PRAF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRAF2_HUMAN
• UniProt AC: O60831
• Protein Name: PRA1 family protein 2
• Gene Name: PRAF2
• Organism: Homo sapiens (Human).
• Sequence Length: 178
• Subcellular Localization: Endosome membrane ; Multi-pass membrane protein .
• Protein Description: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis..
• Protein Sequence: MSEVRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYYQTNYLLCFGIGLALAGYVRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVGLLVLWVAGGACTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEVRLPPL ------CCCCCCCCC	44.81	20071362
19	Phosphorylation	LDDFVLGSARLAAPD HCHHHHCCCHHCCCC	13.17	21712546
152	Ubiquitination	LKNKIENKIESIGLK HHHHHHHHHHHCCCC	34.75	-
152	Malonylation	LKNKIENKIESIGLK HHHHHHHHHHHCCCC	34.75	26320211
159	Ubiquitination	KIESIGLKRTPMGLL HHHHCCCCCCHHHHH	49.35	-
161	Phosphorylation	ESIGLKRTPMGLLLE HHCCCCCCHHHHHHH	18.95	24719451
178	Phosphorylation	GQEQEAGS------- HHHHHCCC-------	44.06	26846344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRAF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRAF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRAF2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PRAF2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.