC	20.82	30266825
757	Phosphorylation	LRSHLDMSWPLFSQG HHHHCCCCCHHHHCC	25.80	-
788	Phosphorylation	VPPRGEDSLEVPVEQ CCCCCCCCCCCCHHH	23.33	21815630
823	Phosphorylation	AKVGYGTSQSCSLLP CCCCCCCCCCCCCCC	18.74	27251275
825	Phosphorylation	VGYGTSQSCSLLPSQ CCCCCCCCCCCCCCC	12.87	27050516
827	Phosphorylation	YGTSQSCSLLPSQVP CCCCCCCCCCCCCCC	37.88	24719451
831	Phosphorylation	QSCSLLPSQVPFETR CCCCCCCCCCCCCCC	43.72	24850871
837	Phosphorylation	PSQVPFETRGPNVDS CCCCCCCCCCCCCCC	41.11	24850871
866	Phosphorylation	GPQGHHRSCLVNSGK CCCCCCCCEECCCCC	13.88	27251275
871	Phosphorylation	HRSCLVNSGKDRLPQ CCCEECCCCCCCCCC	39.48	28348404
883	Phosphorylation	LPQTMEPSPSETSLV CCCCCCCCCCCCCCC	27.96	28555341
885	Phosphorylation	QTMEPSPSETSLVER CCCCCCCCCCCCCCC	58.82	28348404
888	Phosphorylation	EPSPSETSLVERPQV CCCCCCCCCCCCCCC	26.77	30576142
902	Phosphorylation	VGSVVHRTSLGSTLS CCCEEEECCCCCCEE	17.27	26657352
903	Phosphorylation	GSVVHRTSLGSTLSL CCEEEECCCCCCEEE	30.59	25159151
906	Phosphorylation	VHRTSLGSTLSLTRS EEECCCCCCEEECCC	31.31	28450419
907	Phosphorylation	HRTSLGSTLSLTRSP EECCCCCCEEECCCC	20.68	28450419
909	Phosphorylation	TSLGSTLSLTRSPCA CCCCCCEEECCCCCC	27.99	28450419
911	Phosphorylation	LGSTLSLTRSPCALP CCCCEEECCCCCCCC	26.23	28450419
913	Phosphorylation	STLSLTRSPCALPLA CCEEECCCCCCCCHH	21.06	25159151
966	Phosphorylation	ANGEAGRSKDSLSRQ CCCCCCCCHHHHHHH	39.64	25072903
969	Phosphorylation	EAGRSKDSLSRQLSA CCCCCHHHHHHHHHH	31.79	25072903
975	Phosphorylation	DSLSRQLSAMSCSSA HHHHHHHHHHHCHHH	17.37	28450419
978	Phosphorylation	SRQLSAMSCSSAHLH HHHHHHHHCHHHHHH	15.57	28450419
980	Phosphorylation	QLSAMSCSSAHLHSR HHHHHHCHHHHHHHC	24.21	28857561
981	Phosphorylation	LSAMSCSSAHLHSRN HHHHHCHHHHHHHCC	24.84	28857561
986	Phosphorylation	CSSAHLHSRNLHHKW CHHHHHHHCCCCHHH	29.26	27251275
996	O-linked_Glycosylation	LHHKWLHSHSGRPSA CCHHHHHCCCCCCCC	19.71	29237092
996	Phosphorylation	LHHKWLHSHSGRPSA CCHHHHHCCCCCCCC	19.71	20873877
998	Phosphorylation	HKWLHSHSGRPSATS HHHHHCCCCCCCCCC	39.24	20873877
1002	Phosphorylation	HSHSGRPSATSSPDQ HCCCCCCCCCCCCCC	42.70	20873877
1004	Phosphorylation	HSGRPSATSSPDQPS CCCCCCCCCCCCCCC	33.79	20873877
1005	Phosphorylation	SGRPSATSSPDQPSR CCCCCCCCCCCCCCC	39.32	20873877
1006	Phosphorylation	GRPSATSSPDQPSRS CCCCCCCCCCCCCCC	28.30	20873877
1011	Phosphorylation	TSSPDQPSRSHLDDD CCCCCCCCCCCCCCC	40.56	29449344
1023	Phosphorylation	DDDGMSVYTDTIQQR CCCCCCCCHHHHHHH	7.50	27642862
1046	Ubiquitination	QQEVETLKKQVQELK HHHHHHHHHHHHHHH	48.88	-
1047	Ubiquitination	QEVETLKKQVQELKS HHHHHHHHHHHHHHH	59.83	-
1064	Phosphorylation	ESQYLTSSLHFNGDF HHHHHHHCEECCCCC	22.19	-
1094	Phosphorylation	QNCLSRCSTEIFSEA HHHHHHHHHHHHHHC	28.15	27251275
1095	Phosphorylation	NCLSRCSTEIFSEAS HHHHHHHHHHHHHCC	36.40	27251275
1102	Phosphorylation	TEIFSEASWEQVDKQ HHHHHHCCHHHHHHC	27.39	27251275
1114	Phosphorylation	DKQDTEMTRWLPDHL HHCCHHHHHHCCHHH	16.68	28985074
1150	Phosphorylation	NCGNVFCSSCCNQKV CCCCEEEHHHCCCCC	18.23	28348404
1151	Phosphorylation	CGNVFCSSCCNQKVP CCCEEEHHHCCCCCC	24.70	28348404
1168	Phosphorylation	SQQLFEPSRVCKSCY HHHHCCHHHHHHHHH	30.10	28555341
1173	Phosphorylation	EPSRVCKSCYSSLHP CHHHHHHHHHHCCCC	17.11	28450419
1175	Phosphorylation	SRVCKSCYSSLHPTS HHHHHHHHHCCCCCC	14.37	28450419
1176	Phosphorylation	RVCKSCYSSLHPTSS HHHHHHHHCCCCCCC	30.65	28450419
1177	Phosphorylation	VCKSCYSSLHPTSSS HHHHHHHCCCCCCCC	12.29	28450419
1181	Phosphorylation	CYSSLHPTSSSIDLE HHHCCCCCCCCEEEE	30.41	23401153
1182	Phosphorylation	YSSLHPTSSSIDLEL HHCCCCCCCCEEEEE	26.92	28450419
1183	Phosphorylation	SSLHPTSSSIDLELD HCCCCCCCCEEEEEC	33.52	28450419
1184	Phosphorylation	SLHPTSSSIDLELDK CCCCCCCCEEEEECC	21.64	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTMR3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTMR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTMR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTOR_HUMAN	MTOR	physical	26787466
MTMR4_HUMAN	MTMR4	physical	26787466
LST8_HUMAN	MLST8	physical	26787466
RPTOR_HUMAN	RPTOR	physical	26787466
MTMR4_HUMAN	MTMR4	physical	27880917
PLK1_HUMAN	PLK1	physical	27880917
MTMR3_HUMAN	MTMR3	physical	27432908
ORC4_HUMAN	ORC4	physical	27432908
PLK1_HUMAN	PLK1	physical	27432908
HEAT1_HUMAN	HEATR1	physical	27432908
MISSL_HUMAN	MAPK1IP1L	physical	27432908
IPO5_HUMAN	IPO5	physical	27432908
AURKA_HUMAN	AURKA	physical	27432908
SSBP_HUMAN	SSBP1	physical	27432908
NU205_HUMAN	NUP205	physical	27432908

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTMR3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633; SER-647; THR-731AND SER-913, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647, AND MASSSPECTROMETRY.	18220336 [Abstract]