SYT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT3_HUMAN
• UniProt AC: Q9BQG1
• Protein Name: Synaptotagmin-3
• Gene Name: SYT3
• Organism: Homo sapiens (Human).
• Sequence Length: 590
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein .
• Protein Description: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
• Protein Sequence: MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYPRGPDADISVSLLSVIVTFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAGLGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
234	Phosphorylation	PALPRPLTQQTLTSQ CCCCCCCCCCCCCCC	22.70	29449344
237	Phosphorylation	PRPLTQQTLTSQPDP CCCCCCCCCCCCCCC	23.37	29449344
239	Phosphorylation	PLTQQTLTSQPDPSS CCCCCCCCCCCCCCC	28.80	29449344
240	Phosphorylation	LTQQTLTSQPDPSSE CCCCCCCCCCCCCCC	42.71	29449344
245	Phosphorylation	LTSQPDPSSEERPPA CCCCCCCCCCCCCCC	58.73	29449344
246	Phosphorylation	TSQPDPSSEERPPAL CCCCCCCCCCCCCCC	49.19	29449344
275	Phosphorylation	GQIKPELYQGTGPGG HHCCHHHHCCCCCCC	11.84	27642862
284	Methylation	GTGPGGRRSGGGPGS CCCCCCCCCCCCCCC	42.82	-
291	Phosphorylation	RSGGGPGSGEAGTGA CCCCCCCCCCCCCCC	36.27	22210691
296	Phosphorylation	PGSGEAGTGAPCGRI CCCCCCCCCCCCHHH	36.90	22210691
385	Phosphorylation	AQRKLHFSVYDFDRF HHHHCCCEEECCCCC	14.71	24076635
449	Phosphorylation	LPTAGRLTVTIIKAS CCCCCEEEEEEEECC	17.78	-
464	Phosphorylation	NLKAMDLTGFSDPYV CCCCCCCCCCCCHHH	31.73	24719451
467	Phosphorylation	AMDLTGFSDPYVKAS CCCCCCCCCHHHHHH	38.73	-
470	Phosphorylation	LTGFSDPYVKASLIS CCCCCCHHHHHHHHH	21.41	19413330
474	Phosphorylation	SDPYVKASLISEGRR CCHHHHHHHHHHCHH	22.10	-
477	Phosphorylation	YVKASLISEGRRLKK HHHHHHHHHCHHHHH	39.01	-
575	Phosphorylation	VEEKTVTSFTKGSKG HHHCCCHHCCCCCCC	26.95	24719451
580	Phosphorylation	VTSFTKGSKGLSEKE CHHCCCCCCCCCCHH	25.71	22210691
584	Phosphorylation	TKGSKGLSEKENSE- CCCCCCCCCHHCCC-	56.12	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRPQ_HUMAN	SYNCRIP	physical	10734137
SNP25_HUMAN	SNAP25	physical	10692432
SYT3_HUMAN	SYT3	physical	10531343
SYT10_HUMAN	SYT10	physical	28514442
MYH4_HUMAN	MYH4	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
MYH7_HUMAN	MYH7	physical	28514442
MADD_HUMAN	MADD	physical	28514442
PGK2_HUMAN	PGK2	physical	28514442
LMF2_HUMAN	LMF2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.