TFR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFR2_HUMAN
• UniProt AC: Q9UP52
• Protein Name: Transferrin receptor protein 2
• Gene Name: TFR2
• Organism: Homo sapiens (Human).
• Sequence Length: 801
• Subcellular Localization: Cell membrane; Single-pass type II membrane protein.; Isoform Beta: Cytoplasm . Lacks the transmembrane domain. Probably intracellular.
• Protein Description: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation..
• Protein Sequence: MERLWGLFQRAQQLSPRSSQTVYQRVEGPRKGHLEEEEEDGEEGAETLAHFCPMELRGPEPLGSRPRQPNLIPWAAAGRRAAPYLVLTALLIFTGAFLLGYVAFRGSCQACGDSVLVVSEDVNYEPDLDFHQGRLYWSDLQAMFLQFLGEGRLEDTIRQTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLKGPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRHIFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	FQRAQQLSPRSSQTV HHHHHHHCCCCCCHH	17.58	29485707
18	Phosphorylation	AQQLSPRSSQTVYQR HHHHCCCCCCHHHHH	30.13	24719451
23	Phosphorylation	PRSSQTVYQRVEGPR CCCCCHHHHHCCCCC	8.25	21253578
25	Methylation	SSQTVYQRVEGPRKG CCCHHHHHCCCCCCC	15.69	12020385
30	Methylation	YQRVEGPRKGHLEEE HHHCCCCCCCCCCCC	69.33	12020395
31	Ubiquitination	QRVEGPRKGHLEEEE HHCCCCCCCCCCCCC	54.54	19682329
64	Phosphorylation	RGPEPLGSRPRQPNL CCCCCCCCCCCCCCC	46.96	24719451
240	N-linked_Glycosylation	CPYSAIGNVTGELVY CCHHHHCCCCCEEEE	23.28	UniProtKB CARBOHYD
339	N-linked_Glycosylation	TPGFPSFNQTQFPPV CCCCCCCCCCCCCCC	48.61	19159218
365	Phosphorylation	PISADIASRLLRKLK CCCHHHHHHHHHHCC	24.64	20860994
383	Phosphorylation	APQEWQGSLLGSPYH CCCHHCCCCCCCCCC	12.81	28985074
387	Phosphorylation	WQGSLLGSPYHLGPG HCCCCCCCCCCCCCC	23.43	28985074
438 (in isoform 2)	Ubiquitination	-	20.67	21890473
438	Ubiquitination	AQRDAWGPGAAKSAV ECCCCCCCCHHHHHH	20.67	21890473
494 (in isoform 2)	Ubiquitination	-	4.14	21890473
494	Ubiquitination	TEWLEGYLSVLHLKA HHHHHHHHHHHHHEE	4.14	21963094
540	N-linked_Glycosylation	LKQVDSPNHSGQTLY HHHCCCCCCCCCCEE	46.00	UniProtKB CARBOHYD
582 (in isoform 3)	Ubiquitination	-	15.86	21890473
609	Ubiquitination	DTYENLHKVLQGRLP CHHHHHHHHHCCCHH	48.05	21890473
609 (in isoform 1)	Ubiquitination	-	48.05	21890473
638 (in isoform 3)	Ubiquitination	-	7.81	21890473
665 (in isoform 1)	Ubiquitination	-	40.55	21890473
665	Ubiquitination	NEFSGDLKARGLTLQ HHCCCCHHHCCCEEE	40.55	21963094
753	Phosphorylation	DHLRLLRSNSSGTPG HHHHHHHCCCCCCCC	40.82	-
754	N-linked_Glycosylation	HLRLLRSNSSGTPGA HHHHHHCCCCCCCCC	33.49	19159218
765	Phosphorylation	TPGATSSTGFQESRF CCCCCCCCCCCHHHH	41.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRFE_HUMAN	TF	physical	11027676
CD81_HUMAN	CD81	physical	25635054
EXT1_HUMAN	EXT1	physical	28514442
MD2L2_HUMAN	MAD2L2	physical	28514442
DEFM_HUMAN	PDF	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00211: Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
• OMIM Disease
• 604250: Hemochromatosis 3 (HFE3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-339 AND ASN-754, AND MASSSPECTROMETRY.
PubMed: 19159218