SRXN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRXN1_HUMAN
• UniProt AC: Q9BYN0
• Protein Name: Sulfiredoxin-1
• Gene Name: SRXN1
• Organism: Homo sapiens (Human).
• Sequence Length: 137
• Subcellular Localization: Cytoplasm .
• Protein Description: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase..
• Protein Sequence: MGLRAGGTLGRAGAGRGAPEGPGPSGGAQGGSIHSGRIAAVHNVPLSVLIRPLPSVLDPAKVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MGLRAGGTLGR ----CCCCCCCCCCC	26.00	115917857
8	Phosphorylation	MGLRAGGTLGRAGAG CCCCCCCCCCCCCCC	25.73	23312004
11	Methylation	RAGGTLGRAGAGRGA CCCCCCCCCCCCCCC	32.72	24129315
16	Dimethylation	LGRAGAGRGAPEGPG CCCCCCCCCCCCCCC	37.25	-
16	Methylation	LGRAGAGRGAPEGPG CCCCCCCCCCCCCCC	37.25	24129315
32	Phosphorylation	SGGAQGGSIHSGRIA CCCCCCCCCCCCCEE	24.77	23186163
37	Methylation	GGSIHSGRIAAVHNV CCCCCCCCEEEEECC	20.56	80701453
116	Ubiquitination	QRETIPAKLVQSTLS HHCCCCHHHHHHHHH	43.78	33845483
120	Phosphorylation	IPAKLVQSTLSDLRV CCHHHHHHHHHHHHH	24.68	20068231
121	Phosphorylation	PAKLVQSTLSDLRVY CHHHHHHHHHHHHHH	17.12	20068231
123	Phosphorylation	KLVQSTLSDLRVYLG HHHHHHHHHHHHHHC	34.39	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRXN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRXN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRXN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	22939629
TTC1_HUMAN	TTC1	physical	22939629
ZRAB2_HUMAN	ZRANB2	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
TPM1_HUMAN	TPM1	physical	22939629
THADA_HUMAN	THADA	physical	22939629
UBP34_HUMAN	USP34	physical	22939629
TACC3_HUMAN	TACC3	physical	22939629
TPM4_HUMAN	TPM4	physical	22939629
STAT6_HUMAN	STAT6	physical	22939629
UBE2B_HUMAN	UBE2B	physical	22939629
TTC9C_HUMAN	TTC9C	physical	22939629
VATB2_HUMAN	ATP6V1B2	physical	22939629
TPM2_HUMAN	TPM2	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
TLE3_HUMAN	TLE3	physical	22939629
TTL12_HUMAN	TTLL12	physical	22939629
ST1A1_HUMAN	SULT1A1	physical	22939629
TRIP6_HUMAN	TRIP6	physical	22939629
SSA27_HUMAN	SSSCA1	physical	22939629
UBXN7_HUMAN	UBXN7	physical	22939629
TBB6_HUMAN	TUBB6	physical	22939629
UNK_HUMAN	UNK	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
TM1L2_HUMAN	TOM1L2	physical	22939629
COF1_HUMAN	CFL1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.