SYT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT6_HUMAN
• UniProt AC: Q5T7P8
• Protein Name: Synaptotagmin-6
• Gene Name: SYT6
• Organism: Homo sapiens (Human).
• Sequence Length: 510
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein .; Isoform 1: Membrane ; Single-pass membrane protein. Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (B
• Protein Description: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity)..
• Protein Sequence: MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQPPERSPSAAGAGTSVSLLAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSPSSANPPLEALQSPSFRGNMADKLKDPSTLGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLPRQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWNEMLAYPRKPIAHWHSLVEVKKSFKEGNPRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	TSVSLLAVVVIVCGV HHHHHHHHHHHHHHH	3.40	24719451
108	Phosphorylation	PPLEALQSPSFRGNM CCHHHHCCCCCCCCH	24.30	24719451
148	Phosphorylation	IPAEVQMSVKEHIMR CCHHHHHHHHHHHHH	16.97	24719451
163	Phosphorylation	HTRLQRQTTEPASST HHHHHHHCCCCCCCC	35.00	27762562
164	Phosphorylation	TRLQRQTTEPASSTR HHHHHHCCCCCCCCC	31.47	-
169	Phosphorylation	QTTEPASSTRHTSFK HCCCCCCCCCCCCHH	31.41	-
173	Phosphorylation	PASSTRHTSFKRHLP CCCCCCCCCHHHHCC	32.35	27762562
186	Phosphorylation	LPRQMHVSSVDYGNE CCCCCEEECCCCCCC	15.23	24043423
187	Phosphorylation	PRQMHVSSVDYGNEL CCCCEEECCCCCCCC	20.23	24043423
190	Phosphorylation	MHVSSVDYGNELPPA CEEECCCCCCCCCCH	21.50	24043423
202	Phosphorylation	PPAAEQPTSIGRIKP CCHHCCCCCCCCCCH	32.44	24043423
203	Phosphorylation	PAAEQPTSIGRIKPE CHHCCCCCCCCCCHH	29.72	24043423
216	Phosphorylation	PELYKQKSVDGEDAK HHHHHCCCCCCHHHH	23.97	14702039
224	Phosphorylation	VDGEDAKSEATKSCG CCCHHHHHHHHHHHC	33.90	-
227	Phosphorylation	EDAKSEATKSCGKIN HHHHHHHHHHHCCEE	21.31	-
283	Phosphorylation	DRKCKLQTRVHRKTL CCCCCCCCCCCHHCC	45.13	22817900
417	Phosphorylation	RRLKKKKTTIKKNTL CCCCCCCCCCCCCCC	42.50	16111671
418	Phosphorylation	RLKKKKTTIKKNTLN CCCCCCCCCCCCCCC	39.41	16111671
504	Acetylation	VEVKKSFKEGNPRL- HHHHHHHHCCCCCC-	72.33	18585861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
283	T	Phosphorylation	Kinase	PRKCB	P05771-2	GPS
417	T	Phosphorylation	Kinase	PRKCB	P05771-2	GPS
418	T	Phosphorylation	Kinase	PRKCB	P05771-2	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYT6_HUMAN	SYT6	physical	10531343
A4_HUMAN	APP	physical	21832049
ZBT8A_HUMAN	ZBTB8A	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681
SYT10_HUMAN	SYT10	physical	26186194
SYT3_HUMAN	SYT3	physical	26186194
CETN3_HUMAN	CETN3	physical	26186194
SAHH3_HUMAN	AHCYL2	physical	26186194
MADD_HUMAN	MADD	physical	26186194
SYT3_HUMAN	SYT3	physical	28514442
SYT10_HUMAN	SYT10	physical	28514442
SAHH3_HUMAN	AHCYL2	physical	28514442
MADD_HUMAN	MADD	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.