KCTD9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCTD9_HUMAN
• UniProt AC: Q7L273
• Protein Name: BTB/POZ domain-containing protein KCTD9
• Gene Name: KCTD9
• Organism: Homo sapiens (Human).
• Sequence Length: 389
• Protein Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome..
• Protein Sequence: MRRVTLFLNGSPKNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCEGEPFIDPQTDSKPPEGLLGFHTDWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLEEARFFGIDSLIEHLEVAIKNSQPPEDHSPISRKEFVRFLLATPTKSELRCQGLNFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASLKLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEMLTPLHMSQSVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	VTLFLNGSPKNGKVV EEEEECCCCCCCEEE	31.46	26334369
13	Ubiquitination	LFLNGSPKNGKVVAV EEECCCCCCCEEEEE	78.87	27667366
25	Phosphorylation	VAVYGTLSDLLSVAS EEEEEEHHHHHHHHH	26.50	-
29	Phosphorylation	GTLSDLLSVASSKLG EEHHHHHHHHHHHCC	23.96	-
32	Phosphorylation	SDLLSVASSKLGIKA HHHHHHHHHHCCCEE	26.33	-
43	Phosphorylation	GIKATSVYNGKGGLI CCEEEEEECCCCCEE	20.26	29759185
123	Ubiquitination	LAHMFKDKGVWGNKQ HHHHHCCCCCCCCCC	56.82	27667366
129	Ubiquitination	DKGVWGNKQDHRGAF CCCCCCCCCCCCCCE	53.84	27667366
198	Phosphorylation	SQPPEDHSPISRKEF CCCCCCCCCCCHHHH	35.93	25159151
201	Phosphorylation	PEDHSPISRKEFVRF CCCCCCCCHHHHHHH	40.46	17081983
212	Phosphorylation	FVRFLLATPTKSELR HHHHHHCCCCCHHHH	31.31	28674419
215	Ubiquitination	FLLATPTKSELRCQG HHHCCCCCHHHHCCC	43.04	-
241	Ubiquitination	DLRYINFKMANLSRC CHHHHCCEECCHHHC	32.39	-
279	Ubiquitination	CANLQGVKMLCSNAE HCCCCCCEEEECCCC	32.74	29967540
291	Ubiquitination	NAEGASLKLCNFEDP CCCCCEEEECCCCCC	48.80	29967540
302	Ubiquitination	FEDPSGLKANLEGAN CCCCCCCCCCCCCCC	38.46	29967540
311	Ubiquitination	NLEGANLKGVDMEGS CCCCCCCCCCCCCCC	57.61	21906983
331	Ubiquitination	NLRVATLKNAKLKNC EEEEEECCCCCCCCC	50.97	27667366
336	Ubiquitination	TLKNAKLKNCNLRGA ECCCCCCCCCCCCCC	59.76	29967540
371	Ubiquitination	NLRGSNVKGAIFEEM CCCCCCCCCHHHHHH	47.04	21906983
385	Phosphorylation	MLTPLHMSQSVR--- HCCHHHHHCCCC---	14.46	28857561
387	Phosphorylation	TPLHMSQSVR----- CHHHHHCCCC-----	16.74	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCTD9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCTD9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCTD9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F208B_HUMAN	FAM208B	physical	25416956
CBX8_HUMAN	CBX8	physical	25416956
CARD9_HUMAN	CARD9	physical	25416956
F124B_HUMAN	FAM124B	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
LONF1_HUMAN	LONRF1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
NUP53_HUMAN	NUP35	physical	25416956
SYT6_HUMAN	SYT6	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
FBLN1_HUMAN	FBLN1	physical	26186194
KCTD9_HUMAN	KCTD9	physical	21516116
CUL3_HUMAN	CUL3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.