EXD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXD2_HUMAN
• UniProt AC: Q9NVH0
• Protein Name: Exonuclease 3'-5' domain-containing protein 2 {ECO:0000312|HGNC:HGNC:20217}
• Gene Name: EXD2 {ECO:0000312|HGNC:HGNC:20217}
• Organism: Homo sapiens (Human).
• Sequence Length: 621
• Subcellular Localization: Nucleus .
• Protein Description: Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks..
• Protein Sequence: MSRQNLVALTVTTLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQLHSSAPRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYGLVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQVIYAARDAQISVALFLHLLGYPFSRNSPGEKNDDHSSWRKVLEKCQGVVDIPFRSKGMSRLGEEVNGEATESQQKPRNKKSKMDGMVPGNHQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLRFEPAGRPESPGDYYLMVKENLCVVCGKRDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPTQRKEELLQALREFYNTDVVTEEMLQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKFGEDLPIQLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	GIQRRRRSKTSPVTQ HHHHHHHCCCCCCCC	14.73	23927012
35	Ubiquitination	IQRRRRSKTSPVTQQ HHHHHHCCCCCCCCC	24.55	-
36	Phosphorylation	QRRRRSKTSPVTQQP HHHHHCCCCCCCCCH	4.24	25247763
37	Phosphorylation	RRRRSKTSPVTQQPQ HHHHCCCCCCCCCHH	3.55	23927012
40	Phosphorylation	RSKTSPVTQQPQQKV HCCCCCCCCCHHHHH	14.44	29666759
46	Ubiquitination	VTQQPQQKVLGSREL CCCCHHHHHCCCCCC	39.59	-
50	Phosphorylation	PQQKVLGSRELPPPE HHHHHCCCCCCCCCC	4.87	29666759
146	Ubiquitination	PKLICGGKTLPRTLL CCCHHCCCCCCHHHH	56.49	-
160	Phosphorylation	LDILADGTILKVGVG HHHHCCCCEEEEECC	59.80	30576142
169	Phosphorylation	LKVGVGCSEDASKLL EEEECCCCHHHHHHH	33.66	21406692
173	Phosphorylation	VGCSEDASKLLQDYG CCCCHHHHHHHHHHC	32.78	21406692
206	Phosphorylation	NLLCNGLSLKSLAET CCCCCCCCHHHHHHH	53.25	24719451
283	Ubiquitination	SWRKVLEKCQGVVDI HHHHHHHHCCCCEEC	37.70	-
320	Phosphorylation	QKPRNKKSKMDGMVP CCCCCCCCCCCCCCC	8.69	-
321	Methylation	KPRNKKSKMDGMVPG CCCCCCCCCCCCCCC	40.18	-
348	Phosphorylation	KPLGVGYSARKSPLY CCCCCCCCCCCCCCC	7.21	25599653
352	Phosphorylation	VGYSARKSPLYDNCF CCCCCCCCCCCCCCE	7.33	25159151
354	Ubiquitination	YSARKSPLYDNCFLH CCCCCCCCCCCCEEE	68.59	21890473
382	Ubiquitination	KAQWYLDKGIGELVS HHHHHHCCCHHHCCC	29.32	-
396	Ubiquitination	SEEPFVVKLRFEPAG CCCCEEEEEEEECCC	56.94	-
407	Phosphorylation	EPAGRPESPGDYYLM ECCCCCCCCCCEEEE	34.81	26657352
411	Phosphorylation	RPESPGDYYLMVKEN CCCCCCCEEEEEECC	6.58	27251275
412	Phosphorylation	PESPGDYYLMVKENL CCCCCCEEEEEECCE	26.52	27251275
479	Ubiquitination	HLKQQLAKEFQAPIG HHHHHHHHHHCCCCC	34.52	-
479	Ubiquitination	HLKQQLAKEFQAPIG HHHHHHHHHHCCCCC	34.52	21890473
479	Ubiquitination	HLKQQLAKEFQAPIG HHHHHHHHHHCCCCC	34.52	21890473
517	Phosphorylation	LNAESLPTQRKEELL HCCCCCCHHHHHHHH		24247654
568	Phosphorylation	LKVVQCHSQGGLRSL EEEEEECCCCHHHHH		27251275
580	Phosphorylation	RSLMQLESRWRQHFL HHHHHHHHHHHHHHH		-
611	Ubiquitination	NHQKLLRKFGEDLPI HHHHHHHHHCCCCCC		-
621	Phosphorylation	EDLPIQLS------- CCCCCCCC-------		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTIP_HUMAN	RBBP8	physical	26807646
BRCA1_HUMAN	BRCA1	physical	26807646
MRE11_HUMAN	MRE11A	physical	26807646
CLPX_HUMAN	CLPX	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.