NDK3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDK3_HUMAN
• UniProt AC: Q13232
• Protein Name: Nucleoside diphosphate kinase 3
• Gene Name: NME3
• Organism: Homo sapiens (Human).
• Sequence Length: 169
• Protein Description: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis..
• Protein Sequence: MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Ubiquitination	ERTFLAVKPDGVQRR CCEEEEECCCCHHHH	31.61	22817900
29	Acetylation	ERTFLAVKPDGVQRR CCEEEEECCCCHHHH	31.61	27452117
35	Methylation	VKPDGVQRRLVGEIV ECCCCHHHHHHHHHH	31.34	24387917
48	Ubiquitination	IVRRFERKGFKLVAL HHHHHHHCCCHHHHH	62.59	22817900
51	Ubiquitination	RFERKGFKLVALKLV HHHHCCCHHHHHHHH	51.20	21890473
56	Ubiquitination	GFKLVALKLVQASEE CCHHHHHHHHHHCHH	36.55	22817900
61	Phosphorylation	ALKLVQASEELLREH HHHHHHHCHHHHHHH	17.95	22817900
69	Phosphorylation	EELLREHYAELRERP HHHHHHHHHHHHHCC	9.30	-
111	Phosphorylation	SRALIGATNPADAPP HHHHHCCCCCCCCCC	36.20	27050516
137	Phosphorylation	GKNLIHGSDSVESAR CCCEECCCCCHHHHH	16.73	23312004
139	Phosphorylation	NLIHGSDSVESARRE CEECCCCCHHHHHHH	29.49	23312004
142	Phosphorylation	HGSDSVESARREIAL CCCCCHHHHHHHHHH	25.56	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDK3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDK3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDK3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGTA_HUMAN	SGTA	physical	16189514
NDKB_HUMAN	NME2	physical	16169070
NDKA_HUMAN	NME1	physical	11042679
NDKB_HUMAN	NME2	physical	11042679
A4_HUMAN	APP	physical	21832049
SGTA_HUMAN	SGTA	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
NDKB_HUMAN	NME2	physical	28514442
BBS5_HUMAN	BBS5	physical	28514442
PTHB1_HUMAN	BBS9	physical	28514442
NDKM_HUMAN	NME4	physical	28514442
BBS4_HUMAN	BBS4	physical	28514442
TTC8_HUMAN	TTC8	physical	28514442
EXD2_HUMAN	EXD2	physical	28514442
BBS7_HUMAN	BBS7	physical	28514442
BBS2_HUMAN	BBS2	physical	28514442
NDKA_HUMAN	NME1	physical	28514442
PEX14_HUMAN	PEX14	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.