dbPTM

ITPR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ITPR2_HUMAN
UniProt AC	Q14571
Protein Name	Inositol 1,4,5-trisphosphate receptor type 2
Gene Name	ITPR2
Organism	Homo sapiens (Human).
Sequence Length	2701
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein.
Protein Description	Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity)..
Protein Sequence	MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTEKMSSFL ------CCHHHCCEE	56.47	26552605
6	Phosphorylation	--MTEKMSSFLYIGD --CCHHHCCEEEHHH	29.07	26552605
7	Phosphorylation	-MTEKMSSFLYIGDI -CCHHHCCEEEHHHH	18.77	26552605
10	Phosphorylation	EKMSSFLYIGDIVSL HHHCCEEEHHHHHHH	10.80	26552605
16	Phosphorylation	LYIGDIVSLYAEGSV EEHHHHHHHHCCCCC	18.92	26552605
18	Phosphorylation	IGDIVSLYAEGSVNG HHHHHHHHCCCCCCC	8.63	26552605
22	Phosphorylation	VSLYAEGSVNGFIST HHHHCCCCCCCHHHH	12.15	26552605
28	Phosphorylation	GSVNGFISTLGLVDD CCCCCHHHHCCCCCC	18.47	26552605
29	Phosphorylation	SVNGFISTLGLVDDR CCCCHHHHCCCCCCE	21.74	26552605
70	Ubiquitination	MNRYSAQKQYWKAKQ CCHHHHHHHHHHHHH	45.10	-
79	Ubiquitination	YWKAKQAKQGNHTEA HHHHHHHHCCCHHHH	57.13	29967540
91	Ubiquitination	TEAALLKKLQHAAEL HHHHHHHHHHHHHHH	54.04	29967540
117	Phosphorylation	LLGEIVKYSNVIQLL HHHHHHHHHCCEEHE	8.45	-
118	Phosphorylation	LGEIVKYSNVIQLLH HHHHHHHHCCEEHEE	20.92	-
130	Ubiquitination	LLHIKSNKYLTVNKR HEECCCCCEEEECCC	49.04	-
131	Phosphorylation	LHIKSNKYLTVNKRL EECCCCCEEEECCCH	16.32	24719451
133	Phosphorylation	IKSNKYLTVNKRLPA CCCCCEEEECCCHHH	20.95	24719451
136	Ubiquitination	NKYLTVNKRLPALLE CCEEEECCCHHHHHH	51.48	-
144	Ubiquitination	RLPALLEKNAMRVSL CHHHHHHHCCEEEEE	50.40	-
249	Acetylation	LFHAEQEKFLTCDEY EEECHHHCCCCCCHH	45.42	26051181
252	Phosphorylation	AEQEKFLTCDEYEKK CHHHCCCCCCHHHHH	22.50	29052541
258	Acetylation	LTCDEYEKKQHIFLR CCCCHHHHHHCEEEH	57.75	26051181
258	Ubiquitination	LTCDEYEKKQHIFLR CCCCHHHHHHCEEEH	57.75	29967540
267	Phosphorylation	QHIFLRTTLRQSATS HCEEEHHHHHHHCCC	17.32	29759185
276	Phosphorylation	RQSATSATSSKALWE HHHCCCCCCCHHEEE	33.04	-
277	Phosphorylation	QSATSATSSKALWEI HHCCCCCCCHHEEEE	29.56	-
278	Phosphorylation	SATSATSSKALWEIE HCCCCCCCHHEEEEE	20.00	-
301	Phosphorylation	GGAGQWNSLFRFKHL CCCCCCCCCCHHHHC	26.40	24719451
386	Phosphorylation	CLVPRNSYVRLRHLC EECCCCCEEEHEEEC	7.98	-
433	Phosphorylation	KEAFAIVSVPLSEVR CCEEEEEEEEHHHHC	16.35	27762562
437	Phosphorylation	AIVSVPLSEVRDLDF EEEEEEHHHHCCCCC	28.16	27762562
450	Ubiquitination	DFANDANKVLATTVK CCCCCHHHHHHHHHH	40.10	-
458	Ubiquitination	VLATTVKKLENGTIT HHHHHHHHHHCCCCC	57.61	-
463	Phosphorylation	VKKLENGTITQNERR HHHHHCCCCCHHHHH	32.22	30576142
546	Phosphorylation	EDLGDQRYAPYKYML HHHCCCCCCCHHHHH	13.29	-
549	Phosphorylation	GDQRYAPYKYMLRLC CCCCCCCHHHHHHHH	13.43	-
551	Phosphorylation	QRYAPYKYMLRLCYR CCCCCHHHHHHHHHH	8.78	-
569	Acetylation	HSQQDYRKNQEYIAK HHHHHHHHCHHHHHH	57.67	7664419
576	Acetylation	KNQEYIAKNFCVMQS HCHHHHHHHHHEEHH	40.78	7668605
583	Phosphorylation	KNFCVMQSQIGYDIL HHHHEEHHHHCCCCC	12.98	29083192
587	Phosphorylation	VMQSQIGYDILAEDT EEHHHHCCCCCCHHH	11.05	29083192
594	Phosphorylation	YDILAEDTITALLHN CCCCCHHHHHHHHHC	16.25	29083192
596	Phosphorylation	ILAEDTITALLHNNR CCCHHHHHHHHHCCH	17.22	29083192
608	Acetylation	NNRKLLEKHITAKEI CCHHHHHHHCCHHHH	40.03	19608861
608	Ubiquitination	NNRKLLEKHITAKEI CCHHHHHHHCCHHHH	40.03	19608861
613	Acetylation	LEKHITAKEIETFVS HHHHCCHHHHHHHHH	51.04	26051181
658	Phosphorylation	LICKFMLSPGNADIL HHHHHHCCCCCCCEE	20.97	20068231
843	Acetylation	EFVEEYLKEVVNQPF HHHHHHHHHHHCCCC	47.78	19820175
855	Ubiquitination	QPFPFGDKEKNKLTF CCCCCCCHHCCCCCH	71.60	29967540
903	Phosphorylation	VQAPMSSYFERLSKF HHCCCHHHHHHHHCC	11.36	-
909	Ubiquitination	SYFERLSKFQDGGNN HHHHHHHCCCCCCCC	52.19	-
937	Phosphorylation	QMVLSRGSIFPMSVP HHHHHCCCCCCCCCC	21.68	24275569
942	Phosphorylation	RGSIFPMSVPDVPPS CCCCCCCCCCCCCCC	30.64	28122231
953	Phosphorylation	VPPSIHPSKQGSPTE CCCCCCCCCCCCCCC	24.37	20068231
990	Phosphorylation	VRLDYRISYMLSIYK HCCHHHHHHHHHHHH	8.76	24719451
991	Phosphorylation	RLDYRISYMLSIYKK CCHHHHHHHHHHHHH	10.33	24719451
994	Phosphorylation	YRISYMLSIYKKEFG HHHHHHHHHHHHHHC	13.82	25072903
996	Phosphorylation	ISYMLSIYKKEFGED HHHHHHHHHHHHCCC	16.78	25072903
1009	Phosphorylation	EDNDNAETSASGSPD CCCCCCCCCCCCCCC	27.47	28270605
1010	Phosphorylation	DNDNAETSASGSPDT CCCCCCCCCCCCCCC	16.37	28270605
1012	Phosphorylation	DNAETSASGSPDTLL CCCCCCCCCCCCCCC	39.30	28270605
1014	Phosphorylation	AETSASGSPDTLLPS CCCCCCCCCCCCCCC	19.67	25627689
1017	Phosphorylation	SASGSPDTLLPSAIV CCCCCCCCCCCCCCC	33.31	25627689
1021	Phosphorylation	SPDTLLPSAIVPDID CCCCCCCCCCCCCHH	30.51	28270605
1113	Ubiquitination	VDNYKQIKADLDQLR CCCHHHHCCCHHHHH	33.10	29967540
1125	Ubiquitination	QLRLTVEKSELWVEK HHHCEEEHHHHEEEE	44.91	29967540
1133	Phosphorylation	SELWVEKSSNYENGE HHHEEEECCCCCCCC	15.43	28796482
1134	Phosphorylation	ELWVEKSSNYENGEI HHEEEECCCCCCCCC	55.27	28796482
1136	Phosphorylation	WVEKSSNYENGEIGE EEEECCCCCCCCCCC	16.84	28796482
1156	Phosphorylation	GEEPIEESNILSPVQ CCCCCCHHCCCCCCC	19.17	29978859
1160	Phosphorylation	IEESNILSPVQDGTK CCHHCCCCCCCCCCC	21.16	30266825
1166	Phosphorylation	LSPVQDGTKKPQIDS CCCCCCCCCCCCCCC	44.15	30108239
1175	Ubiquitination	KPQIDSNKSNNYRIV CCCCCCCCCCCHHHH	59.52	29967540
1183	Ubiquitination	SNNYRIVKEILIRLS CCCHHHHHHHHHHHH	36.34	-
1232	Ubiquitination	EKNDEKMNEVMNLAH CCCHHHHHHHHHHHH	50.18	21963094
1392	Phosphorylation	CTEGKNVYTEIKCNS HCCCCCEEEEEECCC	14.19	-
1394	Ubiquitination	EGKNVYTEIKCNSLL CCCCEEEEEECCCCC	23.82	21963094
1396	Ubiquitination	KNVYTEIKCNSLLPL CCEEEEEECCCCCCH	22.56	21963094
1416	Ubiquitination	VVTHDDCIPEVKIAY EEECCCCCCCCEEEE	4.13	21963094
1425	Ubiquitination	EVKIAYVNFVNHCYV CCEEEEEEECCCEEE	23.60	21890473
1443	Phosphorylation	VEMKEIYTSNHIWKL HHHHHHHCHHHHHHH	28.81	-
1545	Ubiquitination	RTLAEVAKNRGIAIP HHHHHHHHHCCCEEC	52.97	29967540
1557	Phosphorylation	AIPVDLDSQVNTLFM EECCCCHHHHHHHHH	43.24	20068231
1561	Phosphorylation	DLDSQVNTLFMKSHS CCHHHHHHHHHHCCC	23.63	20068231
1564	Sulfoxidation	SQVNTLFMKSHSNMV HHHHHHHHHCCCHHH	4.97	21406390
1581	Phosphorylation	AAMGWRLSARSGPRF HHHHHHHHHCCCHHH	17.05	23312004
1584	Phosphorylation	GWRLSARSGPRFKEA HHHHHHCCCHHHHHH	53.52	23312004
1587	Ubiquitination	LSARSGPRFKEALGG HHHCCCHHHHHHHCC	59.81	21890473
1589	Ubiquitination	ARSGPRFKEALGGPA HCCCHHHHHHHCCCC	43.27	22817900
1589 (in isoform 1)	Ubiquitination	-	43.27	21890473
1609	Ubiquitination	IIEKLQDVVASLEHQ HHHHHHHHHHHHHHC	2.21	21890473
1685	Acetylation	LREMLEKKDSFVEEG HHHHHHCCCCHHHHC	49.59	7695267
1685	Ubiquitination	LREMLEKKDSFVEEG HHHHHHCCCCHHHHC	49.59	29967540
1703	Phosphorylation	RKILLNRYFKGDYSI HHHHHHHHHCCCEEE	14.47	29449344
1708	Phosphorylation	NRYFKGDYSIGVNGH HHHHCCCEEEECCCC	15.74	-
1709	Phosphorylation	RYFKGDYSIGVNGHL HHHCCCEEEECCCCC	20.01	-
1729	Phosphorylation	KTAQVGGSFSGQDSD CCCCCCCCCCCCCCC	15.43	21815630
1823	Phosphorylation	AAQKEIRSTVTVNTI HHHHHHHCCEEEEEE	32.65	20068231
1824	Phosphorylation	AQKEIRSTVTVNTID HHHHHHCCEEEEEEE	15.45	20068231
1826	Phosphorylation	KEIRSTVTVNTIDLG HHHHCCEEEEEEECC	14.23	20068231
1829	Phosphorylation	RSTVTVNTIDLGNKK HCCEEEEEEECCCCC	16.13	20068231
1845	Phosphorylation	DDDNELMTSGPRMRV CCCCCCCCCCCCEEE	43.06	20860994
1846	Phosphorylation	DDNELMTSGPRMRVR CCCCCCCCCCCEEEC	32.60	21815630
1855	Phosphorylation	PRMRVRDSTLHLKEG CCEEECCCEECCCCC	23.46	23403867
1856	Phosphorylation	RMRVRDSTLHLKEGM CEEECCCEECCCCCC	23.61	23403867
1864	Methylation	LHLKEGMKGQLTEAS ECCCCCCCCCCCCCC	55.12	115971483
1868	Phosphorylation	EGMKGQLTEASSATS CCCCCCCCCCCCCCC	22.93	21406692
1871	Phosphorylation	KGQLTEASSATSKAY CCCCCCCCCCCCCEE	17.80	21406692
1872	Phosphorylation	GQLTEASSATSKAYC CCCCCCCCCCCCEEE	42.48	25159151
1874	Phosphorylation	LTEASSATSKAYCVY CCCCCCCCCCEEEEE	32.48	21406692
1875	Phosphorylation	TEASSATSKAYCVYR CCCCCCCCCEEEEEE	18.27	21406692
1878	Phosphorylation	SSATSKAYCVYRREM CCCCCCEEEEEECCC	6.03	27642862
1910	Phosphorylation	EKSAEEVTMSPAIAI CCCHHHCCCCHHHHH	18.40	-
1912	Phosphorylation	SAEEVTMSPAIAIMQ CHHHCCCCHHHHHHH	11.21	-
2045	Phosphorylation	LQLKNNASKLLLAIM HHHHCCHHHHHHHHH	26.42	29083192
2054	Phosphorylation	LLLAIMESRHDSENA HHHHHHHHCCCCCCH	19.96	29083192
2078	Ubiquitination	RELVDVMKNAYNQGL HHHHHHHHHHHHCCC	37.97	-
2127	Ubiquitination	KLLQQMLKPGSDPDE HHHHHHHCCCCCCCC	41.83	29967540
2204	Phosphorylation	FQQTEDLYNEMKWQK HHHHHHHHHHHHHHH	22.77	28258704
2208	Ubiquitination	EDLYNEMKWQKKIRN HHHHHHHHHHHHHHC	40.05	32015554
2222	Ubiquitination	NNPALFWFSRHISLW CCCHHHHHHHHHHHH	3.44	21963094
2380	Phosphorylation	DLVYREETLLNVIKS HHHHCHHHHHHHHHH	31.62	28258704
2384	Ubiquitination	REETLLNVIKSVTRN CHHHHHHHHHHHCCC	6.18	21963094
2386	Ubiquitination	ETLLNVIKSVTRNGR HHHHHHHHHHCCCCH	34.29	21963094
2390	Ubiquitination	NVIKSVTRNGRSIIL HHHHHHCCCCHHHHH	41.26	22817900
2395	Ubiquitination	VTRNGRSIILTAVLA HCCCCHHHHHHHHHH	2.63	21963094
2406	Ubiquitination	AVLALILVYLFSIIG HHHHHHHHHHHHHHH	2.86	21963094
2446	O-linked_Glycosylation	QVPTMTLTTMMEACA CCCCCCHHHHHHHHH	11.95	OGP
2447	O-linked_Glycosylation	VPTMTLTTMMEACAK CCCCCHHHHHHHHHH	20.03	OGP
2552	Ubiquitination	ADLRSEKQKKEEILK HHHHCHHHHHHHHHH	58.98	22817900
2554	Ubiquitination	LRSEKQKKEEILKTT HHCHHHHHHHHHHHH	59.07	22817900
2557	Ubiquitination	EKQKKEEILKTTCFI HHHHHHHHHHHHHHH	5.12	21963094
2559	Ubiquitination	QKKEEILKTTCFICG HHHHHHHHHHHHHCC	47.66	21963094
2574	Ubiquitination	LERDKFDNKTVSFEE CCCCCCCCCEECHHH	45.06	22817900
2579	Ubiquitination	FDNKTVSFEEHIKSE CCCCEECHHHHHHCH	12.72	21963094
2605	Phosphorylation	LVKVKDPTEYTGPES EEECCCCCCCCCCHH	52.32	20068231
2607	Phosphorylation	KVKDPTEYTGPESYV ECCCCCCCCCCHHHH	21.34	20068231
2608	Phosphorylation	VKDPTEYTGPESYVA CCCCCCCCCCHHHHH	39.77	20068231
2612	Phosphorylation	TEYTGPESYVAQMIV CCCCCCHHHHHHHHH	28.21	20068231
2613	Phosphorylation	EYTGPESYVAQMIVE CCCCCHHHHHHHHHH	9.72	20068231
2633	Phosphorylation	FPRMRAMSLVSNEGD HHHHHHHHHHCCCCC	25.32	29255136
2636	Phosphorylation	MRAMSLVSNEGDSEQ HHHHHHHCCCCCHHH	34.16	25159151
2641	Phosphorylation	LVSNEGDSEQNEIRS HHCCCCCHHHHHHHH	52.52	23403867
2652	Ubiquitination	EIRSLQEKLESTMSL HHHHHHHHHHHHHHH	44.59	-
2655	Phosphorylation	SLQEKLESTMSLVKQ HHHHHHHHHHHHHHH	39.59	23403867
2656	Phosphorylation	LQEKLESTMSLVKQL HHHHHHHHHHHHHHH	11.03	23403867
2658	Phosphorylation	EKLESTMSLVKQLSG HHHHHHHHHHHHHHH	30.05	23403867
2661	Ubiquitination	ESTMSLVKQLSGQLA HHHHHHHHHHHHHHH	51.30	32015554
2664	Phosphorylation	MSLVKQLSGQLAELK HHHHHHHHHHHHHHH	23.23	28348404
2671	Ubiquitination	SGQLAELKEQMTEQR HHHHHHHHHHHHHHH	37.09	29967540
2675	Phosphorylation	AELKEQMTEQRKNKQ HHHHHHHHHHHHHHH	28.76	-
2689	Phosphorylation	QRLGFLGSNTPHVNH HHHCCCCCCCCCCCC	39.41	28555341
2691	Phosphorylation	LGFLGSNTPHVNHHM HCCCCCCCCCCCCCC	19.23	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
937	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
937	S	Phosphorylation		-
Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ITPR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ITPR2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
106190	Anhidrosis, isolated, with normal sweat glands (ANHD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00201	Caffeine

Regulatory Network of ITPR2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-608, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1160, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1160, AND MASSSPECTROMETRY.	18691976 [Abstract]

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