RRAS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRAS_HUMAN
• UniProt AC: P10301
• Protein Name: Ras-related protein R-Ras
• Gene Name: RRAS
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side. Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
• Protein Description: Regulates the organization of the actin cytoskeleton. [PubMed: 16537651]
• Protein Sequence: MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSGAASGT ------CCCCCCCCC	37.16	28857561
3	Phosphorylation	-----MSSGAASGTG -----CCCCCCCCCC	31.02	28857561
9	Phosphorylation	SSGAASGTGRGRPRG CCCCCCCCCCCCCCC	22.62	-
11	Methylation	GAASGTGRGRPRGGG CCCCCCCCCCCCCCC	37.47	115492893
31	Ubiquitination	PPPSETHKLVVVGGG CCCCCCCEEEEECCC	50.85	-
52	Phosphorylation	LTIQFIQSYFVSDYD HHHHHHHHHHCCCCC	18.74	22210691
56	Phosphorylation	FIQSYFVSDYDPTIE HHHHHHCCCCCCCCC	22.13	22210691
58	Phosphorylation	QSYFVSDYDPTIEDS HHHHCCCCCCCCCCC	19.13	-
66	Phosphorylation	DPTIEDSYTKICSVD CCCCCCCCCEEECCC	25.11	10570155
67	Phosphorylation	PTIEDSYTKICSVDG CCCCCCCCEEECCCC	20.20	22210691
93	Sulfoxidation	GQEEFGAMREQYMRA CHHHHHHHHHHHHHC	5.05	21406390
121	Ubiquitination	QSFNEVGKLFTQILR CHHHHHHHHHHHHHC	45.67	-
143	Ubiquitination	PVVLVGNKADLESQR CEEEECCHHHHHHHC	37.03	-
192	Ubiquitination	QLVRAVRKYQEQELP HHHHHHHHHHHHCCC	44.69	21906983
193	Phosphorylation	LVRAVRKYQEQELPP HHHHHHHHHHHCCCC	13.50	25072903
201	Phosphorylation	QEQELPPSPPSAPRK HHHCCCCCCCCCCCC	47.72	30266825
204	Phosphorylation	ELPPSPPSAPRKKGG CCCCCCCCCCCCCCC	55.05	21815630
213	S-palmitoylation	PRKKGGGCPCVLL-- CCCCCCCCCCEEC--	2.39	12890755
215	Methylation	KKGGGCPCVLL---- CCCCCCCCEEC----	3.81	-
215	Geranylgeranylation	KKGGGCPCVLL---- CCCCCCCCEEC----	3.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	Y	Phosphorylation	Kinase	EPHB2	P29323	PSP
66	Y	Phosphorylation	Kinase	SRC	P12931	PSP
66	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
201	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
201	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRAS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRAS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNDS_HUMAN	RALGDS	physical	7809086
EF1A1_HUMAN	EEF1A1	physical	18624398
RM36_HUMAN	MRPL36	physical	18624398

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.