MYH7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYH7_HUMAN
• UniProt AC: P12883
• Protein Name: Myosin-7
• Gene Name: MYH7
• Organism: Homo sapiens (Human).
• Sequence Length: 1935
• Subcellular Localization: Cytoplasm, myofibril . Cytoplasm, myofibril, sarcomere . Thick filaments of the myofibrils.
• Protein Description: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle..
• Protein Sequence: MGDSEMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSREGGKVTAETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGDSEMAVFGA ----CCHHHHHHHHH	39.89	20068231
15	Phosphorylation	VFGAAAPYLRKSEKE HHHHCHHHHCHHHHH	17.89	30257219
19	Phosphorylation	AAPYLRKSEKERLEA CHHHHCHHHHHHHHH	47.68	22673903
34	Acetylation	QTRPFDLKKDVFVPD CCCCCCCCCCEECCC	49.09	30584839
35	Acetylation	TRPFDLKKDVFVPDD CCCCCCCCCEECCCC	67.43	30584905
53	Phosphorylation	FVKAKIVSREGGKVT HHHEEEEECCCCEEE	28.25	26437602
60	Phosphorylation	SREGGKVTAETEYGK ECCCCEEEEEEECCC	23.43	26437602
63	Phosphorylation	GGKVTAETEYGKTVT CCEEEEEEECCCEEE	31.85	-
65	Phosphorylation	KVTAETEYGKTVTVK EEEEEEECCCEEEEC	31.20	26437602
68	Phosphorylation	AETEYGKTVTVKEDQ EEEECCCEEEECHHH	19.62	26437602
70	Phosphorylation	TEYGKTVTVKEDQVM EECCCEEEECHHHHH	30.96	26437602
103	Phosphorylation	LHEPAVLYNLKDRYG HCCHHHHCCCCCCCC	16.32	-
129	"N6,N6,N6-trimethyllysine"	CVTVNPYKWLPVYTP EEEECCCCCCCCCCH	43.44	-
129	Acetylation	CVTVNPYKWLPVYTP EEEECCCCCCCCCCH	43.44	30584923
129	Methylation	CVTVNPYKWLPVYTP EEEECCCCCCCCCCH	43.44	-
162	Phosphorylation	FSISDNAYQYMLTDR EECCCCCCHHHCCCC	13.36	-
164	Phosphorylation	ISDNAYQYMLTDREN CCCCCCHHHCCCCCC	4.96	-
167	Phosphorylation	NAYQYMLTDRENQSI CCCHHHCCCCCCCEE	19.24	-
173	Phosphorylation	LTDRENQSILITGES CCCCCCCEEEEECCC	30.83	26437602
180	Phosphorylation	SILITGESGAGKTVN EEEEECCCCCCCCCC	34.98	26437602
210	Phosphorylation	DRSKKDQSPGKGTLE CCCCCCCCCCCCCHH	45.83	26437602
215	Phosphorylation	DQSPGKGTLEDQIIQ CCCCCCCCHHHHHHH	30.38	22673903
234	Ubiquitination	LEAFGNAKTVRNDNS HHHHCCCEEECCCCC	52.10	22817900
241	Phosphorylation	KTVRNDNSSRFGKFI EEECCCCCCCCCEEE	26.25	29514088
242	Phosphorylation	TVRNDNSSRFGKFIR EECCCCCCCCCEEEE	37.57	29514088
246	Ubiquitination	DNSSRFGKFIRIHFG CCCCCCCEEEEEEEC	34.60	-
255	Phosphorylation	IRIHFGATGKLASAD EEEEECCCCCCCCCC	34.92	26437602
260	Phosphorylation	GATGKLASADIETYL CCCCCCCCCCHHHHH	36.59	22673903
265	Phosphorylation	LASADIETYLLEKSR CCCCCHHHHHHHCCE	21.58	22673903
266	Phosphorylation	ASADIETYLLEKSRV CCCCHHHHHHHCCEE	9.12	22673903
270	Ubiquitination	IETYLLEKSRVIFQL HHHHHHHCCEEEEEE	43.46	29901268
348	Phosphorylation	FTSEEKNSMYKLTGA CCCCCCCCHHHHHHH	34.26	19845377
350	Phosphorylation	SEEKNSMYKLTGAIM CCCCCCHHHHHHHHH	11.58	19845377
363	Acetylation	IMHFGNMKFKLKQRE HHHHCCCEEEEHHHH	43.26	30584917
378	Phosphorylation	EQAEPDGTEEADKSA HHCCCCCCCHHHHHH	37.72	26437602
384	Phosphorylation	GTEEADKSAYLMGLN CCCHHHHHHHHHCCC	23.77	26437602
386	Phosphorylation	EEADKSAYLMGLNSA CHHHHHHHHHCCCHH	12.33	22673903
392	Phosphorylation	AYLMGLNSADLLKGL HHHHCCCHHHHHHCC	28.36	26437602
410	Phosphorylation	RVKVGNEYVTKGQNV CEEECCCEECCCCCH	19.88	19764811
412	Phosphorylation	KVGNEYVTKGQNVQQ EECCCEECCCCCHHH	28.67	26437602
413	Acetylation	VGNEYVTKGQNVQQV ECCCEECCCCCHHHH	48.75	30584929
422	Phosphorylation	QNVQQVIYATGALAK CCHHHHHHHHHHHHH	10.15	26437602
424	Phosphorylation	VQQVIYATGALAKAV HHHHHHHHHHHHHHH	13.15	20068231
441	Phosphorylation	RMFNWMVTRINATLE HHHHHHHHHHHHHCC	15.10	20068231
446	Phosphorylation	MVTRINATLETKQPR HHHHHHHHCCCCCCC	22.19	20068231
449	Phosphorylation	RINATLETKQPRQYF HHHHHCCCCCCCCEE	37.78	20068231
502	Acetylation	VLEQEEYKKEGIEWT EECHHHHHHCCCCEE	47.86	30584857
549	Acetylation	KATDMTFKAKLFDNH CCCCCCHHHHHHHCC	35.13	30584821
560	Phosphorylation	FDNHLGKSANFQKPR HHCCCCCCCCCCCCC	27.01	22673903
582	Phosphorylation	AHFSLIHYAGIVDYN HHHHHHHHCCCCCHH	10.26	-
588	Phosphorylation	HYAGIVDYNIIGWLQ HHCCCCCHHHHHHHH	9.43	-
604	Phosphorylation	NKDPLNETVVGLYQK CCCCCCHHHHHHHHH	21.30	-
609	Phosphorylation	NETVVGLYQKSSLKL CHHHHHHHHHHHHHH	14.15	26437602
612	Phosphorylation	VVGLYQKSSLKLLST HHHHHHHHHHHHHHH	25.94	22468782
613	Phosphorylation	VGLYQKSSLKLLSTL HHHHHHHHHHHHHHH	36.24	22468782
619	Phosphorylation	SSLKLLSTLFANYAG HHHHHHHHHHHHHCC	26.34	22468782
624	Phosphorylation	LSTLFANYAGADAPI HHHHHHHHCCCCCCC	11.72	23403867
642	Phosphorylation	KGKAKKGSSFQTVSA CCCCCCCCCHHHHHH	36.54	26437602
643	Phosphorylation	GKAKKGSSFQTVSAL CCCCCCCCHHHHHHH	30.00	26437602
646	Phosphorylation	KKGSSFQTVSALHRE CCCCCHHHHHHHHHH	17.89	22673903
648	Phosphorylation	GSSFQTVSALHRENL CCCHHHHHHHHHHHH	28.62	26437602
660	Phosphorylation	ENLNKLMTNLRSTHP HHHHHHHHHHHHHCC	41.35	19764811
664	Phosphorylation	KLMTNLRSTHPHFVR HHHHHHHHHCCCEEE	33.94	26437602
665	Phosphorylation	LMTNLRSTHPHFVRC HHHHHHHHCCCEEEE	32.75	26437602
678	Phosphorylation	RCIIPNETKSPGVMD EEECCCCCCCCCCCC	43.38	26437602
680	Phosphorylation	IIPNETKSPGVMDNP ECCCCCCCCCCCCCC	34.01	26437602
715	Phosphorylation	GFPNRILYGDFRQRY CCCCCEEECCHHHHH	16.57	-
738	Phosphorylation	PEGQFIDSRKGAEKL CCCCCCCCCCHHHHH	30.95	19764811
747	Phosphorylation	KGAEKLLSSLDIDHN CHHHHHHHCCCCCCC	39.01	22673903
748	Phosphorylation	GAEKLLSSLDIDHNQ HHHHHHHCCCCCCCC	29.99	22673903
756	Phosphorylation	LDIDHNQYKFGHTKV CCCCCCCCCCCCHHH	17.38	-
757	Acetylation	DIDHNQYKFGHTKVF CCCCCCCCCCCHHHH	34.80	7923645
782	Phosphorylation	EMRDERLSRIITRIQ HHHHHHHHHHHHHHH	27.88	26437602
786	Phosphorylation	ERLSRIITRIQAQSR HHHHHHHHHHHHHHH	21.24	26437602
810	Phosphorylation	KLLERRDSLLVIQWN HHHHHCCCEEEEEEE	23.07	22673903
842	Phosphorylation	KIKPLLKSAEREKEM HHHHHHHHHHHHHHH	35.02	26437602
851	Phosphorylation	EREKEMASMKEEFTR HHHHHHHHHHHHHHH	29.13	26437602
853	Acetylation	EKEMASMKEEFTRLK HHHHHHHHHHHHHHH	52.15	7959727
857	Phosphorylation	ASMKEEFTRLKEALE HHHHHHHHHHHHHHH	38.07	26437602
865	Acetylation	RLKEALEKSEARRKE HHHHHHHHHHHHHHH	55.22	7959633
866	Phosphorylation	LKEALEKSEARRKEL HHHHHHHHHHHHHHH	27.41	20068231
879	Phosphorylation	ELEEKMVSLLQEKND HHHHHHHHHHHHHCC	21.62	26437602
937	Phosphorylation	EEMNAELTAKKRKLE HHHHHHHHHHHHHHH	28.12	26437602
939	Acetylation	MNAELTAKKRKLEDE HHHHHHHHHHHHHHH	48.12	30584959
942	Acetylation	ELTAKKRKLEDECSE HHHHHHHHHHHHHHH	66.17	30584971
948	Phosphorylation	RKLEDECSELKRDID HHHHHHHHHHCCCHH	43.87	26437602
951	Acetylation	EDECSELKRDIDDLE HHHHHHHCCCHHHHH	43.93	30584845
960	Phosphorylation	DIDDLELTLAKVEKE CHHHHHHHHHHHHHH	18.46	22673903
979	Phosphorylation	ENKVKNLTEEMAGLD HHHHHHHHHHHCCHH	39.01	22673903
993	Phosphorylation	DEIIAKLTKEKKALQ HHHHHHHHHHHHHHH	36.13	22673903
1019	Phosphorylation	AEEDKVNTLTKAKVK HHHHHHHHHHHHHHH	38.50	19764811
1021	Phosphorylation	EDKVNTLTKAKVKLE HHHHHHHHHHHHHHH	27.24	22673903
1037	Phosphorylation	QVDDLEGSLEQEKKV HHHHCCCCHHHHHHH	21.25	19764811
1042	Acetylation	EGSLEQEKKVRMDLE CCCHHHHHHHHHHHH	57.15	30584851
1043	Acetylation	GSLEQEKKVRMDLER CCHHHHHHHHHHHHH	34.03	30584881
1052	Acetylation	RMDLERAKRKLEGDL HHHHHHHHHHHHHCH	57.18	7833903
1062	Phosphorylation	LEGDLKLTQESIMDL HHHCHHCCHHHHHHH	28.80	22673903
1065	Phosphorylation	DLKLTQESIMDLEND CHHCCHHHHHHHHHH	17.25	22673903
1102	O-linked_Glycosylation	EDEQALGSQLQKKLK HHHHHHHHHHHHHHH	28.68	14794529
1102	Phosphorylation	EDEQALGSQLQKKLK HHHHHHHHHHHHHHH	28.68	19764811
1106	Acetylation	ALGSQLQKKLKELQA HHHHHHHHHHHHHHH	69.53	30584875
1107	Acetylation	LGSQLQKKLKELQAR HHHHHHHHHHHHHHH	52.40	30584953
1127	Phosphorylation	EELEAERTARAKVEK HHHHHHHHHHHHHHH	16.41	19764811
1137	Phosphorylation	AKVEKLRSDLSRELE HHHHHHHHHHHHHHH	54.03	19764811
1140	Phosphorylation	EKLRSDLSRELEEIS HHHHHHHHHHHHHHH	28.79	19764811
1158	Phosphorylation	EEAGGATSVQIEMNK HHCCCCCEEEEECCH	16.10	26437602
1165	Acetylation	SVQIEMNKKREAEFQ EEEEECCHHHHHHHH	52.47	30584887
1182	Phosphorylation	RRDLEEATLQHEATA HHHHHHHHHHHHHHH	30.17	19764811
1188	Phosphorylation	ATLQHEATAAALRKK HHHHHHHHHHHHHHH	17.53	19764811
1199	Phosphorylation	LRKKHADSVAELGEQ HHHHHHHHHHHHHHH	24.82	19764811
1222	Phosphorylation	QKLEKEKSEFKLELD HHHHHHHHCCCEEHH	49.73	26437602
1232	Phosphorylation	KLELDDVTSNMEQII CEEHHHHCCCHHHHH	22.75	22673903
1233	Phosphorylation	LELDDVTSNMEQIIK EEHHHHCCCHHHHHH	33.74	22673903
1251	Phosphorylation	NLEKMCRTLEDQMNE HHHHHHHHHHHHHHH	29.58	26437602
1261	Phosphorylation	DQMNEHRSKAEETQR HHHHHHHHHHHHHHH	37.82	26437602
1266	Phosphorylation	HRSKAEETQRSVNDL HHHHHHHHHHHHHHH	22.31	19764811
1269	Phosphorylation	KAEETQRSVNDLTSQ HHHHHHHHHHHHHHH	18.56	19764811
1274	Phosphorylation	QRSVNDLTSQRAKLQ HHHHHHHHHHHHHHH	26.19	26437602
1275	Phosphorylation	RSVNDLTSQRAKLQT HHHHHHHHHHHHHHH	25.60	19764811
1282	O-linked_Glycosylation	SQRAKLQTENGELSR HHHHHHHHCCCHHHH	41.68	30620550
1282	Phosphorylation	SQRAKLQTENGELSR HHHHHHHHCCCHHHH	41.68	19764811
1288	Phosphorylation	QTENGELSRQLDEKE HHCCCHHHHHHHHHH	17.43	26437602
1299	O-linked_Glycosylation	DEKEALISQLTRGKL HHHHHHHHHHHHCCC	21.71	35087091
1299	Phosphorylation	DEKEALISQLTRGKL HHHHHHHHHHHHCCC	21.71	19764811
1302	Phosphorylation	EALISQLTRGKLTYT HHHHHHHHHCCCCHH	29.73	26437602
1305	Acetylation	ISQLTRGKLTYTQQL HHHHHHCCCCHHHHH	34.07	30584941
1307	Phosphorylation	QLTRGKLTYTQQLED HHHHCCCCHHHHHHH	28.19	19764811
1308	Phosphorylation	LTRGKLTYTQQLEDL HHHCCCCHHHHHHHH	17.00	19764811
1309	Phosphorylation	TRGKLTYTQQLEDLK HHCCCCHHHHHHHHH	12.47	19764811
1316	Acetylation	TQQLEDLKRQLEEEV HHHHHHHHHHHHHHH	50.88	15609095
1324	Trimethylation	RQLEEEVKAKNALAH HHHHHHHHHHHHHHH	57.85	-
1324	Methylation	RQLEEEVKAKNALAH HHHHHHHHHHHHHHH	57.85	-
1335	Phosphorylation	ALAHALQSARHDCDL HHHHHHHHHHHHHHH	28.28	26437602
1347	Phosphorylation	CDLLREQYEEETEAK HHHHHHHHHHHHHHH	22.13	22673903
1351	Phosphorylation	REQYEEETEAKAELQ HHHHHHHHHHHHHHH	44.52	26437602
1362	Phosphorylation	AELQRVLSKANSEVA HHHHHHHHHHHHHHH	27.19	19764811
1366	Phosphorylation	RVLSKANSEVAQWRT HHHHHHHHHHHHHHH	38.00	19764811
1373	Phosphorylation	SEVAQWRTKYETDAI HHHHHHHHHHHHHHH	34.71	26437602
1375	Phosphorylation	VAQWRTKYETDAIQR HHHHHHHHHHHHHHH	24.37	19764811
1377	Phosphorylation	QWRTKYETDAIQRTE HHHHHHHHHHHHHHH	27.86	19764811
1383	Phosphorylation	ETDAIQRTEELEEAK HHHHHHHHHHHHHHH	19.89	20068231
1390	Acetylation	TEELEEAKKKLAQRL HHHHHHHHHHHHHHH	54.44	19863679
1391	Acetylation	EELEEAKKKLAQRLQ HHHHHHHHHHHHHHH	61.13	30584869
1392	Acetylation	ELEEAKKKLAQRLQE HHHHHHHHHHHHHHH	48.63	30584947
1412	Phosphorylation	EAVNAKCSSLEKTKH HHHHHHCHHHHHHHH	36.93	26437602
1413	Phosphorylation	AVNAKCSSLEKTKHR HHHHHCHHHHHHHHH	50.44	26437602
1435	Phosphorylation	LMVDVERSNAAAAAL HHHHHHHHHHHHHHH	19.81	26437602
1444	Acetylation	AAAAALDKKQRNFDK HHHHHHHHHHHCHHH	52.21	30584863
1445	Acetylation	AAAALDKKQRNFDKI HHHHHHHHHHCHHHH	54.91	30584893
1460	Phosphorylation	LAEWKQKYEESQSEL HHHHHHHHHHHHHHH	23.57	22817900
1463	Phosphorylation	WKQKYEESQSELESS HHHHHHHHHHHHHHH	27.37	26437602
1465	Phosphorylation	QKYEESQSELESSQK HHHHHHHHHHHHHHH	54.12	19764811
1469	Phosphorylation	ESQSELESSQKEARS HHHHHHHHHHHHHHH	51.17	26437602
1470	Phosphorylation	SQSELESSQKEARSL HHHHHHHHHHHHHHH	35.58	22673903
1476	Phosphorylation	SSQKEARSLSTELFK HHHHHHHHHHHHHHH	33.45	19764811
1478	Phosphorylation	QKEARSLSTELFKLK HHHHHHHHHHHHHHH	22.53	19764811
1479	Phosphorylation	KEARSLSTELFKLKN HHHHHHHHHHHHHHH	41.84	19764811
1488	Phosphorylation	LFKLKNAYEESLEHL HHHHHHHHHHHHHHH	29.62	26437602
1491	Phosphorylation	LKNAYEESLEHLETF HHHHHHHHHHHHHHH	27.41	26437602
1497	Phosphorylation	ESLEHLETFKRENKN HHHHHHHHHHHHCCC	40.59	26437602
1499	Acetylation	LEHLETFKRENKNLQ HHHHHHHHHHCCCHH	67.24	160919
1510	Phosphorylation	KNLQEEISDLTEQLG CCHHHHHHHHHHHHC	29.82	19764811
1513	Phosphorylation	QEEISDLTEQLGSSG HHHHHHHHHHHCCCC	27.03	26437602
1518	Phosphorylation	DLTEQLGSSGKTIHE HHHHHHCCCCCHHHH	44.50	19764811
1519	Phosphorylation	LTEQLGSSGKTIHEL HHHHHCCCCCHHHHH	42.37	-
1522	Phosphorylation	QLGSSGKTIHELEKV HHCCCCCHHHHHHHH	30.96	26437602
1542	Phosphorylation	AEKMELQSALEEAEA HHHHHHHHHHHHHHH	47.66	26437602
1550	Phosphorylation	ALEEAEASLEHEEGK HHHHHHHHHHHHCHH	26.29	26437602
1587	Acetylation	DEEMEQAKRNHLRVV HHHHHHHHHHHHHHH	54.12	160767
1596	O-linked_Glycosylation	NHLRVVDSLQTSLDA HHHHHHHHHHHHCCH	15.69	9537795
1596	Phosphorylation	NHLRVVDSLQTSLDA HHHHHHHHHHHHCCH	15.69	19764811
1599	Phosphorylation	RVVDSLQTSLDAETR HHHHHHHHHCCHHHC	36.23	19764811
1600	Phosphorylation	VVDSLQTSLDAETRS HHHHHHHHCCHHHCC	15.99	19764811
1605	Phosphorylation	QTSLDAETRSRNEAL HHHCCHHHCCHHHHH	35.35	26437602
1607	Phosphorylation	SLDAETRSRNEALRV HCCHHHCCHHHHHHH	47.05	26437602
1630	Phosphorylation	NEMEIQLSHANRMAA CHHHHHHHHHHHHHH	12.27	19764811
1645	Phosphorylation	EAQKQVKSLQSLLKD HHHHHHHHHHHHHHH	32.55	26437602
1648	Phosphorylation	KQVKSLQSLLKDTQI HHHHHHHHHHHHHCC	40.75	26437602
1653	Phosphorylation	LQSLLKDTQIQLDDA HHHHHHHHCCCHHHH	26.45	26437602
1695	Phosphorylation	LRAVVEQTERSRKLA HHHHHHHHHHHHHHH	21.62	26437602
1698	Phosphorylation	VVEQTERSRKLAEQE HHHHHHHHHHHHHHH	27.77	26437602
1710	O-linked_Glycosylation	EQELIETSERVQLLH HHHHHHHHHHHHHHH	15.60	14794517
1710	Phosphorylation	EQELIETSERVQLLH HHHHHHHHHHHHHHH	15.60	26437602
1718	Phosphorylation	ERVQLLHSQNTSLIN HHHHHHHHCCHHHHH	25.70	19764811
1721	Phosphorylation	QLLHSQNTSLINQKK HHHHHCCHHHHHHHH	19.78	19764811
1722	Phosphorylation	LLHSQNTSLINQKKK HHHHCCHHHHHHHHH	34.50	19764811
1727	Acetylation	NTSLINQKKKMDADL CHHHHHHHHHCCCCH	50.28	30584899
1735	Phosphorylation	KKMDADLSQLQTEVE HHCCCCHHHHHHHHH	29.41	22673903
1739	Phosphorylation	ADLSQLQTEVEEAVQ CCHHHHHHHHHHHHH	51.06	22673903
1760	Phosphorylation	EKAKKAITDAAMMAE HHHHHHHHHHHHHHH	25.17	30576142
1770	Acetylation	AMMAEELKKEQDTSA HHHHHHHHHHHCCHH	58.50	30584965
1771	Ubiquitination	MMAEELKKEQDTSAH HHHHHHHHHHCCHHH	73.55	30230243
1775	Phosphorylation	ELKKEQDTSAHLERM HHHHHHCCHHHHHHH	27.75	26437602
1776	Phosphorylation	LKKEQDTSAHLERMK HHHHHCCHHHHHHHH	23.21	26437602
1784	Acetylation	AHLERMKKNMEQTIK HHHHHHHHHHHHHHH	52.78	20167786
1789	Phosphorylation	MKKNMEQTIKDLQHR HHHHHHHHHHHHHHH	19.38	26437602
1806	Acetylation	EAEQIALKGGKKQLQ HHHHHHHHHCHHHHH	57.50	19817631
1809	Acetylation	QIALKGGKKQLQKLE HHHHHHCHHHHHHHH	46.12	30584827
1810	Acetylation	IALKGGKKQLQKLEA HHHHHCHHHHHHHHH	60.56	30584911
1831	Acetylation	NELEAEQKRNAESVK HHHHHHHHHCHHHHC	38.84	30584833
1836	Phosphorylation	EQKRNAESVKGMRKS HHHHCHHHHCCHHHH	27.07	26437602
1848	Ubiquitination	RKSERRIKELTYQTE HHHHHHHHHHHCCCH	44.88	-
1851	Phosphorylation	ERRIKELTYQTEEDR HHHHHHHHCCCHHHH	18.06	19764811
1852	Phosphorylation	RRIKELTYQTEEDRK HHHHHHHCCCHHHHH	26.51	26437602
1854	Phosphorylation	IKELTYQTEEDRKNL HHHHHCCCHHHHHHH	30.81	26437602
1859	Acetylation	YQTEEDRKNLLRLQD CCCHHHHHHHHHHHH	65.35	30584935
1878	Phosphorylation	LQLKVKAYKRQAEEA HHHHHHHHHHHHHHH	10.86	24719451
1891	Phosphorylation	EAEEQANTNLSKFRK HHHHHHCCCHHHHHH	40.32	19764811
1894	Phosphorylation	EQANTNLSKFRKVQH HHHCCCHHHHHHHHH	31.64	19764811
1915	Phosphorylation	ERADIAESQVNKLRA HHHHHHHHHHHHHHH	30.33	19764811
1924	Phosphorylation	VNKLRAKSRDIGTKG HHHHHHHHCCCCCCC	33.91	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYH7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYH7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYH7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KXDL1_HUMAN	KXD1	physical	25416956
ACTN2_HUMAN	ACTN2	physical	26344197
ACTN3_HUMAN	ACTN3	physical	26344197
TPM2_HUMAN	TPM2	physical	26344197
AFF1_HUMAN	AFF1	physical	26496610
DPOD1_HUMAN	POLD1	physical	26496610
CANB1_HUMAN	PPP3R1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
TAF11_HUMAN	TAF11	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
KEAP1_HUMAN	KEAP1	physical	26496610
PDCD6_HUMAN	PDCD6	physical	26496610
SC61B_HUMAN	SEC61B	physical	26496610
PRDX5_HUMAN	PRDX5	physical	26496610
VATD_HUMAN	ATP6V1D	physical	26496610
SIR6_HUMAN	SIRT6	physical	26496610
CLSPN_HUMAN	CLSPN	physical	26496610
FA58A_HUMAN	FAM58A	physical	26496610
SYTC2_HUMAN	TARSL2	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 192600: Cardiomyopathy, familial hypertrophic 1 (CMH1)
• 608358: Myopathy, myosin storage (MYOMS)
• 181430: Scapuloperoneal myopathy MYH7-related (SPMM)
• 613426: Cardiomyopathy, dilated 1S (CMD1S)
• 160500: Myopathy, distal, 1 (MPD1)
• 255160: Myopathy, myosin storage, autosomal recessive (MSMB)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1037, AND MASSSPECTROMETRY.
PubMed: 17287340