dbPTM

DDX46_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX46_HUMAN
UniProt AC	Q7L014
Protein Name	Probable ATP-dependent RNA helicase DDX46
Gene Name	DDX46
Organism	Homo sapiens (Human).
Sequence Length	1031
Subcellular Localization	Nucleus speckle . Nucleus, Cajal body . Membrane Lipid-anchor . Present in Cajal bodies (CBs) and nuclear speckles.
Protein Description	Plays an essential role in splicing, either prior to, or during splicing A complex formation..
Protein Sequence	MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYKVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGRESRHYR ------CCCCCHHHH	54.06	25255805
18	Phosphorylation	RSASRGRSGSRSRSR HHHCCCCCCCCCCCC	43.90	21601212
20	Phosphorylation	ASRGRSGSRSRSRSP HCCCCCCCCCCCCCC	28.47	21601212
22	Phosphorylation	RGRSGSRSRSRSPSD CCCCCCCCCCCCCCH	35.98	24144214
24	Phosphorylation	RSGSRSRSRSPSDKR CCCCCCCCCCCCHHH	38.05	27794612
26	Phosphorylation	GSRSRSRSPSDKRSK CCCCCCCCCCHHHCC	29.96	27794612
28	Phosphorylation	RSRSRSPSDKRSKRG CCCCCCCCHHHCCCC	57.94	22496350
40	Phosphorylation	KRGDDRRSRSRDRDR CCCCCHHHHHHHHHH	35.19	20068231
42	Phosphorylation	GDDRRSRSRDRDRRR CCCHHHHHHHHHHHH	39.52	20068231
52	Phosphorylation	RDRRRERSRSRDKRR HHHHHHHHHHHHHHH	29.83	20068231
54	Phosphorylation	RRRERSRSRDKRRSR HHHHHHHHHHHHHHH	46.18	20068231
60	Phosphorylation	RSRDKRRSRSRDRKR HHHHHHHHHHHHHHH	38.34	20068231
62	Phosphorylation	RDKRRSRSRDRKRLR HHHHHHHHHHHHHHH	39.52	20068231
71	Phosphorylation	DRKRLRRSRSRERDR HHHHHHHHHHHHHHH	28.33	24719451
73	Phosphorylation	KRLRRSRSRERDRSR HHHHHHHHHHHHHHH	39.48	20068231
79	Phosphorylation	RSRERDRSRERRRSR HHHHHHHHHHHHHHH	42.66	30576142
85	Phosphorylation	RSRERRRSRSRDRRR HHHHHHHHHHHHHHH	32.56	20068231
87	Phosphorylation	RERRRSRSRDRRRSR HHHHHHHHHHHHHHH	39.52	20068231
95	Phosphorylation	RDRRRSRSRSRGRRS HHHHHHHHHHHCCCC	35.54	-
102	Phosphorylation	SRSRGRRSRSSSPGN HHHHCCCCCCCCCCC	34.84	30576142
104	Phosphorylation	SRGRRSRSSSPGNKS HHCCCCCCCCCCCCC	36.09	20068231
105	Phosphorylation	RGRRSRSSSPGNKSK HCCCCCCCCCCCCCC	39.17	30576142
106	Phosphorylation	GRRSRSSSPGNKSKK CCCCCCCCCCCCCCC	37.77	28176443
113	Methylation	SPGNKSKKTENRSRS CCCCCCCCCCCCCCC	69.07	23748837
118	Phosphorylation	SKKTENRSRSKEKTD CCCCCCCCCCCCCCC	53.11	24719451
120	Phosphorylation	KTENRSRSKEKTDGG CCCCCCCCCCCCCCC	46.54	25072903
124	Phosphorylation	RSRSKEKTDGGESSK CCCCCCCCCCCCCCC	40.75	25072903
129	Phosphorylation	EKTDGGESSKEKKKD CCCCCCCCCCHHCCC	50.41	25072903
130	Phosphorylation	KTDGGESSKEKKKDK CCCCCCCCCHHCCCC	40.30	28985074
155	Ubiquitination	AGNFDQNKLEEEMRK CCCCCHHHHHHHHHH	52.20	-
160	Sulfoxidation	QNKLEEEMRKRKERV HHHHHHHHHHHHHHH	7.47	21406390
179	Sulfoxidation	EEQRKKAMENIGELK HHHHHHHHHHHHHHH	5.79	21406390
186	Sumoylation	MENIGELKKEIEEMK HHHHHHHHHHHHHHH	44.02	-
186	Sumoylation	MENIGELKKEIEEMK HHHHHHHHHHHHHHH	44.02	28112733
197	Ubiquitination	EEMKQGKKWSLEDDD HHHHCCCCCCCCCCC	49.17	-
199	Phosphorylation	MKQGKKWSLEDDDDD HHCCCCCCCCCCCCC	30.66	25159151
246	Phosphorylation	VKKFNMRSVKGGGGN HHHHCCCCCCCCCCC	19.88	26074081
262	Phosphorylation	KKSGPTVTKVVTVVT CCCCCEEEEEEEEEE	22.17	21601212
263	Acetylation	KSGPTVTKVVTVVTT CCCCEEEEEEEEEEE	30.30	19608861
266	Phosphorylation	PTVTKVVTVVTTKKA CEEEEEEEEEEECEE	16.55	21601212
271	Acetylation	VVTVVTTKKAVVDSD EEEEEEECEEEECCC	29.39	25953088
271	Ubiquitination	VVTVVTTKKAVVDSD EEEEEEECEEEECCC	29.39	-
272	Ubiquitination	VTVVTTKKAVVDSDK EEEEEECEEEECCCH	44.30	-
277	Phosphorylation	TKKAVVDSDKKKGEL ECEEEECCCHHHCCC	39.45	21815630
279	2-Hydroxyisobutyrylation	KAVVDSDKKKGELME EEEECCCHHHCCCCC	61.41	-
279	Acetylation	KAVVDSDKKKGELME EEEECCCHHHCCCCC	61.41	23749302
280	Acetylation	AVVDSDKKKGELMEN EEECCCHHHCCCCCC	71.63	30583755
294	Phosphorylation	NDQDAMEYSSEEEEV CCHHHHHCCCHHHHH	12.38	21712546
295	Phosphorylation	DQDAMEYSSEEEEVD CHHHHHCCCHHHHHH	20.26	18388127
296	Phosphorylation	QDAMEYSSEEEEVDL HHHHHCCCHHHHHHH	48.39	18388127
305	Phosphorylation	EEEVDLQTALTGYQT HHHHHHHHHHHHHHH	30.82	23898821
308	Phosphorylation	VDLQTALTGYQTKQR HHHHHHHHHHHHHHC	31.23	20068231
310	Phosphorylation	LQTALTGYQTKQRKL HHHHHHHHHHHHCCC	14.05	20363803
312	Phosphorylation	TALTGYQTKQRKLLE HHHHHHHHHHCCCCC	22.21	20068231
316	Ubiquitination	GYQTKQRKLLEPVDH HHHHHHCCCCCCCCC	55.73	-
325	2-Hydroxyisobutyrylation	LEPVDHGKIEYEPFR CCCCCCCCCCEECCC	29.01	-
325	Acetylation	LEPVDHGKIEYEPFR CCCCCCCCCCEECCC	29.01	26051181
325	Sumoylation	LEPVDHGKIEYEPFR CCCCCCCCCCEECCC	29.01	28112733
325	Ubiquitination	LEPVDHGKIEYEPFR CCCCCCCCCCEECCC	29.01	-
328	Phosphorylation	VDHGKIEYEPFRKNF CCCCCCCEECCCCCE	32.16	21406692
333	Ubiquitination	IEYEPFRKNFYVEVP CCEECCCCCEEEEHH	52.35	-
336	Phosphorylation	EPFRKNFYVEVPELA ECCCCCEEEEHHHHH	12.70	29083192
345	Sulfoxidation	EVPELAKMSQEEVNV EHHHHHHCCHHHHCE	4.09	21406390
346	Phosphorylation	VPELAKMSQEEVNVF HHHHHHCCHHHHCEE	33.46	25849741
357	Sulfoxidation	VNVFRLEMEGITVKG HCEEEEEEECEEECC	7.28	21406390
361	Phosphorylation	RLEMEGITVKGKGCP EEEEECEEECCCCCC	27.33	20068231
363	Acetylation	EMEGITVKGKGCPKP EEECEEECCCCCCCC	46.37	25953088
365	Acetylation	EGITVKGKGCPKPIK ECEEECCCCCCCCCH	52.18	25953088
382	Acetylation	VQCGISMKILNSLKK HHCCHHHHHHHHHHH	36.93	26051181
386	Phosphorylation	ISMKILNSLKKHGYE HHHHHHHHHHHCCCC	37.81	25599653
388	2-Hydroxyisobutyrylation	MKILNSLKKHGYEKP HHHHHHHHHCCCCCC	42.41	-
388	Acetylation	MKILNSLKKHGYEKP HHHHHHHHHCCCCCC	42.41	25953088
388	Ubiquitination	MKILNSLKKHGYEKP HHHHHHHHHCCCCCC	42.41	-
389	Methylation	KILNSLKKHGYEKPT HHHHHHHHCCCCCCC	47.78	23748837
392	Phosphorylation	NSLKKHGYEKPTPIQ HHHHHCCCCCCCCCC	22.09	21406692
394	Acetylation	LKKHGYEKPTPIQTQ HHHCCCCCCCCCCCC	45.79	26051181
396	Phosphorylation	KHGYEKPTPIQTQAI HCCCCCCCCCCCCHH	44.05	21406692
400	Phosphorylation	EKPTPIQTQAIPAIM CCCCCCCCCHHCHHH	22.23	21406692
408	Phosphorylation	QAIPAIMSGRDLIGI CHHCHHHCCCCEEEE	25.27	21406692
417	Acetylation	RDLIGIAKTGSGKTI CCEEEEEECCCCHHH	52.04	25953088
417	Ubiquitination	RDLIGIAKTGSGKTI CCEEEEEECCCCHHH	52.04	-
422	Ubiquitination	IAKTGSGKTIAFLLP EEECCCCHHHHHHHH	38.15	-
439	Phosphorylation	RHIMDQRSLEEGEGP HHHHHHHHHHCCCCC	34.20	-
452	Phosphorylation	GPIAVIMTPTRELAL CCEEEEECCCHHHHH	15.47	-
454	Phosphorylation	IAVIMTPTRELALQI EEEEECCCHHHHHHH	27.84	-
462	Phosphorylation	RELALQITKECKKFS HHHHHHHHHHHHHHH	14.08	-
463	Acetylation	ELALQITKECKKFSK HHHHHHHHHHHHHHC	63.84	26051181
470	Acetylation	KECKKFSKTLGLRVV HHHHHHHCHHCCEEE	51.40	26051181
480	Phosphorylation	GLRVVCVYGGTGISE CCEEEEEECCCCHHH	12.52	28152594
483	Phosphorylation	VVCVYGGTGISEQIA EEEEECCCCHHHHHH	27.29	28152594
493	Acetylation	SEQIAELKRGAEIIV HHHHHHHHCCCEEEE	40.05	25953088
493	Ubiquitination	SEQIAELKRGAEIIV HHHHHHHHCCCEEEE	40.05	-
524	Phosphorylation	VTNLRRVTYVVLDEA CCCCCEEEEEEEECH	14.59	-
525	Phosphorylation	TNLRRVTYVVLDEAD CCCCEEEEEEEECHH	5.91	28787133
551	Methylation	MRIVDNVRPDRQTVM HHHHHCCCCCCCEEE	33.39	-
554	Methylation	VDNVRPDRQTVMFSA HHCCCCCCCEEEEEE	36.43	-
556	Phosphorylation	NVRPDRQTVMFSATF CCCCCCCEEEEEECH	18.16	24043423
560	Phosphorylation	DRQTVMFSATFPRAM CCCEEEEEECHHHHH	14.33	24043423
562	Phosphorylation	QTVMFSATFPRAMEA CEEEEEECHHHHHHH	32.73	24043423
576	Phosphorylation	ALARRILSKPIEVQV HHHHHHHCCCEEEEE	33.73	-
577	Acetylation	LARRILSKPIEVQVG HHHHHHCCCEEEEEC	46.71	26051181
577	Malonylation	LARRILSKPIEVQVG HHHHHHCCCEEEEEC	46.71	30639696
577	Ubiquitination	LARRILSKPIEVQVG HHHHHHCCCEEEEEC	46.71	-
591	Phosphorylation	GGRSVVCSDVEQQVI CCEEEECCCCCCEEE	32.83	-
604	Acetylation	VIVIEEEKKFLKLLE EEEEEHHHHHHHHHH	52.70	26051181
616	Phosphorylation	LLELLGHYQESGSVI HHHHHCCCCCCCCEE	16.51	22167270
619	Phosphorylation	LLGHYQESGSVIIFV HHCCCCCCCCEEEEE	22.35	22167270
621	Phosphorylation	GHYQESGSVIIFVDK CCCCCCCCEEEEECC	21.30	22167270
637	Ubiquitination	EHADGLLKDLMRASY HCCCHHHHHHHHHCC	54.59	-
643	Phosphorylation	LKDLMRASYPCMSLH HHHHHHHCCCHHHCC	21.17	26126808
644	Phosphorylation	KDLMRASYPCMSLHG HHHHHHCCCHHHCCC	10.24	26126808
656	Phosphorylation	LHGGIDQYDRDSIIN CCCCCCCCCHHHHHH	14.81	24719451
660	Phosphorylation	IDQYDRDSIINDFKN CCCCCHHHHHHHCCC	26.68	23532336
666	Acetylation	DSIINDFKNGTCKLL HHHHHHCCCCCEEEE	58.28	26051181
669	Phosphorylation	INDFKNGTCKLLVAT HHHCCCCCEEEEEEH	18.83	-
677	O-linked_Glycosylation	CKLLVATSVAARGLD EEEEEEHHHHHCCCC	10.46	30059200
710	Phosphorylation	YVHRAGRTGRAGNKG HHHHCCCCCCCCCCC	30.06	21406692
716	Ubiquitination	RTGRAGNKGYAYTFI CCCCCCCCCEEEEEE	52.99	-
718	Phosphorylation	GRAGNKGYAYTFITE CCCCCCCEEEEEEEH	9.69	28152594
720	Phosphorylation	AGNKGYAYTFITEDQ CCCCCEEEEEEEHHH	8.16	21406692
721	Phosphorylation	GNKGYAYTFITEDQA CCCCEEEEEEEHHHH	10.61	28152594
724	Phosphorylation	GYAYTFITEDQARYA CEEEEEEEHHHHHHH	29.35	21406692
730	Phosphorylation	ITEDQARYAGDIIKA EEHHHHHHHHHHHHH	20.25	24719451
736	Ubiquitination	RYAGDIIKALELSGT HHHHHHHHHHHHCCC	47.45	-
741	Phosphorylation	IIKALELSGTAVPPD HHHHHHHCCCCCCCC	25.40	28348404
743	Phosphorylation	KALELSGTAVPPDLE HHHHHCCCCCCCCHH	22.55	28348404
757	Acetylation	EKLWSDFKDQQKAEG HHHHHHHHHHHHHHC	60.67	25953088
757	Ubiquitination	EKLWSDFKDQQKAEG HHHHHHHHHHHHHHC	60.67	-
765	Ubiquitination	DQQKAEGKIIKKSSG HHHHHHCCEEECCCC	32.53	-
768	Acetylation	KAEGKIIKKSSGFSG HHHCCEEECCCCCCC	50.50	18527865
770	Phosphorylation	EGKIIKKSSGFSGKG HCCEEECCCCCCCCC	30.59	28985074
771	Phosphorylation	GKIIKKSSGFSGKGF CCEEECCCCCCCCCC	53.38	26546556
774	Phosphorylation	IKKSSGFSGKGFKFD EECCCCCCCCCCCCC	43.02	26546556
776	Acetylation	KSSGFSGKGFKFDET CCCCCCCCCCCCCHH	61.04	19608861
776	Ubiquitination	KSSGFSGKGFKFDET CCCCCCCCCCCCCHH	61.04	19608861
779	Sumoylation	GFSGKGFKFDETEQA CCCCCCCCCCHHHHH	61.65	-
779	Acetylation	GFSGKGFKFDETEQA CCCCCCCCCCHHHHH	61.65	23954790
779	Sumoylation	GFSGKGFKFDETEQA CCCCCCCCCCHHHHH	61.65	28112733
779	Ubiquitination	GFSGKGFKFDETEQA CCCCCCCCCCHHHHH	61.65	-
783	Phosphorylation	KGFKFDETEQALANE CCCCCCHHHHHHHHH	34.93	25159151
792	Ubiquitination	QALANERKKLQKAAL HHHHHHHHHHHHHHH	52.21	-
804	Phosphorylation	AALGLQDSDDEDAAV HHHCCCCCCCHHHCC	33.72	29255136
819	Phosphorylation	DIDEQIESMFNSKKR CHHHHHHHHHCCCHH	30.24	28176443
823	Phosphorylation	QIESMFNSKKRVKDM HHHHHHCCCHHHHHC	28.43	23403867
830	Sulfoxidation	SKKRVKDMAAPGTSS CCHHHHHCCCCCCCC	2.58	21406390
835	Phosphorylation	KDMAAPGTSSVPAPT HHCCCCCCCCCCCCC	19.44	28348404
836	Phosphorylation	DMAAPGTSSVPAPTA HCCCCCCCCCCCCCC	34.94	28348404
837	Phosphorylation	MAAPGTSSVPAPTAG CCCCCCCCCCCCCCC	31.77	28348404
848	Acetylation	PTAGNAEKLEIAKRL CCCCCHHHHHHHHHH	49.35	23954790
848	Ubiquitination	PTAGNAEKLEIAKRL CCCCCHHHHHHHHHH	49.35	19608861
853	Ubiquitination	AEKLEIAKRLALRIN HHHHHHHHHHHHHHH	54.31	-
869	Phosphorylation	QKNLGIESQDVMQQA HHHCCCCCHHHHHHH	29.75	24532841
882	Methylation	QATNAILRGGTILAP HHHHHHHCCCCEECC	35.07	-
883	Methylation	ATNAILRGGTILAPT HHHHHHCCCCEECCC	33.86	-
885	Phosphorylation	NAILRGGTILAPTVS HHHHCCCCEECCCCC	18.68	28555341
890	Phosphorylation	GGTILAPTVSAKTIA CCCEECCCCCHHHHH	22.83	25159151
892	Phosphorylation	TILAPTVSAKTIAEQ CEECCCCCHHHHHHH	26.90	25159151
893	Phosphorylation	ILAPTVSAKTIAEQL EECCCCCHHHHHHHH	14.52	-
894	2-Hydroxyisobutyrylation	LAPTVSAKTIAEQLA ECCCCCHHHHHHHHH	32.72	-
894	Acetylation	LAPTVSAKTIAEQLA ECCCCCHHHHHHHHH	32.72	25953088
894	Ubiquitination	LAPTVSAKTIAEQLA ECCCCCHHHHHHHHH	32.72	21906983
895	Phosphorylation	APTVSAKTIAEQLAE CCCCCHHHHHHHHHH	25.74	21406692
895	Ubiquitination	APTVSAKTIAEQLAE CCCCCHHHHHHHHHH	25.74	21890473
896	Phosphorylation	PTVSAKTIAEQLAEK CCCCHHHHHHHHHHH	3.81	-
903	Acetylation	IAEQLAEKINAKLNY HHHHHHHHHHHHHCC	35.34	25953088
903	Ubiquitination	IAEQLAEKINAKLNY HHHHHHHHHHHHHCC	35.34	21890473
904	Acetylation	AEQLAEKINAKLNYV HHHHHHHHHHHHCCC	4.57	-
904	Ubiquitination	AEQLAEKINAKLNYV HHHHHHHHHHHHCCC	4.57	-
907	Acetylation	LAEKINAKLNYVPLE HHHHHHHHHCCCCHH	32.55	20167786
907	Sumoylation	LAEKINAKLNYVPLE HHHHHHHHHCCCCHH	32.55	28112733
907	Ubiquitination	LAEKINAKLNYVPLE HHHHHHHHHCCCCHH	32.55	21906983
908	Acetylation	AEKINAKLNYVPLEK HHHHHHHHCCCCHHH	5.34	-
908	Ubiquitination	AEKINAKLNYVPLEK HHHHHHHHCCCCHHH	5.34	21890473
910	Phosphorylation	KINAKLNYVPLEKQE HHHHHHCCCCHHHHH	17.55	28796482
911	Phosphorylation	INAKLNYVPLEKQEE HHHHHCCCCHHHHHH	4.19	-
915	Acetylation	LNYVPLEKQEEERQD HCCCCHHHHHHHHCC	71.36	20167786
915	Sumoylation	LNYVPLEKQEEERQD HCCCCHHHHHHHHCC	71.36	28112733
916	Acetylation	NYVPLEKQEEERQDG CCCCHHHHHHHHCCC	54.69	-
916	Ubiquitination	NYVPLEKQEEERQDG CCCCHHHHHHHHCCC	54.69	-
928	Phosphorylation	QDGGQNESFKRYEEE CCCCCCHHHHHHHHH	43.55	29255136
929	Phosphorylation	DGGQNESFKRYEEEL CCCCCHHHHHHHHHH	4.21	20068231
930	Acetylation	GGQNESFKRYEEELE CCCCHHHHHHHHHHC	64.45	20167786
931	Acetylation	GQNESFKRYEEELEI CCCHHHHHHHHHHCC	41.93	-
931	Ubiquitination	GQNESFKRYEEELEI CCCHHHHHHHHHHCC	41.93	-
932	Phosphorylation	QNESFKRYEEELEIN CCHHHHHHHHHHCCC	28.43	28122231
933	Phosphorylation	NESFKRYEEELEIND CHHHHHHHHHHCCCC	49.37	-
944	Phosphorylation	EINDFPQTARWKVTS CCCCCCCCCCEEECC	20.59	-
945	Phosphorylation	INDFPQTARWKVTSK CCCCCCCCCEEECCH	15.30	-
952	Ubiquitination	ARWKVTSKEALQRIS CCEEECCHHHHHHHH	37.33	-
953	Ubiquitination	RWKVTSKEALQRISE CEEECCHHHHHHHHH	55.14	-
959	Phosphorylation	KEALQRISEYSEAAI HHHHHHHHHHHCCEE	32.44	25072903
961	Phosphorylation	ALQRISEYSEAAITI HHHHHHHHHCCEEEE	12.67	25072903
962	Phosphorylation	LQRISEYSEAAITIR HHHHHHHHCCEEEEE	19.39	25072903
967	Phosphorylation	EYSEAAITIRGTYFP HHHCCEEEEECCCCC	10.41	25072903
971	Phosphorylation	AAITIRGTYFPPGKE CEEEEECCCCCCCCC	16.49	25072903
972	Phosphorylation	AITIRGTYFPPGKEP EEEEECCCCCCCCCC	19.53	25072903
1006	Phosphorylation	QKAKAEITRLIKEEL HHHHHHHHHHHHHHH	15.78	21406692
1007	Phosphorylation	KAKAEITRLIKEELI HHHHHHHHHHHHHHH	39.82	-
1010	2-Hydroxyisobutyrylation	AEITRLIKEELIRLQ HHHHHHHHHHHHHHH	50.13	-
1010	Acetylation	AEITRLIKEELIRLQ HHHHHHHHHHHHHHH	50.13	26051181
1010	Ubiquitination	AEITRLIKEELIRLQ HHHHHHHHHHHHHHH	50.13	21890473
1011	Ubiquitination	EITRLIKEELIRLQN HHHHHHHHHHHHHHH	51.55	-
1019	Phosphorylation	ELIRLQNSYQPTNKG HHHHHHHCCCCCCCC	16.51	28152594
1020	Nitration	LIRLQNSYQPTNKGR HHHHHHCCCCCCCCC	26.51	-
1020	Phosphorylation	LIRLQNSYQPTNKGR HHHHHHCCCCCCCCC	26.51	28152594
1023	Phosphorylation	LQNSYQPTNKGRYKV HHHCCCCCCCCCCCC	33.75	28152594
1025	Acetylation	NSYQPTNKGRYKVL- HCCCCCCCCCCCCC-	47.44	25953088
1025	Ubiquitination	NSYQPTNKGRYKVL- HCCCCCCCCCCCCC-	47.44	-
1026	Ubiquitination	SYQPTNKGRYKVL-- CCCCCCCCCCCCC--	39.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX46_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX46_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX46_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRS11_HUMAN	SRSF11	physical	22939629
SF3A3_HUMAN	SF3A3	physical	22939629
SIM20_HUMAN	SMIM20	physical	22939629
GEMI5_HUMAN	GEMIN5	physical	22939629
LIPR2_HUMAN	PNLIPRP2	physical	22939629
TPM2_HUMAN	TPM2	physical	22939629
SRPK2_HUMAN	SRPK2	physical	22365833
PPIA_HUMAN	PPIA	physical	26344197
SF3A3_HUMAN	SF3A3	physical	26344197
SIN3A_HUMAN	SIN3A	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX46_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-263 AND LYS-776, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-294; SER-295; SER-296;THR-305 AND SER-804, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-804, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-294; SER-295; SER-296AND SER-804, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-79; SER-295;SER-296 AND SER-804, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-804, AND MASSSPECTROMETRY.	15302935 [Abstract]