dbPTM

ATX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATX2_HUMAN
UniProt AC	Q99700
Protein Name	Ataxin-2
Gene Name	ATXN2
Organism	Homo sapiens (Human).
Sequence Length	1313
Subcellular Localization	Cytoplasm.
Protein Description	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane..
Protein Sequence	MRSAAAAPRSPAVATESRRFAAARWPGWRSLQRPARRSGRGGGGAAPGPYPSAAPPPPGPGPPPSRQSSPPSASDCFGSNGNGGGAFRPGSRRLLGLGGPPRPFVVLLLPLASPGAPPAAPTRASPLGARASPPRSGVSLARPAPGCPRPACEPVYGPLTMSLKPQQQQQQQQQQQQQQQQQQQQQQQPPPAAANVRKPGGSGLLASPAAAPSPSSSSVSSSSATAPSSVVAATSGGGRPGLGRGRNSNKGLPQSTISFDGIYANMRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSDFVVVQFKDMDSSYAKRDAFTDSAISAKVNGEHKEKDLEPWDAGELTANEELEALENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNSSEREGHSINTRENKYIPPGQRNREVISWGSGRQNSPRMGQPGSGSMPSRSTSHTSDFNPNSGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPNSLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQNSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPAGNKENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNREGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTSSPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAVPNMPQQRQDQHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPAAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MRSAAAAPR ------CCCCCCCCC	46.43	-
3	Phosphorylation	-----MRSAAAAPRS -----CCCCCCCCCC	33.83	21964256
9	Methylation	RSAAAAPRSPAVATE CCCCCCCCCCCCCCC	51.01	-
40	Methylation	RPARRSGRGGGGAAP CCHHHCCCCCCCCCC	41.66	-
113	Phosphorylation	VLLLPLASPGAPPAA EEEEECCCCCCCCCC	31.39	25332170
122	Phosphorylation	GAPPAAPTRASPLGA CCCCCCCCCCCCCCC	33.85	25332170
139	Phosphorylation	SPPRSGVSLARPAPG CCCCCCCCCCCCCCC	21.60	26699800
202	Phosphorylation	NVRKPGGSGLLASPA CCCCCCCCCCCCCCC	31.98	24275569
207	Phosphorylation	GGSGLLASPAAAPSP CCCCCCCCCCCCCCC	18.29	24275569
213	O-linked_Glycosylation	ASPAAAPSPSSSSVS CCCCCCCCCCCCCCC	32.46	30059200
213	Phosphorylation	ASPAAAPSPSSSSVS CCCCCCCCCCCCCCC	32.46	26055452
215	Phosphorylation	PAAAPSPSSSSVSSS CCCCCCCCCCCCCCC	47.38	24275569
216	Phosphorylation	AAAPSPSSSSVSSSS CCCCCCCCCCCCCCC	29.98	24275569
217	Phosphorylation	AAPSPSSSSVSSSSA CCCCCCCCCCCCCCC	38.81	24275569
218	Phosphorylation	APSPSSSSVSSSSAT CCCCCCCCCCCCCCC	28.15	27690223
220	Phosphorylation	SPSSSSVSSSSATAP CCCCCCCCCCCCCCC	26.84	27690223
221	Phosphorylation	PSSSSVSSSSATAPS CCCCCCCCCCCCCCC	26.59	27690223
222	Phosphorylation	SSSSVSSSSATAPSS CCCCCCCCCCCCCCC	19.24	27690223
223	Phosphorylation	SSSVSSSSATAPSSV CCCCCCCCCCCCCCE	31.42	27690223
225	Phosphorylation	SVSSSSATAPSSVVA CCCCCCCCCCCCEEE	40.84	27690223
228	Phosphorylation	SSSATAPSSVVAATS CCCCCCCCCEEECCC	33.04	27690223
229	Phosphorylation	SSATAPSSVVAATSG CCCCCCCCEEECCCC	21.39	27690223
235	Phosphorylation	SSVVAATSGGGRPGL CCEEECCCCCCCCCC	30.62	24275569
244	Methylation	GGRPGLGRGRNSNKG CCCCCCCCCCCCCCC	46.04	-
246	Methylation	RPGLGRGRNSNKGLP CCCCCCCCCCCCCCC	41.88	-
248	Phosphorylation	GLGRGRNSNKGLPQS CCCCCCCCCCCCCCC	38.26	20068231
255	Phosphorylation	SNKGLPQSTISFDGI CCCCCCCCCEECCHH	26.26	20068231
256	Phosphorylation	NKGLPQSTISFDGIY CCCCCCCCEECCHHH	18.52	20068231
258	Phosphorylation	GLPQSTISFDGIYAN CCCCCCEECCHHHHC	19.85	20068231
263	Phosphorylation	TISFDGIYANMRMVH CEECCHHHHCCCHHH	9.46	20068231
273	Phosphorylation	MRMVHILTSVVGSKC CCHHHHHHHHHCCCE	20.90	20068231
274	Phosphorylation	RMVHILTSVVGSKCE CHHHHHHHHHCCCEE	16.03	20068231
278	Phosphorylation	ILTSVVGSKCEVQVK HHHHHHCCCEEEEEE	23.63	20068231
290	Phosphorylation	QVKNGGIYEGVFKTY EEECCCEEEEEEECC	15.20	25159151
297	Phosphorylation	YEGVFKTYSPKCDLV EEEEEECCCCCCCEE	24.46	22817900
298	Phosphorylation	EGVFKTYSPKCDLVL EEEEECCCCCCCEEE	24.10	24719451
300	Acetylation	VFKTYSPKCDLVLDA EEECCCCCCCEEEEE	34.15	26051181
300	Ubiquitination	VFKTYSPKCDLVLDA EEECCCCCCCEEEEE	34.15	-
301	S-nitrosocysteine	FKTYSPKCDLVLDAA EECCCCCCCEEEEEH	5.77	-
301	S-nitrosylation	FKTYSPKCDLVLDAA EECCCCCCCEEEEEH	5.77	19483679
311	Ubiquitination	VLDAAHEKSTESSSG EEEEHHHHHCCCCCC	53.46	-
327	Phosphorylation	KREEIMESILFKCSD CHHHHHHHHHHHHCC	13.76	20068231
345	Phosphorylation	VQFKDMDSSYAKRDA EEEECCCCHHHCCCC	20.72	30576142
347	Phosphorylation	FKDMDSSYAKRDAFT EECCCCHHHCCCCCC	21.79	-
349	2-Hydroxyisobutyrylation	DMDSSYAKRDAFTDS CCCCHHHCCCCCCHH	42.45	-
349	Ubiquitination	DMDSSYAKRDAFTDS CCCCHHHCCCCCCHH	42.45	2190698
349 (in isoform 1)	Ubiquitination	-	42.45	21906983
349 (in isoform 2)	Ubiquitination	-	42.45	21906983
349 (in isoform 4)	Ubiquitination	-	42.45	21906983
356	Phosphorylation	KRDAFTDSAISAKVN CCCCCCHHHHHHHCC	25.17	25159151
361	Ubiquitination	TDSAISAKVNGEHKE CHHHHHHHCCCCCCC	29.46	-
393	Phosphorylation	EALENDVSNGWDPND HHHHHHHCCCCCHHH	32.27	20068231
413	Phosphorylation	EENYGVVSTYDSSLS HHHCEEEEEECCCCC	20.88	27251275
414	Phosphorylation	ENYGVVSTYDSSLSS HHCEEEEEECCCCCE	21.53	27251275
415	Phosphorylation	NYGVVSTYDSSLSSY HCEEEEEECCCCCEE	13.30	27251275
417	Phosphorylation	GVVSTYDSSLSSYTV EEEEEECCCCCEEEE	23.82	27251275
418	Phosphorylation	VVSTYDSSLSSYTVP EEEEECCCCCEEEEE	29.40	27251275
431	Phosphorylation	VPLERDNSEEFLKRE EECCCCCCHHHHHHH	42.67	25159151
436	Sumoylation	DNSEEFLKREARANQ CCCHHHHHHHHHHHH	54.21	-
436	Sumoylation	DNSEEFLKREARANQ CCCHHHHHHHHHHHH	54.21	17000644
436	Ubiquitination	DNSEEFLKREARANQ CCCHHHHHHHHHHHH	54.21	-
450	Phosphorylation	QLAEEIESSAQYKAR HHHHHHHHHHHHHHH	36.31	28555341
451	Phosphorylation	LAEEIESSAQYKARV HHHHHHHHHHHHHHH	13.45	28555341
454	Phosphorylation	EIESSAQYKARVALE HHHHHHHHHHHHHHC	13.31	29978859
455	Ubiquitination	IESSAQYKARVALEN HHHHHHHHHHHHHCC	20.03	-
465	Methylation	VALENDDRSEEEKYT HHHCCCCCCHHHHHH	49.16	-
465	Phosphorylation	VALENDDRSEEEKYT HHHCCCCCCHHHHHH	49.16	18669648
466	Phosphorylation	ALENDDRSEEEKYTA HHCCCCCCHHHHHHH	57.25	30266825
470	Acetylation	DDRSEEEKYTAVQRN CCCCHHHHHHHHHCC	51.70	26051181
470	Ubiquitination	DDRSEEEKYTAVQRN CCCCHHHHHHHHHCC	51.70	-
471	Phosphorylation	DRSEEEKYTAVQRNS CCCHHHHHHHHHCCC	11.83	23927012
472	Phosphorylation	RSEEEKYTAVQRNSS CCHHHHHHHHHCCCC	31.27	30266825
477	Phosphorylation	KYTAVQRNSSEREGH HHHHHHCCCCCCCCC	32.56	18669648
478	Phosphorylation	YTAVQRNSSEREGHS HHHHHCCCCCCCCCC	35.45	25159151
479	Phosphorylation	TAVQRNSSEREGHSI HHHHCCCCCCCCCCC	44.19	23401153
485	Phosphorylation	SSEREGHSINTRENK CCCCCCCCCCCCCCC	28.52	23186163
505	Phosphorylation	QRNREVISWGSGRQN CCCCCEEECCCCCCC	30.47	20873877
508	Phosphorylation	REVISWGSGRQNSPR CCEEECCCCCCCCCC	25.25	23401153
510	Methylation	VISWGSGRQNSPRMG EEECCCCCCCCCCCC	33.92	-
513	Phosphorylation	WGSGRQNSPRMGQPG CCCCCCCCCCCCCCC	12.92	20068231
515	Methylation	SGRQNSPRMGQPGSG CCCCCCCCCCCCCCC	41.50	-
521	Phosphorylation	PRMGQPGSGSMPSRS CCCCCCCCCCCCCCC	34.08	25159151
523	Phosphorylation	MGQPGSGSMPSRSTS CCCCCCCCCCCCCCC	29.26	22199227
526	Phosphorylation	PGSGSMPSRSTSHTS CCCCCCCCCCCCCCC	30.16	20068231
528	O-linked_Glycosylation	SGSMPSRSTSHTSDF CCCCCCCCCCCCCCC	38.30	30059200
528	Phosphorylation	SGSMPSRSTSHTSDF CCCCCCCCCCCCCCC	38.30	25690035
529	O-linked_Glycosylation	GSMPSRSTSHTSDFN CCCCCCCCCCCCCCC	24.34	30059200
529	Phosphorylation	GSMPSRSTSHTSDFN CCCCCCCCCCCCCCC	24.34	21712546
530	Phosphorylation	SMPSRSTSHTSDFNP CCCCCCCCCCCCCCC	26.47	21712546
532	Phosphorylation	PSRSTSHTSDFNPNS CCCCCCCCCCCCCCC	29.74	28450419
533	O-linked_Glycosylation	SRSTSHTSDFNPNSG CCCCCCCCCCCCCCC	34.48	30059200
533	Phosphorylation	SRSTSHTSDFNPNSG CCCCCCCCCCCCCCC	34.48	25394399
539	Phosphorylation	TSDFNPNSGSDQRVV CCCCCCCCCCCCCEE	40.71	28555341
541	O-linked_Glycosylation	DFNPNSGSDQRVVNG CCCCCCCCCCCEECC	30.32	30059200
553	Phosphorylation	VNGGVPWPSPCPSPS ECCCCCCCCCCCCCC	23.48	18669648
554	Phosphorylation	NGGVPWPSPCPSPSS CCCCCCCCCCCCCCC	34.95	26055452
557	Phosphorylation	VPWPSPCPSPSSRPP CCCCCCCCCCCCCCC	53.29	18669648
558	Phosphorylation	PWPSPCPSPSSRPPS CCCCCCCCCCCCCCH	44.10	26055452
560	Phosphorylation	PSPCPSPSSRPPSRY CCCCCCCCCCCCHHC	43.23	28450419
561	Phosphorylation	SPCPSPSSRPPSRYQ CCCCCCCCCCCHHCC	52.79	30175587
565	Phosphorylation	SPSSRPPSRYQSGPN CCCCCCCHHCCCCCC	46.43	28450419
569	Phosphorylation	RPPSRYQSGPNSLPP CCCHHCCCCCCCCCC	47.48	27251275
573	Phosphorylation	RYQSGPNSLPPRAAT HCCCCCCCCCCCCCC	45.44	24719451
580	Phosphorylation	SLPPRAATPTRPPSR CCCCCCCCCCCCCCC	24.98	29255136
582	Phosphorylation	PPRAATPTRPPSRPP CCCCCCCCCCCCCCC	51.99	29255136
586	Phosphorylation	ATPTRPPSRPPSRPS CCCCCCCCCCCCCCC	61.16	29255136
590	Phosphorylation	RPPSRPPSRPSRPPS CCCCCCCCCCCCCCC	60.55	22210691
593	Phosphorylation	SRPPSRPSRPPSHPS CCCCCCCCCCCCCCC	57.20	29255136
597	Phosphorylation	SRPSRPPSHPSAHGS CCCCCCCCCCCCCCC	51.19	29255136
600	Phosphorylation	SRPPSHPSAHGSPAP CCCCCCCCCCCCCCC	27.72	29255136
604	Phosphorylation	SHPSAHGSPAPVSTM CCCCCCCCCCCCCCC	14.18	30576142
609	Phosphorylation	HGSPAPVSTMPKRMS CCCCCCCCCCCCCCC	20.23	29255136
610	Phosphorylation	GSPAPVSTMPKRMSS CCCCCCCCCCCCCCC	37.41	30576142
616	Phosphorylation	STMPKRMSSEGPPRM CCCCCCCCCCCCCCC	29.30	29255136
617	Phosphorylation	TMPKRMSSEGPPRMS CCCCCCCCCCCCCCC	36.91	29255136
622	Methylation	MSSEGPPRMSPKAQR CCCCCCCCCCHHHHC	41.15	-
624	Phosphorylation	SEGPPRMSPKAQRHP CCCCCCCCHHHHCCC	25.24	20201521
635	Methylation	QRHPRNHRVSAGRGS HCCCCCCCCCCCCCC	27.86	-
637	Phosphorylation	HPRNHRVSAGRGSIS CCCCCCCCCCCCCHH	25.59	20068231
640	Asymmetric dimethylarginine	NHRVSAGRGSISSGL CCCCCCCCCCHHHCC	35.09	-
640	Methylation	NHRVSAGRGSISSGL CCCCCCCCCCHHHCC	35.09	24129315
642	Phosphorylation	RVSAGRGSISSGLEF CCCCCCCCHHHCCCC	20.24	26055452
644	Phosphorylation	SAGRGSISSGLEFVS CCCCCCHHHCCCCHH	21.76	29978859
645	Phosphorylation	AGRGSISSGLEFVSH CCCCCHHHCCCCHHC	45.81	29978859
651	Phosphorylation	SSGLEFVSHNPPSEA HHCCCCHHCCCCHHC	23.91	29978859
656	Phosphorylation	FVSHNPPSEAATPPV CHHCCCCHHCCCCCC	40.92	27732954
660	Phosphorylation	NPPSEAATPPVARTS CCCHHCCCCCCEEEC	34.86	28985074
665	Methylation	AATPPVARTSPSGGT CCCCCCEEECCCCCC	35.65	-
665	Phosphorylation	AATPPVARTSPSGGT CCCCCCEEECCCCCC	35.65	18669648
666	O-linked_Glycosylation	ATPPVARTSPSGGTW CCCCCEEECCCCCCH	34.94	30059200
666	Phosphorylation	ATPPVARTSPSGGTW CCCCCEEECCCCCCH	34.94	23927012
667	Phosphorylation	TPPVARTSPSGGTWS CCCCEEECCCCCCHH	16.12	25159151
669	Phosphorylation	PVARTSPSGGTWSSV CCEEECCCCCCHHHH	50.01	23927012
671	Phosphorylation	ARTSPSGGTWSSVVS EEECCCCCCHHHHHC	28.48	18669648
672	Phosphorylation	RTSPSGGTWSSVVSG EECCCCCCHHHHHCC	26.21	30266825
674	Phosphorylation	SPSGGTWSSVVSGVP CCCCCCHHHHHCCCC	17.06	30266825
675	Phosphorylation	PSGGTWSSVVSGVPR CCCCCHHHHHCCCCC	20.35	23927012
678	Phosphorylation	GTWSSVVSGVPRLSP CCHHHHHCCCCCCCC	31.73	23927012
683	Phosphorylation	VVSGVPRLSPKTHRP HHCCCCCCCCCCCCC	9.34	18669648
684	Phosphorylation	VSGVPRLSPKTHRPR HCCCCCCCCCCCCCC	26.15	25159151
687	Phosphorylation	VPRLSPKTHRPRSPR CCCCCCCCCCCCCCC	26.88	27174698
692	Phosphorylation	PKTHRPRSPRQNSIG CCCCCCCCCCCCCCC	27.41	20068231
697	Phosphorylation	PRSPRQNSIGNTPSG CCCCCCCCCCCCCCC	24.43	22199227
701	Phosphorylation	RQNSIGNTPSGPVLA CCCCCCCCCCCCCCC	17.39	22199227
703	Phosphorylation	NSIGNTPSGPVLASP CCCCCCCCCCCCCCC	54.40	22199227
709	Phosphorylation	PSGPVLASPQAGIIP CCCCCCCCCCCCCCC	17.24	22199227
717	Phosphorylation	PQAGIIPTEAVAMPI CCCCCCCCCHHCCCC	26.60	28450419
727	Phosphorylation	VAMPIPAASPTPASP HCCCCCCCCCCCCCC	15.64	18669648
728	Phosphorylation	AMPIPAASPTPASPA CCCCCCCCCCCCCCC	31.26	30175587
729	Phosphorylation	MPIPAASPTPASPAS CCCCCCCCCCCCCCC	37.36	18669648
730	Phosphorylation	PIPAASPTPASPASN CCCCCCCCCCCCCCC	29.05	28102081
733	Phosphorylation	AASPTPASPASNRAV CCCCCCCCCCCCCCC	23.39	28102081
736	Phosphorylation	PTPASPASNRAVTPS CCCCCCCCCCCCCCC	30.17	28102081
740	Phosphorylation	SPASNRAVTPSSEAK CCCCCCCCCCCHHHH	7.95	18669648
741	Phosphorylation	PASNRAVTPSSEAKD CCCCCCCCCCHHHHH	19.23	23401153
742	Phosphorylation	ASNRAVTPSSEAKDS CCCCCCCCCHHHHHH	29.29	18669648
743	Phosphorylation	SNRAVTPSSEAKDSR CCCCCCCCHHHHHHH	31.29	28176443
744	Phosphorylation	NRAVTPSSEAKDSRL CCCCCCCHHHHHHHH	42.66	25159151
749	Phosphorylation	PSSEAKDSRLQDQRQ CCHHHHHHHHHHHHH	33.90	28985074
758	Phosphorylation	LQDQRQNSPAGNKEN HHHHHHCCCCCCCCC	14.05	23401153
770	Phosphorylation	KENIKPNETSPSFSK CCCCCCCCCCCCHHH	60.22	17287340
771	Phosphorylation	ENIKPNETSPSFSKA CCCCCCCCCCCHHHH	53.21	29255136
772	Phosphorylation	NIKPNETSPSFSKAE CCCCCCCCCCHHHHH	16.62	29255136
774	Phosphorylation	KPNETSPSFSKAENK CCCCCCCCHHHHHHC	41.75	30266825
776	O-linked_Glycosylation	NETSPSFSKAENKGI CCCCCCHHHHHHCCC	34.98	30059200
776	Phosphorylation	NETSPSFSKAENKGI CCCCCCHHHHHHCCC	34.98	22167270
781	Ubiquitination	SFSKAENKGISPVVS CHHHHHHCCCCHHHH	49.48	-
783	Phosphorylation	SKAENKGISPVVSEH HHHHHCCCCHHHHHH	4.49	18220336
784	Phosphorylation	KAENKGISPVVSEHR HHHHCCCCHHHHHHH	21.95	29255136
788	Phosphorylation	KGISPVVSEHRKQID CCCCHHHHHHHHHHH	28.11	25159151
801	Sumoylation	IDDLKKFKNDFRLQP HHHHHHHCCCCCCCC	65.57	-
801	Sumoylation	IDDLKKFKNDFRLQP HHHHHHHCCCCCCCC	65.57	17000644
810	Phosphorylation	DFRLQPSSTSESMDQ CCCCCCCCCCHHHHH	42.51	23186163
811	Phosphorylation	FRLQPSSTSESMDQL CCCCCCCCCHHHHHH	40.63	23917254
812	Phosphorylation	RLQPSSTSESMDQLL CCCCCCCCHHHHHHH	29.62	23186163
814	Phosphorylation	QPSSTSESMDQLLNK CCCCCCHHHHHHHHH	27.68	23186163
815	Sulfoxidation	PSSTSESMDQLLNKN CCCCCHHHHHHHHHC	3.14	21406390
821	Ubiquitination	SMDQLLNKNREGEKS HHHHHHHHCCCCHHH	58.30	-
827	Phosphorylation	NKNREGEKSRDLIKD HHCCCCHHHHHHHHH	62.74	17287340
828	Phosphorylation	KNREGEKSRDLIKDK HCCCCHHHHHHHHHH	27.07	22817900
838	Phosphorylation	LIKDKIEPSAKDSFI HHHHHCCCCHHHHHC	42.96	17287340
839	Phosphorylation	IKDKIEPSAKDSFIE HHHHCCCCHHHHHCC	34.85	22817900
843	Phosphorylation	IEPSAKDSFIENSSS CCCCHHHHHCCCCCC	27.67	23927012
848	Phosphorylation	KDSFIENSSSNCTSG HHHHCCCCCCCCCCC	23.50	23401153
849	Phosphorylation	DSFIENSSSNCTSGS HHHCCCCCCCCCCCC	36.83	23401153
850	Phosphorylation	SFIENSSSNCTSGSS HHCCCCCCCCCCCCC	35.43	30278072
853	Phosphorylation	ENSSSNCTSGSSKPN CCCCCCCCCCCCCCC	40.13	30278072
854	Phosphorylation	NSSSNCTSGSSKPNS CCCCCCCCCCCCCCC	38.59	30278072
855	Phosphorylation	SSSNCTSGSSKPNSP CCCCCCCCCCCCCCC	20.13	18669648
856	Phosphorylation	SSNCTSGSSKPNSPS CCCCCCCCCCCCCCC	34.65	30278072
857	Phosphorylation	SNCTSGSSKPNSPSI CCCCCCCCCCCCCCC	56.51	25159151
860	Phosphorylation	TSGSSKPNSPSISPS CCCCCCCCCCCCCHH	71.00	18669648
861	Phosphorylation	SGSSKPNSPSISPSI CCCCCCCCCCCCHHH	28.66	25159151
862	Phosphorylation	GSSKPNSPSISPSIL CCCCCCCCCCCHHHH	42.18	18669648
863	Phosphorylation	SSKPNSPSISPSILS CCCCCCCCCCHHHHC	35.20	23927012
864	Phosphorylation	SKPNSPSISPSILSN CCCCCCCCCHHHHCC	8.79	18669648
865	Phosphorylation	KPNSPSISPSILSNT CCCCCCCCHHHHCCC	19.55	23927012
867	Phosphorylation	NSPSISPSILSNTEH CCCCCCHHHHCCCCC	29.39	30278072
870	Phosphorylation	SISPSILSNTEHKRG CCCHHHHCCCCCCCC	39.78	30278072
872	Phosphorylation	SPSILSNTEHKRGPE CHHHHCCCCCCCCCC	35.77	30278072
881	Phosphorylation	HKRGPEVTSQGVQTS CCCCCCCCCCCCCCC	17.42	23663014
882	Phosphorylation	KRGPEVTSQGVQTSS CCCCCCCCCCCCCCC	30.07	23663014
887	Phosphorylation	VTSQGVQTSSPACKQ CCCCCCCCCCHHHHH	28.85	30266825
888	Phosphorylation	TSQGVQTSSPACKQE CCCCCCCCCHHHHHC	19.75	23401153
889	Phosphorylation	SQGVQTSSPACKQEK CCCCCCCCHHHHHCC	21.65	19664994
893	Acetylation	QTSSPACKQEKDDKE CCCCHHHHHCCCCHH	64.69	26051181
893	Sumoylation	QTSSPACKQEKDDKE CCCCHHHHHCCCCHH	64.69	28112733
911	Ubiquitination	DAAEQVRKSTLNPNA HHHHHHHHHHCCCCC	49.27	-
913	Phosphorylation	AEQVRKSTLNPNAKE HHHHHHHHCCCCCHH	33.32	-
925	Phosphorylation	AKEFNPRSFSQPKPS CHHCCCCCCCCCCCC	30.43	26434776
927	Phosphorylation	EFNPRSFSQPKPSTT HCCCCCCCCCCCCCC	46.98	26074081
932	Phosphorylation	SFSQPKPSTTPTSPR CCCCCCCCCCCCCCC	51.55	26657352
933	Phosphorylation	FSQPKPSTTPTSPRP CCCCCCCCCCCCCCC	45.37	29255136
934	Phosphorylation	SQPKPSTTPTSPRPQ CCCCCCCCCCCCCCC	28.98	25849741
936	Phosphorylation	PKPSTTPTSPRPQAQ CCCCCCCCCCCCCCC	49.63	29255136
937	Phosphorylation	KPSTTPTSPRPQAQP CCCCCCCCCCCCCCC	21.81	29255136
945	Phosphorylation	PRPQAQPSPSMVGHQ CCCCCCCCCHHCCCC	19.95	26074081
947	Phosphorylation	PQAQPSPSMVGHQQP CCCCCCCHHCCCCCC	30.36	26074081
955	Phosphorylation	MVGHQQPTPVYTQPV HCCCCCCCCCCCCCC	22.50	26074081
958	Phosphorylation	HQQPTPVYTQPVCFA CCCCCCCCCCCCEEC	10.81	26074081
998	Methylation	VNQAKTYRAVPNMPQ CCCCCCEECCCCCCH	34.05	-
1030	Phosphorylation	AGPPIAATPPAYSTQ CCCCCCCCCCCCCCC	22.30	26074081
1105	Phosphorylation	HEQTHAMYACPKLPY CCCCCCCEECCCCCC	13.06	-
1204	Phosphorylation	GLAPTPPSMTPASNT CCCCCCCCCCCCCCC	36.17	26074081
1206	Phosphorylation	APTPPSMTPASNTQS CCCCCCCCCCCCCCC	21.75	26074081
1209	Phosphorylation	PPSMTPASNTQSPQN CCCCCCCCCCCCCCC	41.43	26074081
1211	Phosphorylation	SMTPASNTQSPQNSF CCCCCCCCCCCCCCC	28.12	26074081
1213	Phosphorylation	TPASNTQSPQNSFPA CCCCCCCCCCCCCCH	26.81	26074081
1217	Phosphorylation	NTQSPQNSFPAAQQT CCCCCCCCCCHHHEE	27.62	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATX2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCG1_HUMAN	CHGB	physical	16169070
EGFR_HUMAN	EGFR	physical	18602463
IDH3B_HUMAN	IDH3B	physical	16713569
NCOA4_HUMAN	NCOA4	physical	16713569
RPA12_HUMAN	ZNRD1	physical	16713569
ACTN1_HUMAN	ACTN1	physical	16713569
ACTN2_HUMAN	ACTN2	physical	16713569
KBP_HUMAN	KIAA1279	physical	16713569
SH3G3_HUMAN	SH3GL3	physical	16713569
TDRD7_HUMAN	TDRD7	physical	16713569
BAG6_HUMAN	BAG6	physical	16713569
SH3G2_HUMAN	SH3GL2	physical	16713569
SH3G3_HUMAN	SH3GL3	physical	16115810
SH3G2_HUMAN	SH3GL2	physical	16115810
GPKOW_HUMAN	GPKOW	physical	22939629
TCPE_HUMAN	CCT5	physical	22939629
PABP1_HUMAN	PABPC1	physical	15663938
SH3G3_HUMAN	SH3GL3	physical	18602463
SH3G2_HUMAN	SH3GL2	physical	18602463
LSM12_HUMAN	LSM12	physical	26344197
PABP1_HUMAN	PABPC1	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
183090	Spinocerebellar ataxia 2 (SCA2)
183090	Amyotrophic lateral sclerosis 13 (ALS13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATX2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-684 AND SER-749, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667; SER-857; SER-861;SER-863 AND SER-865, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466; SER-554; SER-558;SER-684; THR-741; SER-744; SER-849; SER-857; SER-861; SER-863; SER-888AND SER-889, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667 AND SER-784, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-772, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-771; SER-772; SER-828AND SER-839, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-771; SER-772 ANDSER-776, AND MASS SPECTROMETRY.	17924679 [Abstract]