HMOX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMOX2_HUMAN
• UniProt AC: P30519
• Protein Name: Heme oxygenase 2
• Gene Name: HMOX2
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Subcellular Localization: Microsome. Endoplasmic reticulum.
• Protein Description: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter..
• Protein Sequence: MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYNMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGALEGSSCPFRTAMAVLRKPSLQFILAAGVALAAGLLAWYYM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAEVETSE ------CCCCEECCC	32.89	30108239
2	Acetylation	------MSAEVETSE ------CCCCEECCC	32.89	25944712
7	Phosphorylation	-MSAEVETSEGVDES -CCCCEECCCCCCHH	36.94	30108239
8	Phosphorylation	MSAEVETSEGVDESE CCCCEECCCCCCHHH	20.88	30108239
14	Phosphorylation	TSEGVDESEKKNSGA CCCCCCHHHHHCCCH	50.69	30108239
19	Phosphorylation	DESEKKNSGALEKEN CHHHHHCCCHHHHHH	34.03	28450419
24	Ubiquitination	KNSGALEKENQMRMA HCCCHHHHHHHHHHH	63.92	-
24	2-Hydroxyisobutyrylation	KNSGALEKENQMRMA HCCCHHHHHHHHHHH	63.92	-
30	Sulfoxidation	EKENQMRMADLSELL HHHHHHHHHHHHHHH	2.60	21406390
34	Phosphorylation	QMRMADLSELLKEGT HHHHHHHHHHHHHHH	27.09	21712546
38	Ubiquitination	ADLSELLKEGTKEAH HHHHHHHHHHHHHHH	67.72	-
38	Acetylation	ADLSELLKEGTKEAH HHHHHHHHHHHHHHH	67.72	26051181
55	Ubiquitination	AENTQFVKDFLKGNI HHHHHHHHHHHCCCH	44.01	21890473
59	Ubiquitination	QFVKDFLKGNIKKEL HHHHHHHCCCHHHHH	50.32	-
59	2-Hydroxyisobutyrylation	QFVKDFLKGNIKKEL HHHHHHHCCCHHHHH	50.32	-
59	Malonylation	QFVKDFLKGNIKKEL HHHHHHHCCCHHHHH	50.32	26320211
79	Phosphorylation	TALYFTYSALEEEME HHHHHHHHHHHHHHH	24.26	14527438
109	Ubiquitination	ELHRKEALTKDMEYF HHHHHHHHHHHHHHH	6.84	21890473
115	Phosphorylation	ALTKDMEYFFGENWE HHHHHHHHHHCCCHH	9.51	26074081
157	Phosphorylation	VAHAYTRYMGDLSGG HHHHHHHHHCCCCHH	9.54	21406692
158	Sulfoxidation	AHAYTRYMGDLSGGQ HHHHHHHHCCCCHHH	2.80	21406390
162	Phosphorylation	TRYMGDLSGGQVLKK HHHHCCCCHHHHHHH	45.69	21406692
168	2-Hydroxyisobutyrylation	LSGGQVLKKVAQRAL CCHHHHHHHHHHHHH	46.47	-
169	Ubiquitination	SGGQVLKKVAQRALK CHHHHHHHHHHHHHC	38.35	-
176	Ubiquitination	KVAQRALKLPSTGEG HHHHHHHCCCCCCCC	58.32	-
179	Phosphorylation	QRALKLPSTGEGTQF HHHHCCCCCCCCCEE	60.52	28348404
180	Phosphorylation	RALKLPSTGEGTQFY HHHCCCCCCCCCEEE	36.99	28348404
184	Phosphorylation	LPSTGEGTQFYLFEN CCCCCCCCEEEEEEC	15.94	28348404
199	Ubiquitination	VDNAQQFKQLYRARM CCCHHHHHHHHHHHH	34.75	-
199	Acetylation	VDNAQQFKQLYRARM CCCHHHHHHHHHHHH	34.75	26051181
202	Phosphorylation	AQQFKQLYRARMNAL HHHHHHHHHHHHHHH	10.34	-
206	Sulfoxidation	KQLYRARMNALDLNM HHHHHHHHHHHCCCC	3.16	30846556
213	Sulfoxidation	MNALDLNMKTKERIV HHHHCCCCCHHHHHH	8.30	30846556
214	Acetylation	NALDLNMKTKERIVE HHHCCCCCHHHHHHH	56.20	25953088
214	Ubiquitination	NALDLNMKTKERIVE HHHCCCCCHHHHHHH	56.20	-
216	Acetylation	LDLNMKTKERIVEEA HCCCCCHHHHHHHHH	39.20	19813205
225	Ubiquitination	RIVEEANKAFEYNMQ HHHHHHHHHHHHHHH	62.59	-
229	Phosphorylation	EANKAFEYNMQIFNE HHHHHHHHHHHHHHH	14.96	29978859
242	O-linked_Glycosylation	NELDQAGSTLARETL HHHHHHCCHHHHHHH	24.22	29351928
242	Phosphorylation	NELDQAGSTLARETL HHHHHHCCHHHHHHH	24.22	24173317
243	O-linked_Glycosylation	ELDQAGSTLARETLE HHHHHCCHHHHHHHH	24.42	29351928
259	Ubiquitination	GFPVHDGKGDMRKCP CCCCCCCCCCHHCCC	58.77	-
262	Sulfoxidation	VHDGKGDMRKCPFYA CCCCCCCHHCCCCCE	6.34	21406390
264	Ubiquitination	DGKGDMRKCPFYAAE CCCCCHHCCCCCEEC	39.35	-
268	Phosphorylation	DMRKCPFYAAEQDKG CHHCCCCCEECCCCC	7.05	25159151
280	Phosphorylation	DKGALEGSSCPFRTA CCCCCCCCCCHHHHH	21.28	23312004
281	Phosphorylation	KGALEGSSCPFRTAM CCCCCCCCCHHHHHH	36.34	23312004
282	S-nitrosylation	GALEGSSCPFRTAMA CCCCCCCCHHHHHHH	3.85	22178444
286	Phosphorylation	GSSCPFRTAMAVLRK CCCCHHHHHHHHHCC	22.59	-
295	Phosphorylation	MAVLRKPSLQFILAA HHHHCCCCHHHHHHH	37.53	22496350
314	Phosphorylation	AAGLLAWYYM----- HHHHHHHHHC-----	5.53	-
315	Phosphorylation	AGLLAWYYM------ HHHHHHHHC------	5.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMOX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMOX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMOX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAP1_HUMAN	HAP1	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
GASP1_HUMAN	GPRASP1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
MED31_HUMAN	MED31	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
MIC60_HUMAN	IMMT	physical	21900206
EIF3C_HUMAN	EIF3C	physical	21900206
TIP_HUMAN	ITFG1	physical	21900206
GCR_HUMAN	NR3C1	physical	21900206
A2MG_HUMAN	A2M	physical	21900206
NKRF_HUMAN	NKRF	physical	21900206
GIT1_HUMAN	GIT1	physical	21900206
HAP1_HUMAN	HAP1	physical	21900206
CE126_HUMAN	KIAA1377	physical	21900206
ATPB_HUMAN	ATP5B	physical	21900206
PLXB2_HUMAN	PLXNB2	physical	21900206
BL1S2_HUMAN	BLOC1S2	physical	21900206
JADE1_HUMAN	JADE1	physical	21900206
INP5K_HUMAN	INPP5K	physical	21900206
ZFP28_HUMAN	ZFP28	physical	21900206
SHC1_HUMAN	SHC1	physical	21900206
ZN746_HUMAN	ZNF746	physical	21900206
CEBPZ_HUMAN	CEBPZ	physical	21900206
RBBP4_HUMAN	RBBP4	physical	21900206
NDUS2_HUMAN	NDUFS2	physical	21900206
SNX5_HUMAN	SNX5	physical	21900206
SNX7_HUMAN	SNX7	physical	21900206
SKA2_HUMAN	SKA2	physical	21988832
POTEE_HUMAN	POTEE	physical	26186194
SNG1_HUMAN	SYNGR1	physical	26186194
TM214_HUMAN	TMEM214	physical	26186194
ALG2_HUMAN	ALG2	physical	26186194
CGT_HUMAN	UGT8	physical	26186194
PRAF2_HUMAN	PRAF2	physical	26186194
GBB2_HUMAN	GNB2	physical	26186194
ADPGK_HUMAN	ADPGK	physical	26186194
CISD2_HUMAN	CISD2	physical	26186194
PTN1_HUMAN	PTPN1	physical	26186194
TM205_HUMAN	TMEM205	physical	26186194
LMF2_HUMAN	LMF2	physical	26186194
POTEE_HUMAN	POTEE	physical	28514442
ALG2_HUMAN	ALG2	physical	28514442
CGT_HUMAN	UGT8	physical	28514442
ADPGK_HUMAN	ADPGK	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
PRAF2_HUMAN	PRAF2	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
LMF2_HUMAN	LMF2	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442
TM205_HUMAN	TMEM205	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.