dbPTM

POTEE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POTEE_HUMAN
UniProt AC	Q6S8J3
Protein Name	POTE ankyrin domain family member E
Gene Name	POTEE
Organism	Homo sapiens (Human).
Sequence Length	1075
Subcellular Localization
Protein Description
Protein Sequence	MVVEVDSMPAASSVKKPFGLRSKMGKWCCRCFPCYRESGKSNVGTSGDHDDSAMKTLRSKMGKWCHHCFPCCRGSGKSNVGASGDHDDSAMKTLRNKMGKWCCHCFPCCRGSGKSKVGAWGDYDDSAFMEPRYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQELKLTSEEESQRFKGSENSQPEKMSQELEINKDGDREVEEEMKKHESNNVGLLENLTNGVTAGNGDNGLIPQRKSRTPENQQFPDNESEEYHRICELLSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDVLHENSTLREEIAMLRLELDTMKHQSQLREKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVPSLYTSGRTTGIVMDSGDGVTHTVPIYEGNALPHATLRLDLAGRELPDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMMKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVVEVDSMPAASSV -CCEEECCCCCCCCC	31.66	29083192
12	Phosphorylation	VDSMPAASSVKKPFG ECCCCCCCCCCCCCC	37.46	23663014
13	Phosphorylation	DSMPAASSVKKPFGL CCCCCCCCCCCCCCC	32.98	29083192
15	Ubiquitination	MPAASSVKKPFGLRS CCCCCCCCCCCCCCC	57.59	23000965
16	Ubiquitination	PAASSVKKPFGLRSK CCCCCCCCCCCCCCC	43.34	23000965
41	Phosphorylation	CYRESGKSNVGTSGD CCCCCCCCCCCCCCC	40.03	30576142
52	Phosphorylation	TSGDHDDSAMKTLRS CCCCCCHHHHHHHHH	36.00	30576142
55	Ubiquitination	DHDDSAMKTLRSKMG CCCHHHHHHHHHHHC	44.09	23000965
55 (in isoform 1)	Ubiquitination	-	44.09	21906983
55 (in isoform 2)	Ubiquitination	-	44.09	21906983
55 (in isoform 3)	Ubiquitination	-	44.09	21906983
56	Phosphorylation	HDDSAMKTLRSKMGK CCHHHHHHHHHHHCC	17.83	-
60	Ubiquitination	AMKTLRSKMGKWCHH HHHHHHHHHCCHHHH	45.28	23000965
75	Phosphorylation	CFPCCRGSGKSNVGA HHHHCCCCCCCCCCC	24.56	22210691
77	Ubiquitination	PCCRGSGKSNVGASG HHCCCCCCCCCCCCC	40.32	23000965
78	Phosphorylation	CCRGSGKSNVGASGD HCCCCCCCCCCCCCC	40.03	-
83	Phosphorylation	GKSNVGASGDHDDSA CCCCCCCCCCCCHHH	38.53	22210691
92	Ubiquitination	DHDDSAMKTLRNKMG CCCHHHHHHHHHHHC	44.09	23000965
92 (in isoform 1)	Ubiquitination	-	44.09	21906983
92 (in isoform 2)	Ubiquitination	-	44.09	21906983
92 (in isoform 3)	Ubiquitination	-	44.09	21906983
97	Ubiquitination	AMKTLRNKMGKWCCH HHHHHHHHHCCCHHH	42.46	23000965
114	Ubiquitination	PCCRGSGKSKVGAWG CCCCCCCCCCCCCCC	49.12	23000965
116	Ubiquitination	CRGSGKSKVGAWGDY CCCCCCCCCCCCCCC	48.45	23000965
116 (in isoform 1)	Ubiquitination	-	48.45	21906983
116 (in isoform 2)	Ubiquitination	-	48.45	21906983
116 (in isoform 3)	Ubiquitination	-	48.45	21906983
142	Ubiquitination	VRGEDLDKLHRAAWW ECCHHHHHHHHHHHC	54.19	23000965
171	Acetylation	TDVNKKDKQKRTALH CCCCHHHHHHHHHHH	67.60	11794865
175	Phosphorylation	KKDKQKRTALHLASA HHHHHHHHHHHHHHC	40.38	-
190	Acetylation	NGNSEVVKLLLDRRC CCCHHHHHHHHHCCC	38.30	11794873
266	Ubiquitination	LLYGADIESKNKHGL HHHCCCHHHCCCCCC	57.09	22817900
267	Phosphorylation	LYGADIESKNKHGLT HHCCCHHHCCCCCCC	41.69	26074081
267	Ubiquitination	LYGADIESKNKHGLT HHCCCHHHCCCCCCC	41.69	22817900
268	Ubiquitination	YGADIESKNKHGLTP HCCCHHHCCCCCCCC	58.17	23000965
270	Ubiquitination	ADIESKNKHGLTPLL CCHHHCCCCCCCCCE	42.67	23000965
274	Phosphorylation	SKNKHGLTPLLLGVH HCCCCCCCCCEEEHH	19.24	-
278	Ubiquitination	HGLTPLLLGVHEQKQ CCCCCCEEEHHHHHH	9.92	23000965
280	Ubiquitination	LTPLLLGVHEQKQQV CCCCEEEHHHHHHHH	4.53	23000965
295	Ubiquitination	VKFLIKKKANLNALD HHHHHHHCCCCCHHH	37.19	-
300	Ubiquitination	KKKANLNALDRYGRT HHCCCCCHHHHHCCH	17.63	22817900
366	Ubiquitination	DYKEKQMLKISSENS CHHHHHCCCCCCCCC	4.06	22817900
369	Phosphorylation	EKQMLKISSENSNPE HHHCCCCCCCCCCHH	29.97	23322592
370	Phosphorylation	KQMLKISSENSNPEQ HHCCCCCCCCCCHHH	44.25	23322592
382	Phosphorylation	PEQELKLTSEEESQR HHHHHCCCCHHHHHH	32.29	23322592
383	Phosphorylation	EQELKLTSEEESQRF HHHHCCCCHHHHHHH	54.14	23322592
387	Phosphorylation	KLTSEEESQRFKGSE CCCCHHHHHHHCCCC	29.90	23322592
395	Ubiquitination	QRFKGSENSQPEKMS HHHCCCCCCCCHHHH	47.87	22817900
400	Ubiquitination	SENSQPEKMSQELEI CCCCCCHHHHHHEEE	51.00	22817900
402	Phosphorylation	NSQPEKMSQELEINK CCCCHHHHHHEEECC	31.41	23403867
468	Phosphorylation	PDNESEEYHRICELL CCCCCHHHHHHHHHH	7.73	18180459
478	Phosphorylation	ICELLSDYKEKQMPK HHHHHHHHHHHHCCC	20.05	-
488	Phosphorylation	KQMPKYSSENSNPEQ HHCCCCCCCCCCHHH	37.39	-
495	Ubiquitination	SENSNPEQDLKLTSE CCCCCHHHHHCCCCH	63.69	22817900
497	Ubiquitination	NSNPEQDLKLTSEEE CCCHHHHHCCCCHHH	4.97	21963094
501	Phosphorylation	EQDLKLTSEEESQRL HHHHCCCCHHHHHHH	54.14	-
520	Ubiquitination	NGQPEKRSQEPEINK CCCCCCCCCCCCCCC	50.38	21963094
547	Phosphorylation	EEMKKHGSTHVGFPE HHHHHHCCCCCCCCC	18.30	20860994
548	Phosphorylation	EMKKHGSTHVGFPEN HHHHHCCCCCCCCCC	25.77	20860994
561	Phosphorylation	ENLTNGATAGNGDDG CCCCCCCCCCCCCCC	36.17	20860994
566	Ubiquitination	GATAGNGDDGLIPPR CCCCCCCCCCCCCCC	51.29	22817900
567	Ubiquitination	ATAGNGDDGLIPPRK CCCCCCCCCCCCCCC	56.02	22817900
568	Ubiquitination	TAGNGDDGLIPPRKS CCCCCCCCCCCCCCC	30.19	22817900
576	Ubiquitination	LIPPRKSRTPESQQF CCCCCCCCCCCHHCC	58.28	22817900
577	Ubiquitination	IPPRKSRTPESQQFP CCCCCCCCCCHHCCC	38.20	22817900
578	Ubiquitination	PPRKSRTPESQQFPD CCCCCCCCCHHCCCC	37.82	22817900
600	Ubiquitination	SDEQNDTQKQFCEEQ CCCCCHHHHHHHHHH	40.18	22817900
610	Ubiquitination	FCEEQNTGILHDEIL HHHHHCCCCCCCEEE	28.19	22817900
666	Ubiquitination	RLELDTMKHQSQLRE HHHHHHHHHHHHHHH	40.35	22817900
675	Acetylation	QSQLREKKYLEDIES HHHHHHHHHHHHHHH	50.76	7491971
676	Phosphorylation	SQLREKKYLEDIESV HHHHHHHHHHHHHHH	26.79	28258704
676	Ubiquitination	SQLREKKYLEDIESV HHHHHHHHHHHHHHH	26.79	22817900
682	Phosphorylation	KYLEDIESVKKKNDN HHHHHHHHHHHHCCH	39.30	20068231
684	Ubiquitination	LEDIESVKKKNDNLL HHHHHHHHHHCCHHH	68.27	22817900
685	Acetylation	EDIESVKKKNDNLLK HHHHHHHHHCCHHHH	55.44	7678581
685	Ubiquitination	EDIESVKKKNDNLLK HHHHHHHHHCCHHHH	55.44	22817900
686	Acetylation	DIESVKKKNDNLLKA HHHHHHHHCCHHHHH	64.91	7491979
686	Ubiquitination	DIESVKKKNDNLLKA HHHHHHHHCCHHHHH	64.91	22817900
692	Acetylation	KKNDNLLKALQLNEL HHCCHHHHHHHCCCC	50.66	7491987
695	Ubiquitination	DNLLKALQLNELTMD CHHHHHHHCCCCCCC	47.29	22817900
700	Ubiquitination	ALQLNELTMDDDTAV HHHCCCCCCCCCCEE	16.63	22817900
705	Phosphorylation	ELTMDDDTAVLVIDN CCCCCCCCEEEEEEC	26.17	24850871
705	Ubiquitination	ELTMDDDTAVLVIDN CCCCCCCCEEEEEEC	26.17	22817900
710	Ubiquitination	DDTAVLVIDNGSGMC CCCEEEEEECCCCCC	2.73	22817900
714	Phosphorylation	VLVIDNGSGMCKAGF EEEEECCCCCCCCCC	29.61	-
718	Ubiquitination	DNGSGMCKAGFAGDD ECCCCCCCCCCCCCC	42.52	22817900
733	Phosphorylation	APRAVFPSIVGRPRQ CCHHHCHHHCCCCCC	20.59	30266825
752	Phosphorylation	GGMHQKESYVGKEAQ CCCCCCCCCCCHHHH	31.96	29978859
753	Phosphorylation	GMHQKESYVGKEAQS CCCCCCCCCCHHHHC	17.82	29978859
760	Phosphorylation	YVGKEAQSKRGILTL CCCHHHHCCCCEEEE	31.22	29978859
766	Phosphorylation	QSKRGILTLKYPMEH HCCCCEEEEECCCHH	21.20	23403867
768	Methylation	KRGILTLKYPMEHGI CCCEEEEECCCHHCC	41.91	-
769	Phosphorylation	RGILTLKYPMEHGII CCEEEEECCCHHCCC	15.78	-
777	Phosphorylation	PMEHGIITNWDDMEK CCHHCCCCCHHHHHH	28.47	22817900
784	Sumoylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-
784	Ubiquitination	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	22817900
789	Phosphorylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	27273156
791	Phosphorylation	KIWHHTFYNELRVAP HHHHHHHHCCCCCCC	14.64	27273156
795	Ubiquitination	HTFYNELRVAPEEHP HHHHCCCCCCCCCCC	19.17	22817900
797	Ubiquitination	FYNELRVAPEEHPIL HHCCCCCCCCCCCEE	10.19	21963094
805	Ubiquitination	PEEHPILLTEAPLNP CCCCCEEEEECCCCC	4.15	22817900
806	Phosphorylation	EEHPILLTEAPLNPK CCCCEEEEECCCCCC	27.01	-
807	Ubiquitination	EHPILLTEAPLNPKA CCCEEEEECCCCCCC	48.54	21963094
813	Ubiquitination	TEAPLNPKANREKMT EECCCCCCCCHHHHH	58.16	27667366
818	Ubiquitination	NPKANREKMTQIMFE CCCCCHHHHHHHHHH	43.97	22817900
820	Phosphorylation	KANREKMTQIMFETF CCCHHHHHHHHHHHC	26.47	-
820	Ubiquitination	KANREKMTQIMFETF CCCHHHHHHHHHHHC	26.47	21963094
830	Ubiquitination	MFETFNTPAMYVAIQ HHHHCCCHHHHHHHH	19.01	21963094
855	Phosphorylation	TTGIVMDSGDGVTHT CEEEEEECCCCCEEE	22.23	30140170
860	Phosphorylation	MDSGDGVTHTVPIYE EECCCCCEEEEEEEC	19.84	-
862	Phosphorylation	SGDGVTHTVPIYEGN CCCCCEEEEEEECCC	20.72	30140170
866	Phosphorylation	VTHTVPIYEGNALPH CEEEEEEECCCCCCC	16.24	22817900
875	Phosphorylation	GNALPHATLRLDLAG CCCCCCCEEEEHHCC	14.91	22817900
891	Acetylation	ELPDYLMKILTERGY CCHHHHHHHHHHCCC	31.78	26210075
901	Phosphorylation	TERGYRFTTMAEREI HHCCCCCCCHHHHHH	13.48	23403867
902	Phosphorylation	ERGYRFTTMAEREIV HCCCCCCCHHHHHHH	16.21	23403867
913	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	18526125
913	Ubiquitination	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	21906983
913 (in isoform 1)	Ubiquitination	-	53.75	21906983
915	Ubiquitination	IVRDIKEKLCYVALD HHHHHHHHHHEEECC	38.56	21963094
915 (in isoform 1)	Ubiquitination	-	38.56	21906983
917	S-palmitoylation	RDIKEKLCYVALDFE HHHHHHHHEEECCHH	3.68	29575903
918	Phosphorylation	DIKEKLCYVALDFEQ HHHHHHHEEECCHHH	10.13	27461979
927	Sulfoxidation	ALDFEQEMATAASSS ECCHHHHHHHHHCCC	3.92	28183972
929	Phosphorylation	DFEQEMATAASSSSL CHHHHHHHHHCCCCC	22.80	27461979
932	Phosphorylation	QEMATAASSSSLEKS HHHHHHHCCCCCCCC	28.43	30278072
933	Phosphorylation	EMATAASSSSLEKSY HHHHHHCCCCCCCCE	21.15	30278072
934	Phosphorylation	MATAASSSSLEKSYE HHHHHCCCCCCCCEE	36.13	30278072
935	Phosphorylation	ATAASSSSLEKSYEL HHHHCCCCCCCCEEC	42.36	30278072
938	Ubiquitination	ASSSSLEKSYELPDG HCCCCCCCCEECCCC	64.73	21963094
939	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCCCEECCCCC	17.92	29255136
940	Phosphorylation	SSSLEKSYELPDGQV CCCCCCCEECCCCCE	32.33	29255136
949	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	26846344
971	O-linked_Glycosylation	PCFLGMESCGIHETT CCCCCHHHCCCCHHH	14.57	29351928
971	Phosphorylation	PCFLGMESCGIHETT CCCCCHHHCCCCHHH	14.57	27251275
977	Phosphorylation	ESCGIHETTFNSIMK HHCCCCHHHHHHHHH	23.64	30140170
978	Phosphorylation	SCGIHETTFNSIMKS HCCCCHHHHHHHHHC	20.17	30140170
981	O-linked_Glycosylation	IHETTFNSIMKSDVD CCHHHHHHHHHCCCC	21.62	29351928
985	Phosphorylation	TFNSIMKSDVDIRKD HHHHHHHCCCCCCHH	26.03	-
991	Sumoylation	KSDVDIRKDLYTNTV HCCCCCCHHHCCCCE	53.04	-
994	Phosphorylation	VDIRKDLYTNTVLSG CCCCHHHCCCCEECC	14.21	18083107
997	Phosphorylation	RKDLYTNTVLSGGTT CHHHCCCCEECCCCC	18.28	20068231
1000	Phosphorylation	LYTNTVLSGGTTMYP HCCCCEECCCCCCCC	30.73	20068231
1003	Phosphorylation	NTVLSGGTTMYPGMA CCEECCCCCCCCCHH	16.35	20068231
1004	Phosphorylation	TVLSGGTTMYPGMAH CEECCCCCCCCCHHH	20.27	20068231
1006	Phosphorylation	LSGGTTMYPGMAHRM ECCCCCCCCCHHHHH	8.44	19534553
1059	Ubiquitination	FQQMWISKQEYDESG HHHHHHHCCCCCCCC	37.71	-
1062	Phosphorylation	MWISKQEYDESGPSI HHHHCCCCCCCCCCC	23.63	23401153
1065	Phosphorylation	SKQEYDESGPSIVHR HCCCCCCCCCCCCCC	53.78	23401153
1068	Phosphorylation	EYDESGPSIVHRKCF CCCCCCCCCCCCCCC	40.54	30266825
1073	Neddylation	GPSIVHRKCF----- CCCCCCCCCC-----	25.72	32015554
1073	Ubiquitination	GPSIVHRKCF----- CCCCCCCCCC-----	25.72	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of POTEE_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POTEE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POTEE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of POTEE_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POTEE_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-866 AND THR-875, ANDMASS SPECTROMETRY.	19367720 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-684, AND MASSSPECTROMETRY.	17370265 [Abstract]