NFYC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NFYC_HUMAN
• UniProt AC: Q13952
• Protein Name: Nuclear transcription factor Y subunit gamma
• Gene Name: NFYC
• Organism: Homo sapiens (Human).
• Sequence Length: 458
• Subcellular Localization: Nucleus.
• Protein Description: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors..
• Protein Sequence: MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQGQRNASQGKPRRCLKETLQITQTEVQQGQQQFSQFTDGQRNSVQQARVSELTGEAEPREVKATGNSTPCTSSLPTTHPPSHRAGASCVCCSQPQQSSTSPPPSDALQWVVVEVSGTPNQLETHRELHAPLPGMTSLSPLHPSQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 5)	Phosphorylation	-	34.86	24719451
2	Phosphorylation	------MSTEGGFGG ------CCCCCCCCC	34.86	24719451
3	Phosphorylation	-----MSTEGGFGGT -----CCCCCCCCCC	37.03	28464451
10	Phosphorylation	TEGGFGGTSSSDAQQ CCCCCCCCCCHHHHH	26.30	28348404
11	Phosphorylation	EGGFGGTSSSDAQQS CCCCCCCCCHHHHHH	30.99	28348404
12	Phosphorylation	GGFGGTSSSDAQQSL CCCCCCCCHHHHHHH	31.88	28348404
13	Phosphorylation	GFGGTSSSDAQQSLQ CCCCCCCHHHHHHHH	36.41	28464451
36	Ubiquitination	EIRNLTVKDFRVQEL HHHCCCCCCCCCCCC	46.01	21890473
36	Ubiquitination	EIRNLTVKDFRVQEL HHHCCCCCCCCCCCC	46.01	23000965
36	Ubiquitination	EIRNLTVKDFRVQEL HHHCCCCCCCCCCCC	46.01	21890473
36 (in isoform 3)	Ubiquitination	-	46.01	21890473
36 (in isoform 2)	Ubiquitination	-	46.01	21890473
36 (in isoform 1)	Ubiquitination	-	46.01	21890473
36	Ubiquitination	EIRNLTVKDFRVQEL HHHCCCCCCCCCCCC	46.01	21890473
36	Ubiquitination	EIRNLTVKDFRVQEL HHHCCCCCCCCCCCC	46.01	21890473
53	Ubiquitination	ARIKKIMKLDEDVKM HHHHHHHCCCCCHHC	57.15	-
56	Ubiquitination	KKIMKLDEDVKMISA HHHHCCCCCHHCCCC	75.13	23000965
59 (in isoform 1)	Ubiquitination	-	42.72	21890473
59 (in isoform 2)	Ubiquitination	-	42.72	21890473
59 (in isoform 3)	Ubiquitination	-	42.72	21890473
59	Ubiquitination	MKLDEDVKMISAEAP HCCCCCHHCCCCCHH	42.72	21963094
79	Ubiquitination	AAQIFITELTLRAWI HHHHHHHHHHHEEEE	34.63	21963094
92	2-Hydroxyisobutyrylation	WIHTEDNKRRTLQRN EEECCCCCCCEECHH	56.42	-
92	Ubiquitination	WIHTEDNKRRTLQRN EEECCCCCCCEECHH	56.42	-
103	Sulfoxidation	LQRNDIAMAITKFDQ ECHHHHHHHHHEHHH	2.57	21406390
106	Phosphorylation	NDIAMAITKFDQFDF HHHHHHHHEHHHCCE	19.00	23663014
124	Ubiquitination	IVPRDELKPPKRQEE ECCHHHCCCCCCHHH	58.17	-
127	Ubiquitination	RDELKPPKRQEEVRQ HHHCCCCCCHHHHHH	75.21	-
258	O-linked_Glycosylation	IRLAQPVSGTQVVQG EEEECCCCCCEEEEH	42.69	30059200
260	O-linked_Glycosylation	LAQPVSGTQVVQGQI EECCCCCCEEEEHHH	15.64	30059200
282	Phosphorylation	QQGQRNASQGKPRRC HHHHHHHHCCCCCHH	42.91	22985185
285	Ubiquitination	QRNASQGKPRRCLKE HHHHHCCCCCHHHHH	27.93	-
325	Phosphorylation	SVQQARVSELTGEAE HHHHHHHHHHHCCCC	22.72	28555341
339	Phosphorylation	EPREVKATGNSTPCT CCCEEECCCCCCCCC	31.04	23312004
339	O-linked_Glycosylation	EPREVKATGNSTPCT CCCEEECCCCCCCCC	31.04	30059200
342	Phosphorylation	EVKATGNSTPCTSSL EEECCCCCCCCCCCC	34.76	25159151
343	Phosphorylation	VKATGNSTPCTSSLP EECCCCCCCCCCCCC	26.78	25159151
343	O-linked_Glycosylation	VKATGNSTPCTSSLP EECCCCCCCCCCCCC	26.78	30059200
346	Phosphorylation	TGNSTPCTSSLPTTH CCCCCCCCCCCCCCC	23.66	23312004
346	O-linked_Glycosylation	TGNSTPCTSSLPTTH CCCCCCCCCCCCCCC	23.66	30059200
347	Phosphorylation	GNSTPCTSSLPTTHP CCCCCCCCCCCCCCC	36.27	23312004
348	Phosphorylation	NSTPCTSSLPTTHPP CCCCCCCCCCCCCCC	21.88	23312004
351	Phosphorylation	PCTSSLPTTHPPSHR CCCCCCCCCCCCCCC	42.92	23312004
352	Phosphorylation	CTSSLPTTHPPSHRA CCCCCCCCCCCCCCC	30.37	23312004
356	Phosphorylation	LPTTHPPSHRAGASC CCCCCCCCCCCCCEE	30.01	28555341
373	Phosphorylation	CSQPQQSSTSPPPSD ECCCCCCCCCCCCCC	28.68	22210691
375	Phosphorylation	QPQQSSTSPPPSDAL CCCCCCCCCCCCCCC	37.04	22210691
410	Phosphorylation	HAPLPGMTSLSPLHP CCCCCCCCCCCCCCH	32.22	26074081
411	Phosphorylation	APLPGMTSLSPLHPS CCCCCCCCCCCCCHH	20.25	26074081
413	Phosphorylation	LPGMTSLSPLHPSQQ CCCCCCCCCCCHHHH	25.78	26074081
418	Phosphorylation	SLSPLHPSQQLYQIQ CCCCCCHHHHHEEEE	21.58	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NFYC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NFYC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NFYC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYC_HUMAN	MYC	physical	10446203
ATF6A_HUMAN	ATF6	physical	11158310
ATF6B_HUMAN	ATF6B	physical	11158310
P73_HUMAN	TP73	physical	12167641
DYST_HUMAN	DST	physical	20936779
CASB_HUMAN	CSN2	physical	20936779
NC2B_HUMAN	DR1	physical	20936779
NFYA_HUMAN	NFYA	physical	20936779
NFYB_HUMAN	NFYB	physical	20936779
SP1_HUMAN	SP1	physical	20936779
SRBP2_HUMAN	SREBF2	physical	20936779
LMO4_HUMAN	LMO4	physical	20936779
ADNP2_HUMAN	ADNP2	physical	20936779
ATF6A_HUMAN	ATF6	physical	20936779
POGZ_HUMAN	POGZ	physical	20936779
CIC_HUMAN	CIC	physical	20936779
ZDH17_HUMAN	ZDHHC17	physical	20936779
BICRL_HUMAN	GLTSCR1L	physical	20936779
BICRA_HUMAN	GLTSCR1	physical	20936779
ARID2_HUMAN	ARID2	physical	20936779
HDAC1_HUMAN	HDAC1	physical	19351825
TAF12_HUMAN	TAF12	physical	11689552
TAF11_HUMAN	TAF11	physical	11689552
TAF6_HUMAN	TAF6	physical	11689552
KAT2B_HUMAN	KAT2B	physical	15454570
P73_HUMAN	TP73	physical	15454570
SNX2_HUMAN	SNX2	physical	21988832
COR1B_HUMAN	CORO1B	physical	26344197
COR1C_HUMAN	CORO1C	physical	26344197
NC2B_HUMAN	DR1	physical	26344197
NFYB_HUMAN	NFYB	physical	26344197
NFYB_HUMAN	NFYB	physical	28514442
PON1_HUMAN	PON1	physical	28514442
NUCG_HUMAN	ENDOG	physical	28514442
PON3_HUMAN	PON3	physical	28514442
NFKB1_HUMAN	NFKB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.