LSM11_HUMAN - dbPTM
LSM11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LSM11_HUMAN
UniProt AC P83369
Protein Name U7 snRNA-associated Sm-like protein LSm11
Gene Name LSM11
Organism Homo sapiens (Human).
Sequence Length 360
Subcellular Localization Nucleus .
Protein Description Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA..
Protein Sequence MEERERGARSAGAGSPARPPSPRLDVSSDSFDPLLALYAPRLPPIPYPNAPCFNNVAEYESFLRTGVRGGGRGRGRARGAAAGSGVPAAPGPSGRTRRRPDAPAPDPERIQRLRRLMVAKEEGDGAAGAGRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKLASVWGRADTGRGSHKRSRSVPSSLQASAREESRSELSGRTTRTDGSSVGGTFSRATTLSRGQSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationERERGARSAGAGSPA
HHHHHHHCCCCCCCC		30.4423927012
15PhosphorylationARSAGAGSPARPPSP
HHCCCCCCCCCCCCC		18.1730266825
21PhosphorylationGSPARPPSPRLDVSS
CCCCCCCCCCCCCCC		25.9030266825
27PhosphorylationPSPRLDVSSDSFDPL
CCCCCCCCCCCCCHH		28.2628387310
28PhosphorylationSPRLDVSSDSFDPLL
CCCCCCCCCCCCHHH		36.8028387310
30PhosphorylationRLDVSSDSFDPLLAL
CCCCCCCCCCHHHHH		33.2324732914
38PhosphorylationFDPLLALYAPRLPPI
CCHHHHHHCCCCCCC		14.67-
41MethylationLLALYAPRLPPIPYP
HHHHHCCCCCCCCCC		52.21-
59PhosphorylationCFNNVAEYESFLRTG
CCCCHHHHHHHHHHC		13.72-
78MethylationGRGRGRARGAAAGSG
CCCCCCCCCCCCCCC		33.64115482347
84PhosphorylationARGAAAGSGVPAAPG
CCCCCCCCCCCCCCC		31.7124425749
93PhosphorylationVPAAPGPSGRTRRRP
CCCCCCCCCCCCCCC		46.9924425749
120SumoylationLRRLMVAKEEGDGAA
HHHHHHHHHCCCCCC		44.9128112733
120UbiquitinationLRRLMVAKEEGDGAA
HHHHHHHHHCCCCCC		44.91-
154PhosphorylationRMPLHEGSPLGELHR
CCCCCCCCCHHHHHH		17.6120873877
199PhosphorylationKFWNMALTDVDETYR
HHHHHHCCCCCHHHC		25.1627251275
204PhosphorylationALTDVDETYRKPVLG
HCCCCCHHHCCCCCC		24.9427251275
237UbiquitinationKLQDSSKKEADSKSA
CCCCCCCCCCCCCHH		61.1424816145
242UbiquitinationSKKEADSKSAVEDST
CCCCCCCCHHHCHHH		42.8729967540
263PhosphorylationTSTWKLASVWGRADT
CCCCHHHHHHCCCCC		28.9226434776
278PhosphorylationGRGSHKRSRSVPSSL
CCCCCCCCCCCCCHH		33.4423927012
279MethylationRGSHKRSRSVPSSLQ
CCCCCCCCCCCCHHH		45.7824391393
280PhosphorylationGSHKRSRSVPSSLQA
CCCCCCCCCCCHHHH		39.3623927012
283PhosphorylationKRSRSVPSSLQASAR
CCCCCCCCHHHHHHH		41.3428450419
284PhosphorylationRSRSVPSSLQASARE
CCCCCCCHHHHHHHH		20.5930576142
288PhosphorylationVPSSLQASAREESRS
CCCHHHHHHHHHHHH		18.2026434776
304PhosphorylationLSGRTTRTDGSSVGG
HCCCEECCCCCCCCC		42.4918767875
307PhosphorylationRTTRTDGSSVGGTFS
CEECCCCCCCCCCCC		25.3518767875
308PhosphorylationTTRTDGSSVGGTFSR
EECCCCCCCCCCCCC		30.2518767875
312PhosphorylationDGSSVGGTFSRATTL
CCCCCCCCCCCCCCC		16.7118767875
315MethylationSVGGTFSRATTLSRG
CCCCCCCCCCCCCCC		31.59115482355
320PhosphorylationFSRATTLSRGQSRKK
CCCCCCCCCCCCCCC		32.07-
321MethylationSRATTLSRGQSRKKK
CCCCCCCCCCCCCCC		50.7380701201
335PhosphorylationKRKPKVDYQQVFTRH
CCCCCCCHHHHHHHH		12.1127642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LSM11_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LSM11_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LSM11_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN473_HUMANZNF473physical
12975319
ANM5_HUMANPRMT5physical
16087681
MEP50_HUMANWDR77physical
16087681
ICLN_HUMANCLNS1Aphysical
16087681
TAF5L_HUMANTAF5Lphysical
22939629
TOP3A_HUMANTOP3Aphysical
22939629
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LSM11_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-21, AND MASSSPECTROMETRY.

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