RUXE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUXE_HUMAN
• UniProt AC: P62304
• Protein Name: Small nuclear ribonucleoprotein E
• Gene Name: SNRPE
• Organism: Homo sapiens (Human).
• Sequence Length: 92
• Subcellular Localization: Cytoplasm, cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
• Protein Description: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development..
• Protein Sequence: MAYRGQGQKVQKVMVQPINLIFRYLQNRSRIQVWLYEQVNMRIEGCIIGFDEYMNLVLDDAEEIHSKTKSRKQLGRIMLKGDNITLLQSVSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MAYRGQGQKVQ ----CCCCCCCCCCE	22.78	115367917
9	Methylation	AYRGQGQKVQKVMVQ CCCCCCCCCEEEEEE	54.15	116252477
9	Ubiquitination	AYRGQGQKVQKVMVQ CCCCCCCCCEEEEEE	54.15	23000965
12	Acetylation	GQGQKVQKVMVQPIN CCCCCCEEEEEEHHH	34.97	25825284
12	Ubiquitination	GQGQKVQKVMVQPIN CCCCCCEEEEEEHHH	34.97	23000965
12	Methylation	GQGQKVQKVMVQPIN CCCCCCEEEEEEHHH	34.97	76997627
12	2-Hydroxyisobutyrylation	GQGQKVQKVMVQPIN CCCCCCEEEEEEHHH	34.97	-
14	Sulfoxidation	GQKVQKVMVQPINLI CCCCEEEEEEHHHHH	2.74	21406390
54	Ubiquitination	IIGFDEYMNLVLDDA EEEHHHHHHHHHCCH	2.69	22053931
59	Ubiquitination	EYMNLVLDDAEEIHS HHHHHHHCCHHHHHH	45.66	22053931
65	Ubiquitination	LDDAEEIHSKTKSRK HCCHHHHHHHCCCHH	26.90	22053931
67	Ubiquitination	DAEEIHSKTKSRKQL CHHHHHHHCCCHHHH	45.90	21906983
68	Phosphorylation	AEEIHSKTKSRKQLG HHHHHHHCCCHHHHC	36.95	-
69	Ubiquitination	EEIHSKTKSRKQLGR HHHHHHCCCHHHHCC	52.58	-
72	Ubiquitination	HSKTKSRKQLGRIML HHHCCCHHHHCCEEE	57.89	21963094
78	Ubiquitination	RKQLGRIMLKGDNIT HHHHCCEEEECCCEE	2.81	21963094
80	Acetylation	QLGRIMLKGDNITLL HHCCEEEECCCEEEE	47.00	26051181
80	Ubiquitination	QLGRIMLKGDNITLL HHCCEEEECCCEEEE	47.00	21963094
85	Phosphorylation	MLKGDNITLLQSVSN EEECCCEEEEEECCC	27.89	21406692
89	Phosphorylation	DNITLLQSVSN---- CCEEEEEECCC----	27.73	21406692
91	Phosphorylation	ITLLQSVSN------ EEEEEECCC------	41.91	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUXE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUXE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUXE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUXF_HUMAN	SNRPF	physical	9417867
HS90A_HUMAN	HSP90AA1	physical	16322212
SMD1_HUMAN	SNRPD1	physical	22939629
SRRM1_HUMAN	SRRM1	physical	22939629
SNR40_HUMAN	SNRNP40	physical	22939629
TOP2B_HUMAN	TOP2B	physical	22939629
RUXF_HUMAN	SNRPF	physical	22365833
IL7RA_HUMAN	IL7R	physical	23151878
OLA1_HUMAN	OLA1	physical	22863883
MARE1_HUMAN	MAPRE1	physical	22863883
SMD2_HUMAN	SNRPD2	physical	22863883
1433Z_HUMAN	YWHAZ	physical	22863883
RSMN_HUMAN	SNRPN	physical	28514442
SF3A2_HUMAN	SF3A2	physical	28514442
CMTR2_HUMAN	CMTR2	physical	28514442
STPAP_HUMAN	TUT1	physical	28514442
NADAP_HUMAN	SLC4A1AP	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
U2AFM_HUMAN	ZRSR2	physical	28514442
RUXF_HUMAN	SNRPF	physical	28514442
U1SBP_HUMAN	SNRNP35	physical	28514442
SNR48_HUMAN	SNRNP48	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442
RBM40_HUMAN	RNPC3	physical	28514442
GPT11_HUMAN	GPATCH11	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
SNR27_HUMAN	SNRNP27	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
PDCD7_HUMAN	PDCD7	physical	28514442
AKA7A_HUMAN	AKAP7	physical	28514442
AKA7G_HUMAN	AKAP7	physical	28514442
LSM11_HUMAN	LSM11	physical	28514442
ICLN_HUMAN	CLNS1A	physical	28514442
AQR_HUMAN	AQR	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
PRPF3_HUMAN	PRPF3	physical	28514442
ZN830_HUMAN	ZNF830	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
DDX46_HUMAN	DDX46	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
PAXB1_HUMAN	PAXBP1	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
RSRC1_HUMAN	RSRC1	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
GCFC2_HUMAN	GCFC2	physical	28514442
HTSF1_HUMAN	HTATSF1	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
SF3B2_HUMAN	SF3B2	physical	28514442
GEMI8_HUMAN	GEMIN8	physical	28514442
TOE1_HUMAN	TOE1	physical	28514442
TGS1_HUMAN	TGS1	physical	28514442
EAPP_HUMAN	EAPP	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
DDX23_HUMAN	DDX23	physical	28514442
RU2B_HUMAN	SNRPB2	physical	28514442
SMD1_HUMAN	SNRPD1	physical	28514442
C19L1_HUMAN	CWF19L1	physical	28514442
RU2A_HUMAN	SNRPA1	physical	28514442
SPN1_HUMAN	SNUPN	physical	28514442
CCD84_HUMAN	CCDC84	physical	28514442
SART3_HUMAN	SART3	physical	28514442
CD2B2_HUMAN	CD2BP2	physical	28514442
GEMI5_HUMAN	GEMIN5	physical	28514442
MEPCE_HUMAN	MEPCE	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
ZGPAT_HUMAN	ZGPAT	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
TSSC4_HUMAN	TSSC4	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
GEMI2_HUMAN	GEMIN2	physical	28514442
GEMI4_HUMAN	GEMIN4	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
PRP6_HUMAN	PRPF6	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
SR140_HUMAN	U2SURP	physical	28514442
PRP8_HUMAN	PRPF8	physical	28514442
CHERP_HUMAN	CHERP	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
SNRPA_HUMAN	SNRPA	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
SF3B3_HUMAN	SF3B3	physical	28514442
DDX20_HUMAN	DDX20	physical	28514442
RSMB_HUMAN	SNRPB	physical	28514442
CDC5L_HUMAN	CDC5L	physical	28514442
SF3B4_HUMAN	SF3B4	physical	28514442
RBM42_HUMAN	RBM42	physical	28514442
SNUT1_HUMAN	SART1	physical	28514442
PRP4_HUMAN	PRPF4	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
LSM2_HUMAN	LSM2	physical	28514442
GEMI6_HUMAN	GEMIN6	physical	28514442
U5S1_HUMAN	EFTUD2	physical	28514442
ZMAT5_HUMAN	ZMAT5	physical	28514442
DDX42_HUMAN	DDX42	physical	28514442
SMD3_HUMAN	SNRPD3	physical	28514442
RBM5_HUMAN	RBM5	physical	28514442
SNR40_HUMAN	SNRNP40	physical	28514442
SF3B5_HUMAN	SF3B5	physical	28514442
RED_HUMAN	IK	physical	28514442
PRP31_HUMAN	PRPF31	physical	28514442
SF3B6_HUMAN	SF3B6	physical	28514442
PKRI1_HUMAN	PRKRIP1	physical	28514442
ANM5_HUMAN	PRMT5	physical	28514442
CDC37_HUMAN	CDC37	physical	16322212
HSP74_HUMAN	HSPA4	physical	16322212
RUXE_HUMAN	SNRPE	physical	17074813

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615059: Hypotrichosis 11 (HYPT11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.