ADNP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADNP2_HUMAN
• UniProt AC: Q6IQ32
• Protein Name: Activity-dependent neuroprotector homeobox protein 2
• Gene Name: ADNP2
• Organism: Homo sapiens (Human).
• Sequence Length: 1131
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MFQIPVENLDNIRKVRKKVKGILVDIGLDSCKELLKDLKGFDPGEKYFHNTSWGDVSLWEPSGKKVRYRTKPYCCGLCKYSTKVLTSFKNHLHRYHEDEIDQELVIPCPNCVFASQPKVVGRHFRMFHAPVRKVQNYTVNILGETKSSRSDVISFTCLKCNFSNTLYYSMKKHVLVAHFHYLINSYFGLRTEEMGEQPKTNDTVSIEKIPPPDKYYCKKCNANASSQDALMYHILTSDIHRDLENKLRSVISEHIKRTGLLKQTHIAPKPAAHLAAPANGSAPSAPAQPPCFHLALPQNSPSPAAGQPVTVAQGAPGSLTHSPPAAGQSHMTLVSSPLPVGQNSLTLQPPAPQPVFLSHGVPLHQSVNPPVLPLSQPVGPVNKSVGTSVLPINQTVRPGVLPLTQPVGPINRPVGPGVLPVSPSVTPGVLQAVSPGVLSVSRAVPSGVLPAGQMTPAGQMTPAGVIPGQTATSGVLPTGQMVQSGVLPVGQTAPSRVLPPGQTAPLRVISAGQVVPSGLLSPNQTVSSSAVVPVNQGVNSGVLQLSQPVVSGVLPVGQPVRPGVLQLNQTVGTNILPVNQPVRPGASQNTTFLTSGSILRQLIPTGKQVNGIPTYTLAPVSVTLPVPPGGLATVAPPQMPIQLLPSGAAAPMAGSMPGMPSPPVLVNAAQSVFVQASSSAADTNQVLKQAKQWKTCPVCNELFPSNVYQVHMEVAHKHSESKSGEKLEPEKLAACAPFLKWMREKTVRCLSCKCLVSEEELIHHLLMHGLGCLFCPCTFHDIKGLSEHSRNRHLGKKKLPMDYSNRGFQLDVDANGNLLFPHLDFITILPKEKLGEREVYLAILAGIHSKSLVPVYVKVRPQAEGTPGSTGKRVSTCPFCFGPFVTTEAYELHLKERHHIMPTVHTVLKSPAFKCIHCCGVYTGNMTLAAIAVHLVRCRSAPKDSSSDLQAQPGFIHNSELLLVSGEVMHDSSFSVKRKLPDGHLGAEDQRHGEEQPPILNADAAPGPEKVTSVVPFKRQRNESRTEGPIVKDEALQILALDPKKYEGRSYEEKKQFLKDYFHKKPYPSKKEIELLSSLFWVWKIDVASFFGKRRYICMKAIKNHKPSVLLGFDMSELKNVKHRLNFEYEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	KELLKDLKGFDPGEK HHHHHHHCCCCCCCC	68.60	-
46	Ubiquitination	KGFDPGEKYFHNTSW CCCCCCCCCCCCCCC	60.16	-
62	Phosphorylation	DVSLWEPSGKKVRYR CCEEECCCCCEEEEC	52.29	46159865
80	Phosphorylation	YCCGLCKYSTKVLTS CCCCHHCCCHHHHHH	22.15	21577397
89	Ubiquitination	TKVLTSFKNHLHRYH HHHHHHHHHHHHHCC	43.13	-
118	Sumoylation	CVFASQPKVVGRHFR CEEECCCCEECCCEE	41.75	28112733
138	Phosphorylation	VRKVQNYTVNILGET CEECCCEEEEECCCC	18.02	25690035
145	Phosphorylation	TVNILGETKSSRSDV EEEECCCCCCCCCCE	34.13	25690035
146	Sumoylation	VNILGETKSSRSDVI EEECCCCCCCCCCEE	41.97	28112733
147	Phosphorylation	NILGETKSSRSDVIS EECCCCCCCCCCEEE	38.10	29978859
148	Phosphorylation	ILGETKSSRSDVISF ECCCCCCCCCCEEEE	37.04	29978859
199	Ubiquitination	EEMGEQPKTNDTVSI HHCCCCCCCCCCCCC	60.70	21906983
208	Ubiquitination	NDTVSIEKIPPPDKY CCCCCCEECCCCCCC	59.86	-
246	Ubiquitination	IHRDLENKLRSVISE HHHHHHHHHHHHHHH	35.58	-
256	Ubiquitination	SVISEHIKRTGLLKQ HHHHHHHHHHCCCCC	45.90	-
262	Ubiquitination	IKRTGLLKQTHIAPK HHHHCCCCCCCCCCC	59.18	-
300	Phosphorylation	HLALPQNSPSPAAGQ EEECCCCCCCCCCCC	22.85	26074081
302	Phosphorylation	ALPQNSPSPAAGQPV ECCCCCCCCCCCCCE	27.30	26074081
310	Phosphorylation	PAAGQPVTVAQGAPG CCCCCCEEEECCCCC	19.46	26074081
318	Phosphorylation	VAQGAPGSLTHSPPA EECCCCCCCCCCCCC	29.09	26074081
320	Phosphorylation	QGAPGSLTHSPPAAG CCCCCCCCCCCCCCC	23.23	26074081
322	Phosphorylation	APGSLTHSPPAAGQS CCCCCCCCCCCCCCC	27.61	26074081
329	Phosphorylation	SPPAAGQSHMTLVSS CCCCCCCCCEEEEEC	17.82	26074081
404	Phosphorylation	RPGVLPLTQPVGPIN CCCCCCCCCCCCCCC	28.96	26074081
422	Phosphorylation	GPGVLPVSPSVTPGV CCCCCCCCCCCCCCH	14.98	26074081
424	Phosphorylation	GVLPVSPSVTPGVLQ CCCCCCCCCCCCHHH	30.99	26074081
426	Phosphorylation	LPVSPSVTPGVLQAV CCCCCCCCCCHHHHC	20.75	26074081
439	Phosphorylation	AVSPGVLSVSRAVPS HCCCCEEEEECCCCC	18.68	24719451
731	Ubiquitination	GEKLEPEKLAACAPF CCCCCHHHHHHHHHH	54.89	-
740	Ubiquitination	AACAPFLKWMREKTV HHHHHHHHHHHHHHH	39.05	-
797	Ubiquitination	RNRHLGKKKLPMDYS CCCCCCCCCCCCCCC	58.71	-
798	Ubiquitination	NRHLGKKKLPMDYSN CCCCCCCCCCCCCCC	62.40	-
803	Phosphorylation	KKKLPMDYSNRGFQL CCCCCCCCCCCCEEE	11.12	26074081
804	Phosphorylation	KKLPMDYSNRGFQLD CCCCCCCCCCCEEEE	18.78	26074081
840	Phosphorylation	KLGEREVYLAILAGI HHCCHHHHHHHHHCC	5.90	7608371
858	Ubiquitination	SLVPVYVKVRPQAEG CEEEEEEEECCCCCC	18.16	-
866	Phosphorylation	VRPQAEGTPGSTGKR ECCCCCCCCCCCCCE	18.91	25159151
869	Phosphorylation	QAEGTPGSTGKRVST CCCCCCCCCCCEECC	34.88	25159151
870	Phosphorylation	AEGTPGSTGKRVSTC CCCCCCCCCCEECCC	53.27	27732954
872	Ubiquitination	GTPGSTGKRVSTCPF CCCCCCCCEECCCCC	50.11	21906983
872	Acetylation	GTPGSTGKRVSTCPF CCCCCCCCEECCCCC	50.11	25953088
906	Phosphorylation	HIMPTVHTVLKSPAF CCCCCHHHHHHCCCH	24.17	101545307
909	Ubiquitination	PTVHTVLKSPAFKCI CCHHHHHHCCCHHHE	50.48	-
910	Phosphorylation	TVHTVLKSPAFKCIH CHHHHHHCCCHHHEE	19.80	101545299
975	Phosphorylation	VMHDSSFSVKRKLPD EECCCCCEEEECCCC	28.77	46159871
979	Sumoylation	SSFSVKRKLPDGHLG CCCEEEECCCCCCCC	59.67	28112733
979	Ubiquitination	SSFSVKRKLPDGHLG CCCEEEECCCCCCCC	59.67	-
1018	Acetylation	VTSVVPFKRQRNESR CCEEEECCCCCCCCC	41.36	30586779
1018	Ubiquitination	VTSVVPFKRQRNESR CCEEEECCCCCCCCC	41.36	-
1018	Sumoylation	VTSVVPFKRQRNESR CCEEEECCCCCCCCC	41.36	28112733
1024	Phosphorylation	FKRQRNESRTEGPIV CCCCCCCCCCCCCCC	48.31	25159151
1026	Phosphorylation	RQRNESRTEGPIVKD CCCCCCCCCCCCCCC	55.35	21406692
1032	Ubiquitination	RTEGPIVKDEALQIL CCCCCCCCCHHHHHE	51.04	21906983
1032	Sumoylation	RTEGPIVKDEALQIL CCCCCCCCCHHHHHE	51.04	25114211
1044	Ubiquitination	QILALDPKKYEGRSY HHEECCCCCCCCCCH	68.59	-
1046	Phosphorylation	LALDPKKYEGRSYEE EECCCCCCCCCCHHH	29.73	50563783
1050	Phosphorylation	PKKYEGRSYEEKKQF CCCCCCCCHHHHHHH	47.99	50563789
1051	Phosphorylation	KKYEGRSYEEKKQFL CCCCCCCHHHHHHHH	27.09	50563795
1055	Ubiquitination	GRSYEEKKQFLKDYF CCCHHHHHHHHHHHH	49.95	-
1059	Ubiquitination	EEKKQFLKDYFHKKP HHHHHHHHHHHCCCC	52.23	-
1061	Phosphorylation	KKQFLKDYFHKKPYP HHHHHHHHHCCCCCC	13.14	82119
1067	Phosphorylation	DYFHKKPYPSKKEIE HHHCCCCCCCHHHHH	29.08	7315801
1093	Ubiquitination	DVASFFGKRRYICMK HHHHHCCCCCEEHHH	28.66	-
1108	Phosphorylation	AIKNHKPSVLLGFDM HHHHCCCEEEEEECH	30.15	24719451
1116	Phosphorylation	VLLGFDMSELKNVKH EEEEECHHHHCCCHH	41.44	24719451
1119	Ubiquitination	GFDMSELKNVKHRLN EECHHHHCCCHHHHC	56.49	-
1129	Phosphorylation	KHRLNFEYEP----- HHHHCCCCCC-----	29.39	46159881

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADNP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADNP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADNP2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ADNP2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.