dbPTM

SRPK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRPK2_HUMAN
UniProt AC	P78362
Protein Name	SRSF protein kinase 2
Gene Name	SRPK2 {ECO:0000312\|EMBL:AAH68547.1}
Organism	Homo sapiens (Human).
Sequence Length	688
Subcellular Localization	Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.
Protein Description	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles..
Protein Sequence	MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVNSEKSS ------CCCCCCCCC	29.97	23663014
5	Phosphorylation	---MSVNSEKSSSSE ---CCCCCCCCCCCC	44.22	23663014
8	Phosphorylation	MSVNSEKSSSSERPE CCCCCCCCCCCCCCC	31.25	23663014
9	Phosphorylation	SVNSEKSSSSERPEP CCCCCCCCCCCCCCC	49.29	23663014
10	Phosphorylation	VNSEKSSSSERPEPQ CCCCCCCCCCCCCCC	43.22	23401153
11	Phosphorylation	NSEKSSSSERPEPQQ CCCCCCCCCCCCCCC	39.30	23663014
41	Phosphorylation	PPPLPDPTPPEPEEE CCCCCCCCCCCCHHH	59.88	28464451
52	Phosphorylation	PEEEILGSDDEEQED CHHHCCCCCCCCCCC	38.14	20363803
63	Phosphorylation	EQEDPADYCKGGYHP CCCCHHHHCCCCCCC	9.73	20873877
110	Acetylation	GKRFVAMKVVKSAQH CCEEEEEEHHHHCHH	33.85	25953088
110	Ubiquitination	GKRFVAMKVVKSAQH CCEEEEEEHHHHCHH	33.85	-
127	Acetylation	ETALDEIKLLKCVRE HHHHHHHHHHHHHHC	45.80	26051181
127	Ubiquitination	ETALDEIKLLKCVRE HHHHHHHHHHHHHHC	45.80	-
129	Phosphorylation	ALDEIKLLKCVRESD HHHHHHHHHHHHCCC	3.25	27642862
130	Ubiquitination	LDEIKLLKCVRESDP HHHHHHHHHHHCCCC	40.91	-
179	Ubiquitination	HLLKWIIKSNYQGLP HHHHHHHHCCCCCCC	24.42	21890473
180	Phosphorylation	LLKWIIKSNYQGLPV HHHHHHHCCCCCCCH	30.29	28796482
182	Phosphorylation	KWIIKSNYQGLPVRC HHHHHCCCCCCCHHH	15.85	28796482
190	Ubiquitination	QGLPVRCVKSIIRQV CCCCHHHHHHHHHHH	3.69	21890473
203	Phosphorylation	QVLQGLDYLHSKCKI HHHHHHHHHHHCCEE	16.03	26074081
206	Phosphorylation	QGLDYLHSKCKIIHT HHHHHHHHCCEEEEC	36.83	26074081
209	Ubiquitination	DYLHSKCKIIHTDIK HHHHHCCEEEECCCC	48.72	-
213	Phosphorylation	SKCKIIHTDIKPENI HCCEEEECCCCHHHE	29.07	26074081
216	Ubiquitination	KIIHTDIKPENILMC EEEECCCCHHHEEEE	49.44	-
228	Phosphorylation	LMCVDDAYVRRMAAE EEEECHHHHHHHHHH	11.07	26074081
237	Phosphorylation	RRMAAEATEWQKAGA HHHHHHHHHHHHCCC	29.30	22210691
241	Ubiquitination	AEATEWQKAGAPPPS HHHHHHHHCCCCCCC	50.27	-
248	Phosphorylation	KAGAPPPSGSAVSTA HCCCCCCCCCCCCCC	51.67	25159151
250	Phosphorylation	GAPPPSGSAVSTAPQ CCCCCCCCCCCCCCC	29.81	25159151
253	Phosphorylation	PPSGSAVSTAPQQKP CCCCCCCCCCCCCCC	20.68	28555341
254	Phosphorylation	PSGSAVSTAPQQKPI CCCCCCCCCCCCCCC	35.44	28555341
259	Phosphorylation	VSTAPQQKPIGKISK CCCCCCCCCCCCCCH	33.10	27251275
285	Ubiquitination	RQAELLEKRLQEIEE HHHHHHHHHHHHHHH	59.38	-
300	Ubiquitination	LEREAERKIIEENIT HHHHHHHHHHHHHCC	39.27	-
307	Phosphorylation	KIIEENITSAAPSND HHHHHHCCCCCCCCC	24.72	29978859
308	Phosphorylation	IIEENITSAAPSNDQ HHHHHCCCCCCCCCC	20.73	29978859
312	Phosphorylation	NITSAAPSNDQDGEY HCCCCCCCCCCCCCC	48.59	29978859
319	Phosphorylation	SNDQDGEYCPEVKLK CCCCCCCCCCCCEEE	20.87	28796482
324	Acetylation	GEYCPEVKLKTTGLE CCCCCCCEEEECCHH	42.47	26051181
326	Ubiquitination	YCPEVKLKTTGLEEA CCCCCEEEECCHHHH	38.02	-
327	Phosphorylation	CPEVKLKTTGLEEAA CCCCEEEECCHHHHH	36.21	28555341
328	Phosphorylation	PEVKLKTTGLEEAAE CCCEEEECCHHHHHH	37.88	21815630
330	Phosphorylation	VKLKTTGLEEAAEAE CEEEECCHHHHHHHH	5.16	27642862
376	Phosphorylation	ELANIDPTWIESPKT HHHCCCCCEECCCCC	35.01	22496350
380	Phosphorylation	IDPTWIESPKTNGHI CCCCEECCCCCCCCC	23.67	25159151
383	Phosphorylation	TWIESPKTNGHIENG CEECCCCCCCCCCCC	50.22	26074081
391	Phosphorylation	NGHIENGPFSLEQQL CCCCCCCCCCHHHCC	27.51	27251275
393	Phosphorylation	HIENGPFSLEQQLDD CCCCCCCCHHHCCCC	33.84	26074081
423	Phosphorylation	LDEPNAESDYTYSSS CCCCCCCCCCCCCCC	33.24	-
427	Phosphorylation	NAESDYTYSSSYEQF CCCCCCCCCCCHHHH	10.59	-
448	Phosphorylation	GRHKIPESQFPEFST CCCCCCHHHCCCCCC	31.59	28985074
469	Phosphorylation	LEPVACGSVLSEGSP CCCEECCCCCCCCCC	21.55	28348404
472	Phosphorylation	VACGSVLSEGSPLTE EECCCCCCCCCCCCC	37.44	25921289
475	Phosphorylation	GSVLSEGSPLTEQEE CCCCCCCCCCCCCCC	16.82	25921289
478	Phosphorylation	LSEGSPLTEQEESSP CCCCCCCCCCCCCCC	38.72	25921289
483	Phosphorylation	PLTEQEESSPSHDRS CCCCCCCCCCCCCCC	46.96	26657352
484	Phosphorylation	LTEQEESSPSHDRSR CCCCCCCCCCCCCCC	33.43	28464451
486	Phosphorylation	EQEESSPSHDRSRTV CCCCCCCCCCCCCCC	39.71	22210691
490	Phosphorylation	SSPSHDRSRTVSASS CCCCCCCCCCCCHHH	38.06	23663014
492	Phosphorylation	PSHDRSRTVSASSTG CCCCCCCCCCHHHCC	21.76	25463755
494	Phosphorylation	HDRSRTVSASSTGDL CCCCCCCCHHHCCCC	23.09	29255136
495	Phosphorylation	DRSRTVSASSTGDLP CCCCCCCHHHCCCCC	11.81	27251275
496	Phosphorylation	RSRTVSASSTGDLPK CCCCCCHHHCCCCCH	22.41	29255136
497	Phosphorylation	SRTVSASSTGDLPKA CCCCCHHHCCCCCHH	35.81	29255136
498	Phosphorylation	RTVSASSTGDLPKAK CCCCHHHCCCCCHHH	32.02	29255136
503	Ubiquitination	SSTGDLPKAKTRAAD HHCCCCCHHHHHHHH	70.57	-
505	Phosphorylation	TGDLPKAKTRAADLL CCCCCHHHHHHHHHC	44.67	27251275
508	Phosphorylation	LPKAKTRAADLLVNP CCHHHHHHHHHCCCC	15.57	27251275
509	Phosphorylation	PKAKTRAADLLVNPL CHHHHHHHHHCCCCC	12.51	27251275
527	Ubiquitination	NADKIRVKIADLGNA CCCCEEEEEHHHCCC	23.48	-
539	Acetylation	GNACWVHKHFTEDIQ CCCEEEEHHHCCCHH	30.69	25825284
539	Ubiquitination	GNACWVHKHFTEDIQ CCCEEEEHHHCCCHH	30.69	-
542	Phosphorylation	CWVHKHFTEDIQTRQ EEEEHHHCCCHHHCC	32.25	23403867
547	Phosphorylation	HFTEDIQTRQYRSIE HHCCCHHHCCCEEEE	21.77	29255136
548	Methylation	FTEDIQTRQYRSIEV HCCCHHHCCCEEEEE	18.37	-
588	Phosphorylation	DYLFEPHSGEDYSRD CCCCCCCCCCCCCCC	55.37	-
608	Phosphorylation	HIIELLGSIPRHFAL HHHHHHCCCCHHHHH	29.41	25849741
616	Phosphorylation	IPRHFALSGKYSREF CCHHHHHCCCHHHHH	29.79	21712546
618	Acetylation	RHFALSGKYSREFFN HHHHHCCCHHHHHHH	36.36	26051181
618	Ubiquitination	RHFALSGKYSREFFN HHHHHCCCHHHHHHH	36.36	-
637	Ubiquitination	LRHITKLKPWSLFDV HHHCCCCCCCHHHHH	46.10	-
640	O-linked_Glycosylation	ITKLKPWSLFDVLVE CCCCCCCHHHHHHHH	27.90	30059200

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
492	T	Phosphorylation	Kinase	AKT1	P31749	Uniprot
494	S	Phosphorylation	Kinase	P70S6K	P23443	PSP
494	S	Phosphorylation	Kinase	SRPK2	P78362	PSP
497	S	Phosphorylation	Kinase	CK1A	P48729	PSP
588	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
492	T	Phosphorylation		19592491
Phosphorylation at Thr-492 by PKB/AKT1 enhances its stimulatory activity in triggering cyclin-D1 (CCND1) expression and promoting apoptosis in neurons, which can be blocked by YWHAB.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRPK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AF2_HUMAN	U2AF2	physical	16189514
SRSF1_HUMAN	SRSF1	physical	9472028
SRSF3_HUMAN	SRSF3	physical	9472028
SRSF2_HUMAN	SRSF2	physical	9472028
SRSF5_HUMAN	SRSF5	physical	9472028
SRSF6_HUMAN	SRSF6	physical	9472028
U2AF2_HUMAN	U2AF2	physical	9472028
RU17_HUMAN	SNRNP70	physical	9472028
LC7L3_HUMAN	LUC7L3	physical	12565863
SRSF1_HUMAN	SRSF1	physical	12565863
SRSF1_HUMAN	SRSF1	physical	10196197
A4_HUMAN	APP	physical	21832049
RU17_HUMAN	SNRNP70	physical	22365833
U2AF1_HUMAN	U2AF1	physical	22365833
DDX46_HUMAN	DDX46	physical	22365833
RBM23_HUMAN	RBM23	physical	22365833
RBM39_HUMAN	RBM39	physical	22365833
PR38A_HUMAN	PRPF38A	physical	22365833
CTBL1_HUMAN	CTNNBL1	physical	22365833
SNIP1_HUMAN	SNIP1	physical	22365833
RNPS1_HUMAN	RNPS1	physical	22365833
ACINU_HUMAN	ACIN1	physical	22365833
ARGL1_HUMAN	ARGLU1	physical	22365833
SNR27_HUMAN	SNRNP27	physical	22365833
YTDC1_HUMAN	YTHDC1	physical	23602568
RBM39_HUMAN	RBM39	physical	23602568
U2AF2_HUMAN	U2AF2	physical	23602568
DDX21_HUMAN	DDX21	physical	23602568
LUC7L_HUMAN	LUC7L	physical	23602568
U2AF1_HUMAN	U2AF1	physical	23602568
SRRM1_HUMAN	SRRM1	physical	23602568
PABP4_HUMAN	PABPC4	physical	23602568
PRP4B_HUMAN	PRPF4B	physical	23602568
SRRM2_HUMAN	SRRM2	physical	23602568
PININ_HUMAN	PNN	physical	23602568
SRPK2_HUMAN	SRPK2	physical	23602568
SMD1_HUMAN	SNRPD1	physical	23602568
IF4A3_HUMAN	EIF4A3	physical	23602568
HNRPM_HUMAN	HNRNPM	physical	23602568
RU17_HUMAN	SNRNP70	physical	23602568
NOP2_HUMAN	NOP2	physical	23602568
DHX15_HUMAN	DHX15	physical	23602568
SNRPA_HUMAN	SNRPA	physical	23602568
RU1C_HUMAN	SNRPC	physical	23602568
SRSF6_HUMAN	SRSF6	physical	23602568
PCBP1_HUMAN	PCBP1	physical	23602568
BCLF1_HUMAN	BCLAF1	physical	23602568
RBBP6_HUMAN	RBBP6	physical	23602568
PABP1_HUMAN	PABPC1	physical	23602568
MMTA2_HUMAN	C1orf35	physical	23602568
ACINU_HUMAN	ACIN1	physical	23602568
RNC_HUMAN	DROSHA	physical	23602568
LC7L2_HUMAN	LUC7L2	physical	23602568
SRSF8_HUMAN	SRSF8	physical	23602568
SRSF2_HUMAN	SRSF2	physical	23602568
HNRPC_HUMAN	HNRNPC	physical	23602568
RBM8A_HUMAN	RBM8A	physical	23602568
MGN_HUMAN	MAGOH	physical	23602568
SRSF7_HUMAN	SRSF7	physical	23602568
ZO2_HUMAN	TJP2	physical	23602568
ALMS1_HUMAN	ALMS1	physical	23602568
HNRC1_HUMAN	HNRNPCL1	physical	23602568
LC7L3_HUMAN	LUC7L3	physical	23602568
CLASR_HUMAN	CLASRP	physical	23602568
DIDO1_HUMAN	DIDO1	physical	23602568
DDX50_HUMAN	DDX50	physical	23602568
DDX46_HUMAN	DDX46	physical	23602568
RSMB_HUMAN	SNRPB	physical	23602568
DGCR8_HUMAN	DGCR8	physical	23602568
TR150_HUMAN	THRAP3	physical	23602568
HNRH2_HUMAN	HNRNPH2	physical	23602568
DX39A_HUMAN	DDX39A	physical	23602568
DX39B_HUMAN	DDX39B	physical	23602568
CPSF6_HUMAN	CPSF6	physical	23602568
SON_HUMAN	SON	physical	23602568
CPSF5_HUMAN	NUDT21	physical	23602568
NSG1_HUMAN	NSG1	physical	23602568
CHTOP_HUMAN	CHTOP	physical	23602568
CDK13_HUMAN	CDK13	physical	23602568
FOXN3_HUMAN	FOXN3	physical	23602568
IF1AY_HUMAN	EIF1AY	physical	23602568
CHD2_HUMAN	CHD2	physical	23602568
TR10C_HUMAN	TNFRSF10C	physical	23602568
CSKP_HUMAN	CASK	physical	23602568
AURKA_HUMAN	AURKA	physical	23602568
IKKA_HUMAN	CHUK	physical	23602568
ARC1B_HUMAN	ARPC1B	physical	23602568
UBD_HUMAN	UBD	physical	23602568
NCK2_HUMAN	NCK2	physical	23602568
SAHH2_HUMAN	AHCYL1	physical	23602568
TLE4_HUMAN	TLE4	physical	23602568
ERN1_HUMAN	ERN1	physical	23602568
DNJC8_HUMAN	DNAJC8	physical	23602568
GBRAP_HUMAN	GABARAP	physical	23602568
ZRAB2_HUMAN	ZRANB2	physical	23602568
TYDP2_HUMAN	TDP2	physical	23602568
PAK4_HUMAN	PAK4	physical	23602568
ABL1_HUMAN	ABL1	physical	23602568
DPOLB_HUMAN	POLB	physical	23602568
NELFE_HUMAN	NELFE	physical	23602568
ERCC3_HUMAN	ERCC3	physical	23602568
MK_HUMAN	MDK	physical	23602568
PSA3_HUMAN	PSMA3	physical	23602568
DDX6_HUMAN	DDX6	physical	23602568
PTBP1_HUMAN	PTBP1	physical	23602568
APEX1_HUMAN	APEX1	physical	23602568
T2EA_HUMAN	GTF2E1	physical	23602568
SORCN_HUMAN	SRI	physical	23602568
1433B_HUMAN	YWHAB	physical	23602568
RL22_HUMAN	RPL22	physical	23602568
MAGB1_HUMAN	MAGEB1	physical	23602568
CBX5_HUMAN	CBX5	physical	23602568
CLK1_HUMAN	CLK1	physical	23602568
CLK3_HUMAN	CLK3	physical	23602568
CDK7_HUMAN	CDK7	physical	23602568
ADPRH_HUMAN	ADPRH	physical	23602568
TPD52_HUMAN	TPD52	physical	23602568
RWD2B_HUMAN	RWDD2B	physical	23602568
YPEL3_HUMAN	YPEL3	physical	23602568
FGF12_HUMAN	FGF12	physical	23602568
WDR5_HUMAN	WDR5	physical	23602568
PPIA_HUMAN	PPIA	physical	23602568
RL41_HUMAN	RPL41	physical	23602568
TRA2B_HUMAN	TRA2B	physical	23602568
RNF4_HUMAN	RNF4	physical	23602568
RT06_HUMAN	MRPS6	physical	23602568
SRSF3_HUMAN	SRSF3	physical	23602568
SRSF1_HUMAN	SRSF1	physical	23602568
AAPK1_HUMAN	PRKAA1	physical	23602568
SRSF9_HUMAN	SRSF9	physical	23602568
SRSF5_HUMAN	SRSF5	physical	23602568
IFIT5_HUMAN	IFIT5	physical	23602568
MPP3_HUMAN	MPP3	physical	23602568
TCOF_HUMAN	TCOF1	physical	23602568
TRA2A_HUMAN	TRA2A	physical	23602568
DHX8_HUMAN	DHX8	physical	23602568
NC2A_HUMAN	DRAP1	physical	23602568
BRD3_HUMAN	BRD3	physical	23602568
SC23B_HUMAN	SEC23B	physical	23602568
HMGN3_HUMAN	HMGN3	physical	23602568
U2AFM_HUMAN	ZRSR2	physical	23602568
ENOX2_HUMAN	ENOX2	physical	23602568
U1SBP_HUMAN	SNRNP35	physical	23602568
CD046_HUMAN	C4orf46	physical	23602568
NCBP3_HUMAN	C17orf85	physical	23602568
TAF7L_HUMAN	TAF7L	physical	23602568
FA76B_HUMAN	FAM76B	physical	23602568
ATAT_HUMAN	ATAT1	physical	23602568
AR6P4_HUMAN	ARL6IP4	physical	23602568
AMERL_HUMAN	AMMECR1L	physical	23602568
CSAG1_HUMAN	CSAG1	physical	23602568
RSRC2_HUMAN	RSRC2	physical	23602568
NPM2_HUMAN	NPM2	physical	23602568
RBM23_HUMAN	RBM23	physical	23602568
CAND1_HUMAN	CAND1	physical	23602568
LCA5_HUMAN	LCA5	physical	23602568
F90A1_HUMAN	FAM90A1	physical	23602568
MAPK5_HUMAN	MAPKAPK5	physical	23602568
CC28A_HUMAN	CCDC28A	physical	23602568
RHG12_HUMAN	ARHGAP12	physical	23602568
CHERP_HUMAN	CHERP	physical	23602568
AGRG5_HUMAN	GPR114	physical	23602568
DAW1_HUMAN	DAW1	physical	23602568
CLD19_HUMAN	CLDN19	physical	23602568
MARHA_HUMAN	MARCH10	physical	23602568
PR38A_HUMAN	PRPF38A	physical	23602568
LRN4L_HUMAN	LRRN4CL	physical	23602568
DBF4B_HUMAN	DBF4B	physical	23602568
TNIP2_HUMAN	TNIP2	physical	23602568
MCLN3_HUMAN	MCOLN3	physical	23602568
ES8L3_HUMAN	EPS8L3	physical	23602568
CP078_HUMAN	C16orf78	physical	23602568
D42E1_HUMAN	SDR42E1	physical	23602568
TRI41_HUMAN	TRIM41	physical	23602568
SNR27_HUMAN	SNRNP27	physical	23602568
SREK1_HUMAN	SREK1	physical	23602568
SRS12_HUMAN	SRSF12	physical	23602568
TITIN_HUMAN	TTN	physical	23602568
RTF1_HUMAN	RTF1	physical	23602568
RIT1_HUMAN	RIT1	physical	23602568
CR025_HUMAN	C18orf25	physical	23602568
EVI5L_HUMAN	EVI5L	physical	23602568
RL39L_HUMAN	RPL39L	physical	23602568
CCD97_HUMAN	CCDC97	physical	23602568
PELI1_HUMAN	PELI1	physical	23602568
NGLY1_HUMAN	NGLY1	physical	23602568
RSRC1_HUMAN	RSRC1	physical	23602568
EGLN2_HUMAN	EGLN2	physical	23602568
UB2E2_HUMAN	UBE2E2	physical	23602568
ALKB3_HUMAN	ALKBH3	physical	23602568
YPEL2_HUMAN	YPEL2	physical	23602568
RBM15_HUMAN	RBM15	physical	23602568
RIT2_HUMAN	RIT2	physical	23602568
VRK1_HUMAN	VRK1	physical	23602568
SELS_HUMAN	VIMP	physical	23602568
CCM2_HUMAN	CCM2	physical	23602568
RSRP1_HUMAN	RSRP1	physical	23602568
HIRP3_HUMAN	HIRIP3	physical	23602568
LCE3D_HUMAN	LCE3D	physical	23602568
NSRP1_HUMAN	NSRP1	physical	23602568
GBRL1_HUMAN	GABARAPL1	physical	23602568
KCNN2_HUMAN	KCNN2	physical	23602568
BORG4_HUMAN	CDC42EP4	physical	23602568
E41L1_HUMAN	EPB41L1	physical	23602568
OCEL1_HUMAN	OCEL1	physical	23602568
ZMAT4_HUMAN	ZMAT4	physical	23602568
E41LA_HUMAN	EPB41L4A	physical	23602568
PDE7B_HUMAN	PDE7B	physical	23602568
NXT2_HUMAN	NXT2	physical	23602568
ABC3C_HUMAN	APOBEC3C	physical	23602568
HOME3_HUMAN	HOMER3	physical	23602568
CBLN4_HUMAN	CBLN4	physical	23602568
ARGL1_HUMAN	ARGLU1	physical	23602568
NSE4A_HUMAN	NSMCE4A	physical	23602568
SLAI2_HUMAN	SLAIN2	physical	23602568
NUP50_HUMAN	NUP50	physical	23602568
BAIP2_HUMAN	BAIAP2	physical	23602568
DRG1_HUMAN	DRG1	physical	23602568
NOP16_HUMAN	NOP16	physical	23602568
PPIL1_HUMAN	PPIL1	physical	23602568
HBS1L_HUMAN	HBS1L	physical	23602568
MB212_HUMAN	MAB21L2	physical	23602568
SP16H_HUMAN	SUPT16H	physical	23602568
SNURF_HUMAN	SNURF	physical	23602568
CCG2_HUMAN	CACNG2	physical	23602568
STON1_HUMAN	STON1	physical	23602568
SRPK2_HUMAN	SRPK2	physical	25416956
U2AF1_HUMAN	U2AF1	physical	25416956
ZSC9_HUMAN	ZSCAN9	physical	25416956
U2AFM_HUMAN	ZRSR2	physical	25416956
FXR2_HUMAN	FXR2	physical	25416956
RBM39_HUMAN	RBM39	physical	25416956
RNPS1_HUMAN	RNPS1	physical	25416956
SNR27_HUMAN	SNRNP27	physical	25416956
LUZP4_HUMAN	LUZP4	physical	25416956
PR38A_HUMAN	PRPF38A	physical	25416956
SRPK2_HUMAN	SRPK2	physical	18082144
NOP2_HUMAN	NOP2	physical	26344197
PPM1G_HUMAN	PPM1G	physical	26344197
PRP8_HUMAN	PRPF8	physical	26344197
CE042_HUMAN	C5orf42	physical	26167880
ACTB_HUMAN	ACTB	physical	26167880
ACTG_HUMAN	ACTG1	physical	26167880
ATS18_HUMAN	ADAMTS18	physical	26167880
AKP13_HUMAN	AKAP13	physical	26167880
ALDOA_HUMAN	ALDOA	physical	26167880
PPBT_HUMAN	ALPL	physical	26167880
ANK3_HUMAN	ANK3	physical	26167880
ANFY1_HUMAN	ANKFY1	physical	26167880
ANR35_HUMAN	ANKRD35	physical	26167880
AP1M1_HUMAN	AP1M1	physical	26167880
BIG3_HUMAN	KIAA1244	physical	26167880
ARSG_HUMAN	ARSG	physical	26167880
ARLY_HUMAN	ASL	physical	26167880
BAG3_HUMAN	BAG3	physical	26167880
BAZ1A_HUMAN	BAZ1A	physical	26167880
BCL9L_HUMAN	BCL9L	physical	26167880
BCLF1_HUMAN	BCLAF1	physical	26167880
BUD13_HUMAN	BUD13	physical	26167880
EFC12_HUMAN	EFCAB12	physical	26167880
ELP6_HUMAN	ELP6	physical	26167880
CAPS2_HUMAN	CADPS2	physical	26167880
CACO1_HUMAN	CALCOCO1	physical	26167880
CAMP1_HUMAN	CAMSAP1	physical	26167880
CAR11_HUMAN	CARD11	physical	26167880
CHSP1_HUMAN	CARHSP1	physical	26167880
MTCL1_HUMAN	MTCL1	physical	26167880
CCD86_HUMAN	CCDC86	physical	26167880
CC88B_HUMAN	CCDC88B	physical	26167880
CDK12_HUMAN	CDK12	physical	26167880
CDK13_HUMAN	CDK13	physical	26167880
CE170_HUMAN	CEP170	physical	26167880
CHD1L_HUMAN	CHD1L	physical	26167880
CHK2_HUMAN	CHEK2	physical	26167880
CLAP1_HUMAN	CLASP1	physical	26167880
CLAP2_HUMAN	CLASP2	physical	26167880
CLASR_HUMAN	CLASRP	physical	26167880
CLCKA_HUMAN	CLCNKA	physical	26167880
CLUS_HUMAN	CLU	physical	26167880
CPSF7_HUMAN	CPSF7	physical	26167880
CRTC1_HUMAN	CRTC1	physical	26167880
YBOX3_HUMAN	YBX3	physical	26167880
DCA10_HUMAN	DCAF10	physical	26167880
DDX21_HUMAN	DDX21	physical	26167880
DX39B_HUMAN	DDX39B	physical	26167880
DDX3X_HUMAN	DDX3X	physical	26167880
DDX46_HUMAN	DDX46	physical	26167880
DDX50_HUMAN	DDX50	physical	26167880
DIDO1_HUMAN	DIDO1	physical	26167880
DYH6_HUMAN	DNAH6	physical	26167880
DYH9_HUMAN	DNAH9	physical	26167880
DOCK3_HUMAN	DOCK3	physical	26167880
ECT2_HUMAN	ECT2	physical	26167880
EED_HUMAN	EED	physical	26167880
EIF3A_HUMAN	EIF3A	physical	26167880
IF4B_HUMAN	EIF4B	physical	26167880
IF4G1_HUMAN	EIF4G1	physical	26167880
ELAV3_HUMAN	ELAVL3	physical	26167880
ENSA_HUMAN	ENSA	physical	26167880
E41LB_HUMAN	EPB41L4B	physical	26167880
EPM2A_HUMAN	EPM2A	physical	26167880
ES8L1_HUMAN	EPS8L1	physical	26167880
ERBB3_HUMAN	ERBB3	physical	26167880
RB6I2_HUMAN	ERC1	physical	26167880
FA5_HUMAN	F5	physical	26167880
AMER1_HUMAN	AMER1	physical	26167880
TGRM1_HUMAN	FAM179B	physical	26167880
FA43A_HUMAN	FAM43A	physical	26167880
NXPE4_HUMAN	NXPE4	physical	26167880
FBX24_HUMAN	FBXO24	physical	26167880
FCHO1_HUMAN	FCHO1	physical	26167880
FGFR3_HUMAN	FGFR3	physical	26167880
FIP1_HUMAN	FIP1L1	physical	26167880
FMNL1_HUMAN	FMNL1	physical	26167880
FXR2_HUMAN	FXR2	physical	26167880
GBF1_HUMAN	GBF1	physical	26167880
GCC2_HUMAN	GCC2	physical	26167880
VKGC_HUMAN	GGCX	physical	26167880
GHR_HUMAN	GHR	physical	26167880
GLRA4_HUMAN	GLRA4	physical	26167880
NOP53_HUMAN	GLTSCR2	physical	26167880
GBGT2_HUMAN	GNGT2	physical	26167880
GSE1_HUMAN	GSE1	physical	26167880
NOG1_HUMAN	GTPBP4	physical	26167880
GXLT2_HUMAN	GXYLT2	physical	26167880
HERC3_HUMAN	HERC3	physical	26167880
H2B1K_HUMAN	HIST1H2BK	physical	26167880
ZEP1_HUMAN	HIVEP1	physical	26167880
HMGA1_HUMAN	HMGA1	physical	26167880
HMGN2_HUMAN	HMGN2	physical	26167880
HMGX4_HUMAN	HMGXB4	physical	26167880
ROA1_HUMAN	HNRNPA1	physical	26167880
ROA3_HUMAN	HNRNPA3	physical	26167880
HNRPC_HUMAN	HNRNPC	physical	26167880
HNRPK_HUMAN	HNRNPK	physical	26167880
HTSF1_HUMAN	HTATSF1	physical	26167880
IRS2_HUMAN	IRS2	physical	26167880
ISLR_HUMAN	ISLR	physical	26167880
JHD2C_HUMAN	JMJD1C	physical	26167880
KANK2_HUMAN	KANK2	physical	26167880
KHDR1_HUMAN	KHDRBS1	physical	26167880
KIF11_HUMAN	KIF11	physical	26167880
K2C78_HUMAN	KRT78	physical	26167880
LBR_HUMAN	LBR	physical	26167880
LDHC_HUMAN	LDHC	physical	26167880
LMNA_HUMAN	LMNA	physical	26167880
LMNB1_HUMAN	LMNB1	physical	26167880
LMO7_HUMAN	LMO7	physical	26167880
LRC34_HUMAN	LRRC34	physical	26167880
LRC52_HUMAN	LRRC52	physical	26167880
LUC7L_HUMAN	LUC7L	physical	26167880
MACF1_HUMAN	MACF1	physical	26167880
MAP1S_HUMAN	MAP1S	physical	26167880
MAP4_HUMAN	MAP4	physical	26167880
MAP7_HUMAN	MAP7	physical	26167880
MA7D1_HUMAN	MAP7D1	physical	26167880
MAPK3_HUMAN	MAPKAPK3	physical	26167880
MARE1_HUMAN	MAPRE1	physical	26167880
MAST2_HUMAN	MAST2	physical	26167880
MATR3_HUMAN	MATR3	physical	26167880
MDC1_HUMAN	MDC1	physical	26167880
MFS10_HUMAN	MFSD10	physical	26167880
MIB2_HUMAN	MIB2	physical	26167880
MIPO1_HUMAN	MIPOL1	physical	26167880
M3K20_HUMAN	ZAK	physical	26167880
MMP23_HUMAN	MMP23B	physical	26167880
MYCB2_HUMAN	MYCBP2	physical	26167880
MYLIP_HUMAN	MYLIP	physical	26167880
MY18B_HUMAN	MYO18B	physical	26167880
MYO1E_HUMAN	MYO1E	physical	26167880
MZT2B_HUMAN	MZT2B	physical	26167880
NADK_HUMAN	NADK	physical	26167880
NAGK_HUMAN	NAGK	physical	26167880
NUCL_HUMAN	NCL	physical	26167880
NGDN_HUMAN	NGDN	physical	26167880
NKAP_HUMAN	NKAP	physical	26167880
NOLC1_HUMAN	NOLC1	physical	26167880
NTH_HUMAN	NTHL1	physical	26167880
NXF1_HUMAN	NXF1	physical	26167880
OTOF_HUMAN	OTOF	physical	26167880
PALLD_HUMAN	PALLD	physical	26167880
PCBP1_HUMAN	PCBP1	physical	26167880
PCF11_HUMAN	PCF11	physical	26167880
PDCL3_HUMAN	PDCL3	physical	26167880
PHF6_HUMAN	PHF6	physical	26167880
PHLB1_HUMAN	PHLDB1	physical	26167880
PK1L2_HUMAN	PKD1L2	physical	26167880
PKHA5_HUMAN	PLEKHA5	physical	26167880
PNM8B_HUMAN	PNMAL2	physical	26167880
PININ_HUMAN	PNN	physical	26167880
PDIP3_HUMAN	POLDIP3	physical	26167880
PPHLN_HUMAN	PPHLN1	physical	26167880
PPIA_HUMAN	PPIA	physical	26167880
IASPP_HUMAN	PPP1R13L	physical	26167880
PR38A_HUMAN	PRPF38A	physical	26167880
PR38B_HUMAN	PRPF38B	physical	26167880
PRP4B_HUMAN	PRPF4B	physical	26167880
PRC2A_HUMAN	PRRC2A	physical	26167880
PRC2B_HUMAN	PRRC2B	physical	26167880
PRC2C_HUMAN	PRRC2C	physical	26167880
PSD13_HUMAN	PSMD13	physical	26167880
PTN22_HUMAN	PTPN22	physical	26167880
RABE1_HUMAN	RABEP1	physical	26167880
RGRF1_HUMAN	RASGRF1	physical	26167880
RBM15_HUMAN	RBM15	physical	26167880
RB15B_HUMAN	RBM15B	physical	26167880
RBM19_HUMAN	RBM19	physical	26167880
RBM39_HUMAN	RBM39	physical	26167880
RBMX_HUMAN	RBMX	physical	26167880
RIPK3_HUMAN	RIPK3	physical	26167880
RN219_HUMAN	RNF219	physical	26167880
RL13_HUMAN	RPL13	physical	26167880
RL34_HUMAN	RPL34	physical	26167880
RL37_HUMAN	RPL37	physical	26167880
RLA2_HUMAN	RPLP2	physical	26167880
RS26_HUMAN	RPS26	physical	26167880
RIR2B_HUMAN	RRM2B	physical	26167880
RRP1_HUMAN	RRP1	physical	26167880
RRP1B_HUMAN	RRP1B	physical	26167880
RL1D1_HUMAN	RSL1D1	physical	26167880
RXFP1_HUMAN	RXFP1	physical	26167880
S10A4_HUMAN	S100A4	physical	26167880
SAFB1_HUMAN	SAFB	physical	26167880
SNUT1_HUMAN	SART1	physical	26167880
SBK1_HUMAN	SBK1	physical	26167880
SFR19_HUMAN	SCAF1	physical	26167880
SDK2_HUMAN	SDK2	physical	26167880
SC16B_HUMAN	SEC16B	physical	26167880
IC1_HUMAN	SERPING1	physical	26167880
PNISR_HUMAN	PNISR	physical	26167880
SGPL1_HUMAN	SGPL1	physical	26167880
SI1L3_HUMAN	SIPA1L3	physical	26167880
S13A2_HUMAN	SLC13A2	physical	26167880
VGLU2_HUMAN	SLC17A6	physical	26167880
SLFN5_HUMAN	SLFN5	physical	26167880
SLTM_HUMAN	SLTM	physical	26167880
SMHD1_HUMAN	SMCHD1	physical	26167880
SNIP1_HUMAN	SNIP1	physical	26167880
RU17_HUMAN	SNRNP70	physical	26167880
SON_HUMAN	SON	physical	26167880
SPDEF_HUMAN	SPDEF	physical	26167880
MINT_HUMAN	SPEN	physical	26167880
SRC_HUMAN	SRC	physical	26167880
SRPK2_HUMAN	SRPK2	physical	26167880
SRRM1_HUMAN	SRRM1	physical	26167880
SRRM2_HUMAN	SRRM2	physical	26167880
SRS11_HUMAN	SRSF11	physical	26167880
SRSF3_HUMAN	SRSF3	physical	26167880
SRSF6_HUMAN	SRSF6	physical	26167880
SRXN1_HUMAN	SRXN1	physical	26167880
SYCP2_HUMAN	SYCP2	physical	26167880
TEAN2_HUMAN	TCEANC2	physical	26167880
ZO2_HUMAN	TJP2	physical	26167880
MACOI_HUMAN	TMEM57	physical	26167880
LAP2A_HUMAN	TMPO	physical	26167880
LAP2B_HUMAN	TMPO	physical	26167880
TM11A_HUMAN	TMPRSS11A	physical	26167880
TYB10_HUMAN	TMSB10	physical	26167880
TP8L2_HUMAN	TNFAIP8L2	physical	26167880
TENS3_HUMAN	TNS3	physical	26167880
TOP1_HUMAN	TOP1	physical	26167880
TRA2A_HUMAN	TRA2A	physical	26167880
TRA2B_HUMAN	TRA2B	physical	26167880
TRIPC_HUMAN	TRIP12	physical	26167880
TBA1B_HUMAN	TUBA1B	physical	26167880
THIO_HUMAN	TXN	physical	26167880
UBR4_HUMAN	UBR4	physical	26167880
REN3B_HUMAN	UPF3B	physical	26167880
UBP36_HUMAN	USP36	physical	26167880
SNUT2_HUMAN	USP39	physical	26167880
VAC14_HUMAN	VAC14	physical	26167880
VTM2L_HUMAN	VSTM2L	physical	26167880
WDR24_HUMAN	WDR24	physical	26167880
WDR70_HUMAN	WDR70	physical	26167880
XRCC5_HUMAN	XRCC5	physical	26167880
YRDC_HUMAN	YRDC	physical	26167880
YTDC2_HUMAN	YTHDC2	physical	26167880
ZC3HD_HUMAN	ZC3H13	physical	26167880
ZCH18_HUMAN	ZC3H18	physical	26167880
NO40_HUMAN	ZCCHC17	physical	26167880
ZDHC5_HUMAN	ZDHHC5	physical	26167880
ZC3H1_HUMAN	ZFC3H1	physical	26167880
ZFHX4_HUMAN	ZFHX4	physical	26167880
ZFP91_HUMAN	ZFP91	physical	26167880
ZMYM4_HUMAN	ZMYM4	physical	26167880
ZN140_HUMAN	ZNF140	physical	26167880
ZN234_HUMAN	ZNF234	physical	26167880
ZN529_HUMAN	ZNF529	physical	26167880
ZN592_HUMAN	ZNF592	physical	26167880
ZN593_HUMAN	ZNF593	physical	26167880
ZN616_HUMAN	ZNF616	physical	26167880
ACINU_HUMAN	ACIN1	physical	19592491
SRSF2_HUMAN	SRSF2	physical	19592491
AKT1_HUMAN	AKT1	physical	19592491

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00173	Adenine

Regulatory Network of SRPK2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494; SER-497 ANDTHR-498, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-497, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-494; SER-497AND THR-547, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cellcycle and cell death in neurons."; Jang S.W., Liu X., Fu H., Rees H., Yepes M., Levey A., Ye K.; J. Biol. Chem. 284:24512-24525(2009). Cited for: FUNCTION, PHOSPHORYLATION AT THR-492 BY PKB/AKT1, AND INTERACTION WITHPKB/AKT1; YWHAB; YWHAE AND SFN.	19592491 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-319, AND MASSSPECTROMETRY.	15592455 [Abstract]

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