dbPTM

DUS7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DUS7_HUMAN
UniProt AC	Q16829
Protein Name	Dual specificity protein phosphatase 7 {ECO:0000312\|HGNC:HGNC:3073}
Gene Name	DUSP7 {ECO:0000312\|HGNC:HGNC:3073}
Organism	Homo sapiens (Human).
Sequence Length	419
Subcellular Localization	Cytoplasm .
Protein Description	Dual specificity protein phosphatase. [PubMed: 9788880 Shows high activity towards MAPK1/ERK2]
Protein Sequence	MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASSEQLYFSTPTNHNLFPLNTLEST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MKNQLRGPP ------CCCCCCCCC	54.09	-
19 (in isoform 2)	Ubiquitination	-	8.16	21906983
106	Ubiquitination	LMLRRLRKGNLPIRS HHHHHHHCCCCCHHH	57.66	29967540
121	Ubiquitination	IIPNHADKERFATRC CCCCCCCHHHHHHHH	52.12	29967540
132	Phosphorylation	ATRCKAATVLLYDEA HHHHHCEEEEEEEHH	19.29	-
136	Phosphorylation	KAATVLLYDEATAEW HCEEEEEEEHHHCCC	13.94	-
140	Phosphorylation	VLLYDEATAEWQPEP EEEEEHHHCCCCCCC	24.06	-
152	Phosphorylation	PEPGAPASVLGLLLQ CCCCCCHHHHHHHHH	19.47	-
169	Phosphorylation	RDDGCQAYYLQGGFN CCCCCCEEEEECCCH	4.46	22817900
170	Phosphorylation	DDGCQAYYLQGGFNK CCCCCEEEEECCCHH	8.79	-
217	Phosphorylation	LRISSDCSDGESDRE EEEECCCCCCCCCCC	54.35	26471730
221	Phosphorylation	SDCSDGESDRELPSS CCCCCCCCCCCCCCC	47.71	26471730
268	Ubiquitination	TNLDVLGKYGIKYIL CCHHHHHHHCCEEEE	35.82	-
315	Phosphorylation	QFFPEAISFIDEARS HHCHHHHHHHHHHHH	24.17	18220336
318	Phosphorylation	PEAISFIDEARSKKC HHHHHHHHHHHHCCC	41.30	18220336
336	Phosphorylation	VHCLAGISRSVTVTV HHHHHCCCHHHHHHH	20.00	22210691
338	Phosphorylation	CLAGISRSVTVTVAY HHHCCCHHHHHHHHH	18.49	22817900
340	Phosphorylation	AGISRSVTVTVAYLM HCCCHHHHHHHHHHH	16.23	22210691
342	Phosphorylation	ISRSVTVTVAYLMQK CCHHHHHHHHHHHHH	7.05	22210691
345	Phosphorylation	SVTVTVAYLMQKMNL HHHHHHHHHHHHHCC	9.81	22210691
353	Phosphorylation	LMQKMNLSLNDAYDF HHHHHCCCHHHHHHH	21.81	22210691
358	Phosphorylation	NLSLNDAYDFVKRKK CCCHHHHHHHHHHHH	16.87	22210691
362	Ubiquitination	NDAYDFVKRKKSNIS HHHHHHHHHHHCCCC	59.50	-
365	Ubiquitination	YDFVKRKKSNISPNF HHHHHHHHCCCCCCC	53.41	-
365 (in isoform 1)	Ubiquitination	-	53.41	21906983
366	Phosphorylation	DFVKRKKSNISPNFN HHHHHHHCCCCCCCC	42.29	28176443
369	Phosphorylation	KRKKSNISPNFNFMG HHHHCCCCCCCCHHH	20.31	25159151
388	Phosphorylation	FERTLGLSSPCDNHA HHHHHCCCCCCCCCC	30.36	26074081
389	Phosphorylation	ERTLGLSSPCDNHAS HHHHCCCCCCCCCCC	34.29	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:24656772

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DUS7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DUS7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1A1_HUMAN	EEF1A1	physical	21900206
DUS9_HUMAN	DUSP9	physical	26186194
NFH_HUMAN	NEFH	physical	26186194
CDK18_HUMAN	CDK18	physical	26186194
SPOP_HUMAN	SPOP	physical	27622336
DUS9_HUMAN	DUSP9	physical	28514442
CDK18_HUMAN	CDK18	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DUS7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366, AND MASSSPECTROMETRY.	18220336 [Abstract]