EFC12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFC12_HUMAN
• UniProt AC: Q6NXP0
• Protein Name: EF-hand calcium-binding domain-containing protein 12
• Gene Name: EFCAB12
• Organism: Homo sapiens (Human).
• Sequence Length: 572
• Protein Sequence: MDDDYEAYHSLFLSLLGLCPSKTPINENAPVFDPEPVIAHCFKQFQQKDFRLPQTRRRIIMVPRKEDQTPLNPASQPQAPPKPIPSFKVLEARDIQEQPEDRKTWLSQRSKLRQELESFGDVKRWLENKPSITPSEAKVLHMIHEEQSAQPNASQATTRTTRKKAPRLSRLSRQMVPQLQLPEPPALSVMYSYLHSRKIKILEIFHKVGQGENQRITREEFIAAVKAVGVPLKNQEVEDIVIYLSSLGKHNTITMDILANTYKQWSMAQQRSSLATAREHYILAKHRDSLKGPLKKQEVDSAPQLPKVDLLTVPAVDTQMETRPMTLEEMEEVGKRYRERQRQHKLTIPSIQYTEQCHLVRCGNRHFDEHCLPSTIHGDMRELIDSARRHNFLVYLQCWKLCKSYGLPLTEDILMKALLYPGDKIIFQMDKVCPIRQPGGYYSDWKVFSPNLALLRSQGPGKSKRTDKKTPKKSKKMRFKEFEEFTRKLKVKRSSGLQQTHPNSFWPGHLLDKLQLYLPTVATDRSLALFSCVQHQPHVYPATYHPDHWWPLRNKNYMTHAHYDAAKVYYIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	VPRKEDQTPLNPASQ CCCCCCCCCCCCCCC		-
75	Phosphorylation	QTPLNPASQPQAPPK CCCCCCCCCCCCCCC		-
103	Ubiquitination	QEQPEDRKTWLSQRS HCCCCCHHHHHHHHH		-
110	Phosphorylation	KTWLSQRSKLRQELE HHHHHHHHHHHHHHH		22817900
172	Phosphorylation	APRLSRLSRQMVPQL CHHHHHHHHHCCCCC		27174698
188	Phosphorylation	LPEPPALSVMYSYLH CCCCCHHHHHHHHHH		25262027
191	Phosphorylation	PPALSVMYSYLHSRK CCHHHHHHHHHHHCC		25262027
192	Phosphorylation	PALSVMYSYLHSRKI CHHHHHHHHHHHCCE		25262027
193	Phosphorylation	ALSVMYSYLHSRKIK HHHHHHHHHHHCCEE		25262027
196	Phosphorylation	VMYSYLHSRKIKILE HHHHHHHHCCEEHHH		25262027
252	Phosphorylation	SSLGKHNTITMDILA HHCCCCCCCHHHHHH		22210691
254	Phosphorylation	LGKHNTITMDILANT CCCCCCCHHHHHHHH		22210691
261	Phosphorylation	TMDILANTYKQWSMA HHHHHHHHHHHHHHH		22210691
301	Phosphorylation	LKKQEVDSAPQLPKV CCHHCCCCCCCCCCC		18491316
337	Phosphorylation	MEEVGKRYRERQRQH HHHHHHHHHHHHHHH		-
543	Phosphorylation	QPHVYPATYHPDHWW CCCCCCCCCCCCCCC		-
544	Phosphorylation	PHVYPATYHPDHWWP CCCCCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFC12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFC12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFC12_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EFC12_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.