ES8L3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ES8L3_HUMAN
• UniProt AC: Q8TE67
• Protein Name: Epidermal growth factor receptor kinase substrate 8-like protein 3
• Gene Name: EPS8L3
• Organism: Homo sapiens (Human).
• Sequence Length: 593
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGLPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEEVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRPSSRAI ------CCCCCCHHE	53.55	24719451
10	Phosphorylation	RPSSRAIYLHRKEYS CCCCHHEEECHHHHH	8.75	23312004
16	Phosphorylation	IYLHRKEYSQNLTSE EEECHHHHHHCCCCC	20.70	26657352
17	Phosphorylation	YLHRKEYSQNLTSEP EECHHHHHHCCCCCC	17.43	28857561
21	Phosphorylation	KEYSQNLTSEPTLLQ HHHHHCCCCCCCHHH	38.30	23312004
22	Phosphorylation	EYSQNLTSEPTLLQH HHHHCCCCCCCHHHH	44.75	23312004
25	Phosphorylation	QNLTSEPTLLQHRVE HCCCCCCCHHHHHHH	35.73	23312004
154	Phosphorylation	LEEELEQRPRLGGLQ HHHHHHHCCCCCCCC	14.66	27251275
154 (in isoform 3)	Phosphorylation	-	14.66	27251275
183	Phosphorylation	LPMEQARYLEPGIPP CCHHHHHHCCCCCCC	20.59	28442448
184	Phosphorylation	PMEQARYLEPGIPPE CHHHHHHCCCCCCCC	5.51	27642862
197	Phosphorylation	PEQPHQRTLEHSLPP CCCCCCCCHHCCCCC	29.90	27696853
201	Phosphorylation	HQRTLEHSLPPSPRP CCCCHHCCCCCCCCC	32.94	26657352
205	Phosphorylation	LEHSLPPSPRPLPRH HHCCCCCCCCCCCCC	31.44	26657352
213	Phosphorylation	PRPLPRHTSAREPSA CCCCCCCCCCCCCCC	25.92	28857561
214	Phosphorylation	RPLPRHTSAREPSAF CCCCCCCCCCCCCCC	21.14	26657352
219	Phosphorylation	HTSAREPSAFTLPPP CCCCCCCCCCCCCCC	31.12	28857561
229	Phosphorylation	TLPPPRRSSSPEDPE CCCCCCCCCCCCCHH	36.13	23663014
230	Phosphorylation	LPPPRRSSSPEDPER CCCCCCCCCCCCHHH	48.37	27696853
231	Phosphorylation	PPPRRSSSPEDPERD CCCCCCCCCCCHHHH	33.29	27696853
320	Phosphorylation	LVHILFKSLNFILAR HHHHHHHHHHHHHHH	22.63	24719451
321	Phosphorylation	VHILFKSLNFILARC HHHHHHHHHHHHHHC	6.64	24719451
415	Phosphorylation	PVSLRRGSHRLGSTS CCHHCCCCCCCCCCC	12.01	-
420	Phosphorylation	RGSHRLGSTSHFPQE CCCCCCCCCCCCCCH	31.18	26657352
421	Phosphorylation	GSHRLGSTSHFPQEK CCCCCCCCCCCCCHH	25.15	29116813
422	Phosphorylation	SHRLGSTSHFPQEKT CCCCCCCCCCCCHHC	25.48	29802988
429	Phosphorylation	SHFPQEKTHNHDPQP CCCCCHHCCCCCCCC	27.45	23312004
441	Phosphorylation	PQPGDPNSRPSSPKP CCCCCCCCCCCCCCC	51.46	23663014
444	Phosphorylation	GDPNSRPSSPKPAQP CCCCCCCCCCCCCCC	59.15	23663014
445	Phosphorylation	DPNSRPSSPKPAQPA CCCCCCCCCCCCCCC	39.36	23663014
459	Phosphorylation	ALKMQVLYEFEARNP CHHHEEEEEECCCCC	21.51	28442448
460	Phosphorylation	LKMQVLYEFEARNPR HHHEEEEEECCCCCC	32.61	27642862
496	Phosphorylation	VKNEAGRSGYIPSNI EECCCCCCCCCCHHH	34.72	23312004
498	Phosphorylation	NEAGRSGYIPSNILE CCCCCCCCCCHHHCC	15.77	23312004
501	Phosphorylation	GRSGYIPSNILEPLQ CCCCCCCHHHCCCCC	27.26	23663014
511	Phosphorylation	LEPLQPGTPGTQGQS CCCCCCCCCCCCCCC	25.81	23663014
512	Phosphorylation	EPLQPGTPGTQGQSP CCCCCCCCCCCCCCC	50.15	27251275
514	Phosphorylation	LQPGTPGTQGQSPSR CCCCCCCCCCCCCCC	30.63	23663014
518	Phosphorylation	TPGTQGQSPSRVPML CCCCCCCCCCCCCEE	31.50	23663014
520	Phosphorylation	GTQGQSPSRVPMLRL CCCCCCCCCCCEEEE	51.67	23663014
528	Phosphorylation	RVPMLRLSSRPEEVT CCCEEEECCCCHHHH	20.19	26657352
553	Phosphorylation	ATVRTLGSLTGSQLL CHHHHHHHCCCHHEE	26.35	26657352
555	Phosphorylation	VRTLGSLTGSQLLRI HHHHHHCCCHHEEEE	36.16	26657352
557	Phosphorylation	TLGSLTGSQLLRIRP HHHHCCCHHEEEECC	16.66	24670416
580	Phosphorylation	QEAPRILSRLEAVRR CCHHHHHHHHHHHHH	32.23	24719451
592	Phosphorylation	VRRMLGISP------ HHHHHCCCC------	23.82	27987026

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ES8L3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ES8L3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ES8L3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABI1_HUMAN	ABI1	physical	14565974
NMD3_MOUSE	Nmd3	physical	17124247

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.