RWD2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RWD2B_HUMAN
• UniProt AC: P57060
• Protein Name: RWD domain-containing protein 2B
• Gene Name: RWDD2B
• Organism: Homo sapiens (Human).
• Sequence Length: 319
• Protein Sequence: MKIELSMQPWNPGYSSEGATAQETYTCPKMIEMEQAEAQLAELDLLASMFPGENELIVNDQLAVAELKDCIEKKTMEGRSSKVYFTINMNLDVSDEKMAMFSLACILPFKYPAVLPEITVRSVLLSRSQQTQLNTDLTAFLQKHCHGDVCILNATEWVREHASGYVSRDTSSSPTTGSTVQSVDLIFTRLWIYSHHIYNKCKRKNILEWAKELSLSGFSMPGKPGVVCVEGPQSACEEFWSRLRKLNWKRILIRHREDIPFDGTNDETERQRKFSIFEEKVFSVNGARGNHMDFGQLYQFLNTKGCGDVFQMFFGVEGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Ubiquitination	LKDCIEKKTMEGRSS HHHHHHHHCCCCCCC	40.07	-
119	Phosphorylation	PAVLPEITVRSVLLS CCCCCCCHHHHHHHC	14.27	-
170	Phosphorylation	SGYVSRDTSSSPTTG CCCCCCCCCCCCCCC	29.42	30108239
171	Phosphorylation	GYVSRDTSSSPTTGS CCCCCCCCCCCCCCC	32.86	30278072
172	Phosphorylation	YVSRDTSSSPTTGST CCCCCCCCCCCCCCC	42.29	30278072
173	Phosphorylation	VSRDTSSSPTTGSTV CCCCCCCCCCCCCCH	26.49	30278072
175	Phosphorylation	RDTSSSPTTGSTVQS CCCCCCCCCCCCHHH	45.82	30278072
176	Phosphorylation	DTSSSPTTGSTVQSV CCCCCCCCCCCHHHH	32.30	30108239
178	Phosphorylation	SSSPTTGSTVQSVDL CCCCCCCCCHHHHHH	24.26	30108239
179	Phosphorylation	SSPTTGSTVQSVDLI CCCCCCCCHHHHHHH	24.74	30108239
179	O-linked_Glycosylation	SSPTTGSTVQSVDLI CCCCCCCCHHHHHHH	24.74	OGP
182	Phosphorylation	TTGSTVQSVDLIFTR CCCCCHHHHHHHHHH	17.17	27690223
204	Malonylation	IYNKCKRKNILEWAK HHHHHHHCCHHHHHH	33.56	26320211
273	Ubiquitination	DETERQRKFSIFEEK CHHHHHHHHHCEEEE	34.82	29967540
275	Phosphorylation	TERQRKFSIFEEKVF HHHHHHHHCEEEEEE	29.42	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RWD2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RWD2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RWD2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GA45G_HUMAN	GADD45G	physical	16189514
A4_HUMAN	APP	physical	21832049
IKZF1_HUMAN	IKZF1	physical	25416956
GA45G_HUMAN	GADD45G	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
K1958_HUMAN	KIAA1958	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681
ARMT1_HUMAN	C6orf211	physical	26186194
MYH11_HUMAN	MYH11	physical	26186194
PLSI_HUMAN	PLS1	physical	26186194
PDLI5_HUMAN	PDLIM5	physical	26186194
H1BP3_HUMAN	HS1BP3	physical	26186194
DCAF5_HUMAN	DCAF5	physical	26186194
NEUG_HUMAN	NRGN	physical	26186194
UBR7_HUMAN	UBR7	physical	26186194
GLP3L_HUMAN	GOLPH3L	physical	26186194
DENR_HUMAN	DENR	physical	26186194
IKZF1_HUMAN	IKZF1	physical	21516116
MYH11_HUMAN	MYH11	physical	28514442
PDLI5_HUMAN	PDLIM5	physical	28514442
DCAF5_HUMAN	DCAF5	physical	28514442
NEUG_HUMAN	NRGN	physical	28514442
GLP3L_HUMAN	GOLPH3L	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442
ARMT1_HUMAN	C6orf211	physical	28514442
DENR_HUMAN	DENR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.