CCG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCG2_HUMAN
• UniProt AC: Q9Y698
• Protein Name: Voltage-dependent calcium channel gamma-2 subunit
• Gene Name: CACNG2
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome .
• Protein Description: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state..
• Protein Sequence: MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	GTDYWLYSRGVCKTK CCCCHHEECCCCCCC	22.01	24719451
48	N-linked_Glycosylation	KTKSVSENETSKKNE CCCCCCCCCCCCCCH	50.79	UniProtKB CARBOHYD
59	Phosphorylation	KKNEEVMTHSGLWRT CCCHHCHHHCCHHHH	20.33	22167270
61	Phosphorylation	NEEVMTHSGLWRTCC CHHCHHHCCHHHHHC	26.81	23532336
125	Phosphorylation	GGLCIAASEFYKTRH CHHHHHHHHHHHHHH	21.15	-
217	Phosphorylation	ATARATDYLQASAIT HHHHHHHHHHHHHHH	9.07	27196784
228	Phosphorylation	SAITRIPSYRYRYQR HHHHCCCCHHHHHHC	21.63	24719451
229	Phosphorylation	AITRIPSYRYRYQRR HHHCCCCHHHHHHCC	13.30	-
239	Phosphorylation	RYQRRSRSSSRSTEP HHHCCCCCCCCCCCC	33.63	-
240	Phosphorylation	YQRRSRSSSRSTEPS HHCCCCCCCCCCCCC	28.76	22210691
241	Phosphorylation	QRRSRSSSRSTEPSH HCCCCCCCCCCCCCC	31.34	22210691
249	Phosphorylation	RSTEPSHSRDASPVG CCCCCCCCCCCCCCC	35.87	25307156
253	Phosphorylation	PSHSRDASPVGIKGF CCCCCCCCCCCCCCC	25.14	25307156
271	Phosphorylation	PSTEISMYTLSRDPL CCCEEEEEECCCCCC	9.57	27196784
321	Phosphorylation	NTANRRTTPV----- CCCCCCCCCC-----	21.90	11805122

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCG2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
321	T	Phosphorylation	Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRIA4_HUMAN	GRIA4	physical	11140673
GRIA1_HUMAN	GRIA1	physical	11140673
GRIA2_HUMAN	GRIA2	physical	11140673
DLG4_HUMAN	DLG4	physical	11140673
DLG1_HUMAN	DLG1	physical	11140673
NMDZ1_HUMAN	GRIN1	physical	11140673
A4_HUMAN	APP	physical	21832049
ITPR2_HUMAN	ITPR2	physical	26186194
HBS1L_HUMAN	HBS1L	physical	26186194
GOPC_HUMAN	GOPC	physical	26186194
MTCH2_HUMAN	MTCH2	physical	26186194
KC1E_HUMAN	CSNK1E	physical	26186194
KC1D_HUMAN	CSNK1D	physical	26186194
CCNT1_HUMAN	CCNT1	physical	26186194
STAT3_HUMAN	STAT3	physical	26186194
ATF1_HUMAN	ATF1	physical	26186194
EPHA7_HUMAN	EPHA7	physical	26186194
HBS1L_HUMAN	HBS1L	physical	28514442
KC1E_HUMAN	CSNK1E	physical	28514442
GOPC_HUMAN	GOPC	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
CCNT1_HUMAN	CCNT1	physical	28514442
KC1D_HUMAN	CSNK1D	physical	28514442
ITPR2_HUMAN	ITPR2	physical	28514442
EPHA7_HUMAN	EPHA7	physical	28514442
ATF1_HUMAN	ATF1	physical	28514442
MSTO1_HUMAN	MSTO1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614256: Mental retardation, autosomal dominant 10 (MRD10)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00898: Ethanol