ST1A1_HUMAN - dbPTM
ST1A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ST1A1_HUMAN
UniProt AC P50225
Protein Name Sulfotransferase 1A1
Gene Name SULT1A1
Organism Homo sapiens (Human).
Sequence Length 295
Subcellular Localization Cytoplasm.
Protein Description Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk..
Protein Sequence MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16UbiquitinationRPPLEYVKGVPLIKY
CCCCHHHCCCHHHHH		53.97-
33PhosphorylationEALGPLQSFQARPDD
HHHCCHHHHCCCCCC		27.3228857561
49PhosphorylationLISTYPKSGTTWVSQ
EEEECCCCCCCHHHH		36.55-
69UbiquitinationYQGGDLEKCHRAPIF
HHCCCHHHHCCCCEE		42.51-
85UbiquitinationRVPFLEFKAPGIPSG
ECCEEEEECCCCCCC		44.2721906983
91PhosphorylationFKAPGIPSGMETLKD
EECCCCCCCHHHHCC		49.1828857561
95PhosphorylationGIPSGMETLKDTPAP
CCCCCHHHHCCCCCC		30.1628857561
97UbiquitinationPSGMETLKDTPAPRL
CCCHHHHCCCCCCHH		67.9621906983
99PhosphorylationGMETLKDTPAPRLLK
CHHHHCCCCCCHHHH		21.5528857561
106AcetylationTPAPRLLKTHLPLAL
CCCCHHHHHCCCHHH		38.1919608861
106UbiquitinationTPAPRLLKTHLPLAL
CCCCHHHHHCCCHHH		38.1921890473
107PhosphorylationPAPRLLKTHLPLALL
CCCHHHHHCCCHHHC		28.72-
117PhosphorylationPLALLPQTLLDQKVK
CHHHCCHHHHCCCCE		27.61-
119UbiquitinationALLPQTLLDQKVKVV
HHCCHHHHCCCCEEE		8.1222817900
122UbiquitinationPQTLLDQKVKVVYVA
CHHHHCCCCEEEEEE		43.632190698
123UbiquitinationQTLLDQKVKVVYVAR
HHHHCCCCEEEEEEC		4.7722817900
124UbiquitinationTLLDQKVKVVYVARN
HHHCCCCEEEEEECC		32.7833845483
138PhosphorylationNAKDVAVSYYHFYHM
CCHHHHHHHHEHHHH		15.3828258704
140PhosphorylationKDVAVSYYHFYHMAK
HHHHHHHHEHHHHCC		4.30-
176UbiquitinationYGSWYQHVQEWWELS
CCHHHHHHHHHHHHH		3.0521890473
188UbiquitinationELSRTHPVLYLFYED
HHHCCCCEEHHCHHH		4.2121890473
193PhosphorylationHPVLYLFYEDMKENP
CCEEHHCHHHHHHCH		14.3921253578
197UbiquitinationYLFYEDMKENPKREI
HHCHHHHHHCHHHHH		67.6621890473
201UbiquitinationEDMKENPKREIQKIL
HHHHHCHHHHHHHHH		74.3922817900
205UbiquitinationENPKREIQKILEFVG
HCHHHHHHHHHHHHH		23.2232015554
213UbiquitinationKILEFVGRSLPEETV
HHHHHHHCCCCHHHH		29.7121890473
230AcetylationVVQHTSFKEMKKNPM
EEECCCHHHHHCCCC		57.5810652617
241PhosphorylationKNPMTNYTTVPQEFM
CCCCCCCCCCCHHHH		24.3229116813
242PhosphorylationNPMTNYTTVPQEFMD
CCCCCCCCCCHHHHH		21.5929116813
251PhosphorylationPQEFMDHSISPFMRK
CHHHHHCCCCHHHHC		22.0929116813
253PhosphorylationEFMDHSISPFMRKGM
HHHHCCCCHHHHCCC		18.3325159151
283UbiquitinationFDADYAEKMAGCSLS
CCHHHHHHHCCCCEE		26.3632015554
288UbiquitinationAEKMAGCSLSFRSEL
HHHHCCCCEEECCCC		26.5722817900
288PhosphorylationAEKMAGCSLSFRSEL
HHHHCCCCEEECCCC		26.5720873877
290PhosphorylationKMAGCSLSFRSEL--
HHCCCCEEECCCC--		11.4320873877
292UbiquitinationAGCSLSFRSEL----
CCCCEEECCCC----		26.3322817900
293PhosphorylationGCSLSFRSEL-----
CCCEEECCCC-----		41.0426434776
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ST1A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ST1A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ST1A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YAP1_HUMANYAP1physical
22939629
STMN2_HUMANSTMN2physical
22939629
TPM1_HUMANTPM1physical
22939629
UBE2B_HUMANUBE2Bphysical
22939629
TRIP6_HUMANTRIP6physical
22939629
VATB2_HUMANATP6V1B2physical
22939629
TTC1_HUMANTTC1physical
22939629
UBP34_HUMANUSP34physical
22939629
CHIP_HUMANSTUB1physical
22939629
THADA_HUMANTHADAphysical
22939629
TM1L2_HUMANTOM1L2physical
22939629
STAM1_HUMANSTAMphysical
22939629
UBE2A_HUMANUBE2Aphysical
22939629
TPM4_HUMANTPM4physical
22939629
TBB6_HUMANTUBB6physical
22939629
UBXN7_HUMANUBXN7physical
22939629
ANCHR_HUMANZFYVE19physical
22939629
ZPR1_HUMANZPR1physical
22939629
UBE4B_HUMANUBE4Bphysical
22939629
UBXN1_HUMANUBXN1physical
22939629
TPM2_HUMANTPM2physical
22939629
SUMO1_HUMANSUMO1physical
22939629
UCHL3_HUMANUCHL3physical
22939629
TMOD3_HUMANTMOD3physical
22939629
ZRAB2_HUMANZRANB2physical
22939629
SYUG_HUMANSNCGphysical
22939629
TEBP_HUMANPTGES3physical
22939629
ST2B1_HUMANSULT2B1physical
25416956
ST1A3_HUMANSULT1A3physical
26186194
ST1A4_HUMANSULT1A3physical
26186194
ST1A2_HUMANSULT1A2physical
26186194
ST1A2_HUMANSULT1A2physical
28514442
ST1A3_HUMANSULT1A3physical
28514442
ST1A4_HUMANSULT1A3physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00316Acetaminophen
DB00675Tamoxifen
Regulatory Network of ST1A1_HUMAN

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Related Literatures of Post-Translational Modification

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