LSMD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSMD1_HUMAN
• UniProt AC: Q9BRA0
• Protein Name: N-alpha-acetyltransferase 38, NatC auxiliary subunit
• Gene Name: NAA38
• Organism: Homo sapiens (Human).
• Sequence Length: 125
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues..
• Protein Sequence: MAGAGPTMLLREENGCCSRRQSSSSAGDSDGEREDSAAERARQQLEALLNKTMRIRMTDGRTLVGCFLCTDRDCNVILGSAQEFLKPSDSFSAGEPRVLGLAMVPGHHIVSIEVQRESLTGPPYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGAGPTML ------CCCCCCCEE	19.28	22814378
7	Phosphorylation	-MAGAGPTMLLREEN -CCCCCCCEEEECCC	21.38	22210691
18	Phosphorylation	REENGCCSRRQSSSS ECCCCCCCCCCCCCC	34.28	22777824
22	Phosphorylation	GCCSRRQSSSSAGDS CCCCCCCCCCCCCCC	30.31	29255136
23	Phosphorylation	CCSRRQSSSSAGDSD CCCCCCCCCCCCCCC	21.70	29255136
24	Phosphorylation	CSRRQSSSSAGDSDG CCCCCCCCCCCCCCC	29.47	29255136
25	Phosphorylation	SRRQSSSSAGDSDGE CCCCCCCCCCCCCCC	37.91	29255136
29	Phosphorylation	SSSSAGDSDGEREDS CCCCCCCCCCCCCHH	46.74	29255136
36	Phosphorylation	SDGEREDSAAERARQ CCCCCCHHHHHHHHH	25.32	24275569
51	Ubiquitination	QLEALLNKTMRIRMT HHHHHHHHCCEEEEC	43.60	21890473
51 (in isoform 1)	Ubiquitination	-	43.60	21890473
86	Ubiquitination	GSAQEFLKPSDSFSA CCHHHHCCCCCCCCC	48.04	-
88	Phosphorylation	AQEFLKPSDSFSAGE HHHHCCCCCCCCCCC	44.28	21406692
90	Phosphorylation	EFLKPSDSFSAGEPR HHCCCCCCCCCCCCE	25.99	21406692
92	Phosphorylation	LKPSDSFSAGEPRVL CCCCCCCCCCCCEEE	39.04	21712546
99	Ubiquitination	SAGEPRVLGLAMVPG CCCCCEEEEEEEECC	4.99	-
99 (in isoform 2)	Ubiquitination	-	4.99	21890473
134	Ubiquitination	---------------- ----------------		-
134 (in isoform 2)	Ubiquitination	-		-
138	Phosphorylation	-------------------- --------------------		-
140	Phosphorylation	---------------------- ----------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSMD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSMD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSMD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PR20E_HUMAN	PRR20A	physical	25416956
PR20C_HUMAN	PRR20A	physical	25416956
PR20D_HUMAN	PRR20A	physical	25416956
PR20B_HUMAN	PRR20A	physical	25416956
PR20A_HUMAN	PRR20A	physical	25416956
API5_HUMAN	API5	physical	26344197
LSM7_HUMAN	LSM7	physical	26344197
AFAD_HUMAN	MLLT4	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-25 AND SER-29,AND MASS SPECTROMETRY.
PubMed: 18669648