PTAFR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTAFR_HUMAN
• UniProt AC: P25105
• Protein Name: Platelet-activating factor receptor
• Gene Name: PTAFR
• Organism: Homo sapiens (Human).
• Sequence Length: 342
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system..
• Protein Sequence: MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
136	Phosphorylation	NTRKRGISLSLVIWV CHHHCCCCHHHHHHH	18.09	-
169	N-linked_Glycosylation	PDSAGSGNVTRCFEH CCCCCCCCCCHHHHH	33.41	UniProtKB CARBOHYD
309	Phosphorylation	KHLTEKFYSMRSSRK HHHHHHHHHHHHCCC	16.78	25690035
310	Phosphorylation	HLTEKFYSMRSSRKC HHHHHHHHHHHCCCC	15.73	24719451
313	Phosphorylation	EKFYSMRSSRKCSRA HHHHHHHHCCCCCCC	26.34	30108239
314	Phosphorylation	KFYSMRSSRKCSRAT HHHHHHHCCCCCCCC	25.95	30108239
318	Phosphorylation	MRSSRKCSRATTDTV HHHCCCCCCCCCCCE	28.16	28270605
321	Phosphorylation	SRKCSRATTDTVTEV CCCCCCCCCCCEEEE	24.88	28060719
322	Phosphorylation	RKCSRATTDTVTEVV CCCCCCCCCCEEEEE	28.78	24719451
324	Phosphorylation	CSRATTDTVTEVVVP CCCCCCCCEEEEEEE	27.51	28060719
326	Phosphorylation	RATTDTVTEVVVPFN CCCCCCEEEEEEEHH	25.75	28060719
339	Phosphorylation	FNQIPGNSLKN---- HHHCCCCCCCC----	46.78	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTAFR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTAFR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTAFR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARRB2_HUMAN	ARRB2	physical	11729201
FAK1_HUMAN	PTK2	physical	20576130
JAK2_HUMAN	JAK2	physical	14500680
TYK2_HUMAN	TYK2	physical	14500680
SPA24_HUMAN	SPATA24	physical	21988832
CLH1_HUMAN	CLTC	physical	22707565
ARRB1_HUMAN	ARRB1	physical	11729201

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D01652: Apafant (JAN/USAN/INN)
• D02590: Israpafant (JAN/INN)
• D04724: Lexipafant (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.