ATF6B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATF6B_HUMAN
• UniProt AC: Q99941
• Protein Name: Cyclic AMP-dependent transcription factor ATF-6 beta
• Gene Name: ATF6B
• Organism: Homo sapiens (Human).
• Sequence Length: 703
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type II membrane protein.; Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
• Protein Description: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE..
• Protein Sequence: MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDGSSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGEVLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASLLSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTRKPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLPRPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPPSAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAFPGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKSQPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRDHLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTSTVPPSLRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELMLLSE ------CCHHHHHHH	20.73	22223895
89	Phosphorylation	FPDLQVKSEPSSPCS CCCCCCCCCCCCCCC	56.75	22777824
92	Phosphorylation	LQVKSEPSSPCSSSS CCCCCCCCCCCCCHH	42.75	25159151
93	Phosphorylation	QVKSEPSSPCSSSSL CCCCCCCCCCCCHHC	40.41	22777824
96	Phosphorylation	SEPSSPCSSSSLSSE CCCCCCCCCHHCCCC	36.32	26074081
97	Phosphorylation	EPSSPCSSSSLSSES CCCCCCCCHHCCCCH	30.57	26074081
98	Phosphorylation	PSSPCSSSSLSSESS CCCCCCCHHCCCCHH	21.00	26074081
99	Phosphorylation	SSPCSSSSLSSESSR CCCCCCHHCCCCHHC	33.93	26074081
101	Phosphorylation	PCSSSSLSSESSRLS CCCCHHCCCCHHCCC	33.73	26552605
102	Phosphorylation	CSSSSLSSESSRLST CCCHHCCCCHHCCCC	46.95	26552605
104	Phosphorylation	SSSLSSESSRLSTEP CHHCCCCHHCCCCCC	23.78	26552605
105	Phosphorylation	SSLSSESSRLSTEPS HHCCCCHHCCCCCCC	32.94	26552605
112	Phosphorylation	SRLSTEPSSEALGVG HCCCCCCCHHHCCCC	34.28	24719451
113	Phosphorylation	RLSTEPSSEALGVGE CCCCCCCHHHCCCCC	37.29	27251275
146	Phosphorylation	DPTSSFETVQINVIP CCCCCCCEEEEEEEC	18.72	29759185
155	Phosphorylation	QINVIPTSDDSSDVQ EEEEECCCCCCCCCC	33.78	29759185
158	Phosphorylation	VIPTSDDSSDVQTKI EECCCCCCCCCCCEE	33.17	29759185
200	Phosphorylation	EEVLEVKTESLSPSG CEEEEEECCCCCCCC	35.66	26074081
202	Phosphorylation	VLEVKTESLSPSGCL EEEEECCCCCCCCCE	39.10	26074081
204	Phosphorylation	EVKTESLSPSGCLLW EEECCCCCCCCCEEE	26.71	26074081
206	Phosphorylation	KTESLSPSGCLLWDV ECCCCCCCCCEEECC	38.47	26074081
279	Phosphorylation	LVQPPPVSPVVLIQG HCCCCCCCCEEEEEC	20.11	24719451
305	Ubiquitination	SLPRPERKSIVPAPM CCCCCCCCCCCCCCC	42.76	-
306	Phosphorylation	LPRPERKSIVPAPMP CCCCCCCCCCCCCCC	34.73	24719451
324	Ubiquitination	CPPEVDAKLLKRQQR CCHHHHHHHHHHHHH	50.30	-
327	Ubiquitination	EVDAKLLKRQQRMIK HHHHHHHHHHHHHHH	59.61	-
346	Ubiquitination	ACQSRRKKKEYLQGL HHHHHHHHHHHHHHH	49.37	-
347	Ubiquitination	CQSRRKKKEYLQGLE HHHHHHHHHHHHHHH	55.41	-
476	N-linked_Glycosylation	TDQPSFSNLTAFPGG CCCCCCCCCCCCCCC	39.12	UniProtKB CARBOHYD
478	Phosphorylation	QPSFSNLTAFPGGAK CCCCCCCCCCCCCHH	30.42	26074081
505	N-linked_Glycosylation	SSDCRHFNRTESLRL CCCCCCCCHHHHHHH	43.79	UniProtKB CARBOHYD
546	Phosphorylation	KSQPRKKSPPVKAVP HCCCCCCCCCCCCCC	37.15	-
564	Phosphorylation	PGPPERDSVGQLQLY CCCCCCCCCCCEEEE	34.08	30576142
571	Phosphorylation	SVGQLQLYRHPDRSQ CCCCEEEECCCCCCC	8.23	25003641
593	Phosphorylation	DRREDTFYVVSFRRD HCCCCCEEEEEEECC	11.31	27642862
610	N-linked_Glycosylation	LLPAISHNKTSRPKM CHHHHCCCCCCCCCE	42.37	UniProtKB CARBOHYD
618	Phosphorylation	KTSRPKMSLVMPAMA CCCCCCEEEEECCCC	24.76	30206219
627	N-linked_Glycosylation	VMPAMAPNETLSGRG EECCCCCCCCCCCCC	45.40	UniProtKB CARBOHYD
629	Phosphorylation	PAMAPNETLSGRGAP CCCCCCCCCCCCCCC	32.63	30206219
631	Phosphorylation	MAPNETLSGRGAPGD CCCCCCCCCCCCCCC	33.59	30206219
668	Ubiquitination	TVPPSLRKQPSPTPG CCCHHHCCCCCCCCC	72.37	-
676	N-linked_Glycosylation	QPSPTPGNATGGPLP CCCCCCCCCCCCCCC	35.22	UniProtKB CARBOHYD
685	O-linked_Glycosylation	TGGPLPVSAASQAHQ CCCCCCCCHHHHHHH	19.04	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATF6B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATF6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATF6B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZHANG_HUMAN	CREBZF	physical	23661758
ATF6B_HUMAN	ATF6B	physical	23661758
XBP1_HUMAN	XBP1	physical	23661758
TEX15_HUMAN	TEX15	physical	26186194
CPT2_HUMAN	CPT2	physical	26186194
OXSM_HUMAN	OXSM	physical	26186194
GLSK_HUMAN	GLS	physical	26186194
KAD4_HUMAN	AK4	physical	26186194
RWD2B_HUMAN	RWDD2B	physical	26186194
LYRM7_HUMAN	LYRM7	physical	26186194
RAB2A_HUMAN	RAB2A	physical	26186194
PICAL_HUMAN	PICALM	physical	26186194
RWD2B_HUMAN	RWDD2B	physical	28514442
TEX15_HUMAN	TEX15	physical	28514442
OXSM_HUMAN	OXSM	physical	28514442
KAD4_HUMAN	AK4	physical	28514442
NEB1_HUMAN	PPP1R9A	physical	28514442
LYRM7_HUMAN	LYRM7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.