PK1L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PK1L2_HUMAN
• UniProt AC: Q7Z442
• Protein Name: Polycystic kidney disease protein 1-like 2
• Gene Name: PKD1L2
• Organism: Homo sapiens (Human).
• Sequence Length: 2459
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May function as an ion-channel regulator. May function as a G-protein-coupled receptor..
• Protein Sequence: MSAVGLVLLVLALRLRATTVKPEEGSFCSNSQVAFRDACYEFVPLGRTFRDAQSWCEGQGGHLVFIQDEGTQWFLQKHISQDREWWIGLTWNLARNGTTEGPGTWLDTSNVTYSNWHGGQAAAAPDTCGHIGRGPSSEWVTSDCAQTFAFMCEFRVGQSLACEGLNATVHCGLGQVIQVQDAVYGRQNPHFCTQDAGRPSDLEQGCSWANVKEEVAGQCQELQSCQVAADETYFGNLCPTQGSYLWVQYQCREALQLMVSSESFIFDNVTISLTWLLSPYIGNLSCIISTGDSHTFDPYNPPSVSSNVTHQFTSPGEFTVFAECTTSEWHVTAQRQVTVRDKMETLSVTACSGLSQSGAGPLCQAVFGDPLWIQVELDGGTGVTYTVLLGDITLAESTTQKGSLPYNLILDRETQKLMGPGRHRLEIQATGNTTTSTISRNITVHLVELLSGLQASWASDHLELGQDLLITISLAQGTPEELTFEVAGLNATFSHEQVSFGEPFGICRLAVPVEGTFLVTMLVRNAFSNLSLEIGNITITAPSGLQEPSGMNAEGKSKDKGDMEVYIQPGPYVDPFTTVTLGWPDNDKELRFQWSCGSCWALWSSCVERQLLRTDQRELVVPASCLPPPDSAVTLRLAVLRGQELENRAEQCLYVSAPWELRPRVSCERNCRPVNASKDILLRVTMGEDSPVAMFSWYLDNTPTEQAEPLLDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQWEASLALQHASEALLTVSAKARPEDQRRQAATRDLFQAVGSVLEASLSNRPEEPAEASSSQIATVLRLLRVMEHVQTTLLLGKLPGGLPAMLATPSISVYTNRIQPWSWQGSSLRPDAADSATFMLPAASSLSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRVTSPSGQLIPVKNLSENIEILLPRHSQRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWRPDIALTLSLGYGYHPNKSSYDAQTHLVPMVAPDELPTWILSPQDLRFGEGVYYLTVVPESDLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSGCQVGPRTSPYQTHCLCNHLTFFGSTFLVMSNAINIHQTAELFATFEDNPVVVTTVGCLCVVYVLVVIWARRKDAQDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHLADPDTPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNSWLSINVGDCVLDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCCFSLLLCTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPRVAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDSVNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAARSGPWKDSAYRQCLYLQLEHVEQELRLVGPRGFSQPHSHAQALRQLQTLKGGLGVQPGTWAPAHASALQVSKPPQGLPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAVSFVESMFVTQPLKVLGFAAFFALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRDVYQPPLTAAIEKMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQHSFTRGFSGVLGFREFFKWANTTLVSNLYGHPPGFITDGNSKLVGSAQIRQVRVQESSCPLAQQPQAYLNGCRAPYSLDAEDMADYGEGWNATTLSEWQYQSQDQRQGYPIWGKLTVYRGGGYVVPLGTDRQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTLETSALGTFFTHAALQSLRLYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETWGYFCSKWNLLELAIILASWSALAVFVKRAVLAERDLQRCRNHREEGISFSETAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLFDAAETMVSLQLGIFNYEEVLDYSPVLGSFLIGSCIVFMTFVVLNLFISVILVAFSEEQKYYQLSEEGEIVDLLLMKILSFLGIKSKREEPGSSREQPGSLSQTRHSRPAQALPKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAVGLVLL ------CCHHHHHHH	42.86	-
90	Phosphorylation	REWWIGLTWNLARNG CCEEEEEEEEHHHCC	13.70	24043423
96	N-linked_Glycosylation	LTWNLARNGTTEGPG EEEEHHHCCCCCCCC	46.70	UniProtKB CARBOHYD
110	N-linked_Glycosylation	GTWLDTSNVTYSNWH CEEEECCCCEEECCC	32.04	UniProtKB CARBOHYD
268	N-linked_Glycosylation	SESFIFDNVTISLTW CCCCCCCCEEEEHHH	23.29	UniProtKB CARBOHYD
307	N-linked_Glycosylation	NPPSVSSNVTHQFTS CCCCCCCCCEEECCC	34.89	UniProtKB CARBOHYD
338	Phosphorylation	VTAQRQVTVRDKMET EEEEEEEEHHHCCEE	11.07	24719451
441	N-linked_Glycosylation	TTSTISRNITVHLVE CCCHHHCCEEHHHHH	27.73	UniProtKB CARBOHYD
516	Phosphorylation	LAVPVEGTFLVTMLV EECCCCCHHHHHHHH	10.57	-
536	N-linked_Glycosylation	NLSLEIGNITITAPS CCEEEECCEEEECCC	33.61	UniProtKB CARBOHYD
753	Phosphorylation	EVIRIRATALTRHAY CEEEEEEEEHHHCCC	16.61	28634120
756	Phosphorylation	RIRATALTRHAYGED EEEEEEHHHCCCCCC	20.25	21712546
760	Phosphorylation	TALTRHAYGEDTYVI EEHHHCCCCCCEEEE	18.21	23898821
764	Phosphorylation	RHAYGEDTYVISTVP HCCCCCCEEEEEECC	18.52	23898821
765	Phosphorylation	HAYGEDTYVISTVPP CCCCCCEEEEEECCC	14.22	23898821
768	Phosphorylation	GEDTYVISTVPPREV CCCEEEEEECCCCCC	17.20	23898821
769	Phosphorylation	EDTYVISTVPPREVP CCEEEEEECCCCCCC	26.38	23898821
786	Phosphorylation	TIAPEEGTVLTSFAI EECCCCCCEEEEEEE	18.67	26074081
789	Phosphorylation	PEEGTVLTSFAIFCN CCCCCEEEEEEEEEC	19.91	26074081
790	Phosphorylation	EEGTVLTSFAIFCNA CCCCEEEEEEEEECC	14.44	26074081
798	Phosphorylation	FAIFCNASTALGPLE EEEEECCCCCCCCCE	10.54	26074081
799	Phosphorylation	AIFCNASTALGPLEF EEEECCCCCCCCCEE	24.40	26074081
918	Phosphorylation	ESQGSGQSLSIDVRQ HCCCCCCCCEEHHHH	27.84	-
1078	Phosphorylation	TNRIQPWSWQGSSLR ECCCCCCCCCCCCCC	19.06	27251275
1082	Phosphorylation	QPWSWQGSSLRPDAA CCCCCCCCCCCCCCC	15.88	27251275
1083	Phosphorylation	PWSWQGSSLRPDAAD CCCCCCCCCCCCCCC	34.91	27251275
1133	Phosphorylation	ARSHFDVSGTVGGLR CCCCCCCCCEECCEE	30.50	27251275
1135	Phosphorylation	SHFDVSGTVGGLRVT CCCCCCCEECCEEEE	14.42	27251275
1142	Phosphorylation	TVGGLRVTSPSGQLI EECCEEEECCCCCEE	28.61	28122231
1143	Phosphorylation	VGGLRVTSPSGQLIP ECCEEEECCCCCEEE	17.76	28122231
1145	Phosphorylation	GLRVTSPSGQLIPVK CEEEECCCCCEEECC	38.65	28122231
1176	N-linked_Glycosylation	HSQPTVLNLTSPEAL CCCCCEEECCCCCEE	36.62	UniProtKB CARBOHYD
1186	N-linked_Glycosylation	SPEALWVNVTSGEAT CCCEEEEEECCCEEE	21.55	UniProtKB CARBOHYD
1207	Phosphorylation	WRPDIALTLSLGYGY ECCCEEEEEEECCCC	12.79	28331001
1214	Phosphorylation	TLSLGYGYHPNKSSY EEEECCCCCCCCCCC	12.96	28331001
1407	Phosphorylation	HRRGAATSSKVTVTL CCCCCCCCCEEEEEE	24.36	27282143
1518	Phosphorylation	EQDRKQFSHLFFMKT HHHHHHHHEEEEEEC	19.45	-
1525	Phosphorylation	SHLFFMKTSAGFQDG HEEEEEECCCCCCCC	16.42	-
1554	Phosphorylation	FTRVQRVSCCFSLLL CCHHHHHHHHHHHHH	13.83	30206219
1558	Phosphorylation	QRVSCCFSLLLCTML HHHHHHHHHHHHHHH	12.28	30206219
1563	Phosphorylation	CFSLLLCTMLTSIMF HHHHHHHHHHHHHHH	18.38	30206219
1566	Phosphorylation	LLLCTMLTSIMFWGV HHHHHHHHHHHHHCC	12.84	30206219
1567	Phosphorylation	LLCTMLTSIMFWGVP HHHHHHHHHHHHCCC	14.22	30206219
1635	Phosphorylation	TGKWDRGSPNLTPSP CCCCCCCCCCCCCCC	16.12	-
1639	Phosphorylation	DRGSPNLTPSPQPME CCCCCCCCCCCCCCC	28.49	-
1641	Phosphorylation	GSPNLTPSPQPMEDG CCCCCCCCCCCCCCC	30.82	22210691
1656	Phosphorylation	LLTPEAVTKDVSRIV CCCHHHHHHHHHHHH	28.68	-
1665	Phosphorylation	DVSRIVSSLFKALKV HHHHHHHHHHHHCCC	27.25	24719451
1778	Phosphorylation	RGFSQPHSHAQALRQ CCCCCCCHHHHHHHH	27.48	-
1966	Phosphorylation	WMLLLVAYGQRDPSA HHHHHHHHCCCCCHH	13.30	-
2176	Phosphorylation	ALQSLRLYPFTDGWH HHHHCCEECCCCCCC	7.00	24043423
2179	Phosphorylation	SLRLYPFTDGWHPFV HCCEECCCCCCCHHH	29.15	24043423
2193	Phosphorylation	VVAAELIYFLFLLYY HHHHHHHHHHHHHHH	13.57	24043423
2199	Phosphorylation	IYFLFLLYYMVVQGK HHHHHHHHHHHHCCC	7.52	24043423
2200	Phosphorylation	YFLFLLYYMVVQGKR HHHHHHHHHHHCCCC	5.38	24043423
2301	Phosphorylation	NPKMNMITAALRRAW CHHHHHHHHHHHHHH	8.63	-
2306	Methylation	MITAALRRAWGDISG HHHHHHHHHHCCHHH	35.23	24410269
2306	Dimethylation	MITAALRRAWGDISG HHHHHHHHHHCCHHH	35.23	-
2336	Acetylation	SNLIFGWKLRSYKTL HHHHHCCCCCCCHHH	34.11	30591361
2339	Phosphorylation	IFGWKLRSYKTLFDA HHCCCCCCCHHHHHH	41.22	22210691
2340	Phosphorylation	FGWKLRSYKTLFDAA HCCCCCCCHHHHHHH	11.10	22210691
2404	Phosphorylation	AFSEEQKYYQLSEEG HCCHHHHCCCCCCCC	8.99	23663014
2405	Phosphorylation	FSEEQKYYQLSEEGE CCHHHHCCCCCCCCC	15.26	23663014
2408	Phosphorylation	EQKYYQLSEEGEIVD HHHCCCCCCCCCHHH	20.34	23663014
2428	Ubiquitination	ILSFLGIKSKREEPG HHHHCCCCCCCCCCC	48.39	-
2443	Phosphorylation	SSREQPGSLSQTRHS CCCCCCCCCCCCCCC	31.37	24719451
2447	Phosphorylation	QPGSLSQTRHSRPAQ CCCCCCCCCCCCCCC	27.29	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PK1L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PK1L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PK1L2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PK1L2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.