| UniProt ID | DUS9_HUMAN | |
|---|---|---|
| UniProt AC | Q99956 | |
| Protein Name | Dual specificity protein phosphatase 9 | |
| Gene Name | DUSP9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 384 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Inactivates MAP kinases. Has a specificity for the ERK family.. | |
| Protein Sequence | MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLSVRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTLLQKLREEGYLAYYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGSDCSDAESEADRDSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEERHSQEQGSGGQASAASNPPSFFTTPTSDGAFELAPT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Phosphorylation | LWLRRELSPPRPRLL HHHHHHCCCCCCEEE | 28.27 | 30266825 | |
| 33 | Phosphorylation | DCRSRELYESARIGG ECCCHHHHHHHCHHH | 11.77 | 29496907 | |
| 58 | Phosphorylation | LRRLRRGSLSVRALL HHHHHCCCCEEEECC | 18.69 | 21857030 | |
| 60 | Phosphorylation | RLRRGSLSVRALLPG HHHCCCCEEEECCCC | 15.97 | 24719451 | |
| 148 | Phosphorylation | SLAGRAGSSMAPVPG CCCCCCCCCCCCCCC | 18.89 | 25999147 | |
| 149 | Phosphorylation | LAGRAGSSMAPVPGP CCCCCCCCCCCCCCC | 20.32 | 25999147 | |
| 182 | Phosphorylation | ESEADRDSMSCGLDS HCHHHHHHCCCCCCC | 17.31 | 27794612 | |
| 184 | Phosphorylation | EADRDSMSCGLDSEG HHHHHHCCCCCCCCC | 14.69 | 27794612 | |
| 189 | Phosphorylation | SMSCGLDSEGATPPP HCCCCCCCCCCCCCC | 42.86 | 27794612 | |
| 193 | Phosphorylation | GLDSEGATPPPVGLR CCCCCCCCCCCCCCC | 47.38 | 25850435 | |
| 212 | Phosphorylation | VQILPNLYLGSARDS EEECCCEECCCCCCC | 18.69 | 21955146 | |
| 215 | Phosphorylation | LPNLYLGSARDSANL CCCEECCCCCCCCCH | 19.96 | 21955146 | |
| 219 | Phosphorylation | YLGSARDSANLESLA ECCCCCCCCCHHHHH | 17.32 | 23312004 | |
| 232 | Phosphorylation | LAKLGIRYILNVTPN HHHCCCCHHHCCCCC | 14.08 | - | |
| 237 | Phosphorylation | IRYILNVTPNLPNFF CCHHHCCCCCCCCHH | 12.84 | 25850435 | |
| 258 | Phosphorylation | HYKQIPISDHWSQNL CCEECCCCHHHHHHH | 20.33 | 23186163 | |
| 262 | Phosphorylation | IPISDHWSQNLSRFF CCCCHHHHHHHHHHC | 13.03 | 29116813 | |
| 266 | Phosphorylation | DHWSQNLSRFFPEAI HHHHHHHHHHCHHHH | 34.29 | 23186163 | |
| 321 | Ubiquitination | NDAYDLVKRKKSNIS HHHHHHHHHHHCCCC | 66.84 | - | |
| 324 | Ubiquitination | YDLVKRKKSNISPNF HHHHHHHHCCCCCCC | 53.41 | 21906983 | |
| 325 | Phosphorylation | DLVKRKKSNISPNFN HHHHHHHCCCCCCCC | 42.29 | 28176443 | |
| 328 | Phosphorylation | KRKKSNISPNFNFMG HHHHCCCCCCCCHHH | 20.31 | 25159151 | |
| 343 | Phosphorylation | QLLDFERSLRLEERH HHHHHHHHHHHHHHH | 15.62 | 29978859 | |
| 351 | Phosphorylation | LRLEERHSQEQGSGG HHHHHHHHCCCCCCC | 41.45 | 29116813 | |
| 356 | Phosphorylation | RHSQEQGSGGQASAA HHHCCCCCCCCCCCC | 39.17 | 29116813 | |
| 361 | Phosphorylation | QGSGGQASAASNPPS CCCCCCCCCCCCCCC | 19.24 | 25137130 | |
| 364 | Phosphorylation | GGQASAASNPPSFFT CCCCCCCCCCCCCCC | 49.97 | 20068231 | |
| 368 | Phosphorylation | SAASNPPSFFTTPTS CCCCCCCCCCCCCCC | 33.96 | 29116813 | |
| 371 | Phosphorylation | SNPPSFFTTPTSDGA CCCCCCCCCCCCCCC | 29.83 | 29116813 | |
| 372 | Phosphorylation | NPPSFFTTPTSDGAF CCCCCCCCCCCCCCC | 21.29 | 29116813 | |
| 374 | Phosphorylation | PSFFTTPTSDGAFEL CCCCCCCCCCCCCCC | 37.04 | 29116813 | |
| 375 | Phosphorylation | SFFTTPTSDGAFELA CCCCCCCCCCCCCCC | 34.94 | 29116813 | |
| 384 | Phosphorylation | GAFELAPT------- CCCCCCCC------- | 45.71 | 30177828 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DUS9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DUS9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DUS9_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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