H1BP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H1BP3_HUMAN
• UniProt AC: Q53T59
• Protein Name: HCLS1-binding protein 3
• Gene Name: HS1BP3
• Organism: Homo sapiens (Human).
• Sequence Length: 392
• Protein Description: May be a modulator of IL-2 signaling..
• Protein Sequence: MQSPAVLVTSRRLQNAHTGLDLTVPQHQEVRGKMMSGHVEYQILVVTRLAAFKSAKHRPEDVVQFLVSKKYSEIEEFYQKLSSRYAAASLPPLPRKVLFVGESDIRERRAVFNEILRCVSKDAELAGSPELLEFLGTRSPGAAGLTSRDSSVLDGTDSQTGNDEEAFDFFEEQDQVAEEGPPVQSLKGEDAEESLEEEEALDPLGIMRSKKPKKHPKVAVKAKPSPRLTIFDEEVDPDEGLFGPGRKLSPQDPSEDVSSVDPLKLFDDPDLGGAIPLGDSLLLPAACESGGPTPSLSHRDASKELFRVEEDLDQILNLGAEPKPKPQLKPKPPVAAKPVIPRKPAVPPKAGPAEAVAGQQKPQEQIQAMDEMDILQYIQDHDTPAQAAPSLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MQSPAVLV -------CCCCCEEE	8.86	22814378
3	Phosphorylation	-----MQSPAVLVTS -----CCCCCEEEEC	17.33	29255136
9	Phosphorylation	QSPAVLVTSRRLQNA CCCCEEEECHHCHHC	16.62	20068231
10	Phosphorylation	SPAVLVTSRRLQNAH CCCEEEECHHCHHCC	14.13	20068231
18	Phosphorylation	RRLQNAHTGLDLTVP HHCHHCCCCCCCCCC	36.71	28857561
23	Phosphorylation	AHTGLDLTVPQHQEV CCCCCCCCCCCHHHH	29.79	23312004
69	2-Hydroxyisobutyrylation	VVQFLVSKKYSEIEE HHHHHHCCCHHHHHH	48.53	-
70	Ubiquitination	VQFLVSKKYSEIEEF HHHHHCCCHHHHHHH	46.64	-
85	Phosphorylation	YQKLSSRYAAASLPP HHHHHHHHHHHHCCC	11.53	22817900
89	Phosphorylation	SSRYAAASLPPLPRK HHHHHHHHCCCCCCE	36.36	28857561
96	Ubiquitination	SLPPLPRKVLFVGES HCCCCCCEEEEEECH	41.15	-
120	Phosphorylation	NEILRCVSKDAELAG HHHHHHHHCCHHHCC	28.57	25954137
128	Phosphorylation	KDAELAGSPELLEFL CCHHHCCCHHHHHHH	15.03	20068231
137	Phosphorylation	ELLEFLGTRSPGAAG HHHHHHCCCCCCCCC	30.07	28450419
139	Phosphorylation	LEFLGTRSPGAAGLT HHHHCCCCCCCCCCC	27.76	29255136
146	Phosphorylation	SPGAAGLTSRDSSVL CCCCCCCCCCCCCCC	22.31	28450419
147	Phosphorylation	PGAAGLTSRDSSVLD CCCCCCCCCCCCCCC	38.85	28450419
150	Phosphorylation	AGLTSRDSSVLDGTD CCCCCCCCCCCCCCC	22.64	20873877
151	Phosphorylation	GLTSRDSSVLDGTDS CCCCCCCCCCCCCCC	30.87	20873877
156	Phosphorylation	DSSVLDGTDSQTGND CCCCCCCCCCCCCCC	31.95	27251275
158	Phosphorylation	SVLDGTDSQTGNDEE CCCCCCCCCCCCCHH	29.49	26657352
160	Phosphorylation	LDGTDSQTGNDEEAF CCCCCCCCCCCHHHH	41.74	26657352
185	Phosphorylation	EEGPPVQSLKGEDAE HHCCCCCCCCCCCHH	32.08	20873877
194	Phosphorylation	KGEDAEESLEEEEAL CCCCHHHHHHHHHHH	32.36	29255136
209	Phosphorylation	DPLGIMRSKKPKKHP CHHHHCCCCCCCCCC	27.87	26657352
221	Acetylation	KHPKVAVKAKPSPRL CCCCEEEECCCCCCE	40.74	25953088
229	Phosphorylation	AKPSPRLTIFDEEVD CCCCCCEEEECCCCC	22.37	22817900
249	Phosphorylation	FGPGRKLSPQDPSED CCCCCCCCCCCCCCC	24.45	23927012
254	Phosphorylation	KLSPQDPSEDVSSVD CCCCCCCCCCCCCCC	55.51	30266825
258	Phosphorylation	QDPSEDVSSVDPLKL CCCCCCCCCCCCCCC	36.65	23403867
259	Phosphorylation	DPSEDVSSVDPLKLF CCCCCCCCCCCCCCC	30.32	23403867
280	Phosphorylation	GAIPLGDSLLLPAAC CCCCCCCCCCHHHHH	21.08	25159151
289	Phosphorylation	LLPAACESGGPTPSL CHHHHHHCCCCCCCC	49.27	25159151
293	Phosphorylation	ACESGGPTPSLSHRD HHHCCCCCCCCCHHH	28.87	21712546
295	Phosphorylation	ESGGPTPSLSHRDAS HCCCCCCCCCHHHHH	45.01	27251275
297	Phosphorylation	GGPTPSLSHRDASKE CCCCCCCCHHHHHHH	22.33	27251275
302	Phosphorylation	SLSHRDASKELFRVE CCCHHHHHHHHCCCH	30.83	26657352
337	Acetylation	PKPPVAAKPVIPRKP CCCCCCCCCCCCCCC	30.04	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H1BP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H1BP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H1BP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LSMD1_HUMAN	NAA38	physical	26344197
ABTB2_HUMAN	ABTB2	physical	28514442
PDXD1_HUMAN	PDXDC1	physical	28514442
RAD50_HUMAN	RAD50	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-337, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-85; SER-139 AND SER-194,AND MASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, AND MASSSPECTROMETRY.
PubMed: 18669648

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, AND MASSSPECTROMETRY.
PubMed: 16964243