LSM7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSM7_HUMAN
• UniProt AC: Q9UK45
• Protein Name: U6 snRNA-associated Sm-like protein LSm7
• Gene Name: LSM7
• Organism: Homo sapiens (Human).
• Sequence Length: 103
• Subcellular Localization: Nucleus .
• Protein Description: Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome..
• Protein Sequence: MADKEKKKKESILDLSKYIDKTIRVKFQGGREASGILKGFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGLVVCRGTSVVLICPQDGMEAIPNPFIQQQDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADKEKKKK ------CCHHHHHHH	36.26	22814378
7	Ubiquitination	-MADKEKKKKESILD -CCHHHHHHHHHHHH	70.89	-
8	Ubiquitination	MADKEKKKKESILDL CCHHHHHHHHHHHHH	73.22	32142685
9	Ubiquitination	ADKEKKKKESILDLS CHHHHHHHHHHHHHH	66.62	32015554
9	Malonylation	ADKEKKKKESILDLS CHHHHHHHHHHHHHH	66.62	26320211
11	Phosphorylation	KEKKKKESILDLSKY HHHHHHHHHHHHHHH	37.01	20873877
16	Phosphorylation	KESILDLSKYIDKTI HHHHHHHHHHCCCEE	24.07	21815630
17	2-Hydroxyisobutyrylation	ESILDLSKYIDKTIR HHHHHHHHHCCCEEE	54.22	-
17	Ubiquitination	ESILDLSKYIDKTIR HHHHHHHHHCCCEEE	54.22	23000965
17	Acetylation	ESILDLSKYIDKTIR HHHHHHHHHCCCEEE	54.22	23236377
18	Phosphorylation	SILDLSKYIDKTIRV HHHHHHHHCCCEEEE	15.81	23312004
21	Ubiquitination	DLSKYIDKTIRVKFQ HHHHHCCCEEEEEEC	35.97	23000965
22	Phosphorylation	LSKYIDKTIRVKFQG HHHHCCCEEEEEECC	15.40	23312004
26	Ubiquitination	IDKTIRVKFQGGREA CCCEEEEEECCCHHH	23.32	27667366
26	2-Hydroxyisobutyrylation	IDKTIRVKFQGGREA CCCEEEEEECCCHHH	23.32	-
26	Acetylation	IDKTIRVKFQGGREA CCCEEEEEECCCHHH	23.32	25953088
34	Phosphorylation	FQGGREASGILKGFD ECCCHHHCHHHCCCH	22.93	27251275
38	Ubiquitination	REASGILKGFDPLLN HHHCHHHCCCHHHHH	56.46	-
38	Sumoylation	REASGILKGFDPLLN HHHCHHHCCCHHHHH	56.46	-
62	Phosphorylation	MRDPDDQYKLTEDTR ECCCCCCCCCCCCHH	18.24	27642862
63	Ubiquitination	RDPDDQYKLTEDTRQ CCCCCCCCCCCCHHH	43.21	-
85	Glutathionylation	GTSVVLICPQDGMEA CCEEEEECCCCCCCC	1.85	22555962
90	Sulfoxidation	LICPQDGMEAIPNPF EECCCCCCCCCCCHH	4.18	30846556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSM7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSM7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSM7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPY1R_HUMAN	NPY1R	physical	15231747
SMD3_HUMAN	SNRPD3	physical	15231747
MYH13_HUMAN	MYH13	physical	15231747
EXOS8_HUMAN	EXOSC8	physical	15231747
RAB7L_HUMAN	RAB29	physical	15231747
EXOS6_HUMAN	EXOSC6	physical	15231747
TACC1_HUMAN	TACC1	physical	12165861
WDR44_HUMAN	WDR44	physical	22939629
RFX5_HUMAN	RFX5	physical	22939629
ZBT8B_HUMAN	ZBTB8B	physical	22939629
SMD3_HUMAN	SNRPD3	physical	22365833
RUXF_HUMAN	SNRPF	physical	22365833
LSM2_HUMAN	LSM2	physical	22365833
LSM3_HUMAN	LSM3	physical	22365833
LSM4_HUMAN	LSM4	physical	22365833
LSM5_HUMAN	LSM5	physical	22365833
LSM6_HUMAN	LSM6	physical	22365833
RASF5_HUMAN	RASSF5	physical	21988832
PFKAM_HUMAN	PFKM	physical	21988832
SMD3_HUMAN	SNRPD3	physical	21988832
ZSC26_HUMAN	ZSCAN26	physical	21988832
LSM5_HUMAN	LSM5	physical	15231747
LSM4_HUMAN	LSM4	physical	15231747
LSM2_HUMAN	LSM2	physical	15231747
LSM3_HUMAN	LSM3	physical	15231747
LSM6_HUMAN	LSM6	physical	15231747
DDT4L_HUMAN	DDIT4L	physical	25416956
SMD1_HUMAN	SNRPD1	physical	26344197
RUXE_HUMAN	SNRPE	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.