UBE2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2A_HUMAN
• UniProt AC: P49459
• Protein Name: Ubiquitin-conjugating enzyme E2 A
• Gene Name: UBE2A
• Organism: Homo sapiens (Human).
• Sequence Length: 152
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA..
• Protein Sequence: MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Acetylation	FTEEYPNKPPTVRFV ECCCCCCCCCEEEEE	48.12	23954790
66	Ubiquitination	FTEEYPNKPPTVRFV ECCCCCCCCCEEEEE	48.12	21906983
74	Phosphorylation	PPTVRFVSKMFHPNV CCEEEEEHHCCCCCE	18.72	22210691
75	Ubiquitination	PTVRFVSKMFHPNVY CEEEEEHHCCCCCEE	40.04	-
82	Phosphorylation	KMFHPNVYADGSICL HCCCCCEECCCCCHH	12.96	26074081
86	Phosphorylation	PNVYADGSICLDILQ CCEECCCCCHHHHHC	15.63	26074081
120	Phosphorylation	LDEPNPNSPANSQAA HCCCCCCCCCHHHHH	27.01	11953320
124	Phosphorylation	NPNSPANSQAAQLYQ CCCCCCHHHHHHHHH	24.25	20068231
130	Phosphorylation	NSQAAQLYQENKREY HHHHHHHHHHHHHHH	11.16	20068231
142	Phosphorylation	REYEKRVSAIVEQSW HHHHHHHHHHHHHHH	19.13	22617229
148	Phosphorylation	VSAIVEQSWRDC--- HHHHHHHHHCCC---	15.57	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
120	S	Phosphorylation	Kinase	CDK1	P06493	PSP
120	S	Phosphorylation	Kinase	CDK2	P24941	PSP
120	S	Phosphorylation	Kinase	CDK9	P50750	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
120	S	Phosphorylation	Phosphorylation at Ser-120 by CDK9 increases activity towards histone H2B.	22592529

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	12640129
MDM2_HUMAN	MDM2	physical	12640129
CDN2A_HUMAN	CDKN2A	physical	12640129
ARF_HUMAN	CDKN2A	physical	12640129
RAD18_HUMAN	RAD18	physical	19549727
UBR3_HUMAN	UBR3	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
UBR3_HUMAN	UBR3	physical	21816346
DPYL1_HUMAN	CRMP1	physical	21900206
UBR1_HUMAN	UBR1	physical	21900206
BRE1A_HUMAN	RNF20	physical	21443952
RAD18_HUMAN	RAD18	physical	15359278
CDK9_HUMAN	CDK9	physical	22592529
H2B2E_HUMAN	HIST2H2BE	physical	22592529
RAD18_HUMAN	RAD18	physical	21967848
RAD18_HUMAN	RAD18	physical	15509568
P53_HUMAN	TP53	physical	22083959
MDM2_HUMAN	MDM2	physical	22083959
PCNA_HUMAN	PCNA	physical	17108083
RL40_HUMAN	UBA52	physical	22939629
UBQL1_HUMAN	UBQLN1	physical	22939629
UBQL4_HUMAN	UBQLN4	physical	22939629
UNK_HUMAN	UNK	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
UBQL2_HUMAN	UBQLN2	physical	22939629
XPO2_HUMAN	CSE1L	physical	22939629
ZBED1_HUMAN	ZBED1	physical	22939629
UCHL3_HUMAN	UCHL3	physical	22939629
ZWILC_HUMAN	ZWILCH	physical	22939629
ANCHR_HUMAN	ZFYVE19	physical	22939629
VIGLN_HUMAN	HDLBP	physical	22939629
XRN2_HUMAN	XRN2	physical	22939629
UBP1_HUMAN	USP1	physical	22939629
UBE2A_HUMAN	UBE2A	physical	20061386
RAD18_HUMAN	RAD18	physical	25023518
CBX5_HUMAN	CBX5	physical	25384975
UBE2B_HUMAN	UBE2B	physical	25582440
UBC_HUMAN	UBC	physical	25582440
RAD18_HUMAN	RAD18	physical	25582440
SLF1_HUMAN	ANKRD32	physical	25582440
BRE1A_HUMAN	RNF20	physical	25582440
BRE1B_HUMAN	RNF40	physical	25582440
WAC_HUMAN	WAC	physical	25582440
UBR1_HUMAN	UBR1	physical	25582440
UBR2_HUMAN	UBR2	physical	25582440
UBR3_HUMAN	UBR3	physical	25582440
KCMF1_HUMAN	KCMF1	physical	25582440
UBR4_HUMAN	UBR4	physical	25582440
NIPS1_HUMAN	NIPSNAP1	physical	25582440
NPS3A_HUMAN	NIPSNAP3A	physical	25582440
ABHDA_HUMAN	ABHD10	physical	25582440
SSBP_HUMAN	SSBP1	physical	25582440
SYSM_HUMAN	SARS2	physical	25582440
ACOT9_HUMAN	ACOT9	physical	25582440
UBE2A_HUMAN	UBE2A	physical	25582440
KIF2C_HUMAN	KIF2C	physical	26344197
PRP19_HUMAN	PRPF19	physical	26344197
RFA2_HUMAN	RPA2	physical	26344197
RFA3_HUMAN	RPA3	physical	26344197
UB2L3_HUMAN	UBE2L3	physical	26344197
UBXN1_HUMAN	UBXN1	physical	26344197
XIAP_HUMAN	XIAP	physical	26496610
CD59_HUMAN	CD59	physical	26496610
TAXB1_HUMAN	TAX1BP1	physical	26496610
ATX10_HUMAN	ATXN10	physical	26496610
FBXL6_HUMAN	FBXL6	physical	26496610
RAD18_HUMAN	RAD18	physical	26496610
Z512B_HUMAN	ZNF512B	physical	26496610
RETR3_HUMAN	FAM134C	physical	26496610
BRE1A_HUMAN	RNF20	physical	28031328
BRE1B_HUMAN	RNF40	physical	28031328
H2B2E_HUMAN	HIST2H2BE	physical	28031328
P53_HUMAN	TP53	physical	28031328
SPTN2_HUMAN	SPTBN2	physical	28031328
K2C6B_HUMAN	KRT6B	physical	28031328
K2C5_HUMAN	KRT5	physical	28031328
SFPQ_HUMAN	SFPQ	physical	28031328
K1C19_HUMAN	KRT19	physical	28031328
GSTP1_HUMAN	GSTP1	physical	28031328
H2B1D_HUMAN	HIST1H2BD	physical	28031328
H2B1C_HUMAN	HIST1H2BD	physical	28031328
LRC59_HUMAN	LRRC59	physical	28031328
OLA1_HUMAN	OLA1	physical	28031328
NPM3_HUMAN	NPM3	physical	28031328
GNAI3_HUMAN	GNAI3	physical	28031328
ROA2_HUMAN	HNRNPA2B1	physical	28031328
K1C14_HUMAN	KRT14	physical	28031328
RA1L2_HUMAN	HNRNPA1L2	physical	28031328
RL12_HUMAN	RPL12	physical	28031328
DSG2_HUMAN	DSG2	physical	28031328
SRP14_HUMAN	SRP14	physical	28031328
ELAV1_HUMAN	ELAVL1	physical	28031328
HNRPR_HUMAN	HNRNPR	physical	28031328
ARHG2_HUMAN	ARHGEF2	physical	28031328
2ABA_HUMAN	PPP2R2A	physical	28031328
RBBP4_HUMAN	RBBP4	physical	28031328
PLPL6_HUMAN	PNPLA6	physical	28031328
NONO_HUMAN	NONO	physical	28031328
HNRDL_HUMAN	HNRNPDL	physical	28031328
HNRL1_HUMAN	HNRNPUL1	physical	28031328
RIOK1_HUMAN	RIOK1	physical	28031328
SMHD1_HUMAN	SMCHD1	physical	28031328
HNRPC_HUMAN	HNRNPC	physical	28031328
TSR1_HUMAN	TSR1	physical	28031328
BUB3_HUMAN	BUB3	physical	28031328
KIF23_HUMAN	KIF23	physical	28031328
FA98A_HUMAN	FAM98A	physical	28031328
TPR_HUMAN	TPR	physical	28031328
RS23_HUMAN	RPS23	physical	28031328
IF5A1_HUMAN	EIF5A	physical	28031328
MRE11_HUMAN	MRE11A	physical	28031328
LG3BP_HUMAN	LGALS3BP	physical	28031328
IKBL1_HUMAN	NFKBIL1	physical	28031328
ZO2_HUMAN	TJP2	physical	28031328
QCR2_HUMAN	UQCRC2	physical	28031328
TCPW_HUMAN	CCT6B	physical	28031328
RS9_HUMAN	RPS9	physical	28031328
RSMB_HUMAN	SNRPB	physical	28031328
NUCL_HUMAN	NCL	physical	28031328
FLOT2_HUMAN	FLOT2	physical	28031328
CPNE2_HUMAN	CPNE2	physical	28031328
ATD3A_HUMAN	ATAD3A	physical	28031328
LBR_HUMAN	LBR	physical	28031328
U2AF2_HUMAN	U2AF2	physical	28031328
NISCH_HUMAN	NISCH	physical	28031328
CACO2_HUMAN	CALCOCO2	physical	28031328
F184B_HUMAN	FAM184B	physical	28031328
CPSF3_HUMAN	CPSF3	physical	28031328
CTNA2_HUMAN	CTNNA2	physical	28031328
TNIK_HUMAN	TNIK	physical	28031328
NAMPT_HUMAN	NAMPT	physical	28031328
SPB1_HUMAN	FTSJ3	physical	28031328
SYFB_HUMAN	FARSB	physical	28031328
RL35_HUMAN	RPL35	physical	28031328
CD59_HUMAN	CD59	physical	28031328
AAAS_HUMAN	AAAS	physical	28031328
SPTA1_HUMAN	SPTA1	physical	28031328
GCN1_HUMAN	GCN1L1	physical	28031328
ANXA2_HUMAN	ANXA2	physical	28031328
SON_HUMAN	SON	physical	28031328
EIF3D_HUMAN	EIF3D	physical	28031328
RN123_HUMAN	RNF123	physical	28031328
TITIN_HUMAN	TTN	physical	28031328
DOCK7_HUMAN	DOCK7	physical	28031328
PKN3_HUMAN	PKN3	physical	28031328
IF2P_HUMAN	EIF5B	physical	28031328
CLCN7_HUMAN	CLCN7	physical	28031328
TPM4_HUMAN	TPM4	physical	28031328
PLSI_HUMAN	PLS1	physical	28031328
MYL6B_HUMAN	MYL6B	physical	28031328
IF4A3_HUMAN	EIF4A3	physical	28031328
PUF60_HUMAN	PUF60	physical	28031328
CDK5_HUMAN	CDK5	physical	28031328
RL10A_HUMAN	RPL10A	physical	28031328
PLCD3_HUMAN	PLCD3	physical	28031328
RL23_HUMAN	RPL23	physical	28031328
CTNA1_HUMAN	CTNNA1	physical	28031328
DCTN1_HUMAN	DCTN1	physical	28031328
TR150_HUMAN	THRAP3	physical	28031328
BRD9_HUMAN	BRD9	physical	28031328
CSK21_HUMAN	CSNK2A1	physical	28031328
CN37_HUMAN	CNP	physical	28031328
HNRPD_HUMAN	HNRNPD	physical	28031328
YBOX1_HUMAN	YBX1	physical	28031328
PSMF1_HUMAN	PSMF1	physical	28031328
RS15A_HUMAN	RPS15A	physical	28031328
CD2AP_HUMAN	CD2AP	physical	28031328
ABCD3_HUMAN	ABCD3	physical	28031328
EIF3F_HUMAN	EIF3F	physical	28031328
PROF1_HUMAN	PFN1	physical	28031328
DNJA1_HUMAN	DNAJA1	physical	28031328
PSMD3_HUMAN	PSMD3	physical	28031328
SYLC_HUMAN	LARS	physical	28031328
EIF3C_HUMAN	EIF3C	physical	28031328
HNRPQ_HUMAN	SYNCRIP	physical	28031328
ANXA6_HUMAN	ANXA6	physical	28031328
AP1M1_HUMAN	AP1M1	physical	28031328
EMD_HUMAN	EMD	physical	28031328
TOM40_HUMAN	TOMM40	physical	28031328
TES_HUMAN	TES	physical	28031328
ONCO_HUMAN	OCM	physical	28031328
SRSF3_HUMAN	SRSF3	physical	28031328
NU133_HUMAN	NUP133	physical	28031328
RO60_HUMAN	TROVE2	physical	28031328
METK1_HUMAN	MAT1A	physical	28031328
TB10B_HUMAN	TBC1D10B	physical	28031328
CXA1_HUMAN	GJA1	physical	28031328
MERL_HUMAN	NF2	physical	28031328
BTAF1_HUMAN	BTAF1	physical	28031328
DHX15_HUMAN	DHX15	physical	28031328
PDC6I_HUMAN	PDCD6IP	physical	28031328
KEAP1_HUMAN	KEAP1	physical	28031328
CPVL_HUMAN	CPVL	physical	28031328
TCPZ_HUMAN	CCT6A	physical	28031328
DSRAD_HUMAN	ADAR	physical	28031328
THIL_HUMAN	ACAT1	physical	28031328
NSA2_HUMAN	NSA2	physical	28031328
OBSCN_HUMAN	OBSCN	physical	28031328

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300860: Mental retardation, X-linked, syndromic, Nascimento-type (MRXSN)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.