BBS5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BBS5_HUMAN
• UniProt AC: Q8N3I7
• Protein Name: Bardet-Biedl syndrome 5 protein
• Gene Name: BBS5
• Organism: Homo sapiens (Human).
• Sequence Length: 341
• Subcellular Localization: Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Localizes to basal bodies..
• Protein Description: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly..
• Protein Sequence: MSVLDALWEDRDVRFDLSAQQMKTRPGEVLIDCLDSIEDTKGNNGDRGRLLVTNLRILWHSLALSRVNVSVGYNCILNITTRTANSKLRGQTEALYILTKCNSTRFEFIFTNLVPGSPRLFTSVMAVHRAYETSKMYRDFKLRSALIQNKQLRLLPQEHVYDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDSFNVSIPYLQIRSIKIRDSKFGLALVIESSQQSGGYVLGFKIDPVEKLQESVKEINSLHKVYSASPIFGVDYEMEEKPQPLEALTVEQIQDDVEIDSDGHTDAFVAYFADGNKQQDREPVFSEELGLAIEKLKDGFTLQGLWEVMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	RDVRFDLSAQQMKTR CCCCEEECHHHHCCC	26.35	-
24	Phosphorylation	LSAQQMKTRPGEVLI ECHHHHCCCCCCEEE	36.43	-
65	Phosphorylation	LWHSLALSRVNVSVG HHHHHHHHCCCEECC	28.68	24719451
135	Ubiquitination	HRAYETSKMYRDFKL HHHHHHHHHHHCHHH	47.58	-
150	Ubiquitination	RSALIQNKQLRLLPQ HHHHHHCCCCCCCCC	34.04	-
248	Ubiquitination	EKLQESVKEINSLHK HHHHHHHHHHHHHHH	63.26	-
252	Phosphorylation	ESVKEINSLHKVYSA HHHHHHHHHHHHHHC	37.20	30622161
326	Ubiquitination	ELGLAIEKLKDGFTL HHHHHHHHHCCCCEE	55.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BBS5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BBS5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BBS5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLC3_HUMAN	KLC3	physical	25416956
BBS1_HUMAN	BBS1	physical	28514442
BBS7_HUMAN	BBS7	physical	28514442
BBS4_HUMAN	BBS4	physical	28514442
PTHB1_HUMAN	BBS9	physical	28514442
TTC8_HUMAN	TTC8	physical	28514442
BBS2_HUMAN	BBS2	physical	28514442
BBS7_HUMAN	BBS7	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.