HBS1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBS1L_HUMAN
• UniProt AC: Q9Y450
• Protein Name: HBS1-like protein
• Gene Name: HBS1L
• Organism: Homo sapiens (Human).
• Sequence Length: 684
• Protein Sequence: MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQARLYSCLDHMREVLGDAVPDEILIEAVLKNKFDVQKALSGVLEQDRVQSLKDKNEATVSTGKIAKGKPVDSQTSRSESEIVPKVAKMTVSGKKQTMGFEVPGVSSEENGHSFHTPQKGPPIEDAIASSDVLETASKSANPPHTIQASEEQSSTPAPVKKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCITGKIEAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCGPKVPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKFLTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEIKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RHRNVRGYNYDEDFE CCCCCCCCCCCCCCC	10.45	24043423
12	Phosphorylation	RNVRGYNYDEDFEDD CCCCCCCCCCCCCCC	16.54	24043423
22	Phosphorylation	DFEDDDLYGQSVEDD CCCCCCCCCCCCCCC	21.80	24043423
25	Phosphorylation	DDDLYGQSVEDDYCI CCCCCCCCCCCCEEC	24.10	24043423
30	Phosphorylation	GQSVEDDYCISPSTA CCCCCCCEECCHHHH	12.19	26074081
33	Phosphorylation	VEDDYCISPSTAAQF CCCCEECCHHHHHHH	14.83	28464451
35	Phosphorylation	DDYCISPSTAAQFIY CCEECCHHHHHHHHH	24.72	26074081
36	Phosphorylation	DYCISPSTAAQFIYS CEECCHHHHHHHHHC	29.42	18669648
42	Phosphorylation	STAAQFIYSRRDKPS HHHHHHHHCCCCCCC	9.45	26074081
43	Phosphorylation	TAAQFIYSRRDKPSV HHHHHHHCCCCCCCC	18.94	26074081
47	Ubiquitination	FIYSRRDKPSVEPVE HHHCCCCCCCCCCCC	37.06	21906983
47 (in isoform 1)	Ubiquitination	-	37.06	21890473
47 (in isoform 2)	Ubiquitination	-	37.06	21890473
49	Phosphorylation	YSRRDKPSVEPVEEY HCCCCCCCCCCCCCC	44.87	23927012
56	Phosphorylation	SVEPVEEYDYEDLKE CCCCCCCCCHHHHHH	15.43	25159151
58	Phosphorylation	EPVEEYDYEDLKESS CCCCCCCHHHHHHHC	15.50	23927012
62	Ubiquitination	EYDYEDLKESSNSVS CCCHHHHHHHCCCCC	68.80	21906983
62 (in isoform 1)	Ubiquitination	-	68.80	21890473
62 (in isoform 2)	Ubiquitination	-	68.80	21890473
64	Phosphorylation	DYEDLKESSNSVSNH CHHHHHHHCCCCCCC	32.98	30266825
65	Phosphorylation	YEDLKESSNSVSNHQ HHHHHHHCCCCCCCC	33.93	30266825
67	Phosphorylation	DLKESSNSVSNHQLS HHHHHCCCCCCCCCC	28.95	30266825
69	Phosphorylation	KESSNSVSNHQLSGF HHHCCCCCCCCCCCH	28.54	30266825
72	Ubiquitination	SNSVSNHQLSGFDQA CCCCCCCCCCCHHHH	41.39	21890473
74	Phosphorylation	SVSNHQLSGFDQARL CCCCCCCCCHHHHHH	30.74	23927012
82	Phosphorylation	GFDQARLYSCLDHMR CHHHHHHHHHHHHHH	7.56	-
107	Ubiquitination	ILIEAVLKNKFDVQK HHHHHHHCCCCCHHH	52.04	21906983
107 (in isoform 1)	Ubiquitination	-	52.04	21890473
107 (in isoform 2)	Ubiquitination	-	52.04	21890473
109	Ubiquitination	IEAVLKNKFDVQKAL HHHHHCCCCCHHHHH	41.16	-
114	Ubiquitination	KNKFDVQKALSGVLE CCCCCHHHHHHHHHH	51.66	21890473
114 (in isoform 1)	Ubiquitination	-	51.66	21890473
114 (in isoform 2)	Ubiquitination	-	51.66	21890473
117	Phosphorylation	FDVQKALSGVLEQDR CCHHHHHHHHHHHHH	31.54	29255136
124	Methylation	SGVLEQDRVQSLKDK HHHHHHHHHHHHHCC	28.24	-
127	Phosphorylation	LEQDRVQSLKDKNEA HHHHHHHHHHCCCCC	34.23	30266825
135	Phosphorylation	LKDKNEATVSTGKIA HHCCCCCEEECCEEC	14.60	29396449
137	Phosphorylation	DKNEATVSTGKIAKG CCCCCEEECCEECCC	27.39	29396449
138	Phosphorylation	KNEATVSTGKIAKGK CCCCEEECCEECCCC	37.85	29396449
140	Acetylation	EATVSTGKIAKGKPV CCEEECCEECCCCCC	39.31	25953088
140	Ubiquitination	EATVSTGKIAKGKPV CCEEECCEECCCCCC	39.31	21906983
140 (in isoform 1)	Ubiquitination	-	39.31	21890473
140 (in isoform 2)	Ubiquitination	-	39.31	21890473
143	Ubiquitination	VSTGKIAKGKPVDSQ EECCEECCCCCCCCC	71.58	-
149	Phosphorylation	AKGKPVDSQTSRSES CCCCCCCCCCCCCHH	35.28	26699800
151	Phosphorylation	GKPVDSQTSRSESEI CCCCCCCCCCCHHHH	30.02	26699800
152	Phosphorylation	KPVDSQTSRSESEIV CCCCCCCCCCHHHHH	26.60	26699800
154	O-linked_Glycosylation	VDSQTSRSESEIVPK CCCCCCCCHHHHHCC	45.29	30379171
154	Phosphorylation	VDSQTSRSESEIVPK CCCCCCCCHHHHHCC	45.29	28985074
156	Phosphorylation	SQTSRSESEIVPKVA CCCCCCHHHHHCCEE	33.59	28857561
164	Acetylation	EIVPKVAKMTVSGKK HHHCCEEEEEECCCE	37.78	25953088
173	Phosphorylation	TVSGKKQTMGFEVPG EECCCEEECCEECCC	28.30	28555341
180 (in isoform 2)	Phosphorylation	-	36.79	25627689
182	Phosphorylation	GFEVPGVSSEENGHS CEECCCCCCCCCCCC	37.64	22817900
183	Phosphorylation	FEVPGVSSEENGHSF EECCCCCCCCCCCCC	46.66	28555341
189	Phosphorylation	SSEENGHSFHTPQKG CCCCCCCCCCCCCCC	21.81	26074081
192	Phosphorylation	ENGHSFHTPQKGPPI CCCCCCCCCCCCCCH	25.96	25159151
205	Phosphorylation	PIEDAIASSDVLETA CHHHHHHCCHHHHHH	22.43	26074081
206	Phosphorylation	IEDAIASSDVLETAS HHHHHHCCHHHHHHH	23.79	26074081
211	Phosphorylation	ASSDVLETASKSANP HCCHHHHHHHHCCCC	31.88	30576142
213	Phosphorylation	SDVLETASKSANPPH CHHHHHHHHCCCCCC	34.27	25159151
215	Phosphorylation	VLETASKSANPPHTI HHHHHHHCCCCCCCE	30.68	25159151
221	Phosphorylation	KSANPPHTIQASEEQ HCCCCCCCEECCCCC	22.13	29396449
223 (in isoform 2)	Phosphorylation	-	39.74	24719451
225	Phosphorylation	PPHTIQASEEQSSTP CCCCEECCCCCCCCC	25.87	22199227
229	Phosphorylation	IQASEEQSSTPAPVK EECCCCCCCCCCCCC	39.19	25159151
230	Phosphorylation	QASEEQSSTPAPVKK ECCCCCCCCCCCCCC	37.80	25159151
231	Phosphorylation	ASEEQSSTPAPVKKS CCCCCCCCCCCCCCC	28.81	25159151
236	Acetylation	SSTPAPVKKSGKLRQ CCCCCCCCCCCHHHH	39.91	25953088
237	Ubiquitination	STPAPVKKSGKLRQQ CCCCCCCCCCHHHHE	65.75	-
241 (in isoform 2)	Phosphorylation	-	7.34	-
245 (in isoform 2)	Phosphorylation	-	5.07	22115753
246 (in isoform 2)	Phosphorylation	-	31.37	27273156
247 (in isoform 2)	Phosphorylation	-	7.27	22115753
248	Ubiquitination	LRQQIDVKAELEKRQ HHHEEEHHHHHHHHC	32.18	-
249 (in isoform 2)	Phosphorylation	-	26.84	25159151
252 (in isoform 2)	Phosphorylation	-	37.38	28450419
255 (in isoform 2)	Phosphorylation	-	75.86	20873877
294	Acetylation	INKRTMHKYEQESKK CCHHHHHHHHHHHHH	39.39	7966193
299	O-linked_Glycosylation	MHKYEQESKKAGKAS HHHHHHHHHHHCCCC	38.87	30379171
306	Phosphorylation	SKKAGKASFAYAWVL HHHHCCCCEEEEEEE	17.56	29978859
309	Phosphorylation	AGKASFAYAWVLDET HCCCCEEEEEEECCC	10.05	28796482
325	Phosphorylation	EERERGVTMDVGMTK CCHHCCEECCCCCCC	15.52	28857561
326	Sulfoxidation	ERERGVTMDVGMTKF CHHCCEECCCCCCCE	3.50	21406390
330	Sulfoxidation	GVTMDVGMTKFETTT CEECCCCCCCEEECE	3.56	30846556
331	Phosphorylation	VTMDVGMTKFETTTK EECCCCCCCEEECEE	27.01	30576142
332	Ubiquitination	TMDVGMTKFETTTKV ECCCCCCCEEECEEE	32.10	-
336	Phosphorylation	GMTKFETTTKVITLM CCCCEEECEEEEEEE	19.88	29759185
337	Phosphorylation	MTKFETTTKVITLMD CCCEEECEEEEEEEC	30.63	29759185
350 (in isoform 2)	Phosphorylation	-	40.82	21815630
373 (in isoform 2)	Phosphorylation	-	50.83	25159151
375 (in isoform 2)	Phosphorylation	-	38.92	27251275
424	Acetylation	RFQEITGKLGHFLKQ HHHHHHHHHHHHHHH	42.52	25953088
424	Ubiquitination	RFQEITGKLGHFLKQ HHHHHHHHHHHHHHH	42.52	-
424 (in isoform 2)	Phosphorylation	-	42.52	22199227
425 (in isoform 2)	Phosphorylation	-	7.34	22199227
429 (in isoform 2)	Phosphorylation	-	3.14	22199227
430	Acetylation	GKLGHFLKQAGFKES HHHHHHHHHCCCCHH	36.84	25953088
430	Malonylation	GKLGHFLKQAGFKES HHHHHHHHHCCCCHH	36.84	26320211
430	Ubiquitination	GKLGHFLKQAGFKES HHHHHHHHHCCCCHH	36.84	-
435	Acetylation	FLKQAGFKESDVGFI HHHHCCCCHHCCEEE	56.22	25953088
435	Ubiquitination	FLKQAGFKESDVGFI HHHHCCCCHHCCEEE	56.22	-
444 (in isoform 2)	Phosphorylation	-	30.52	28450419
446 (in isoform 2)	Phosphorylation	-	26.75	28450419
453 (in isoform 2)	Phosphorylation	-	4.54	22115753
455 (in isoform 2)	Phosphorylation	-	26.21	24043423
456	Phosphorylation	GENLITRSQSSELTK CCCCCCHHHCHHHHH	26.26	-
461 (in isoform 2)	Phosphorylation	-	6.88	24043423
463	Ubiquitination	SQSSELTKWYKGLCL HHCHHHHHHHHHHHH	62.24	-
465	Phosphorylation	SSELTKWYKGLCLLE CHHHHHHHHHHHHHH	9.20	-
466	Ubiquitination	SELTKWYKGLCLLEQ HHHHHHHHHHHHHHC	44.27	-
467 (in isoform 2)	Phosphorylation	-	13.11	24043423
473 (in isoform 2)	Phosphorylation	-	44.77	28674419
478	Ubiquitination	LEQIDSFKPPQRSID HHCHHHCCCCCCCCC	60.79	-
483 (in isoform 2)	Phosphorylation	-	29.86	22210691
486	Acetylation	PPQRSIDKPFRLCVS CCCCCCCCCCEEEEH	44.37	25953088
486	Ubiquitination	PPQRSIDKPFRLCVS CCCCCCCCCCEEEEH	44.37	-
488 (in isoform 2)	Phosphorylation	-	13.19	22210691
493 (in isoform 2)	Phosphorylation	-	27.36	22210691
497	Ubiquitination	LCVSDVFKDQGSGFC EEEHHHHCCCCCCEE	49.33	-
510 (in isoform 2)	Phosphorylation	-	39.26	25262027
513	Phosphorylation	TGKIEAGYIQTGDRL ECEEEEEEEECCCEE	9.26	20068231
514 (in isoform 2)	Phosphorylation	-	2.64	21406692
515 (in isoform 2)	Phosphorylation	-	30.83	25262027
516	Phosphorylation	IEAGYIQTGDRLLAM EEEEEEECCCEEEEC	31.34	20068231
528	Phosphorylation	LAMPPNETCTVKGIT EECCCCCEEEEEEEE	21.81	20068231
530	Phosphorylation	MPPNETCTVKGITLH CCCCCEEEEEEEEEC	32.45	20068231
541 (in isoform 2)	Phosphorylation	-	10.11	24719451
572	Ubiquitination	GCIFCGPKVPIKACT EEEECCCCCCHHHCC	46.02	-
580	Ubiquitination	VPIKACTRFRARILI CCHHHCCHHCEEEEE	20.95	21890473
602 (in isoform 2)	Phosphorylation	-	3.44	22199227
604	Phosphorylation	GFPVLLHYQTVSEPA CCCEEEEEEECCCHH	13.07	22817900
614 (in isoform 2)	Phosphorylation	-	34.26	22210691
615	Ubiquitination	SEPAVIKRLISVLNK CCHHHHHHHHHHHHH	26.57	21890473
616 (in isoform 2)	Phosphorylation	-	2.65	22210691
618	Phosphorylation	AVIKRLISVLNKSTG HHHHHHHHHHHHCCC	25.74	27067055
622	Acetylation	RLISVLNKSTGEVTK HHHHHHHHCCCCCCC	45.28	25953088
622	Malonylation	RLISVLNKSTGEVTK HHHHHHHHCCCCCCC	45.28	26320211
622	Ubiquitination	RLISVLNKSTGEVTK HHHHHHHHCCCCCCC	45.28	2189047
622 (in isoform 1)	Ubiquitination	-	45.28	21890473
657	Ubiquitination	PIALELYKDFKELGR CHHHHHHHHHHHHCH	70.12	-
657 (in isoform 1)	Ubiquitination	-	70.12	21890473
660	Malonylation	LELYKDFKELGRFML HHHHHHHHHHCHHHH	63.26	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBS1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HBS1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HBS1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UB2G2_HUMAN	UBE2G2	physical	21988832
FANCI_HUMAN	FANCI	physical	22863883
PELO_HUMAN	PELO	physical	25416956
IF2G_HUMAN	EIF2S3	physical	26344197
EXOS9_HUMAN	EXOSC9	physical	27345150
EXOS7_HUMAN	EXOSC7	physical	27345150
EXOS8_HUMAN	EXOSC8	physical	27345150
EXOS3_HUMAN	EXOSC3	physical	27345150
EXOS6_HUMAN	EXOSC6	physical	27345150
EXOS5_HUMAN	EXOSC5	physical	27345150
EXOS4_HUMAN	EXOSC4	physical	27345150
EXOS1_HUMAN	EXOSC1	physical	27345150
EIF1A_HUMAN	EIF1AD	physical	28514442
UHRF1_HUMAN	UHRF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.