| UniProt ID | PFKAL_HUMAN | |
|---|---|---|
| UniProt AC | P17858 | |
| Protein Name | ATP-dependent 6-phosphofructokinase, liver type {ECO:0000255|HAMAP-Rule:MF_03184} | |
| Gene Name | PFKL {ECO:0000312|HGNC:HGNC:8876} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 780 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. [PubMed: 22923583 Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity] | |
| Protein Sequence | MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAVDLEKL ------CCCCCHHHH | 22223895 | ||
| 8 | Ubiquitination | MAAVDLEKLRASGAG CCCCCHHHHHHCCCC | - | ||
| 12 | Phosphorylation | DLEKLRASGAGKAIG CHHHHHHCCCCCEEE | 22210691 | ||
| 16 | Ubiquitination | LRASGAGKAIGVLTS HHHCCCCCEEEEEEC | 21906983 | ||
| 16 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 22 | Phosphorylation | GKAIGVLTSGGDAQG CCEEEEEECCCCHHH | 22210691 | ||
| 23 | Phosphorylation | KAIGVLTSGGDAQGM CEEEEEECCCCHHHH | 22210691 | ||
| 30 | Sulfoxidation | SGGDAQGMNAAVRAV CCCCHHHHHHHHHHH | 21406390 | ||
| 38 | Phosphorylation | NAAVRAVTRMGIYVG HHHHHHHHHCCCEEC | 20068231 | ||
| 43 | Phosphorylation | AVTRMGIYVGAKVFL HHHHCCCEECCEEEE | 20860994 | ||
| 68 (in isoform 2) | Phosphorylation | - | 29116813 | ||
| 69 (in isoform 2) | Phosphorylation | - | 29116813 | ||
| 85 (in isoform 2) | Phosphorylation | - | 29116813 | ||
| 93 | Phosphorylation | SARCKAFTTREGRRA ECEEEEEECHHHHHH | - | ||
| 144 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 144 | Ubiquitination | EELVAEGKISETTAR HHHHHCCCCCHHHHH | 21906983 | ||
| 186 | Sulfoxidation | DSALHRIMEVIDAIT HHHHHHHHHHHHHHH | 28183972 | ||
| 191 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 198 | Phosphorylation | AITTTAQSHQRTFVL HHHHHCHHHHHHHHH | - | ||
| 202 | Phosphorylation | TAQSHQRTFVLEVMG HCHHHHHHHHHHHCH | 21406692 | ||
| 272 | Ubiquitination | GAIDRNGKPISSSYV CCCCCCCCCCCHHHH | - | ||
| 280 | Ubiquitination | PISSSYVKDLVVQRL CCCHHHHHHHHHHHC | - | ||
| 301 | Methylation | TVLGHVQRGGTPSAF EEEECHHHCCCHHHH | - | ||
| 304 | Phosphorylation | GHVQRGGTPSAFDRI ECHHHCCCHHHHHHH | 28857561 | ||
| 306 | Phosphorylation | VQRGGTPSAFDRILS HHHCCCHHHHHHHHH | 22673903 | ||
| 310 | Methylation | GTPSAFDRILSSKMG CCHHHHHHHHHHHHH | 115487073 | ||
| 339 | Phosphorylation | PACVVTLSGNQSVRL CEEEEEECCCCEEEE | 23612710 | ||
| 349 | Sulfoxidation | QSVRLPLMECVQMTK CEEEEEHHHHHHHHH | 21406390 | ||
| 354 | Sulfoxidation | PLMECVQMTKEVQKA EHHHHHHHHHHHHHH | 30846556 | ||
| 356 | Ubiquitination | MECVQMTKEVQKAMD HHHHHHHHHHHHHHC | - | ||
| 365 | Ubiquitination | VQKAMDDKRFDEATQ HHHHHCCCCCHHHHH | - | ||
| 374 | Methylation | FDEATQLRGGSFENN CHHHHHHCCCCCCCC | 115487097 | ||
| 377 | Phosphorylation | ATQLRGGSFENNWNI HHHHCCCCCCCCHHH | 28450419 | ||
| 386 | Ubiquitination | ENNWNIYKLLAHQKP CCCHHHHHHHHCCCC | - | ||
| 392 | Ubiquitination | YKLLAHQKPPKEKSN HHHHHCCCCCCCCCC | - | ||
| 395 | Ubiquitination | LAHQKPPKEKSNFSL HHCCCCCCCCCCCEE | - | ||
| 397 | Ubiquitination | HQKPPKEKSNFSLAI CCCCCCCCCCCEEEE | - | ||
| 414 | Sulfoxidation | VGAPAAGMNAAVRSA CCCCHHCCCHHHHHH | 30846556 | ||
| 420 | Phosphorylation | GMNAAVRSAVRTGIS CCCHHHHHHHHHCCC | 22210691 | ||
| 424 | Phosphorylation | AVRSAVRTGISHGHT HHHHHHHHCCCCCCE | 22210691 | ||
| 461 | Methylation | DVAGWLGRGGSMLGT HCHHHCCCCCCCCCC | 115487081 | ||
| 464 | Phosphorylation | GWLGRGGSMLGTKRT HHCCCCCCCCCCCCC | 20860994 | ||
| 468 | Phosphorylation | RGGSMLGTKRTLPKG CCCCCCCCCCCCCCC | 20860994 | ||
| 469 | Acetylation | GGSMLGTKRTLPKGQ CCCCCCCCCCCCCCC | 25953088 | ||
| 469 | Ubiquitination | GGSMLGTKRTLPKGQ CCCCCCCCCCCCCCC | - | ||
| 471 | Phosphorylation | SMLGTKRTLPKGQLE CCCCCCCCCCCCCHH | 20860994 | ||
| 474 | Ubiquitination | GTKRTLPKGQLESIV CCCCCCCCCCHHHHH | 21906983 | ||
| 474 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 479 | Phosphorylation | LPKGQLESIVENIRI CCCCCHHHHHHHHHC | 21712546 | ||
| 521 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 529 | O-linked_Glycosylation | CVIPATISNNVPGTD EEEECHHCCCCCCCC | 22923583 | ||
| 556 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 556 | Ubiquitination | MESCDRIKQSASGTK HHHCHHHHHCCCCCC | 21906983 | ||
| 558 | Phosphorylation | SCDRIKQSASGTKRR HCHHHHHCCCCCCEE | 28555341 | ||
| 560 | Phosphorylation | DRIKQSASGTKRRVF HHHHHCCCCCCEEEE | 24719451 | ||
| 563 | Ubiquitination | KQSASGTKRRVFIVE HHCCCCCCEEEEEEE | - | ||
| 563 | Acetylation | KQSASGTKRRVFIVE HHCCCCCCEEEEEEE | 24847189 | ||
| 603 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 611 | Sulfoxidation | LKVNVEHMTEKMKTD EEECHHHHHHHHHHH | 30846556 | ||
| 614 | Ubiquitination | NVEHMTEKMKTDIQR CHHHHHHHHHHHHHH | 21906983 | ||
| 614 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 616 | Ubiquitination | EHMTEKMKTDIQRGL HHHHHHHHHHHHHCC | - | ||
| 629 | Ubiquitination | GLVLRNEKCHDYYTT CCEECCCCCCCCCHH | - | ||
| 633 | Phosphorylation | RNEKCHDYYTTEFLY CCCCCCCCCHHHHHH | 19060867 | ||
| 634 | Phosphorylation | NEKCHDYYTTEFLYN CCCCCCCCHHHHHHH | - | ||
| 640 | Phosphorylation | YYTTEFLYNLYSSEG CCHHHHHHHHHCCCC | 19060867 | ||
| 654 | Methylation | GKGVFDCRTNVLGHL CCCEEECCCHHHHHH | 115487089 | ||
| 655 | Phosphorylation | KGVFDCRTNVLGHLQ CCEEECCCHHHHHHH | 21406692 | ||
| 661 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 668 | Phosphorylation | LQQGGAPTPFDRNYG HHCCCCCCCCCCCHH | 21406692 | ||
| 672 | Methylation | GAPTPFDRNYGTKLG CCCCCCCCCHHHHHH | 115487105 | ||
| 674 | Phosphorylation | PTPFDRNYGTKLGVK CCCCCCCHHHHHHHH | 20090780 | ||
| 676 | Phosphorylation | PFDRNYGTKLGVKAM CCCCCHHHHHHHHHH | 21406692 | ||
| 677 | Ubiquitination | FDRNYGTKLGVKAML CCCCHHHHHHHHHHH | - | ||
| 677 | Acetylation | FDRNYGTKLGVKAML CCCCHHHHHHHHHHH | 25953088 | ||
| 681 | Ubiquitination | YGTKLGVKAMLWLSE HHHHHHHHHHHHHHH | - | ||
| 689 | Acetylation | AMLWLSEKLREVYRK HHHHHHHHHHHHHHH | 20167786 | ||
| 694 | Phosphorylation | SEKLREVYRKGRVFA HHHHHHHHHHCCCCC | - | ||
| 706 | Phosphorylation | VFANAPDSACVIGLK CCCCCCCCEEEEECC | 20067319 | ||
| 713 | Ubiquitination | SACVIGLKKKAVAFS CEEEEECCCCEEEEE | - | ||
| 714 | Ubiquitination | ACVIGLKKKAVAFSP EEEEECCCCEEEEEC | - | ||
| 715 | Ubiquitination | CVIGLKKKAVAFSPV EEEECCCCEEEEECC | - | ||
| 720 | Phosphorylation | KKKAVAFSPVTELKK CCCEEEEECCCCCCC | 27067055 | ||
| 726 | Acetylation | FSPVTELKKDTDFEH EECCCCCCCCCCCCC | 23236377 | ||
| 726 | Ubiquitination | FSPVTELKKDTDFEH EECCCCCCCCCCCCC | - | ||
| 726 | Malonylation | FSPVTELKKDTDFEH EECCCCCCCCCCCCC | 26320211 | ||
| 727 | Acetylation | SPVTELKKDTDFEHR ECCCCCCCCCCCCCC | 30585753 | ||
| 743 | Phosphorylation | PREQWWLSLRLMLKM CHHHHHHHHHHHHHH | 28857561 | ||
| 757 | Phosphorylation | MLAQYRISMAAYVSG HHHHHHHHHHHHHHC | 20068231 | ||
| 761 | Phosphorylation | YRISMAAYVSGELEH HHHHHHHHHHCCHHH | 20068231 | ||
| 763 | Phosphorylation | ISMAAYVSGELEHVT HHHHHHHHCCHHHHH | 25849741 | ||
| 770 | Phosphorylation | SGELEHVTRRTLSMD HCCHHHHHHHHCCCC | 20068231 | ||
| 773 | Phosphorylation | LEHVTRRTLSMDKGF HHHHHHHHCCCCCCC | 21712546 | ||
| 775 | Phosphorylation | HVTRRTLSMDKGF-- HHHHHHCCCCCCC-- | 22617229 | ||
| 778 | Acetylation | RRTLSMDKGF----- HHHCCCCCCC----- | 25953088 | ||
| 778 | Ubiquitination | RRTLSMDKGF----- HHHCCCCCCC----- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 773 | T | Phosphorylation | Kinase | PKA-FAMILY | - | GPS |
| 773 | T | Phosphorylation | Kinase | PKA_GROUP | - | PhosphoELM |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 529 | S | Oxidation |
| 22923583 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PFKAL_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KR412_HUMAN | KRTAP4-12 | physical | 16189514 | |
| CSN6_HUMAN | COPS6 | physical | 16169070 | |
| A4_HUMAN | APP | physical | 21832049 | |
| PFKAP_HUMAN | PFKP | physical | 22939629 | |
| PRDX3_HUMAN | PRDX3 | physical | 22939629 | |
| PCBP3_HUMAN | PCBP3 | physical | 22939629 | |
| PFKAM_HUMAN | PFKM | physical | 21988832 | |
| TESK1_HUMAN | TESK1 | physical | 21988832 | |
| NIPA_HUMAN | ZC3HC1 | physical | 22863883 | |
| PFKAL_HUMAN | PFKL | physical | 25416956 | |
| GTPB3_HUMAN | GTPBP3 | physical | 25416956 | |
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| ACPH_HUMAN | APEH | physical | 26344197 | |
| PFKAM_HUMAN | PFKM | physical | 26344197 | |
| KPYM_HUMAN | PKM | physical | 26344197 | |
| PSMG1_HUMAN | PSMG1 | physical | 26344197 | |
| PFKAP_HUMAN | PFKP | physical | 28514442 | |
| TFR2_HUMAN | TFR2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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