TAF11_HUMAN - dbPTM
TAF11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAF11_HUMAN
UniProt AC Q15544
Protein Name Transcription initiation factor TFIID subunit 11
Gene Name TAF11
Organism Homo sapiens (Human).
Sequence Length 211
Subcellular Localization Nucleus.
Protein Description Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively)..
Protein Sequence MDDAHESPSDKGGETGESDETAAVPGDPGATDTDGIPEETDGDADVDLKEAAAEEGELESQDVSDLTTVEREDSSLLNPAAKKLKIDTKEKKEKKQKVDEDEIQKMQILVSSFSEEQLNRYEMYRRSAFPKAAIKRLIQSITGTSVSQNVVIAMSGISKVFVGEVVEEALDVCEKWGEMPPLQPKHMREAVRRLKSKGQIPNSKHKKIIFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDDAHESP
-------CCCCCCCC		10.7020068231
7Phosphorylation-MDDAHESPSDKGGE
-CCCCCCCCCCCCCC		21.6029255136
9PhosphorylationDDAHESPSDKGGETG
CCCCCCCCCCCCCCC		62.3229255136
60PhosphorylationAEEGELESQDVSDLT
HHHCCCCCCCHHHCC		44.2826657352
64PhosphorylationELESQDVSDLTTVER
CCCCCCHHHCCCEEC		34.8821815630
67PhosphorylationSQDVSDLTTVEREDS
CCCHHHCCCEECCCC		33.5128348404
68PhosphorylationQDVSDLTTVEREDSS
CCHHHCCCEECCCCC		27.8927251275
74PhosphorylationTTVEREDSSLLNPAA
CCEECCCCCCCCHHH		20.3821815630
75PhosphorylationTVEREDSSLLNPAAK
CEECCCCCCCCHHHH		49.5521815630
82AcetylationSLLNPAAKKLKIDTK
CCCCHHHHHCCCCHH		61.8226051181
105UbiquitinationVDEDEIQKMQILVSS
CCHHHHHHHHHHHHC		38.1329967540
111PhosphorylationQKMQILVSSFSEEQL
HHHHHHHHCCCHHHH		23.4024719451
112PhosphorylationKMQILVSSFSEEQLN
HHHHHHHCCCHHHHH		25.8828348404
114PhosphorylationQILVSSFSEEQLNRY
HHHHHCCCHHHHHHH		42.0228348404
121PhosphorylationSEEQLNRYEMYRRSA
CHHHHHHHHHHHHCC		12.1830206219
124PhosphorylationQLNRYEMYRRSAFPK
HHHHHHHHHHCCCCH		7.3130206219
131UbiquitinationYRRSAFPKAAIKRLI
HHHCCCCHHHHHHHH		43.95-
155PhosphorylationQNVVIAMSGISKVFV
CCEEEEECCCCEEHH		24.7724400094
158PhosphorylationVIAMSGISKVFVGEV
EEEECCCCEEHHHHH		26.7124400094
204AcetylationKGQIPNSKHKKIIFF
CCCCCCCCCCCEEEC		67.117692113
206AcetylationQIPNSKHKKIIFF--
CCCCCCCCCEEEC--		49.787692121
207AcetylationIPNSKHKKIIFF---
CCCCCCCCEEEC---		40.537692129
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAF11_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAF11_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAF11_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TAF13_HUMANTAF13physical
7729427
TBP_HUMANTBPphysical
7729427
TBP_HUMANTBPphysical
8670810
TAF13_HUMANTAF13physical
9695952
LZTR1_HUMANLZTR1physical
20211142
NFYB_HUMANNFYBphysical
11689552
NFYC_HUMANNFYCphysical
11689552
VDR_HUMANVDRphysical
10744685
THA_HUMANTHRAphysical
10744685
RPB1_HUMANPOLR2Aphysical
15502823
ACTB_HUMANACTBphysical
15502823
TBP_HUMANTBPphysical
10591645
A4_HUMANAPPphysical
21832049
APBP2_HUMANAPPBP2physical
25416956
TAF13_HUMANTAF13physical
29111974
TAF7_HUMANTAF7physical
29111974
TAF1_HUMANTAF1physical
29111974
TAF2_HUMANTAF2physical
29111974
TAF3_HUMANTAF3physical
29111974
TAF4_HUMANTAF4physical
29111974
TAF4B_HUMANTAF4Bphysical
29111974
TAF5_HUMANTAF5physical
29111974
TAF6_HUMANTAF6physical
29111974
TAF8_HUMANTAF8physical
29111974
TAF9_HUMANTAF9physical
29111974
TAF9B_HUMANTAF9Bphysical
29111974
TAF10_HUMANTAF10physical
29111974
TAF11_HUMANTAF11physical
29111974
TAF12_HUMANTAF12physical
29111974
TBP_HUMANTBPphysical
29111974
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAF11_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND MASSSPECTROMETRY.

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