MD2L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MD2L2_HUMAN
• UniProt AC: Q9UI95
• Protein Name: Mitotic spindle assembly checkpoint protein MAD2B
• Gene Name: MAD2L2
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Chromosome . Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.
• Protein Description: Adapter protein able to interact with different proteins and involved in different biological processes. [PubMed: 11459825]
• Protein Sequence: MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSISSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	YPVGIFQKRKKYNVP CCCCCEECCCCCCCC	56.27	21890473
44	Ubiquitination	YPVGIFQKRKKYNVP CCCCCEECCCCCCCC	56.27	21890473
47	Ubiquitination	GIFQKRKKYNVPVQM CCEECCCCCCCCCEE	46.20	-
48	Phosphorylation	IFQKRKKYNVPVQMS CEECCCCCCCCCEEE	25.16	22210691
63	Phosphorylation	CHPELNQYIQDTLHC CCHHHHHHHHHHHHH	10.24	22210691
67	Phosphorylation	LNQYIQDTLHCVKPL HHHHHHHHHHHHHHH	11.30	22210691
72	Ubiquitination	QDTLHCVKPLLEKND HHHHHHHHHHHHCCC	35.03	-
90	Ubiquitination	VVVVILDKEHRPVEK EEEEEECCCCCCCHH	52.56	21890473
90	Ubiquitination	VVVVILDKEHRPVEK EEEEEECCCCCCCHH	52.56	21890473
162	Ubiquitination	AATRNMEKIQVIKDF HHHCCHHHEEEECCC	27.89	21890473
167	Ubiquitination	MEKIQVIKDFPWILA HHHEEEECCCCEEEE	55.23	21890473
190	Ubiquitination	DPRLIPLKTMTSDIL CCCEEECCCCCHHHH	30.78	21890473
190	Ubiquitination	DPRLIPLKTMTSDIL CCCEEECCCCCHHHH	30.78	21890473
190	Acetylation	DPRLIPLKTMTSDIL CCCEEECCCCCHHHH	30.78	25953088
191	Phosphorylation	PRLIPLKTMTSDILK CCEEECCCCCHHHHH	33.11	26552605
193	Phosphorylation	LIPLKTMTSDILKMQ EEECCCCCHHHHHHH	28.60	30622161
194	Phosphorylation	IPLKTMTSDILKMQL EECCCCCHHHHHHHH	16.31	30622161
202	Phosphorylation	DILKMQLYVEERAHK HHHHHHHHHHHHHHC	6.74	24719451
211	Phosphorylation	EERAHKGS------- HHHHHCCC-------	41.68	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MD2L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MD2L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MD2L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC20_HUMAN	CDC20	physical	11459826
ADA15_HUMAN	ADAM15	physical	10527948
ADAM9_HUMAN	ADAM9	physical	10527948
REV3L_HUMAN	REV3L	physical	10660610
MD2L1_HUMAN	MAD2L1	physical	10660610
REV1_HUMAN	REV1	physical	11485998
MD2L2_HUMAN	MAD2L2	physical	11485998
REV3L_HUMAN	REV3L	physical	11485998
FZR1_HUMAN	FZR1	physical	17719540
PDIP2_HUMAN	POLDIP2	physical	20554254
REV1_HUMAN	REV1	physical	21690293
REV1_HUMAN	REV1	physical	22303021
REV3L_HUMAN	REV3L	physical	22303021
REV3L_HUMAN	REV3L	physical	21926160
REV1_HUMAN	REV1	physical	21926160
REV3L_HUMAN	REV3L	physical	20164194
REV3L_HUMAN	REV3L	physical	20054135
TF7L2_HUMAN	TCF7L2	physical	19443654
PRCC_HUMAN	PRCC	physical	11717438
RAN_HUMAN	RAN	physical	19753112
CLCA_HUMAN	CLTA	physical	21152103
YYAP1_HUMAN	YY1AP1	physical	17541814
ELK1_HUMAN	ELK1	physical	17296730
REV1_HUMAN	REV1	physical	23287467
REV3L_HUMAN	REV3L	physical	22859296
REV1_HUMAN	REV1	physical	22859296
PCH2_HUMAN	TRIP13	physical	19060904
KCTD9_HUMAN	KCTD9	physical	25416956
CBX3_HUMAN	CBX3	physical	20850016
CHAP1_HUMAN	CHAMP1	physical	20850016
POGZ_HUMAN	POGZ	physical	20850016
GTF2I_HUMAN	GTF2I	physical	20850016
CBX5_HUMAN	CBX5	physical	20850016
FZR1_HUMAN	FZR1	physical	11459826
ATPO_HUMAN	ATP5O	physical	26496610
SSRD_HUMAN	SSR4	physical	26496610
DCTN3_HUMAN	DCTN3	physical	26496610
POGZ_HUMAN	POGZ	physical	26496610
DICER_HUMAN	DICER1	physical	26496610
CHAP1_HUMAN	CHAMP1	physical	26496610
FZR1_HUMAN	FZR1	physical	24100295
RD23B_HUMAN	RAD23B	physical	28440919

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.