| UniProt ID | CGT_HUMAN | |
|---|---|---|
| UniProt AC | Q16880 | |
| Protein Name | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | |
| Gene Name | UGT8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 541 | |
| Subcellular Localization |
Membrane Single-pass membrane protein . |
|
| Protein Description | Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.. | |
| Protein Sequence | MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MKSYTPYFIL -----CCCCCHHHHH | 32.70 | 27251275 | |
| 4 | Phosphorylation | ----MKSYTPYFILL ----CCCCCHHHHHH | 13.25 | 27251275 | |
| 5 | Phosphorylation | ---MKSYTPYFILLW ---CCCCCHHHHHHH | 20.71 | 27251275 | |
| 7 | Phosphorylation | -MKSYTPYFILLWSA -CCCCCHHHHHHHHH | 8.75 | 27251275 | |
| 78 | N-linked_Glycosylation | QRYPGIFNSTTSDAF CCCCCCCCCCCCHHH | 36.20 | UniProtKB CARBOHYD | |
| 95 | Phosphorylation | SKMRNIFSGRLTAIE HHHHHHHCCCCHHHH | 21.14 | 24719451 | |
| 128 | Ubiquitination | HALIQGLKKEKFDLL HHHHHHHCHHCCCEE | 66.75 | 29967540 | |
| 299 | Phosphorylation | SFGAGVKYLSEDIAN EECCCCHHCCHHHHH | 17.04 | - | |
| 301 | Phosphorylation | GAGVKYLSEDIANKL CCCCHHCCHHHHHHH | 30.08 | - | |
| 324 | Phosphorylation | QKVIWRFSGPKPKNL CEEEEEECCCCCCCC | 45.68 | 22817900 | |
| 333 | N-linked_Glycosylation | PKPKNLGNNTKLIEW CCCCCCCCCCEEEEE | 57.05 | UniProtKB CARBOHYD | |
| 407 | Ubiquitination | EWKTVTEKELYEALV EEEECCHHHHHHHHH | 43.59 | 29967540 | |
| 428 | Ubiquitination | SYRQRAQKLSEIHKD HHHHHHHHHHHHHCC | 53.66 | 29967540 | |
| 442 | N-linked_Glycosylation | DQPGHPVNRTIYWID CCCCCCCCCHHHHHE | 39.57 | UniProtKB CARBOHYD | |
| 444 | Phosphorylation | PGHPVNRTIYWIDYI CCCCCCCHHHHHEEH | 17.14 | 27251275 | |
| 519 | Phosphorylation | HSTVNGHYHNGILNG CCCCCCCCCCCCCCC | 9.81 | - | |
| 528 | Phosphorylation | NGILNGKYKRNGHIK CCCCCCCCCCCCCCC | 19.31 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CGT_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CGT_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CGT_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CGT_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
