| UniProt ID | GTPB3_HUMAN | |
|---|---|---|
| UniProt AC | Q969Y2 | |
| Protein Name | tRNA modification GTPase GTPBP3, mitochondrial | |
| Gene Name | GTPBP3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 492 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.. | |
| Protein Sequence | MWRGLWTLAAQAARGPRRLCTRRSSGAPAPGSGATIFALSSGQGRCGIAVIRTSGPASGHALRILTAPRDLPLARHASLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFANGKLNLTEVEGLADLIHAETEAQRRQALRQLDGELGHLCRGWAETLTKALAHVEAYIDFGEDDNLEEGVLEQADIEVRALQVALGAHLRDARRGQRLRSGVHVVVTGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLREGVGPVEQEGVRRARERLEQADLILAMLDASDLASPSSCNFLATVVASVGAQSPSDSSQRLLLVLNKSDLLSPEGPGPGPDLPPHLLLSCLTGEGLDGLLEALRKELAAVCGDPSTDPPLLTRARHQHHLQGCLDALGHYKQSKDLALAAEALRVARGHLTRLTGGGGTEEILDIIFQDFCVGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | RRLCTRRSSGAPAPG CCEECCCCCCCCCCC | 29.81 | 27050516 | |
| 25 | Phosphorylation | RLCTRRSSGAPAPGS CEECCCCCCCCCCCC | 36.84 | 29214152 | |
| 35 | Phosphorylation | PAPGSGATIFALSSG CCCCCCCEEEEEECC | 21.83 | 27251275 | |
| 83 | Phosphorylation | HASLRLLSDPRSGEP HHHHHHHCCCCCCCC | 50.60 | - | |
| 152 | Ubiquitination | RRAFANGKLNLTEVE HHHHHCCCCCEEEEH | 33.73 | - | |
| 194 | Phosphorylation | LCRGWAETLTKALAH HHHHHHHHHHHHHHH | 31.79 | 22985185 | |
| 248 | Phosphorylation | RRGQRLRSGVHVVVT HHCCCCCCCCEEEEE | 50.16 | - | |
| 255 | Phosphorylation | SGVHVVVTGPPNAGK CCCEEEEECCCCCCH | 32.15 | - | |
| 264 | Phosphorylation | PPNAGKSSLVNLLSR CCCCCHHHHHHHHHC | 39.56 | 24114839 | |
| 272 | Ubiquitination | LVNLLSRKPVSIVSP HHHHHHCCCEEEECC | 46.53 | - | |
| 278 | Phosphorylation | RKPVSIVSPEPGTTR CCCEEEECCCCCCCH | 23.13 | 28555341 | |
| 304 (in isoform 2) | Ubiquitination | - | 21.17 | - | |
| 413 | Ubiquitination | GLLEALRKELAAVCG HHHHHHHHHHHHHHC | 58.91 | - | |
| 431 (in isoform 3) | Ubiquitination | - | 29.59 | 21906983 | |
| 449 | Ubiquitination | LDALGHYKQSKDLAL HHHHHCHHHHHHHHH | 42.28 | - | |
| 452 | Ubiquitination | LGHYKQSKDLALAAE HHCHHHHHHHHHHHH | 55.02 | 2190698 | |
| 474 (in isoform 1) | Ubiquitination | - | 26.56 | 21906983 | |
| 484 (in isoform 2) | Ubiquitination | - | 2.24 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GTPB3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GTPB3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GTPB3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GTPB3_HUMAN | GTPBP3 | physical | 16189514 | |
| PTAFR_HUMAN | PTAFR | physical | 21988832 | |
| GTPB3_HUMAN | GTPBP3 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 616198 | Combined oxidative phosphorylation deficiency 23 (COXPD23) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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