FA98A_HUMAN - dbPTM
FA98A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FA98A_HUMAN
UniProt AC Q8NCA5
Protein Name Protein FAM98A
Gene Name FAM98A
Organism Homo sapiens (Human).
Sequence Length 519
Subcellular Localization
Protein Description Positively stimulates PRMT1-induced protein arginine methylation. [PubMed: 28040436 Involved in skeletal homeostasis (By similarity Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity Promotes colorectal cancer cell malignancy]
Protein Sequence MECDLMETDILESLEDLGYKGPLLEDGALSQAVSAGASSPEFTKLCAWLVSELRVLCKLEENVQATNSPSEAEEFQLEVSGLLGEMNCPYLSLTSGDVTKRLLIQKNCLLLLTYLISELEAARMLCVNAPPKKAQEGGGSEVFQELKGICIALGMSKPPANITMFQFFSGIEKKKLKETLAKVPPNHVGKPLLKKPMGPAHWEKIEAINQAIANEYEVRRKLLIKRLDVTVQSFGWSDRAKSQTEKLAKVYQPKRSVLSPKTTISVAHLLAARQDLSKILRTSSGSIREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQDGPQQQTGGRGGGRGGYEHSSYGGRGGHEQGGGRGGRGGYDHGGRGGGRGNKHQGGWTDGGSGGGGGYQDGGYRDSGFQPGGYHGGHSSGGYQGGGYGGFQTSSSYTGSGYQGGGYQQDNRYQDGGHHGDRGGGRGGRGGRGGRGGRAGQGGGWGGRGSQNYHQGGQFEQHFQHGGYQYNHSGFGQGRHYTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMECDLMETDILESLE
CCCCCCCCHHHHHHH		17.8629759185
13PhosphorylationMETDILESLEDLGYK
CCCHHHHHHHHHCCC		33.3524043423
19PhosphorylationESLEDLGYKGPLLED
HHHHHHCCCCCCCCC		21.7729759185
44UbiquitinationASSPEFTKLCAWLVS
CCCHHHHHHHHHHHH		47.06-
133UbiquitinationCVNAPPKKAQEGGGS
HCCCCCHHHHCCCCH		62.16-
140PhosphorylationKAQEGGGSEVFQELK
HHHCCCCHHHHHHHH		33.58-
176UbiquitinationSGIEKKKLKETLAKV
CCCCHHHHHHHHHCC		9.23-
177AcetylationGIEKKKLKETLAKVP
CCCHHHHHHHHHCCC		58.497468635
182AcetylationKLKETLAKVPPNHVG
HHHHHHHCCCCCCCC		59.397468645
189UbiquitinationKVPPNHVGKPLLKKP
CCCCCCCCCCCCCCC		20.50-
190AcetylationVPPNHVGKPLLKKPM
CCCCCCCCCCCCCCC		31.2526051181
190MalonylationVPPNHVGKPLLKKPM
CCCCCCCCCCCCCCC		31.2526320211
215PhosphorylationINQAIANEYEVRRKL
HHHHHHHHHHHHHHH		33.77-
216PhosphorylationNQAIANEYEVRRKLL
HHHHHHHHHHHHHHH		21.38-
233PhosphorylationRLDVTVQSFGWSDRA
HCCEEEHHHCCCHHH		22.76-
237PhosphorylationTVQSFGWSDRAKSQT
EEHHHCCCHHHHHHH		20.00-
246AcetylationRAKSQTEKLAKVYQP
HHHHHHHHHHHHHCC		58.0725953088
248UbiquitinationKSQTEKLAKVYQPKR
HHHHHHHHHHHCCCC		15.44-
249MalonylationSQTEKLAKVYQPKRS
HHHHHHHHHHCCCCC		52.4926320211
249AcetylationSQTEKLAKVYQPKRS
HHHHHHHHHHCCCCC		52.4926051181
256PhosphorylationKVYQPKRSVLSPKTT
HHHCCCCCCCCCCHH		33.2723312004
258PhosphorylationYQPKRSVLSPKTTIS
HCCCCCCCCCCHHHH		8.3824719451
259PhosphorylationQPKRSVLSPKTTISV
CCCCCCCCCCHHHHH		23.3823312004
262PhosphorylationRSVLSPKTTISVAHL
CCCCCCCHHHHHHHH		32.5223312004
263PhosphorylationSVLSPKTTISVAHLL
CCCCCCHHHHHHHHH		19.8523312004
265PhosphorylationLSPKTTISVAHLLAA
CCCCHHHHHHHHHHH		15.9123312004
277PhosphorylationLAARQDLSKILRTSS
HHHHHCHHHHHHHCC		26.41-
282PhosphorylationDLSKILRTSSGSIRE
CHHHHHHHCCCCHHH		24.6529514088
283PhosphorylationLSKILRTSSGSIREK
HHHHHHHCCCCHHHH		26.6925159151
284PhosphorylationSKILRTSSGSIREKT
HHHHHHCCCCHHHHH		35.6323401153
286PhosphorylationILRTSSGSIREKTAC
HHHHCCCCHHHHHHH		22.0326074081
289UbiquitinationTSSGSIREKTACAIN
HCCCCHHHHHHHHHH		53.76-
296UbiquitinationEKTACAINKVLMGRV
HHHHHHHHHHHCCCC		15.17-
2962-HydroxyisobutyrylationEKTACAINKVLMGRV
HHHHHHHHHHHCCCC		15.17-
297UbiquitinationKTACAINKVLMGRVP
HHHHHHHHHHCCCCC		30.54-
297AcetylationKTACAINKVLMGRVP
HHHHHHHHHHCCCCC		30.5425953088
305MethylationVLMGRVPDRGGRPNE
HHCCCCCCCCCCCCC		60.03-
306MethylationLMGRVPDRGGRPNEI
HCCCCCCCCCCCCCC		43.31-
320SulfoxidationIEPPPPEMPPWQKRQ
CCCCCCCCCCCCCCC		6.2730846556
324UbiquitinationPPEMPPWQKRQDGPQ
CCCCCCCCCCCCCCC		36.5121890473
324UbiquitinationPPEMPPWQKRQDGPQ
CCCCCCCCCCCCCCC		36.51-
324UbiquitinationPPEMPPWQKRQDGPQ
CCCCCCCCCCCCCCC		36.5121890473
325AcetylationPEMPPWQKRQDGPQQ
CCCCCCCCCCCCCCC		48.4326051181
325UbiquitinationPEMPPWQKRQDGPQQ
CCCCCCCCCCCCCCC		48.4321890473
336MethylationGPQQQTGGRGGGRGG
CCCCCCCCCCCCCCC		28.57-
337MethylationPQQQTGGRGGGRGGY
CCCCCCCCCCCCCCC		41.76-
340MethylationQTGGRGGGRGGYEHS
CCCCCCCCCCCCCCC		28.08-
341MethylationTGGRGGGRGGYEHSS
CCCCCCCCCCCCCCC		38.34-
344PhosphorylationRGGGRGGYEHSSYGG
CCCCCCCCCCCCCCC		17.19-
347PhosphorylationGRGGYEHSSYGGRGG
CCCCCCCCCCCCCCC		17.20-
348PhosphorylationRGGYEHSSYGGRGGH
CCCCCCCCCCCCCCC		29.69-
349PhosphorylationGGYEHSSYGGRGGHE
CCCCCCCCCCCCCCC		26.98-
351MethylationYEHSSYGGRGGHEQG
CCCCCCCCCCCCCCC		19.48-
352MethylationEHSSYGGRGGHEQGG
CCCCCCCCCCCCCCC		43.48-
360MethylationGGHEQGGGRGGRGGY
CCCCCCCCCCCCCCC		31.70-
361MethylationGHEQGGGRGGRGGYD
CCCCCCCCCCCCCCC		47.90-
363MethylationEQGGGRGGRGGYDHG
CCCCCCCCCCCCCCC		24.57-
364MethylationQGGGRGGRGGYDHGG
CCCCCCCCCCCCCCC		37.88-
385PhosphorylationNKHQGGWTDGGSGGG
CCCCCCCCCCCCCCC		28.2127251275
388PhosphorylationQGGWTDGGSGGGGGY
CCCCCCCCCCCCCCC		26.4027251275
389PhosphorylationGGWTDGGSGGGGGYQ
CCCCCCCCCCCCCCC		39.5328985074
395PhosphorylationGSGGGGGYQDGGYRD
CCCCCCCCCCCCCCC		13.5028796482
400PhosphorylationGGYQDGGYRDSGFQP
CCCCCCCCCCCCCCC		19.4427251275
483MethylationGQGGGWGGRGSQNYH
CCCCCCCCCCCCCCC		25.02-
484MethylationQGGGWGGRGSQNYHQ
CCCCCCCCCCCCCCC		37.34-
509PhosphorylationGGYQYNHSGFGQGRH
CCCCCCCCCCCCCCC		31.98-
514MethylationNHSGFGQGRHYTS--
CCCCCCCCCCCCC--		20.79-
515MethylationHSGFGQGRHYTS---
CCCCCCCCCCCC---		16.26-
517PhosphorylationGFGQGRHYTS-----
CCCCCCCCCC-----		13.81-
518PhosphorylationFGQGRHYTS------
CCCCCCCCC------		23.1020736484
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FA98A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FA98A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FA98A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CN166_HUMANC14orf166physical
25416956
CN166_HUMANC14orf166physical
26344197
PFKAM_HUMANPFKMphysical
26344197
FBX31_HUMANFBXO31physical
28514442
N4BP2_HUMANN4BP2physical
28514442
BTBD1_HUMANBTBD1physical
28514442
SPAS2_HUMANSPATS2physical
28514442
SFPQ_HUMANSFPQphysical
28514442
HERC2_HUMANHERC2physical
28514442
NEUL4_HUMANNEURL4physical
28514442
ATX2_HUMANATXN2physical
28514442
CSN7A_HUMANCOPS7Aphysical
28514442
CSN7B_HUMANCOPS7Bphysical
28514442
NEUA_HUMANCMASphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FA98A_HUMAN

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Related Literatures of Post-Translational Modification

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