PTHB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTHB1_HUMAN
• UniProt AC: Q3SYG4
• Protein Name: Protein PTHB1
• Gene Name: BBS9
• Organism: Homo sapiens (Human).
• Sequence Length: 887
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
• Protein Description: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization..
• Protein Sequence: MSLFKARDWWSTILGDKEEFDQGCLCLANVDNSGNGQDKIIVGSFMGYLRIFSPHPAKTGDGAQAEDLLLEVDLRDPVLQVEVGKFVSGTEMLHLAVLHSRKLCVYSVSGTLGNVEHGNQCQMKLMYEHNLQRTACNMTYGSFGGVKGRDLICIQSMDGMLMVFEQESYAFGRFLPGFLLPGPLAYSSRTDSFLTVSSCQQVESYKYQVLAFATDADKRQETEQQKLGSGKRLVVDWTLNIGEQALDICIVSFNQSASSVFVLGERNFFCLKDNGQIRFMKKLDWSPSCFLPYCSVSEGTINTLIGNHNNMLHIYQDVTLKWATQLPHIPVAVRVGCLHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPNVQSRELNYDELDVEMKELQKIIKDVNKSQGVWPMTEREDDLNVSVVVSPNFDSVSQATDVEVGTDLVPSVTVKVTLQNRVILQKAKLSVYVQPPLELTCDQFTFEFMTPDLTRTVSFSVYLKRSYTPSELEGNAVVSYSRPTDRNPDGIPRVIQCKFRLPLKLICLPGQPSKTASHKITIDTNKSPVSLLSLFPGFASQSDDDQVNVMGFHFLGGARITVLASKTSQRYRIQSEQFEDLWLITNELILRLQEYFEKQGVKDFACSFSGSIPLQEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLARFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQGNLFQSFTRLKSATHLVILLIALWQKLSADQVAILEAAFLPLQEDTQELGWEETVDAAISHLLKTCLSKSSKEQALNLNSQLNIPKDTSQLKKHITLLCDRLSKGGRLCLSTDAAAPQTMVMPGGCTTIPESDLEERSVEQDSTELFTNHRHLTAETPRPEVSPLQGVSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLFKARDW ------CCCCHHHHH	42.38	24719451
5	Ubiquitination	---MSLFKARDWWST ---CCCCHHHHHHHH	48.05	-
127	Phosphorylation	QCQMKLMYEHNLQRT CEEEEEHHHHCCCCH	25.19	22210691
134	Phosphorylation	YEHNLQRTACNMTYG HHHCCCCHHCCCCCC	23.70	22210691
147	Ubiquitination	YGSFGGVKGRDLICI CCCCCCCCCCEEEEE	52.05	-
226	Ubiquitination	RQETEQQKLGSGKRL HHHHHHHHCCCCCEE	55.28	-
286	Phosphorylation	FMKKLDWSPSCFLPY EEECCCCCCCCCCCE	13.45	22210691
300	Phosphorylation	YCSVSEGTINTLIGN EEECCCCCEEEECCC	13.65	22210691
319	Phosphorylation	LHIYQDVTLKWATQL EEEEEEEEHHHHHCC	30.80	22210691
378	Phosphorylation	VQSRELNYDELDVEM CCCCCCCHHHHHHHH	24.34	28796482
386	Ubiquitination	DELDVEMKELQKIIK HHHHHHHHHHHHHHH	41.59	-
390	Malonylation	VEMKELQKIIKDVNK HHHHHHHHHHHHHHH	60.05	26320211
390	Acetylation	VEMKELQKIIKDVNK HHHHHHHHHHHHHHH	60.05	23749302
473 (in isoform 4)	Phosphorylation	-	19.34	-
494	Phosphorylation	FSVYLKRSYTPSELE EEEEEECCCCHHHEE	31.60	25262027
495	Phosphorylation	SVYLKRSYTPSELEG EEEEECCCCHHHEEC	27.06	25262027
496	Phosphorylation	VYLKRSYTPSELEGN EEEECCCCHHHEECC	22.91	25262027
498	Phosphorylation	LKRSYTPSELEGNAV EECCCCHHHEECCEE	47.19	25262027
507 (in isoform 7)	Phosphorylation	-	15.70	22210691
507	Phosphorylation	LEGNAVVSYSRPTDR EECCEEEEECCCCCC	15.70	25262027
508 (in isoform 7)	Phosphorylation	-	9.33	22210691
508	Phosphorylation	EGNAVVSYSRPTDRN ECCEEEEECCCCCCC	9.33	25262027
509 (in isoform 7)	Phosphorylation	-	25.03	22210691
509	Phosphorylation	GNAVVSYSRPTDRNP CCEEEEECCCCCCCC	25.03	25262027
512	Phosphorylation	VVSYSRPTDRNPDGI EEEECCCCCCCCCCC	46.62	30206219
542	Ubiquitination	CLPGQPSKTASHKIT ECCCCCCCCCCEEEE	55.59	-
549	Phosphorylation	KTASHKITIDTNKSP CCCCEEEEEECCCCC	20.01	-
552	Phosphorylation	SHKITIDTNKSPVSL CEEEEEECCCCCCHH	40.47	-
593	O-linked_Glycosylation	ARITVLASKTSQRYR CEEEEEEECCCCCCC	32.10	30379171
595	O-linked_Glycosylation	ITVLASKTSQRYRIQ EEEEEECCCCCCCCC	27.83	30379171
785	Phosphorylation	HLLKTCLSKSSKEQA HHHHHHCCCCCHHHH	32.41	23532336
788	Phosphorylation	KTCLSKSSKEQALNL HHHCCCCCHHHHHCC	43.90	23532336
789	Ubiquitination	TCLSKSSKEQALNLN HHCCCCCHHHHHCCH	62.02	-
810	Ubiquitination	KDTSQLKKHITLLCD CCHHHHHHHHHHHHH	49.16	-
828	Phosphorylation	KGGRLCLSTDAAAPQ CCCCEEEECCCCCCC	24.20	22210691
836	Phosphorylation	TDAAAPQTMVMPGGC CCCCCCCEEEECCCC	15.63	26074081
844	Phosphorylation	MVMPGGCTTIPESDL EEECCCCCCCCHHHH	30.91	22210691
845	Phosphorylation	VMPGGCTTIPESDLE EECCCCCCCCHHHHH	38.31	26074081
849	Phosphorylation	GCTTIPESDLEERSV CCCCCCHHHHHCCCC	41.98	26074081
880	Phosphorylation	ETPRPEVSPLQGVSE CCCCCCCCCCCCCCC	20.45	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTHB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTHB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTHB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BBS5_HUMAN	BBS5	physical	27173435
BBS1_HUMAN	BBS1	physical	27173435
BBS7_HUMAN	BBS7	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.