| UniProt ID | ZN746_HUMAN | |
|---|---|---|
| UniProt AC | Q6NUN9 | |
| Protein Name | Zinc finger protein 746 | |
| Gene Name | ZNF746 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 644 | |
| Subcellular Localization |
Cytoplasm . Nucleus . Mainly localizes to the cytoplasm probably translocates to the nucleus to repress selected genes. |
|
| Protein Description | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.. | |
| Protein Sequence | MAEAVAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGESPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKTPARGQPLPTPPAPPDPFKSPASKGPLASTDLVTDWTCGLSVLGPTDGGDM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | EAVAAPISPWTMAAT CCCCCCCCHHHHHHH | 17.21 | 24719451 | |
| 27 | Phosphorylation | AMERKIESQAARLLS HHHHHHHHHHHHHHH | 28.70 | 23898821 | |
| 51 | Ubiquitination | KKLADCEKTAVEFGN HHHHHHHHHHHHHHH | 48.38 | - | |
| 69 | Phosphorylation | GKWAVLGTLLQEYGL HHHHHHHHHHHHHCH | 21.82 | - | |
| 74 | Phosphorylation | LGTLLQEYGLLQRRL HHHHHHHHCHHHHHH | 10.50 | 22817900 | |
| 112 | Ubiquitination | ESPKEWGKLEDWQKE CCHHHHCCHHHHHHH | 50.18 | 29967540 | |
| 118 | Ubiquitination | GKLEDWQKELYKHVM CCHHHHHHHHHHHHH | 45.49 | 29967540 | |
| 121 | Phosphorylation | EDWQKELYKHVMRGN HHHHHHHHHHHHCCC | 10.51 | - | |
| 129 | Phosphorylation | KHVMRGNYETLVSLD HHHHCCCHHHHHEEE | 17.08 | - | |
| 137 | Phosphorylation | ETLVSLDYAISKPEV HHHHEEEEECCCHHH | 15.89 | 19835603 | |
| 172 | Phosphorylation | PDVPVDPSPGSGPPV CCCCCCCCCCCCCCC | 37.11 | 28348404 | |
| 189 | Sumoylation | PDLLMQIKQEGELQL CHHHHHHHHHCCCCH | 25.96 | - | |
| 277 | Phosphorylation | LKLNTAASTEDVKIV EEECCCCCCCCEEEE | 29.84 | 27251275 | |
| 278 | Phosphorylation | KLNTAASTEDVKIVI EECCCCCCCCEEEEE | 31.32 | 27251275 | |
| 282 | Sumoylation | AASTEDVKIVIKTEV CCCCCCEEEEEEEEC | 43.51 | 28112733 | |
| 286 | Sumoylation | EDVKIVIKTEVQEEE CCEEEEEEEECCCEE | 27.95 | - | |
| 286 | Sumoylation | EDVKIVIKTEVQEEE CCEEEEEEEECCCEE | 27.95 | 28112733 | |
| 297 | Phosphorylation | QEEEVVATPVHPTDL CCEEEEECCCCCCCH | 17.77 | 27251275 | |
| 298 | Phosphorylation | EEEVVATPVHPTDLE CEEEEECCCCCCCHH | 16.81 | 27251275 | |
| 317 | Phosphorylation | LFGPGQATRFFPSPA EECCCCCCEECCCHH | 21.81 | 26074081 | |
| 322 | Phosphorylation | QATRFFPSPAQEGAW CCCEECCCHHCCCCH | 27.93 | 26074081 | |
| 323 | Phosphorylation | ATRFFPSPAQEGAWE CCEECCCHHCCCCHH | 37.89 | 27251275 | |
| 331 | Phosphorylation | AQEGAWESQGSSFPS HCCCCHHCCCCCCCC | 29.19 | 27732954 | |
| 334 | Phosphorylation | GAWESQGSSFPSQDP CCHHCCCCCCCCCCC | 22.59 | 27732954 | |
| 335 | Phosphorylation | AWESQGSSFPSQDPV CHHCCCCCCCCCCCC | 48.26 | 27732954 | |
| 359 | Phosphorylation | ERDMGELSPAVAQEE CCCCCCCCHHHHCCC | 13.40 | 27732954 | |
| 360 | Phosphorylation | RDMGELSPAVAQEET CCCCCCCHHHHCCCC | 43.29 | 24719451 | |
| 367 | Phosphorylation | PAVAQEETPPGDWLF HHHHCCCCCCCCCCC | 33.75 | 27732954 | |
| 395 | Phosphorylation | PVGLNPRTGPEGLPY CCCCCCCCCCCCCCC | 59.34 | 26074081 | |
| 402 | Phosphorylation | TGPEGLPYSSPDNGE CCCCCCCCCCCCCCC | 27.16 | 26074081 | |
| 403 | Phosphorylation | GPEGLPYSSPDNGEA CCCCCCCCCCCCCCC | 33.19 | 26074081 | |
| 404 | Phosphorylation | PEGLPYSSPDNGEAI CCCCCCCCCCCCCCC | 30.35 | 26074081 | |
| 415 | Phosphorylation | GEAILDPSQAPRPFN CCCCCCHHHCCCCCC | 38.34 | 26074081 | |
| 432 | Acetylation | CKYPGRTKGFGHKPG CCCCCCCCCCCCCCC | 51.38 | 19813371 | |
| 441 | Acetylation | FGHKPGLKKHPAAPP CCCCCCCCCCCCCCC | 55.76 | 19813377 | |
| 481 | Phosphorylation | SCGAPDGSGPGTGGG HCCCCCCCCCCCCCC | 49.55 | - | |
| 490 | Phosphorylation | PGTGGGGSGSGGGGG CCCCCCCCCCCCCCC | 32.82 | 22210691 | |
| 492 | Phosphorylation | TGGGGSGSGGGGGGS CCCCCCCCCCCCCCC | 35.64 | 21712546 | |
| 499 | Phosphorylation | SGGGGGGSGGGSARD CCCCCCCCCCCCCCC | 37.22 | 21712546 | |
| 508 | Phosphorylation | GGSARDGSALRCGEC CCCCCCCCCCCCCCC | 28.55 | 22210691 | |
| 520 | Phosphorylation | GECGRCFTRPAHLIR CCCCCCCCCHHHHHH | 39.09 | 22210691 | |
| 533 | Phosphorylation | IRHRMLHTGERPFPC HHCCCCCCCCCCCCC | 36.45 | 29214152 | |
| 561 | Phosphorylation | IDHYRTHTGVRPFTC HHHHHHCCCCCCEEE | 36.44 | 28555341 | |
| 597 | Methylation | AGAKTPARGQPLPTP CCCCCCCCCCCCCCC | 45.54 | 115920637 | |
| 603 | Phosphorylation | ARGQPLPTPPAPPDP CCCCCCCCCCCCCCC | 49.97 | 22199227 | |
| 604 | Phosphorylation | RGQPLPTPPAPPDPF CCCCCCCCCCCCCCC | 22.55 | 27251275 | |
| 613 | Phosphorylation | APPDPFKSPASKGPL CCCCCCCCCCCCCCC | 26.52 | 22199227 | |
| 616 | Phosphorylation | DPFKSPASKGPLAST CCCCCCCCCCCCCCC | 41.34 | 22199227 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 322 | S | Phosphorylation | Kinase | PINK1 | Q9BXM7 | PSP |
| 613 | S | Phosphorylation | Kinase | PINK1 | Q9BXM7 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | PRKN | O60260 | PMID:21376232 |
| - | K | Ubiquitination | E3 ubiquitin ligase | RNF41 | Q9H4P4 | PMID:18541373 |
| - | K | Ubiquitination | E3 ubiquitin ligase | RNF4 | P78317 | PMID:32197837 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZN746_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZN746_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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